Zimei Bu

Summary

Affiliation: Fox Chase Cancer Center
Country: USA

Publications

  1. ncbi Protein kinase C phosphorylation disrupts Na+/H+ exchanger regulatory factor 1 autoinhibition and promotes cystic fibrosis transmembrane conductance regulator macromolecular assembly
    Jianquan Li
    Basic Science Division and Population Science Division, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    J Biol Chem 282:27086-99. 2007
  2. ncbi Nucleotide binding induces changes in the oligomeric state and conformation of Sec A in a lipid environment: a small-angle neutron-scattering study
    Zimei Bu
    Department of Molecular and Cell Biology, University of Connecticut, 91 N Eagleville Road, Storrs, CT 06269 3125, USA
    J Mol Biol 332:23-30. 2003
  3. ncbi Ezrin controls the macromolecular complexes formed between an adapter protein Na+/H+ exchanger regulatory factor and the cystic fibrosis transmembrane conductance regulator
    Jianquan Li
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    J Biol Chem 280:37634-43. 2005
  4. ncbi Coupled protein domain motion in Taq polymerase revealed by neutron spin-echo spectroscopy
    Zimei Bu
    Fox Chase Cancer Center, 333 Cottman Avenue, Reimann 414, Philadelphia, PA 19111, USA
    Proc Natl Acad Sci U S A 102:17646-51. 2005
  5. ncbi Ezrin induces long-range interdomain allostery in the scaffolding protein NHERF1
    Jianquan Li
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    J Mol Biol 392:166-80. 2009
  6. ncbi Autoinhibitory interactions between the PDZ2 and C-terminal domains in the scaffolding protein NHERF1
    Hong Cheng
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Structure 17:660-9. 2009
  7. ncbi Solution structure of the A4 domain of factor XI sheds light on the mechanism of zymogen activation
    Dharmaraj Samuel
    Division of Basic Science, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Proc Natl Acad Sci U S A 104:15693-8. 2007
  8. ncbi Ligand-induced structural transitions in ErbB receptor extracellular domains
    Jessica P Dawson
    Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, 422 Curie Boulevard, Philadelphia, PA 19104, USA
    Structure 15:942-54. 2007
  9. ncbi Molecular alignment within beta-sheets in Abeta(14-23) fibrils: solid-state NMR experiments and theoretical predictions
    Zimei Bu
    Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    Biophys J 92:594-602. 2007
  10. ncbi Immunization with a single extracellular enveloped virus protein produced in bacteria provides partial protection from a lethal orthopoxvirus infection in a natural host
    Min Fang
    Program of Viral Pathogenesis, Division of Basic Science, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Virology 345:231-43. 2006

Research Grants

  1. Struture snd Dynamic Determinants of Ion Channel Assembly by Adapter Proteins
    Zimei Bu; Fiscal Year: 2009
  2. Struture snd Dynamic Determinants of Ion Channel Assembly by Adapter Proteins
    Zimei Bu; Fiscal Year: 2010

Collaborators

Detail Information

Publications11

  1. ncbi Protein kinase C phosphorylation disrupts Na+/H+ exchanger regulatory factor 1 autoinhibition and promotes cystic fibrosis transmembrane conductance regulator macromolecular assembly
    Jianquan Li
    Basic Science Division and Population Science Division, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    J Biol Chem 282:27086-99. 2007
    ..The results demonstrate that the C-terminal domain of NHERF functions as an intramolecular switch that regulates the binding capability of PDZ2, and thus controls the stoichiometry of NHERF to assemble protein complexes...
  2. ncbi Nucleotide binding induces changes in the oligomeric state and conformation of Sec A in a lipid environment: a small-angle neutron-scattering study
    Zimei Bu
    Department of Molecular and Cell Biology, University of Connecticut, 91 N Eagleville Road, Storrs, CT 06269 3125, USA
    J Mol Biol 332:23-30. 2003
    ....
  3. ncbi Ezrin controls the macromolecular complexes formed between an adapter protein Na+/H+ exchanger regulatory factor and the cystic fibrosis transmembrane conductance regulator
    Jianquan Li
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    J Biol Chem 280:37634-43. 2005
    ....
  4. ncbi Coupled protein domain motion in Taq polymerase revealed by neutron spin-echo spectroscopy
    Zimei Bu
    Fox Chase Cancer Center, 333 Cottman Avenue, Reimann 414, Philadelphia, PA 19111, USA
    Proc Natl Acad Sci U S A 102:17646-51. 2005
    ..The NSE results provide insights into the nature of protein domain motion that are not appreciated by conventional biophysical techniques...
  5. ncbi Ezrin induces long-range interdomain allostery in the scaffolding protein NHERF1
    Jianquan Li
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    J Mol Biol 392:166-80. 2009
    ....
  6. ncbi Autoinhibitory interactions between the PDZ2 and C-terminal domains in the scaffolding protein NHERF1
    Hong Cheng
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Structure 17:660-9. 2009
    ..The findings provide a structural framework for understanding how autoinhibitory interactions modulated the binding properties of NHERF1...
  7. ncbi Solution structure of the A4 domain of factor XI sheds light on the mechanism of zymogen activation
    Dharmaraj Samuel
    Division of Basic Science, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Proc Natl Acad Sci U S A 104:15693-8. 2007
    ..The results are consistent with biochemical evidence that activated FXI cleaves its substrate at two positions without release of an intermediate...
  8. ncbi Ligand-induced structural transitions in ErbB receptor extracellular domains
    Jessica P Dawson
    Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, 422 Curie Boulevard, Philadelphia, PA 19104, USA
    Structure 15:942-54. 2007
    ..These findings explain why tether mutants fail to activate EGF receptor and provide new insight into regulation of ErbB receptor conformation...
  9. ncbi Molecular alignment within beta-sheets in Abeta(14-23) fibrils: solid-state NMR experiments and theoretical predictions
    Zimei Bu
    Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    Biophys J 92:594-602. 2007
    ..While the theoretical predictions are not in exact agreement with the experimental results, they facilitate the design of experiments by suggesting a small number of plausible alignments that are readily distinguished by solid-state NMR...
  10. ncbi Immunization with a single extracellular enveloped virus protein produced in bacteria provides partial protection from a lethal orthopoxvirus infection in a natural host
    Min Fang
    Program of Viral Pathogenesis, Division of Basic Science, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Virology 345:231-43. 2006
    ..coli protects susceptible mice from a lethal ectromelia virus infection. This is the first report that a subunit vaccine can provide protection to a lethal Orthopoxvirus infection in its natural host...
  11. ncbi Structure-specific DNA-induced conformational changes in Taq polymerase revealed by small angle neutron scattering
    Derek L Ho
    National Institute of Standards and Technology, Gaithersburg, Maryland 20898, USA
    J Biol Chem 279:39146-54. 2004
    ..However, interactions between the polymerase and the nuclease domains can assist in the transfer of the DNA substrate from one active site to the other...

Research Grants6

  1. Struture snd Dynamic Determinants of Ion Channel Assembly by Adapter Proteins
    Zimei Bu; Fiscal Year: 2009
    ..A molecular understanding of the macromolecular interactions with CFTR is an essential element for developing a therapeutic strategy for the cure of cystic fibrosis. ..
  2. Struture snd Dynamic Determinants of Ion Channel Assembly by Adapter Proteins
    Zimei Bu; Fiscal Year: 2010
    ..A molecular understanding of the macromolecular interactions with CFTR is an essential element for developing a therapeutic strategy for the cure of cystic fibrosis. ..