Remedios Castelló-Cros

Summary

Affiliation: Fox Chase Cancer Center
Country: USA

Publications

  1. ncbi Staged stromal extracellular 3D matrices differentially regulate breast cancer cell responses through PI3K and beta1-integrins
    Remedios Castelló-Cros
    Cancer Genetics and Signaling Program, Fox Chase Cancer Center, Philadelphia, PA 19111 2497, USA
    BMC Cancer 9:94. 2009
  2. ncbi Glycolytic cancer associated fibroblasts promote breast cancer tumor growth, without a measurable increase in angiogenesis: evidence for stromal-epithelial metabolic coupling
    Gemma Migneco
    Department of Stem Cell Biology and Regenerative Medicine, Thomas Jefferson University, Philadelphia, PA, USA
    Cell Cycle 9:2412-22. 2010
  3. ncbi Matrix remodeling stimulates stromal autophagy, "fueling" cancer cell mitochondrial metabolism and metastasis
    Remedios Castelló-Cros
    The Jefferson Stem Cell Biology and Regenerative Medicine Center, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA
    Cell Cycle 10:2021-34. 2011
  4. ncbi The reverse Warburg effect: glycolysis inhibitors prevent the tumor promoting effects of caveolin-1 deficient cancer associated fibroblasts
    Gloria Bonuccelli
    Department of Stem Cell Biology and Regenerative Medicine, Thomas Jefferson University, Philadelphia, PA, USA
    Cell Cycle 9:1960-71. 2010
  5. ncbi Scleroderma-like properties of skin from caveolin-1-deficient mice: implications for new treatment strategies in patients with fibrosis and systemic sclerosis
    Remedios Castelló-Cros
    The Jefferson Stem Cell Biology and Regenerative Medicine Center, Thomas Jefferson University, Philadelphia, PA, USA
    Cell Cycle 10:2140-50. 2011
  6. ncbi Stromagenesis during tumorigenesis: characterization of tumor-associated fibroblasts and stroma-derived 3D matrices
    Remedios Castelló-Cros
    Fox Chase Cancer Center, Philadelphia, PA, USA
    Methods Mol Biol 522:275-305. 2009
  7. ncbi The reverse Warburg effect: aerobic glycolysis in cancer associated fibroblasts and the tumor stroma
    Stephanos Pavlides
    Department of Stem Cell Biology and Regenerative Medicine, Thomas Jefferson University, Philadelphia, PA, USA
    Cell Cycle 8:3984-4001. 2009
  8. ncbi Fibroblast-derived 3D matrix differentially regulates the growth and drug-responsiveness of human cancer cells
    Ilya Serebriiskii
    Division of Basic Science Tumor Cell Biology, Fox Chase Cancer Center, Philadelphia, PA 19111, United States
    Matrix Biol 27:573-85. 2008

Collaborators

Detail Information

Publications8

  1. ncbi Staged stromal extracellular 3D matrices differentially regulate breast cancer cell responses through PI3K and beta1-integrins
    Remedios Castelló-Cros
    Cancer Genetics and Signaling Program, Fox Chase Cancer Center, Philadelphia, PA 19111 2497, USA
    BMC Cancer 9:94. 2009
    ..The goal of this study was to analyze the direct effects of staged stroma-derived extracellular matrices on breast cancer cell behavior...
  2. ncbi Glycolytic cancer associated fibroblasts promote breast cancer tumor growth, without a measurable increase in angiogenesis: evidence for stromal-epithelial metabolic coupling
    Gemma Migneco
    Department of Stem Cell Biology and Regenerative Medicine, Thomas Jefferson University, Philadelphia, PA, USA
    Cell Cycle 9:2412-22. 2010
    ....
  3. ncbi Matrix remodeling stimulates stromal autophagy, "fueling" cancer cell mitochondrial metabolism and metastasis
    Remedios Castelló-Cros
    The Jefferson Stem Cell Biology and Regenerative Medicine Center, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA
    Cell Cycle 10:2021-34. 2011
    ..Thus, the secretion and remodeling of extracellular matrix components (such as PAI-1/2) can directly regulate both (1) autophagy in stromal fibroblasts and (2) epithelial tumor cell mitochondrial metabolism...
  4. ncbi The reverse Warburg effect: glycolysis inhibitors prevent the tumor promoting effects of caveolin-1 deficient cancer associated fibroblasts
    Gloria Bonuccelli
    Department of Stem Cell Biology and Regenerative Medicine, Thomas Jefferson University, Philadelphia, PA, USA
    Cell Cycle 9:1960-71. 2010
    ..We also identify the stromal expression of PKM2 and LDH-B as new candidate biomarkers for the "Reverse Warburg Effect" or "Stromal-Epithelial Metabolic Coupling" in human breast cancers...
  5. ncbi Scleroderma-like properties of skin from caveolin-1-deficient mice: implications for new treatment strategies in patients with fibrosis and systemic sclerosis
    Remedios Castelló-Cros
    The Jefferson Stem Cell Biology and Regenerative Medicine Center, Thomas Jefferson University, Philadelphia, PA, USA
    Cell Cycle 10:2140-50. 2011
    ..Finally, Cav-1 (-/-) null mice are also a pre-clinical model for a "lethal" tumor micro-environment, possibly explaining the link between fibrosis, tumor progression, and cancer metastasis...
  6. ncbi Stromagenesis during tumorigenesis: characterization of tumor-associated fibroblasts and stroma-derived 3D matrices
    Remedios Castelló-Cros
    Fox Chase Cancer Center, Philadelphia, PA, USA
    Methods Mol Biol 522:275-305. 2009
    ..It describes how to produce and characterize fibroblast-derived 3D matrices. Finally, it describes how to test matrix permissiveness by analyzing the morphology of cancer cells cultured within various 3D matrices...
  7. ncbi The reverse Warburg effect: aerobic glycolysis in cancer associated fibroblasts and the tumor stroma
    Stephanos Pavlides
    Department of Stem Cell Biology and Regenerative Medicine, Thomas Jefferson University, Philadelphia, PA, USA
    Cell Cycle 8:3984-4001. 2009
    ..Thus, an absence of stromal Cav-1 may be a biomarker for the "Reverse Warburg Effect," explaining its powerful predictive value...
  8. ncbi Fibroblast-derived 3D matrix differentially regulates the growth and drug-responsiveness of human cancer cells
    Ilya Serebriiskii
    Division of Basic Science Tumor Cell Biology, Fox Chase Cancer Center, Philadelphia, PA 19111, United States
    Matrix Biol 27:573-85. 2008
    ..Based on these results, we propose that these matrices potentially have value as in vitro drug screening platforms...