RICHARD ZAGER

Summary

Affiliation: Fred Hutchinson Cancer Research Center
Country: USA

Publications

  1. ncbi Acute unilateral ischemic renal injury induces progressive renal inflammation, lipid accumulation, histone modification, and "end-stage" kidney disease
    Richard A Zager
    Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Rm D2 190, Seattle, WA 98109
    Am J Physiol Renal Physiol 301:F1334-45. 2011
  2. ncbi Levosimendan protects against experimental endotoxemic acute renal failure
    Richard A Zager
    Department of Medicine, University of Washington, Seattle, USA
    Am J Physiol Renal Physiol 290:F1453-62. 2006
  3. ncbi Acute nephrotoxic and obstructive injury primes the kidney to endotoxin-driven cytokine/chemokine production
    R A Zager
    Department of Medicine, University of Washington, Seattle, Washington, USA
    Kidney Int 69:1181-8. 2006
  4. ncbi Parenteral iron treatment induces MCP-1 accumulation in plasma, normal kidneys, and in experimental nephropathy
    Richard A Zager
    Department of Medicine, University of Washington, Seattle, Washington 98109, USA
    Kidney Int 68:1533-42. 2005
  5. ncbi Ischemic proximal tubular injury primes mice to endotoxin-induced TNF-alpha generation and systemic release
    R A Zager
    Department of Medicine, University of Washington, Seattle, 98109, USA
    Am J Physiol Renal Physiol 289:F289-97. 2005
  6. ncbi Renal tubular triglyercide accumulation following endotoxic, toxic, and ischemic injury
    Richard A Zager
    Department of Medicine, University of Washington, and Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Kidney Int 67:111-21. 2005
  7. ncbi Parenteral iron compounds sensitize mice to injury-initiated TNF-alpha mRNA production and TNF-alpha release
    Richard A Zager
    University of Washington, Seattle, Washington, USA
    Am J Physiol Renal Physiol 288:F290-7. 2005
  8. ncbi Parenteral iron nephrotoxicity: potential mechanisms and consequences
    Richard A Zager
    Department of Medicine, University of Washington, Seattle, Washington, USA
    Kidney Int 66:144-56. 2004
  9. ncbi Proximal tubular cytochrome c efflux: determinant, and potential marker, of mitochondrial injury
    Richard A Zager
    Department of Medicine, University of Washington, and Fred Hutchinson Cancer Research Center, Seattle, 98109, USA
    Kidney Int 65:2123-34. 2004
  10. ncbi Parenteral iron therapy exacerbates experimental sepsis
    Richard A Zager
    Department of Medicine, University of Washington, and the Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Kidney Int 65:2108-12. 2004

Research Grants

  1. ACUTE RENAL FAILURE--MECHANISMS AND ADAPTIVE RESPONSES
    RICHARD ZAGER; Fiscal Year: 2001
  2. ACUTE RENAL FAILURE--IMPACT OF FLUORINATED ANESTHETICS
    RICHARD ZAGER; Fiscal Year: 2001
  3. Iron Therapy in Renal Disease: Potential Toxicities
    RICHARD ZAGER; Fiscal Year: 2007
  4. Acute Renal Failure: Mechanisms and Adaptive Responses
    RICHARD ZAGER; Fiscal Year: 2007
  5. MECHANISMS IN MYOGLOBINURIC ACUTE RENAL FAILURE
    RICHARD ZAGER; Fiscal Year: 1993

Detail Information

Publications60

  1. ncbi Acute unilateral ischemic renal injury induces progressive renal inflammation, lipid accumulation, histone modification, and "end-stage" kidney disease
    Richard A Zager
    Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Rm D2 190, Seattle, WA 98109
    Am J Physiol Renal Physiol 301:F1334-45. 2011
    ....
  2. ncbi Levosimendan protects against experimental endotoxemic acute renal failure
    Richard A Zager
    Department of Medicine, University of Washington, Seattle, USA
    Am J Physiol Renal Physiol 290:F1453-62. 2006
    ..This suggests that LS, and other K(ATP) channel agonists, have a margin of safety if employed in situations (sepsis syndrome, heart failure) in which severe renal vasoconstriction might lead to ischemic ARF...
  3. ncbi Acute nephrotoxic and obstructive injury primes the kidney to endotoxin-driven cytokine/chemokine production
    R A Zager
    Department of Medicine, University of Washington, Seattle, Washington, USA
    Kidney Int 69:1181-8. 2006
    ....
  4. ncbi Parenteral iron treatment induces MCP-1 accumulation in plasma, normal kidneys, and in experimental nephropathy
    Richard A Zager
    Department of Medicine, University of Washington, Seattle, Washington 98109, USA
    Kidney Int 68:1533-42. 2005
    ..Thus, this study tested whether pro-oxidant iron/carbohydrate complexes, used to treat iron deficiency, induce MCP-1 in renal/extrarenal tissues, in plasma, and in the setting of experimental nephropathy...
  5. ncbi Ischemic proximal tubular injury primes mice to endotoxin-induced TNF-alpha generation and systemic release
    R A Zager
    Department of Medicine, University of Washington, Seattle, 98109, USA
    Am J Physiol Renal Physiol 289:F289-97. 2005
    ..That ischemia can "prime" tubules to LPS response(s) could have potentially important implications for sepsis syndrome, concomitant renal ischemia, and for the induction of ARF...
  6. ncbi Renal tubular triglyercide accumulation following endotoxic, toxic, and ischemic injury
    Richard A Zager
    Department of Medicine, University of Washington, and Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Kidney Int 67:111-21. 2005
    ..However, the fate of triglycerides after acute renal insults is poorly defined. This study sought new insights into this issue...
  7. ncbi Parenteral iron compounds sensitize mice to injury-initiated TNF-alpha mRNA production and TNF-alpha release
    Richard A Zager
    University of Washington, Seattle, Washington, USA
    Am J Physiol Renal Physiol 288:F290-7. 2005
    ....
  8. ncbi Parenteral iron nephrotoxicity: potential mechanisms and consequences
    Richard A Zager
    Department of Medicine, University of Washington, Seattle, Washington, USA
    Kidney Int 66:144-56. 2004
    ..However, concerns of potential iron toxicity persist. Thus, this study was conducted to more fully gauge iron toxicologic profiles and potential determinants thereof...
  9. ncbi Proximal tubular cytochrome c efflux: determinant, and potential marker, of mitochondrial injury
    Richard A Zager
    Department of Medicine, University of Washington, and Fred Hutchinson Cancer Research Center, Seattle, 98109, USA
    Kidney Int 65:2123-34. 2004
    ....
  10. ncbi Parenteral iron therapy exacerbates experimental sepsis
    Richard A Zager
    Department of Medicine, University of Washington, and the Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Kidney Int 65:2108-12. 2004
    ..This raises the possibility that parenteral iron administration might exacerbate a concomitant septic state. This study sought to experimentally test this hypothesis...
  11. ncbi Acute renal failure: determinants and characteristics of the injury-induced hyperinflammatory response
    Richard A Zager
    Department of Medicine, University of Washington, Seattle, WA, USA
    Am J Physiol Renal Physiol 291:F546-56. 2006
    ..This suggests that diverse signaling pathways may be involved...
  12. ncbi Toll-like receptor (TLR4) shedding and depletion: acute proximal tubular cell responses to hypoxic and toxic injury
    Richard A Zager
    Department of Medicine, University of Washington, and the Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Am J Physiol Renal Physiol 292:F304-12. 2007
    ..Rapid postinjury urinary TLR4 excretion suggests its potential utility as a "biomarker" of impending ARF...
  13. ncbi 'Endotoxin tolerance': TNF-alpha hyper-reactivity and tubular cytoresistance in a renal cholesterol loading state
    R A Zager
    Department of Medicine, University of Washington, Seattle, Washington 98109 1024, USA
    Kidney Int 71:496-503. 2007
    ..g., TNF-alpha, iNOS, IL-10); (ii) PT cytoresistance against hypoxic/membrane injury coexists; and (iii) LPS-induced renal/PT cholesterol accumulation may mechanistically contribute to each of these results...
  14. ncbi Acquired cytoresistance in the setting of hematopoietic cell transplantation
    Richard A Zager
    The Clinical Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Clin J Am Soc Nephrol 5:2150-3. 2010
    ....
  15. ncbi Progressive histone alterations and proinflammatory gene activation: consequences of heme protein/iron-mediated proximal tubule injury
    Richard A Zager
    Fred Hutchinson Cancer Research Center and Department of Medicine, University of Washington, Seattle, Washington 98109, USA
    Am J Physiol Renal Physiol 298:F827-37. 2010
    ..Thus they may help sustain a proinflammatory state, despite resolving ARF...
  16. ncbi Uremia impacts renal inflammatory cytokine gene expression in the setting of experimental acute kidney injury
    Richard A Zager
    Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Rm D2 190, Seattle, WA 98109, USA
    Am J Physiol Renal Physiol 297:F961-70. 2009
    ..Changes in gene transcription (as reflected by Pol II recruitment), and possible posttranscriptional modifications (known to be induced by microRNAs), are likely involved...
  17. ncbi Renal ischemia-reperfusion injury upregulates histone-modifying enzyme systems and alters histone expression at proinflammatory/profibrotic genes
    Richard A Zager
    Department of Medicine, University of Washington, and the Clinical Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, WA 98109, USA
    Am J Physiol Renal Physiol 296:F1032-41. 2009
    ....
  18. ncbi Uremia induces proximal tubular cytoresistance and heme oxygenase-1 expression in the absence of acute kidney injury
    Richard A Zager
    Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Rm D2 190, Seattle, WA 98109, USA
    Am J Physiol Renal Physiol 296:F362-8. 2009
    ..g., HO-1 gene activation) are likely involved. Finally, renal HO-1 induction following AKI may reflect direct cell injury effects and adaptations to uremia...
  19. ncbi Growth and development alter susceptibility to acute renal injury
    Richard A Zager
    Department of Medicine, University of Washington, Seattle, Washington, USA
    Kidney Int 74:674-8. 2008
    ..Our study shows that the early phase of mouse growth can profoundly alter renal susceptibility to diverse forms of experimental acute renal injury...
  20. ncbi Maleate nephrotoxicity: mechanisms of injury and correlates with ischemic/hypoxic tubular cell death
    Richard A Zager
    Department of Medicine, Seattle, WA, USA
    Am J Physiol Renal Physiol 294:F187-97. 2008
    ..These results further define critical determinants of maleate nephrotoxicity and suggest that it can serve as a useful adjunct for studies of ischemia/ATP depletion-induced, proximal tubule-specific, cell death...
  21. ncbi Parenteral iron compounds: potent oxidants but mainstays of anemia management in chronic renal disease
    Richard A Zager
    Fred Hutchinson Cancer Research Center, Department of Medicine, University of Washington, Seattle, Washington 98109, USA
    Clin J Am Soc Nephrol 1:S24-31. 2006
    ..By so doing, a better understanding of Fe's potential protean effects on patients with renal disease may result...
  22. ncbi "Subclinical" gentamicin nephrotoxicity: a potential risk factor for exaggerated endotoxin-driven TNF-alpha production
    Richard A Zager
    Department of Medicine, University of Washington, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Rm D2 190, Seattle, WA 98109, USA
    Am J Physiol Renal Physiol 293:F43-9. 2007
    ..Thus gentamicin's activity in Gram-negative sepsis may extend beyond its traditional antimicrobial effect...
  23. ncbi Proximal tubular cholesterol loading after mitochondrial, but not glycolytic, blockade
    Richard A Zager
    Fred Hutchinson Cancer Research Center, University of Washington, Rm D2 190, 1100 Fairview Avenue N, Seattle, WA 98109, USA
    Am J Physiol Renal Physiol 285:F1092-9. 2003
    ....
  24. ncbi Acute tubular injury causes dysregulation of cellular cholesterol transport proteins
    Richard A Zager
    Fred Hutchinson Cancer Research Center, The University of Washington, Seattle, Washington, USA
    Am J Pathol 163:313-20. 2003
    ..Reductions in HK-2 cell SR-B1 and ABCA-1 mRNAs and increases in renal cortical LDL-R mRNA imply that this dysregulation reflects, at least in part, altered genomic/transcriptional events...
  25. ncbi P glycoprotein-mediated cholesterol cycling determines proximal tubular cell viability
    R A Zager
    Department of Medicine, University of Washington, Seattle, Washington, USA
    Kidney Int 60:944-56. 2001
    ..This study assessed whether P glycoprotein inhibitors alter renal tubular FC/CE expression, thereby altering cell integrity...
  26. ncbi Renal cholesterol accumulation: a durable response after acute and subacute renal insults
    R A Zager
    Department of Medicine, Fred Hutchinson Cancer Center, University of Washington, 1100 Fairview Ave N, Rm D2 190, Seattle, WA 98109, USA
    Am J Pathol 159:743-52. 2001
    ..That cholesterol accumulation can result from glomerular injury and dehydration suggests that it is a generic renal stress response, with potential relevance extending beyond just the phenomenon of acquired cytoresistance...
  27. ncbi Cholesterol ester accumulation: an immediate consequence of acute in vivo ischemic renal injury
    R A Zager
    University of Washington and Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Kidney Int 59:1750-61. 2001
    ..The present studies sought to provide initial insights into these issues...
  28. ncbi Changes in free and esterified cholesterol: hallmarks of acute renal tubular injury and acquired cytoresistance
    R A Zager
    Fred Hutchinson Cancer Research Center and the University of Washington, Seattle, Washington 98109 1024, USA
    Am J Pathol 157:1007-16. 2000
    ..Based on previous observations that cholesterol has cytoprotectant properties, the present findings have potential relevance for both the induction and maintenance phases of ARF...
  29. ncbi Polyene antibiotics: relative degrees of in vitro cytotoxicity and potential effects on tubule phospholipid and ceramide content
    R A Zager
    Department of Medicine, University of Washington, Seattle, USA
    Am J Kidney Dis 36:238-49. 2000
    ....
  30. ncbi Plasma membrane cholesterol: a critical determinant of cellular energetics and tubular resistance to attack
    R A Zager
    The Fred Hutchinson Cancer Research Center and the University of Washington, Seattle 98109 1024, USA
    Kidney Int 58:193-205. 2000
    ..The present study was undertaken to better define the effects of membrane cholesterol/microdomains on tubule homeostasis and cell susceptibility to superimposed attack...
  31. ncbi Sphingomyelinase and membrane sphingomyelin content: determinants ofProximal tubule cell susceptibility to injury
    R A Zager
    The Fred Hutchinson Cancer Research Center and the University of Washington, Seattle, Washington, USA
    J Am Soc Nephrol 11:894-902. 2000
    ..The ability of SM to decrease membrane fluidity may explain, at least in part, its cytoprotective effect...
  32. ncbi Increased proximal tubular cholesterol content: implications for cell injury and "acquired cytoresistance"
    R A Zager
    The Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Kidney Int 56:1788-97. 1999
    ..Therefore, this study sought to identify potential changes in plasma membrane lipid composition in CR tubules/renal cortex and, if present, to test whether they might mechanistically contribute to the CR state...
  33. ncbi Plasma membrane phospholipid integrity and orientation during hypoxic and toxic proximal tubular attack
    R A Zager
    The Fred Hutchinson Cancer Research Center, University of Washington, Seattle 98109, USA
    Kidney Int 56:104-17. 1999
    ..The mechanistic importance of PLA2-mediated PL breakdown and possible PL redistribution ("flip flop") to lethal tubule injury has not been well defined. This study was performed to help clarify these issues...
  34. ncbi Calcitriol directly sensitizes renal tubular cells to ATP-depletion- and iron-mediated attack
    R A Zager
    Fred Hutchinson Cancer Research Center and the University of Washington, Seattle, USA
    Am J Pathol 154:1899-909. 1999
    ..Vitamins D(s) may directly, and differentially, increase proximal tubule cell susceptibility to superimposed attack. This property should be considered as new uses for these agents are defined...
  35. ncbi Isoflurane alters proximal tubular cell susceptibility to toxic and hypoxic forms of attack
    R A Zager
    The Fred Hutchinson Cancer Research Center and the University of Washington, Seattle, Washington, USA
    Kidney Int 55:148-59. 1999
    ..Because major surgery often precipitates acute renal failure, this study assessed whether the most commonly used fluorinated anesthetic, isoflurane, alters tubular cell responses to toxic and hypoxic attack...
  36. ncbi Differential effects of glutathione and cysteine on Fe2+, Fe3+, H2O2 and myoglobin-induced proximal tubular cell attack
    R A Zager
    University of Washington, Seattle, USA
    Kidney Int 53:1661-72. 1998
    ..Since the kidney rapidly catabolizes GSH to cysteine, the latter may be at least partially responsible for GSH's reported cytoprotective actions against myoglobinuric acute renal failure...
  37. ncbi Renal cortical cholesterol accumulation is an integral component of the systemic stress response
    R A Zager
    Department of Medicine, University of Washington, and Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Kidney Int 60:2299-310. 2001
    ....
  38. ncbi Altered sphingomyelinase and ceramide expression in the setting of ischemic and nephrotoxic acute renal failure
    R A Zager
    Department of Medicine, University of Washington, Seattle, USA
    Kidney Int 53:573-82. 1998
    ....
  39. ncbi Radiographic contrast media-induced tubular injury: evaluation of oxidant stress and plasma membrane integrity
    Richard A Zager
    The Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Kidney Int 64:128-39. 2003
    ..This study addresses these issues directly at the tubular cell level. Potential alternative mechanisms for RCN have also been sought...
  40. ncbi Parenteral iron formulations: a comparative toxicologic analysis and mechanisms of cell injury
    Richard A Zager
    Department of Medicine, University of Washington, Seattle, WA, USA
    Am J Kidney Dis 40:90-103. 2002
    ..Thus, the present study contrasted pro-oxidant and cytotoxic potentials of four available Fe preparations: Fe dextran (Fe dext), Fe sucrose (Fe sucr), Fe gluconate (Fe gluc), and Fe oligosaccharide (Fe OS)...
  41. ncbi The mevalonate pathway during acute tubular injury: selected determinants and consequences
    Richard A Zager
    Department of Medicine, The University of Washington, and the Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Am J Pathol 161:681-92. 2002
    ..3) Cholesterol accumulation, per se, seems to be the dominant mechanism by which the mevalonate pathway contributes to the postrenal injury cytoresistant state...
  42. ncbi Sepsis syndrome stimulates proximal tubule cholesterol synthesis and suppresses the SR-B1 cholesterol transporter
    Richard A Zager
    Department of Medicine, University of Washington, and the Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Kidney Int 63:123-33. 2003
    ..quot; The present study was performed to help define underlying mechanisms, using experimental sepsis as a test model...
  43. ncbi Parenteral iron formulations differentially affect MCP-1, HO-1, and NGAL gene expression and renal responses to injury
    Ali C M Johnson
    Department of Medicine, University of Washington, Fred Hutchinson Cancer Research Center, Seattle, USA
    Am J Physiol Renal Physiol 299:F426-35. 2010
    ..The clinical implication(s) of the latter, vis a vis the treatment of Fe deficiency in renal disease patients, remains to be defined...
  44. ncbi Experimental glomerulopathy alters renal cortical cholesterol, SR-B1, ABCA1, and HMG CoA reductase expression
    Ali C M Johnson
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Am J Pathol 162:283-91. 2003
    ..However, HMGCR protein/mRNA increments can also result. These seem to reflect a maladaptive response, potentially contributing to a cell cholesterol overload state...
  45. ncbi Altered cholesterol localization and caveolin expression during the evolution of acute renal failure
    Richard A Zager
    Department of Medicine, University of Washington, and Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Kidney Int 61:1674-83. 2002
    ..Are maintenance-phase cholesterol increases accompanied by an up-regulation of caveolin, a DRM/caveolar-associated cholesterol binding protein? (2) Is DRM cholesterol/caveolin homeostasis acutely altered during the induction phase of ARF?..
  46. ncbi Endotoxin mediates recruitment of RNA polymerase II to target genes in acute renal failure
    Masayo Naito
    Department of Medicine, University of Washington, Seattle, Washington, USA
    J Am Soc Nephrol 19:1321-30. 2008
    ..In conclusion, LPS hyperresponsiveness after ARF is likely mediated at the genomic level, possibly by H3K4m3...
  47. ncbi BRG1 increases transcription of proinflammatory genes in renal ischemia
    Masayo Naito
    Department of Medicine, University of Washington, Seattle, WA 98109, USA
    J Am Soc Nephrol 20:1787-96. 2009
    ..In conclusion, BRG1 promotes increased transcription of TNF-alpha and MCP-1 by the proximal tubule in response to renal ischemia...
  48. ncbi Cholesterol-modulating agents kill acute myeloid leukemia cells and sensitize them to therapeutics by blocking adaptive cholesterol responses
    Henry Y Li
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109-1024, USA
    Blood 101:3628-34. 2003
    ....
  49. ncbi Renal ischemia-induced cholesterol loading: transcription factor recruitment and chromatin remodeling along the HMG CoA reductase gene
    Masayo Naito
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Am J Pathol 174:54-62. 2009
    ..In conclusion, I/R activates the HMGCR gene via multiple stress-activated transcriptional and epigenetic pathways, contributing to renal cholesterol loading...
  50. ncbi Triglyceride accumulation in injured renal tubular cells: alterations in both synthetic and catabolic pathways
    Ali C M Johnson
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Kidney Int 67:2196-209. 2005
    ..Simple flux of excess FFAs into triglyceride pools is an overly simplistic view of the post-injury-triglyceride loading state...
  51. ncbi Gentamicin suppresses endotoxin-driven TNF-alpha production in human and mouse proximal tubule cells
    Richard A Zager
    Department of Medicine, University of Washington, Seattle, Washington, USA
    Am J Physiol Renal Physiol 293:F1373-80. 2007
    ..These results, coupled with increases in gut TNF-alpha/MCP-1 mRNAs, imply that gentamicin may exert protean, countervailing actions on systemic cytokine/chemokine production during gram-negative sepsis...
  52. ncbi Dephosphorylation of cell cycle-regulated proteins correlates with anoxia-induced suspended animation in Caenorhabditis elegans
    Pamela A Padilla
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Mol Biol Cell 13:1473-83. 2002
    ..Thus, dephosphorylation of specific proteins correlate with the establishment and/or maintenance of a state of anoxia-induced suspended animation...
  53. ncbi Cholesterol synthesis and import contribute to protective cholesterol increments in acute myeloid leukemia cells
    Deborah E Banker
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Blood 104:1816-24. 2004
    ..Our data suggest that cholesterol synthesis inhibitors may improve the efficacy of standard antileukemia regimens, but that for maximum benefit, therapy may need to be tailored for individual patients with leukemia...
  54. ncbi Adenovirus nephritis in hematopoietic stem-cell transplantation
    Benedetto Bruno
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109-4417, USA
    Transplantation 77:1049-57. 2004
    ..ADV infection was a major cause of death in 17 patients. CONCLUSIONS: ADV nephritis is a specific renal complication in HSCT patients that can be diagnosed by renal biopsy in patients with hematuria and adenoviruria...
  55. ncbi IGF-1 induces rat glomerular mesangial cells to accumulate triglyceride
    Anne K Berfield
    Univ of Washington School of Medicine and Department of Medicine, Veterans Affairs Puget Sound Health Care System, 1660 South Columbian Way, Seattle, WA 98108, USA
    Am J Physiol Renal Physiol 290:F138-47. 2006
    ..These observations are relevant to understanding vascular disease and progressive renal diseases that are accelerated by abnormalities in lipid metabolism...
  56. ncbi MCP-1 gene activation marks acute kidney injury
    Raj Munshi
    Seattle Children s Hospital Medical Center, Seattle, Washington, USA
    J Am Soc Nephrol 22:165-75. 2011
    ..In conclusion, these data suggest that MCP-1 has potential as a biomarker of AKI and provide "proof of concept" that urinary histone assessments provide mechanistic insight among patients with kidney disease...
  57. ncbi Renal cortical albumin gene induction and urinary albumin excretion in response to acute kidney injury
    Lorraine B Ware
    Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Am J Physiol Renal Physiol 300:F628-38. 2011
    ..In addition, the urinary protein data independently indicate that albuminuria, and perhaps ?-fetoprotein, have substantial utility as biomarkers of acute tubular injury...
  58. ncbi HMG-CoA reductase activation and urinary pellet cholesterol elevations in acute kidney injury
    Ali Cm Johnson
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Clin J Am Soc Nephrol 6:2108-13. 2011
    ..This study tested whether these two processes culminate in increased urinary pellet cholesterol content, and whether the latter has potential AKI biomarker utility...
  59. ncbi Intravenous iron therapy in peritoneal dialysis patients: short-term efficacy and long-term issues
    Richard A Zager
    Clin J Am Soc Nephrol 1:353-5. 2006
  60. ncbi Cytotoxicity of S-conjugates of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl) vinyl ether (Compound A) in a human proximal tubular cell line
    T Gul Altuntas
    Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, Ankara, Turkey
    Toxicol Appl Pharmacol 193:55-65. 2003
    ..1 mM. These results show that human proximal tubular cells are relatively resistant to FDVE and FDVE S-conjugate cytotoxicity. This may partially explain the lack of FDVE nephrotoxicity in humans...

Research Grants21

  1. ACUTE RENAL FAILURE--MECHANISMS AND ADAPTIVE RESPONSES
    RICHARD ZAGER; Fiscal Year: 2001
    ....
  2. ACUTE RENAL FAILURE--IMPACT OF FLUORINATED ANESTHETICS
    RICHARD ZAGER; Fiscal Year: 2001
    ....
  3. Iron Therapy in Renal Disease: Potential Toxicities
    RICHARD ZAGER; Fiscal Year: 2007
    ..Potential reasons for these differences will be assessed, with the ultimate goal of defining the safest way of administering parenteral irons to renal disease patients. ..
  4. Acute Renal Failure: Mechanisms and Adaptive Responses
    RICHARD ZAGER; Fiscal Year: 2007
    ....
  5. MECHANISMS IN MYOGLOBINURIC ACUTE RENAL FAILURE
    RICHARD ZAGER; Fiscal Year: 1993
    ..By addressing the above, new insights into heme protein/low molecular weight protein nephrotoxicity and shock-induced renal damage will be obtained which should have direct relevance to crush syndrome induced ARF...