Jeffrey PetersonSummaryAffiliation: Fox Chase Cancer Center Country: USA Publications
Research Grants
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Detail Information
Publications
An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinaseSean W Deacon
Basic Sciences Division, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
Chem Biol 15:322-31. 2008..These studies illustrate an alternative strategy for kinase inhibition and introduce a highly selective, cell-permeable chemical inhibitor of Pak...- Biochemical suppression of small-molecule inhibitors: a strategy to identify inhibitor targets and signaling pathway componentsJeffrey R Peterson
Division of Basic Sciences, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, Pennsylvania 19111, USA
Chem Biol 13:443-52. 2006..This work introduces a general method for using low-micromolar chemical inhibitors to identify both inhibitor targets and other components of a signaling pathway... - Specificity profiling of Pak kinases allows identification of novel phosphorylation sitesUlrike E E Rennefahrt
Division of Basic Science, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
J Biol Chem 282:15667-78. 2007..Collectively, these results elucidate the specificity of Pak kinases and illustrate a general method for the identification of novel sites phosphorylated by Paks... - Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitroHenry E Pelish
Department of Cell Biology and The CBR Institute for Biomedical Research, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts 02115, USA
Nat Chem Biol 2:39-46. 2006..RhoGDI-dependent Cdc42 inhibition by secramine illustrates a new way to inhibit Rho GTPases with small molecules and provides a new means to study Cdc42, RhoGDI and the cellular processes they mediate... - Chemical inhibition of N-WASP by stabilization of a native autoinhibited conformationJeffrey R Peterson
Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA
Nat Struct Mol Biol 11:747-55. 2004..The use of small molecules to bias conformational equilibria represents a potentially general strategy for chemical inhibition of autoinhibited proteins, even in cases where such sites have not been naturally evolved in a target... - Geometric diversity through permutation of backbone configuration in cyclic peptide librariesZachary E Perlman
Department of Systems Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115l, USA
Bioorg Med Chem Lett 15:5329-34. 2005..These concepts were applied to the synthesis of cyclodimeric variants of an inhibitor of actin assembly in Xenopus egg extracts, yielding side chain variants with improved potency over the original scaffold... - Src transforms in a Cool wayJeffrey R Peterson
Nat Cell Biol 8:905-7. 2006
Research Grants
- Allosteric, Small-Molecule Inhibitors of Actin Nucleation by the Formin mDia1Jeffrey Peterson; Fiscal Year: 2007..Future work will apply this screen to a much larger compound collection and we envisage applying a similar strategy to develop inhibitors for other formins. ..
- Specificity of Effector Activation by Rho Family GTPasesJeffrey Peterson; Fiscal Year: 2009..This proposal will illuminate how this coordination could be corrupted in disease and will provide crucial information for the selection of optimal drug targets for new therapeutic approaches. ..
- Specificity of Effector Activation by Rho Family GTPasesJeffrey R Peterson; Fiscal Year: 2010..This proposal will illuminate how this coordination could be corrupted in disease and will provide crucial information for the selection of optimal drug targets for new therapeutic approaches. ..
- Specificity of Effector Activation by Rho Family GTPasesJeffrey Peterson; Fiscal Year: 2009..This proposal will illuminate how this coordination could be corrupted in disease and will provide crucial information for the selection of optimal drug targets for new therapeutic approaches. ..