Research Topics
Genomes and GenesSpecies | E PetersdorfSummaryAffiliation: Fred Hutchinson Cancer Research Center Country: USA Publications
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Publications
Definition of HLA-DQ as a transplantation antigenE W Petersdorf
Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98104, USA
Proc Natl Acad Sci U S A 93:15358-63. 1996..6 (1.2, 2.2; P = 0.003). These results provide evidence that HLA-DQ is a transplant antigen and suggest that evaluation of both HLA-DQB1 and HLA-DRB1 is necessary in selecting potential donors...- Optimal HLA matching in hematopoietic cell transplantationEffie W Petersdorf
Division of Clinical Research, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, D4 100, Seattle, WA 98109 1024, United States
Curr Opin Immunol 20:588-93. 2008..Optimizing the overall outcome of hematopoietic cell transplantation requires an appreciation for the relative importance of HLA factors with respect to other non-genetic factors that also influence transplant outcome... - Tissue typing in support of unrelated hematopoietic cell transplantationE W Petersdorf
Division of Clinical Research, Fred Hutchinson Cancer Research Ctr, Division of Clinical Research, and Department of Medicine, University of Washington, Seattle 98109 1024, USA
Tissue Antigens 61:1-11. 2003.... - Risk assessment in haematopoietic stem cell transplantation: histocompatibilityEffie W Petersdorf
Department of Medicine, University of Washington, 1959 Northeast Pacific, Seattle, WA 98195, USA
Best Pract Res Clin Haematol 20:155-70. 2007..Increased availability of HCT through the use of HLA-mismatched related and unrelated donors is feasible with a more complete understanding of permissible HLA mismatches and the role of NK-KIR genes in transplantation... - Limits of HLA mismatching in unrelated hematopoietic cell transplantationEffie W Petersdorf
Division of Clinical Research, D4 100 Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA
Blood 104:2976-80. 2004..Whenever possible, HLA-C mismatches should be avoided for patients with early stage CML, and HLA-DQB1 mismatches should be avoided for patients with multiple mismatches... - MHC haplotype matching for unrelated hematopoietic cell transplantationEffie W Petersdorf
Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
PLoS Med 4:e8. 2007..Genes that influence transplantation outcome could be identified by using linkage disequilibrium (LD)-mapping approaches, if the extended MHC haplotypes of the unrelated donor and recipient could be defined... - Immunogenomics of unrelated hematopoietic cell transplantationEffie W Petersdorf
University of Washington, Fred Hutchinson Cancer Research Center, D4 100, Seattle, WA 98109, USA
Curr Opin Immunol 18:559-64. 2006..These data show that clinical outcome following transplantation is shaped by the combined effects of many genes within the MHC and their sequence polymorphisms... - HLA matching in allogeneic stem cell transplantationEffie W Petersdorf
University of Washington School of Medicine, Fred Hutchinson Cancer Research Center, Division of Clinical Research, Seattle, Washington 98109, USA
Curr Opin Hematol 11:386-91. 2004..The goal of this review is to summarize new findings in the field of immunogenetics and HCT from unrelated donors using myeloablative conditioning regimens... - Genetics of risk factors for graft-versus-host diseaseEffie W Petersdorf
Department of Medicine, University of Washington, Seattle, WA 98109, USA
Semin Hematol 43:11-23. 2006..The contribution of donor and host genetic differences in cytokine genes in modulating risks of GVHD has recently been recognized... - New advances in hematopoietic cell transplantationEffie W Petersdorf
Division of Clinical Research, Fred Huchinson Cancer Research Center, Seattle, Washington 98109, USA
Curr Opin Hematol 15:549-54. 2008..The present review highlights sentinel work published since 2006 on the definition of the transplantation barrier and the elucidation of cytokine and immune response gene variation in defining posttransplant risks... - The World Marrow Donor Association: 20 years of international collaboration for the support of unrelated donor and cord blood hematopoietic cell transplantationE W Petersdorf
Fred Hutchinson Cancer Research Center and the University of Washington School of Medicine, Seattle, WA 98109, USA
Bone Marrow Transplant 45:807-10. 2010..In this special issue of Bone Marrow Transplantation, the activities of the WMDA and a vision for future directions in the field are presented... - Major-histocompatibility-complex class I alleles and antigens in hematopoietic-cell transplantationE W Petersdorf
Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
N Engl J Med 345:1794-800. 2001..that allele mismatches that are detectable only at the DNA level are less immunogenic than those that are serologically detectable and thereby are associated with a lower risk of graft failure after hematopoietic-cell transplantation.. - Population study of allelic diversity in the human MHC class I-related MIC-A geneE W Petersdorf
Fred Hutchinson Cancer Research Center, 1100 Fairview Ave North, Seattle, WA 98109 1024, USA
Immunogenetics 49:605-12. 1999..These results confirm and extend previous knowledge on the polymorphism of MIC-A. The strong positive linkage of certain MIC-A and HLA-B alleles may have implications for studies related to MHC-associated diseases and transplantation... - Genomics of unrelated-donor hematopoietic cell transplantationE Petersdorf
University of Washington, School of Medicine, 1959 NE Pacific Street, Seattle, Washington 98105, USA
Curr Opin Immunol 13:582-9. 2001..Delineation of the function of these markers as transplantation determinants may provide alternative means for optimizing the results of hematopoietic cell transplantation... - Effect of HLA mismatches on the outcome of hematopoietic transplantsE W Petersdorf
Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109 1024, USA
Curr Opin Immunol 11:521-6. 1999..These findings demonstrate that HLA allelic differences are biologically relevant in human transplantation... - The biological significance of HLA-DP gene variation in haematopoietic cell transplantationE W Petersdorf
Division of Clinical Research, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, D4 100, Seattle, WA 98109 1024, USA
Br J Haematol 112:988-94. 2001..1; P = 0.01). HLA-DP plays an important role in the alloimmune response. A threshold effect of multiple HLA-DP disparities is evident in determining the risk of acute GVHD after haematopoietic cell transplantation from unrelated donors... - MHC microsatellite diversity and linkage disequilibrium among common HLA-A, HLA-B, DRB1 haplotypes: implications for unrelated donor hematopoietic transplantation and disease association studiesM Malkki
The Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Tissue Antigens 66:114-24. 2005..Markers with high HSH values will be most informative in studies investigating MHC region disease-susceptibility genes where HLA haplotypic effects are known to exist... - HLA matching in hematopoietic cell transplantationE M Mickelson
Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
Hum Immunol 61:92-100. 2000..The use of these methods to optimize donor selection will improve both donor identification and the success of unrelated donor transplants... - 14thInternational HLA and Immunogenetics Workshop: report on hematopoietic cell transplantationE Petersdorf
Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Tissue Antigens 69:17-24. 2007.... - The role of HLA matching in hematopoietic cell transplantationJ A Hansen
Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
Rev Immunogenet 1:359-73. 1999..There remain, however, important unanswered questions about the relative importance of different HLA loci in matching strategies, as well as incomplete information about permissible limits of mismatching in different patient populations... - Hematopoietic stem cell transplants from unrelated donorsJ A Hansen
Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
Immunol Rev 157:141-51. 1997..In order to provide transplants for all patients, improved methods for GVHD prophylaxis are needed that will make it possible to safely perform transplants even across limited degrees of HLA disparity... - Mapping MHC-resident transplantation determinantsMari Malkki
The Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
Biol Blood Marrow Transplant 13:986-95. 2007..67; 95% confidence interval, 0.45-0.98; P=.04). These results suggest that Msats may be informative for mapping MHC-resident genetic variation of clinical importance in HCT... - An acute graft-versus-host disease activity index to predict survival after hematopoietic cell transplantation with myeloablative conditioning regimensWendy M Leisenring
Clinical Research Division, Fred Hutchinson Cancer Research Center and the University of Washington School of Medicine, Seattle, 98109, USA
Blood 108:749-55. 2006..These results demonstrate that clinical manifestations of GVHD severity can be used to accurately predict the risk of NRM in real time... - Genetics of allogeneic hematopoietic cell transplantation. Role of HLA matching, functional variation in immune response genesJohn A Hansen
Division of Clinical Research, Fred Hutchinson Cancer Research Center, University of Washington, 1100 Fairview Ave N, D2 100, P O Box 19024, Seattle, WA 98109 1024, USA
Immunol Res 41:56-78. 2008.... - Risk of cervical cancer associated with allergies and polymorphisms in genes in the chromosome 5 cytokine clusterLisa G Johnson
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, PO Box 19024, Seattle, WA 98109, USA
Cancer Epidemiol Biomarkers Prev 20:199-207. 2011.... - Allogeneic hematopoietic stem cell transplantation for myelofibrosisH Joachim Deeg
Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, D1 100, PO Box 19024, Seattle, WA 98109 1024, USA
Blood 102:3912-8. 2003..Results with unrelated donors were comparable with those with HLA-identical sibling transplants. Thus, allogeneic hematopoietic cell transplantation offers long-term relapse-free survival for patients with myelofibrosis... - Human leukocyte antigen matching in unrelated donor hematopoietic cell transplantationEffie W Petersdorf
Division of Clinical Research, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, Seattle, WA 98109, USA
Semin Hematol 42:76-84. 2005..The influence of nongenetic factors on the tolerability of HLA mismatching has recently become evident, demonstrating a need for the integration of both genetic and nongenetic variables in donor selection... - Hematologic responses of patients with MDS to antithymocyte globulin plus etanercept correlate with improved flow scores of marrow cellsH Joachim Deeg
Division of Clinical Research, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, D1 100, PO Box 19024, Seattle, WA 98109 1024, USA
Leuk Res 28:1177-80. 2004..These data show that a combination of ATG plus etanercept offers effective palliative therapy for unselected patients with MDS. Further trials incorporating these two agents are warranted... - Evaluation of a CD25-specific immunotoxin for prevention of graft-versus-host disease after unrelated marrow transplantationPaul J Martin
Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
Biol Blood Marrow Transplant 10:552-60. 2004.... - Increasingly frequent diagnosis of acute gastrointestinal graft-versus-host disease after allogeneic hematopoietic cell transplantationPaul J Martin
Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Biol Blood Marrow Transplant 10:320-7. 2004..A high diagnostic sensitivity and increased awareness that gut GVHD can occur without skin involvement account for the increased incidence of acute GVHD at our center... - Long-range multilocus haplotype phasing of the MHCZhen Guo
Division of Clinical Research, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
Proc Natl Acad Sci U S A 103:6964-9. 2006..Availability of an efficient method for MHC haplotype phase determination will facilitate the mapping of causative MHC-resident genes in many human diseases and has the potential to be broadened to other polymorphic gene complexes... - Cervical and vulvar cancer risk in relation to the joint effects of cigarette smoking and genetic variation in interleukin 2Shehnaz K Hussain
Program in Epidemiology, Division of Public Health Sciences, University of Washington, Seattle, WA, USA
Cancer Epidemiol Biomarkers Prev 17:1790-9. 2008..87; 95% CI, 1.00-3.48), and for carriership of the TTCC/TTCC diplotype (IOR, 2.08; 95% CI, 1.01-4.30). These results suggest that cervical and vulvar SCC risk among cigarette smokers is modified by genetic variation in IL2... - Herpes simplex virus type 2-specific CD8 cytotoxic T lymphocyte cross-reactivity against prevalent HLA class I allelesDavid M Koelle
Department of Medicine, University of Washington, Seattle, USA
Blood 99:3844-7. 2002..Given the prevalence of this viral infection and the HLA alleles involved, it is possible that this cross-reactivity may be involved in clinically significant events... - Oligonucleotide arrays for high-throughput SNPs detection in the MHC class I genes: HLA-B as a model systemZhen Guo
Institute for Systems Biology, Seattle, WA 98105, USA
Genome Res 12:447-57. 2002..The oligonucleotide array method described in this paper provides unambiguous detection of complex heterozygous SNP combinations. This methodological approach may be applied to other highly polymorphic gene systems... - Duration of immunosuppressive treatment for chronic graft-versus-host diseaseBetty L Stewart
Division of Clinical Research, Fred Hutchinson Cancer Research Center, PO Box 19024, Seattle, WA 98109, USA
Blood 104:3501-6. 2004..After the dose of prednisone was taken into account, progressive onset was not associated with an increased risk of nonrelapse mortality... - Structural studies of allelic diversity of the MHC class I homolog MIC-B, a stress-inducible ligand for the activating immunoreceptor NKG2DMargaret A Holmes
Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
J Immunol 169:1395-400. 2002.... - The importance of HLA-DPB1 in unrelated donor hematopoietic cell transplantationBronwen E Shaw
Anthony Nolan Research Institute, London, UK
Blood 110:4560-6. 2007..Knowledge of the DPB1 matching status prior to transplantation will aid in more precise risk stratification for the individual patient... - Nomenclature for factors of the HLA system, 2002Steven G E Marsh
Anthony Nolan Research Institute, Royal Free Hospital, Hampstead, London, United Kingdom
Hum Immunol 63:1213-68. 2002 - Genomic polymorphism and allogeneic hematopoietic transplantation outcomeCharles G Mullighan
Department of Pathology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
Biol Blood Marrow Transplant 12:19-27. 2006.... - Nomenclature for factors of the HLA system, 2002Steven G E Marsh
Anthony Nolan Research Institute, Royal Free Hospital, Hampstead, London, UK
Eur J Immunogenet 29:463-515. 2002 - Nomenclature for Factors of the HLA System, 2004Steven G E Marsh
Anthony Nolan Research Institute, Royal Free Hospital, Pond Street, Hampstead, London NW3 2QG, United Kingdom
Hum Immunol 66:571-636. 2005
Research Grants
- Hematopopietic Stem Cell TransplantationEffie Petersdorf; Fiscal Year: 2007..Successin achieving these goals will broaden the applicability of unrelated HCT to the treatment of blood disorders. ..
- Clinical Significance of MHC Haplotypes in Hematopoietic Cell TransplantationEffie Petersdorf; Fiscal Year: 2007..abstract_text> ..
- SNPs in Lung Cancer Risk and Therapeutic ResponseEffie Petersdorf; Fiscal Year: 2004..abstract_text> ..
- OPTIMIZING BMT FOR CANCER BY GENETIC MATCHING OF DONORSEffie Petersdorf; Fiscal Year: 2003....
- Clinical Significance of MHC Haplotypes in HCTEffie W Petersdorf; Fiscal Year: 2010..We will use the tool to find the genes that are important to transplant success. ..