Jin Qiang Chen

Summary

Affiliation: Fox Chase Cancer Center
Country: USA

Publications

  1. ncbi Binding of MCF-7 cell mitochondrial proteins and recombinant human estrogen receptors alpha and beta to human mitochondrial DNA estrogen response elements
    Jin Q Chen
    Department of Environmental Health Sciences, Division of Toxicological Sciences, Johns Hopkins University Bloomberg School of Public Health, 615 N Wolfe St Baltimore, Maryland 21205 2179, USA
    J Cell Biochem 93:358-73. 2004
  2. ncbi Regulation of mitochondrial respiratory chain structure and function by estrogens/estrogen receptors and potential physiological/pathophysiological implications
    Jin Qiang Chen
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Biochim Biophys Acta 1746:1-17. 2005
  3. ncbi Sodium/potassium ATPase (Na+, K+-ATPase) and ouabain/related cardiac glycosides: A new paradigm for development of anti- breast cancer drugs?
    Jin Qiang Chen
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Breast Cancer Res Treat 96:1-15. 2006
  4. ncbi Regulation of energy metabolism pathways by estrogens and estrogenic chemicals and potential implications in obesity associated with increased exposure to endocrine disruptors
    Jin Qiang Chen
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, PA, 19111, USA
    Biochim Biophys Acta 1793:1128-43. 2009
  5. ncbi ERalpha-negative and triple negative breast cancer: molecular features and potential therapeutic approaches
    Jin Qiang Chen
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Biochim Biophys Acta 1796:162-75. 2009
  6. ncbi Regulation of mitochondrial respiratory chain biogenesis by estrogens/estrogen receptors and physiological, pathological and pharmacological implications
    Jin Qiang Chen
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Biochim Biophys Acta 1793:1540-70. 2009
  7. ncbi ERbeta shifts from mitochondria to nucleus during estrogen-induced neoplastic transformation of human breast epithelial cells and is involved in estrogen-induced synthesis of mitochondrial respiratory chain proteins
    Jin Qiang Chen
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111 2497, USA
    Biochim Biophys Acta 1773:1732-46. 2007
  8. ncbi Estrogen's effects on mitochondrial gene expression: mechanisms and potential contributions to estrogen carcinogenesis
    Jin-Qiang Chen
    Department of Environmental Health Sciences, Division of Toxicological Sciences, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21285, USA
    Ann N Y Acad Sci 1028:258-72. 2004
  9. ncbi Mechanisms of hormone carcinogenesis: evolution of views, role of mitochondria
    Jin Qiang Chen
    Division of Pulmonary and Critical Care, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA 22908 0546, USA
    Adv Exp Med Biol 630:1-18. 2008

Detail Information

Publications9

  1. ncbi Binding of MCF-7 cell mitochondrial proteins and recombinant human estrogen receptors alpha and beta to human mitochondrial DNA estrogen response elements
    Jin Q Chen
    Department of Environmental Health Sciences, Division of Toxicological Sciences, Johns Hopkins University Bloomberg School of Public Health, 615 N Wolfe St Baltimore, Maryland 21205 2179, USA
    J Cell Biochem 93:358-73. 2004
    ..These results indicate that the mitochondrial ERs can interact with mtEREs and suggest that they may be directly involved in E2 induction of mtDNA transcription...
  2. ncbi Regulation of mitochondrial respiratory chain structure and function by estrogens/estrogen receptors and potential physiological/pathophysiological implications
    Jin Qiang Chen
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Biochim Biophys Acta 1746:1-17. 2005
    ....
  3. ncbi Sodium/potassium ATPase (Na+, K+-ATPase) and ouabain/related cardiac glycosides: A new paradigm for development of anti- breast cancer drugs?
    Jin Qiang Chen
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Breast Cancer Res Treat 96:1-15. 2006
    ..Modulators, e.g. ouabain and related digitalis could be useful to develop valuable anti-breast cancer drugs as both Na+, K+-ATPase inhibitors and ER antagonists...
  4. ncbi Regulation of energy metabolism pathways by estrogens and estrogenic chemicals and potential implications in obesity associated with increased exposure to endocrine disruptors
    Jin Qiang Chen
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, PA, 19111, USA
    Biochim Biophys Acta 1793:1128-43. 2009
    ..A better understanding of the cellular and molecular mechanisms underlying obesogen-associated obesity will lead to new approaches for slow down and/or prevention of the increased trend of obesity associated with exposure to obesogens...
  5. ncbi ERalpha-negative and triple negative breast cancer: molecular features and potential therapeutic approaches
    Jin Qiang Chen
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Biochim Biophys Acta 1796:162-75. 2009
    ..Gaining better insights into these molecular pathways in TNBC may lead to identification of novel biomarkers and targets for development of diagnostic and therapeutic approaches for prevention and treatment of TNBC...
  6. ncbi Regulation of mitochondrial respiratory chain biogenesis by estrogens/estrogen receptors and physiological, pathological and pharmacological implications
    Jin Qiang Chen
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Biochim Biophys Acta 1793:1540-70. 2009
    ..We also suggest a novel conceptual approach that will contribute to innovative regimens for the prevention or treatment of a wide variety of medical complications based on E(2)/ER-mediated MRC biogenesis pathway...
  7. ncbi ERbeta shifts from mitochondria to nucleus during estrogen-induced neoplastic transformation of human breast epithelial cells and is involved in estrogen-induced synthesis of mitochondrial respiratory chain proteins
    Jin Qiang Chen
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111 2497, USA
    Biochim Biophys Acta 1773:1732-46. 2007
    ..Our findings provide a new insight into one of the potential roles of ERbeta in human breast cancer...
  8. ncbi Estrogen's effects on mitochondrial gene expression: mechanisms and potential contributions to estrogen carcinogenesis
    Jin-Qiang Chen
    Department of Environmental Health Sciences, Division of Toxicological Sciences, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21285, USA
    Ann N Y Acad Sci 1028:258-72. 2004
    ..Together, these results suggest that the ERs may act as transcription factors directly involved in the regulation by E2 of mtDNA transcription...
  9. ncbi Mechanisms of hormone carcinogenesis: evolution of views, role of mitochondria
    Jin Qiang Chen
    Division of Pulmonary and Critical Care, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA 22908 0546, USA
    Adv Exp Med Biol 630:1-18. 2008
    ....