Research Topics
Species | Martin G BelinskySummaryAffiliation: Fox Chase Cancer Center Country: USA Publications
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Detail Information
Publications
High density DNA array analysis reveals distinct genomic profiles in a subset of gastrointestinal stromal tumorsMartin G Belinsky
Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111 2497, USA
Genes Chromosomes Cancer 48:886-96. 2009..These results suggest that GISTs without activating kinase mutations, whether pediatric or adult, generally exhibit a much lower level of cytogenetic progression than that observed in mutant GISTs...- The insulin-like growth factor system as a potential therapeutic target in gastrointestinal stromal tumorsMartin G Belinsky
Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
Cell Cycle 7:2949-55. 2008..We also discuss how the IGF pathway may provide additional molecular targets for the treatment of GISTs that respond poorly to IM therapy... - Contribution of Abcc10 (Mrp7) to in vivo paclitaxel resistance as assessed in Abcc10(-/-) miceElizabeth A Hopper-Borge
Program in Developmental Therapeutics, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
Cancer Res 71:3649-57. 2011..This is the first demonstration that an ATP-binding cassette transporter other than P-glycoprotein can affect in vivo tissue sensitivity toward taxanes... - Physiological and pharmacological functions of Mrp2, Mrp3 and Mrp4 as determined from recent studies on gene-disrupted miceGary D Kruh
Medical Science Division, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
Cancer Metastasis Rev 26:5-14. 2007..This review will discuss insights into the physiological and pharmacological functions of Mrp2, Mrp3 and Mrp4 afforded by investigations of these new mouse models... - ABCC10, ABCC11, and ABCC12Gary D Kruh
Medical Science Division, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
Pflugers Arch 453:675-84. 2007..The functional characteristics of MRP9 are currently unknown... - The MRP family of drug efflux pumpsGary D Kruh
Medical Science Division, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
Oncogene 22:7537-52. 2003..The review will describe the biochemical properties, drug resistance activities and potential in vivo functions of these unusual pumps... - Targeted ablation of Abcc1 or Abcc3 in Abcc6(-/-) mice does not modify the ectopic mineralization processQiaoli Li
Department of Dermatology and Cutaneous Biology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA
Exp Dermatol 16:853-9. 2007.... - Gene expression signatures and response to imatinib mesylate in gastrointestinal stromal tumorLori Rink
Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
Mol Cancer Ther 8:2172-82. 2009.... - Characterization of the drug resistance and transport properties of multidrug resistance protein 6 (MRP6, ABCC6)Martin G Belinsky
Medical Science Division, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
Cancer Res 62:6172-7. 2002..These results indicate that MRP6 is a glutathione conjugate pump that is able to confer low levels of resistance to certain anticancer agents... - Analysis of the in vivo functions of Mrp3Martin G Belinsky
Medical Science Division, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
Mol Pharmacol 68:160-8. 2005.... - Transport of methotrexate, methotrexate polyglutamates, and 17beta-estradiol 17-(beta-D-glucuronide) by ABCG2: effects of acquired mutations at R482 on methotrexate transportZhe Sheng Chen
Medical Science Division, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
Cancer Res 63:4048-54. 2003..In addition, it is demonstrated that R482 mutations observed in drug-resistant cell lines have profound effects on the in vitro transport properties of the pump... - Characterization of the transport properties of human multidrug resistance protein 7 (MRP7, ABCC10)Zhe Sheng Chen
Medical Sciences Division, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
Mol Pharmacol 63:351-8. 2003..The determination that MRP7 has the facility for mediating the transport of conjugates such as E(2)17betaG indicates that it is a lipophilic anion transporter involved in phase III (cellular extrusion) of detoxification... - MRP8, ATP-binding cassette C11 (ABCC11), is a cyclic nucleotide efflux pump and a resistance factor for fluoropyrimidines 2',3'-dideoxycytidine and 9'-(2'-phosphonylmethoxyethyl)adenineYanping Guo
Medical Science Division, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
J Biol Chem 278:29509-14. 2003..We conclude that MRP8 is an amphipathic anion transporter that is able to efflux cAMP and cGMP and to function as a resistance factor for commonly employed purine and pyrimidine nucleotide analogs... - Analysis of the drug resistance profile of multidrug resistance protein 7 (ABCC10): resistance to docetaxelElizabeth Hopper-Borge
Medical Science Division, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
Cancer Res 64:4927-30. 2004..These results indicate that MRP7, unlike other MRPs, is a resistance factor for taxanes... - Multidrug resistance protein 4 protects bone marrow, thymus, spleen, and intestine from nucleotide analogue-induced damageMartin G Belinsky
Medical Science Division, Department of Pathology, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
Cancer Res 67:262-8. 2007..This is the first demonstration that an ATP-binding cassette transporter can affect in vivo tissue sensitivity towards this class of agents... - Transport of bile acids, sulfated steroids, estradiol 17-beta-D-glucuronide, and leukotriene C4 by human multidrug resistance protein 8 (ABCC11)Zhe Sheng Chen
Medical Science Division, Fox Chase Cancer Center, 333 Cottman Ave, Philadelphia, PA 19111, USA
Mol Pharmacol 67:545-57. 2005..These results suggest that MRP8 participates in physiological processes involving bile acids, conjugated steroids, and cyclic nucleotides and indicate that the pump has complex interactions with its substrates... - Determination of methotrexate and its major metabolite 7-hydroxymethotrexate in mouse plasma and brain tissue by liquid chromatography-tandem mass spectrometryPing Guo
School of Pharmacy, Temple University, Philadelphia, PA 19140, USA
J Pharm Biomed Anal 43:1789-95. 2007..The method has the advantages of low sample volume, rapid clean-up, and the simultaneous measurement of MTX and 7-OH MTX in plasma and brain tissues allowing detailed PK studies to be completed in individual mice...