A Bellacosa

Summary

Affiliation: Fox Chase Cancer Center
Country: USA

Publications

  1. ncbi RNA repair: damage control
    Alfonso Bellacosa
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Curr Biol 13:R482-4. 2003
  2. ncbi Genetic hits and mutation rate in colorectal tumorigenesis: versatility of Knudson's theory and implications for cancer prevention
    Alfonso Bellacosa
    Human Genetics Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Genes Chromosomes Cancer 38:382-8. 2003
  3. ncbi Functional interactions and signaling properties of mammalian DNA mismatch repair proteins
    A Bellacosa
    Human Genetics Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Cell Death Differ 8:1076-92. 2001
  4. ncbi Role of MED1 (MBD4) Gene in DNA repair and human cancer
    A Bellacosa
    Human Genetics Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    J Cell Physiol 187:137-44. 2001
  5. ncbi MED1, a novel human methyl-CpG-binding endonuclease, interacts with DNA mismatch repair protein MLH1
    A Bellacosa
    Divisions of Population Science, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA
    Proc Natl Acad Sci U S A 96:3969-74. 1999
  6. ncbi Effects of provirus integration in the Tpl-1/Ets-1 locus in Moloney murine leukemia virus-induced rat T-cell lymphomas: levels of expression, polyadenylation, transcriptional initiation, and differential splicing of the Ets-1 mRNA
    A Bellacosa
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111
    J Virol 68:2320-30. 1994
  7. ncbi Investigation of the substrate spectrum of the human mismatch-specific DNA N-glycosylase MED1 (MBD4): fundamental role of the catalytic domain
    F Petronzelli
    Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    J Cell Physiol 185:473-80. 2000
  8. ncbi Biphasic kinetics of the human DNA repair protein MED1 (MBD4), a mismatch-specific DNA N-glycosylase
    F Petronzelli
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Biol Chem 275:32422-9. 2000
  9. ncbi Structure, expression and chromosomal mapping of c-akt: relationship to v-akt and its implications
    A Bellacosa
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111
    Oncogene 8:745-54. 1993
  10. ncbi Akt is a direct target of the phosphatidylinositol 3-kinase. Activation by growth factors, v-src and v-Ha-ras, in Sf9 and mammalian cells
    K Datta
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Biol Chem 271:30835-9. 1996

Collaborators

Detail Information

Publications36

  1. ncbi RNA repair: damage control
    Alfonso Bellacosa
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Curr Biol 13:R482-4. 2003
    ..RNA damage can induce apoptosis and may be exploited for anti-cancer chemotherapy. It is a surprise, however, to learn that cells may repair RNA damage, suggesting a far greater significance of RNA in genotoxic stress...
  2. ncbi Genetic hits and mutation rate in colorectal tumorigenesis: versatility of Knudson's theory and implications for cancer prevention
    Alfonso Bellacosa
    Human Genetics Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Genes Chromosomes Cancer 38:382-8. 2003
    ..The beauty of Knudson's two-hit theory is its ability to explain diverse experimental situations and guide specific predictions, including some directly relevant to cancer prevention...
  3. ncbi Functional interactions and signaling properties of mammalian DNA mismatch repair proteins
    A Bellacosa
    Human Genetics Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Cell Death Differ 8:1076-92. 2001
    ..In the future, a deeper understanding of the molecular mechanisms and functional interactions of MMR proteins will lead to the development of more effective cancer prevention and treatment strategies...
  4. ncbi Role of MED1 (MBD4) Gene in DNA repair and human cancer
    A Bellacosa
    Human Genetics Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    J Cell Physiol 187:137-44. 2001
    ..In the future, efforts should be directed toward investigations of the functional role of the MED1 gene in the pathogenesis, prevention, and treatment of human cancer...
  5. ncbi MED1, a novel human methyl-CpG-binding endonuclease, interacts with DNA mismatch repair protein MLH1
    A Bellacosa
    Divisions of Population Science, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA
    Proc Natl Acad Sci U S A 96:3969-74. 1999
    ..In addition, these results suggest that cytosine methylation may play a role in human DNA repair...
  6. ncbi Effects of provirus integration in the Tpl-1/Ets-1 locus in Moloney murine leukemia virus-induced rat T-cell lymphomas: levels of expression, polyadenylation, transcriptional initiation, and differential splicing of the Ets-1 mRNA
    A Bellacosa
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111
    J Virol 68:2320-30. 1994
    ....
  7. ncbi Investigation of the substrate spectrum of the human mismatch-specific DNA N-glycosylase MED1 (MBD4): fundamental role of the catalytic domain
    F Petronzelli
    Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    J Cell Physiol 185:473-80. 2000
    ..This suggests that the catalytic domain is fundamental, and the 5-methylcytosine binding domain dispensable, in determining the substrate spectrum of MED1...
  8. ncbi Biphasic kinetics of the human DNA repair protein MED1 (MBD4), a mismatch-specific DNA N-glycosylase
    F Petronzelli
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Biol Chem 275:32422-9. 2000
    ..Comparison of kinetic profiles revealed that the MED1 5-methylcytosine binding domain and methylation of the mismatched CpG site are not required for efficient catalysis...
  9. ncbi Structure, expression and chromosomal mapping of c-akt: relationship to v-akt and its implications
    A Bellacosa
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111
    Oncogene 8:745-54. 1993
    ..c-akt was mapped by fluorescence in situ hybridization (FISH) to mouse chromosome 12 and rat chromosome 6 in close proximity to the Igh locus...
  10. ncbi Akt is a direct target of the phosphatidylinositol 3-kinase. Activation by growth factors, v-src and v-Ha-ras, in Sf9 and mammalian cells
    K Datta
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Biol Chem 271:30835-9. 1996
    ..The same results support the hypothesis that Akt is a direct target of the PI3-K and identify cytoplasmic signaling molecules that may contribute to the transduction of PI3-K/Akt activation signals...
  11. ncbi Provirus insertion in Tpl-1, an Ets-1-related oncogene, is associated with tumor progression in Moloney murine leukemia virus-induced rat thymic lymphomas
    S E Bear
    Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111
    Proc Natl Acad Sci U S A 86:7495-9. 1989
    ..2 +/- 0.9 centimorgans from the Ets-1 protooncogene. Although the genetic distance between Tpl-1 and Ets-1 indicates that they are different genes, analysis of Tpl-1 cDNA clones revealed that the two are closely related...
  12. ncbi Chromosomal localization of the Ox-44 (CD53) leukocyte antigen gene in man and rodents
    T Taguchi
    Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111
    Cytogenet Cell Genet 64:217-21. 1993
    ..Comparative mapping data presented in this report demonstrate conservation of synteny within the region encompassing this gene in mouse (Cd53), human (CD53), and rat (CD53)...
  13. ncbi A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region
    A Bellacosa
    Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111
    Science 254:274-7. 1991
    ..This suggests that Akt may form a functional link between tyrosine and serine-threonine phosphorylation pathways...
  14. ncbi Isolation, characterization, and mapping to human chromosome 11q24-25 of a cDNA encoding a highly conserved putative transmembrane protein, TMC
    N A Lissy
    Department of Medical Oncology, Fox Chase Cancer Center, Phildelphia, PA 19111, USA
    Biochim Biophys Acta 1306:137-41. 1996
    ..The cDNA clone was mapped to human chromosome 11q24-25 by fluorescence in situ hybridization. mRNA expression was observed in all tissues tested with the highest levels in testes and ovary...
  15. ncbi The rat leukocyte antigen MRC OX-44 is a member of a new family of cell surface proteins which appear to be involved in growth regulation
    A Bellacosa
    Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111
    Mol Cell Biol 11:2864-72. 1991
    ....
  16. ncbi Anti-apoptotic signaling by hepatocyte growth factor/Met via the phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase pathways
    G H Xiao
    Human Genetics Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Proc Natl Acad Sci U S A 98:247-52. 2001
    ..These results demonstrate that HGF/Met is capable of protecting cells from apoptosis by using both PI3-kinase/Akt and, to a lesser extent, MAPK pathways...
  17. ncbi Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase
    N N Ahmed
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Proc Natl Acad Sci U S A 94:3627-32. 1997
    ..The activation of Akt by IL-2 via the PI3-kinase and the rescue of the PI3-kinase-mediated antiapoptotic and proliferative IL-2 signals by catalytically active Akt indicate that these signals are transduced by Akt...
  18. ncbi AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas
    J Q Cheng
    Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111
    Proc Natl Acad Sci U S A 89:9267-71. 1992
    ..We conclude that AKT2 belongs to a distinct subfamily of protein-serine/threonine kinases containing Src homology 2-like domains and that alterations of AKT2 may contribute to the pathogenesis of ovarian carcinomas...
  19. ncbi Recombinant nucleases CEL I from celery and SP I from spinach for mutation detection
    Maxim Pimkin
    Basic Science, Fox Chase Cancer Center, Philadelphia, PA, USA
    BMC Biotechnol 7:29. 2007
    ..Previously, CEL I-like activities were described only in a variety of plants and could not be expressed in an active form in bacteria...
  20. ncbi Activation of AKT kinases in cancer: implications for therapeutic targeting
    Alfonso Bellacosa
    Human Genetics Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Adv Cancer Res 94:29-86. 2005
    ....
  21. ncbi A portrait of AKT kinases: human cancer and animal models depict a family with strong individualities
    Alfonso Bellacosa
    Human Genetics Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    Cancer Biol Ther 3:268-75. 2004
    ....
  22. ncbi The base excision repair enzyme MED1 mediates DNA damage response to antitumor drugs and is associated with mismatch repair system integrity
    Salvatore Cortellino
    Program in Human Genetics, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Proc Natl Acad Sci U S A 100:15071-6. 2003
    ..MED1 defects (much like MMR defects) may impair cell cycle arrest and apoptosis induced by DNA damage...
  23. ncbi One-hit effects in cancer: altered proteome of morphologically normal colon crypts in familial adenomatous polyposis
    Anthony T Yeung
    Division of Basic Science, Fox Chase Cancer Center, Philadelphia, PA 19111 2497, USA
    Cancer Res 68:7579-86. 2008
    ..These changes may represent the earliest biomarkers of colorectal cancer development, potentially leading to the identification of molecular targets for cancer prevention...
  24. ncbi The protein kinase Akt induces epithelial mesenchymal transition and promotes enhanced motility and invasiveness of squamous cell carcinoma lines
    Sylvia Julien Grille
    Developmental Genetics of Melanocytes, UMR 146 CNRS Institut Curie, 91405 Orsay Cedex, France
    Cancer Res 63:2172-8. 2003
    ..These findings suggest that future therapies based on AKT inhibition may complement conventional treatments by controlling tumor cell invasion and metastasis...
  25. ncbi The phosphoinositide 3-kinase/AKT1 pathway involvement in drug and all-trans-retinoic acid resistance of leukemia cells
    Luca M Neri
    Dipartimento di Morfologia ed Embriologia, , Ferrara, Italy
    Mol Cancer Res 1:234-46. 2003
    ..Our findings suggest that an up-regulation of the PI3K/AKT1 pathway might be one of the survival mechanisms responsible for the onset of resistance to chemotherapeutic and differentiating therapy in patients with acute leukemia...
  26. ncbi Comparison of RNA amplification methods and chip platforms for microarray analysis of samples processed by laser capture microdissection
    Elena Caretti
    Human Genetics Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    J Cell Biochem 103:556-63. 2008
    ..986. The quicker NuGEN procedure, when coupled with X3P arrays, also yielded excellent results (correlation of 0.951). These observations will be useful for planning large-scale analyses of LCM-dissected clinical samples...
  27. ncbi Akt induces enhanced myocardial contractility and cell size in vivo in transgenic mice
    Gianluigi Condorelli
    Kimmel Cancer Center, Thomas Jefferson University, 233 South 10th Street, Philadelphia, PA 19107, USA
    Proc Natl Acad Sci U S A 99:12333-8. 2002
    ..In summary, our results not only demonstrate that Akt regulates cardiomyocyte cell size in vivo, but, importantly, show that Akt modulates cardiac contractility in vivo without directly affecting beta-AR signaling capacity...
  28. ncbi Searchable high-resolution 2D gel proteome of the human colon crypt
    Bhavinkumar B Patel
    Division of Basic Science, Medical Science, and Population Science, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Proteome Res 6:2232-8. 2007
    ..These interactive, searchable, hyperlink-enabled proteome maps and gene ontology analyses will facilitate future studies to discover the earliest markers and intervention targets during progression to colon cancer...
  29. ncbi The DNA N-glycosylase MED1 exhibits preference for halogenated pyrimidines and is involved in the cytotoxicity of 5-iododeoxyuridine
    David P Turner
    Human Genetics Program, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Cancer Res 66:7686-93. 2006
    ..These findings establish MED1 as a bona fide repair activity for the removal of halogenated bases and indicate that MED1 may play a significant role in 5IdU cytotoxicity...
  30. ncbi Epithelial-mesenchymal transition in development and cancer: role of phosphatidylinositol 3' kinase/AKT pathways
    Lionel Larue
    Developmental Genetics of Melanocytes, UMR 146, CNRS, Institut Curie, Centre Universitaire, Orsay, France
    Oncogene 24:7443-54. 2005
    ..Interactions between PI3K/AKT and other EMT-inducing pathways are presented, along with a discussion of the therapeutic implications of modulating EMT in order to achieve cancer control...
  31. ncbi Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer
    Giuseppe Viglietto
    Istituto di Endocrinologia ed Oncologia Sperimentale, CNR c o Dipartimento di Biologia e Patologia Cellulare e Molecolare, Naples, Italy
    Nat Med 8:1136-44. 2002
    ....
  32. ncbi [Regulation of E-cadherin by the Akt protein kinase B]
    Sylvia Grille
    Developmental Genetics of Melanocytes, UMR 146 CNRS-Institut Curie, Bat. 110, 91405 Orsay Cedex, France
    J Soc Biol 198:375-8. 2004
    ..At the molecular level, cells expressing a constitutive active form of Akt express also a transcription factor, Snail, known to repress the expression of E-cadherin...
  33. ncbi Use of RNA amplification in the optimal characterization of global gene expression using cDNA microarrays
    Radka Stoyanova
    Division of Population Science, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    J Cell Physiol 201:359-65. 2004
    ..This study indicates that high quality microarray data can be generated from small amounts of RNA, including those extracted from limiting clinical samples and microdissected histological specimens...
  34. ncbi Induction of deoxyribonucleic acid damage by gamma irradiation
    Salvatore Cortellino
    Division of Population Science, Fox Chase Cancer Center, Philadelphia, PA, USA
    Methods Mol Biol 285:127-32. 2004
  35. ncbi Induction of deoxyribonucleic acid damage by alkylating agents
    Salvatore Cortellino
    Division of Population Science, Fox Chase Cancer Center, Philadelphia, PA, USA
    Methods Mol Biol 285:121-5. 2004
  36. ncbi Threonine 308 phosphorylated form of Akt translocates to the nucleus of PC12 cells under nerve growth factor stimulation and associates with the nuclear matrix protein nucleolin
    Paola Borgatti
    Dipartimento di Morfologia ed Embriologia, Sezione di Anatomia Umana, Universita di Ferrara, Ferrara, Italy
    J Cell Physiol 196:79-88. 2003
    ....