P W Wiesenfeld

Summary

Affiliation: Food and Drug Administration
Country: USA

Publications

  1. ncbi Effect of long-chain fatty acids in the culture medium on fatty acid composition of WEHI-3 and J774A.1 cells
    P W Wiesenfeld
    U S Food and Drug Administration, Center for Food Safety and Applied Nutrition, 8301 Murikirk Road, MOD 1, HFS 842, Laurel, MD 20708, USA
    Comp Biochem Physiol B Biochem Mol Biol 128:123-34. 2001
  2. ncbi Flaxseed increased alpha-linolenic and eicosapentaenoic acid and decreased arachidonic acid in serum and tissues of rat dams and offspring
    P W Wiesenfeld
    US Food and Drug Administration, Center for Food Safety and Applied Nutrition, 8301 Muirkirk Road, Laurel, MD 20708, USA
    Food Chem Toxicol 41:841-55. 2003
  3. ncbi Effects of oral androstenedione on phospholipid fatty acids, ATP, caspase-3, prostaglandin E(2) and C-reactive protein in serum and livers of pregnant and non-pregnant female rats
    P W Wiesenfeld
    US FDA, Center for Food Safety and Applied Nutrition, Office of Applied Research and Safety Assessment, 8301 Muirkirk Road, Laurel, MD 20708, USA
    Food Chem Toxicol 44:579-87. 2006
  4. ncbi Impact of high flaxseed diet on mitogen-induced proliferation, IL-2 production, cell subsets and fatty acid composition of spleen cells from pregnant and F1 generation Sprague-Dawley rats
    U S Babu
    US Food and Drug Administration, Center for Food Safety and Applied Nutrition, 8301 Muirkirk Road, Laurel, MD 20708, USA
    Food Chem Toxicol 41:905-15. 2003
  5. ncbi Effects of oral androstenedione on steroid metabolism in liver of pregnant and non-pregnant female rats
    T J Flynn
    US FDA, Center for Food Safety and Applied Nutrition, Office of Applied Research and Safety Assessment, 8301 Muirkirk Road, Laurel, MD 20708, USA
    Food Chem Toxicol 43:537-42. 2005
  6. ncbi Developmental effects of serum from flaxseed-fed rats on cultured rat embryos
    T J Flynn
    Offices of Applied Research and Safety Assessment, FDA, MOD 1 Laboratories, 8301 Muirkirk Road, Laurel, MD 20708, USA
    Food Chem Toxicol 41:835-40. 2003
  7. ncbi A potential mechanism for fumonisin B(1)-mediated hepatocarcinogenesis: cyclin D1 stabilization associated with activation of Akt and inhibition of GSK-3beta activity
    D Ramljak
    Laboratory of Comparative Carcinogenesis, National Cancer Institute, Frederick Cancer Research and Development Center, Building 538, Room 205E, Frederick, MD 21702, USA
    Carcinogenesis 21:1537-46. 2000

Collaborators

Detail Information

Publications7

  1. ncbi Effect of long-chain fatty acids in the culture medium on fatty acid composition of WEHI-3 and J774A.1 cells
    P W Wiesenfeld
    U S Food and Drug Administration, Center for Food Safety and Applied Nutrition, 8301 Murikirk Road, MOD 1, HFS 842, Laurel, MD 20708, USA
    Comp Biochem Physiol B Biochem Mol Biol 128:123-34. 2001
    ..Similar dose-response results were observed in a previous in vivo study using flaxseed, rich in ALA, as a source of PUFA...
  2. ncbi Flaxseed increased alpha-linolenic and eicosapentaenoic acid and decreased arachidonic acid in serum and tissues of rat dams and offspring
    P W Wiesenfeld
    US Food and Drug Administration, Center for Food Safety and Applied Nutrition, 8301 Muirkirk Road, Laurel, MD 20708, USA
    Food Chem Toxicol 41:841-55. 2003
    ..FS more than FLM, changed fatty acids profiles, but FLM and 40% FS significantly reduced serum cholesterol. Dietary 40% FS may have increased oxidative stress as evidenced by a reduction in liver vitamin E...
  3. ncbi Effects of oral androstenedione on phospholipid fatty acids, ATP, caspase-3, prostaglandin E(2) and C-reactive protein in serum and livers of pregnant and non-pregnant female rats
    P W Wiesenfeld
    US FDA, Center for Food Safety and Applied Nutrition, Office of Applied Research and Safety Assessment, 8301 Muirkirk Road, Laurel, MD 20708, USA
    Food Chem Toxicol 44:579-87. 2006
    ..In conclusion, oral androstenedione did not result in overt hepatotoxicity in pregnant female rats, but produced modest changes in lipid metabolism and may impair regeneration of injured hepatic cells or tissue...
  4. ncbi Impact of high flaxseed diet on mitogen-induced proliferation, IL-2 production, cell subsets and fatty acid composition of spleen cells from pregnant and F1 generation Sprague-Dawley rats
    U S Babu
    US Food and Drug Administration, Center for Food Safety and Applied Nutrition, 8301 Muirkirk Road, Laurel, MD 20708, USA
    Food Chem Toxicol 41:905-15. 2003
    ..No significant changes were observed in the cell subsets or IL-2 production by splenic cells from different groups...
  5. ncbi Effects of oral androstenedione on steroid metabolism in liver of pregnant and non-pregnant female rats
    T J Flynn
    US FDA, Center for Food Safety and Applied Nutrition, Office of Applied Research and Safety Assessment, 8301 Muirkirk Road, Laurel, MD 20708, USA
    Food Chem Toxicol 43:537-42. 2005
    ....
  6. ncbi Developmental effects of serum from flaxseed-fed rats on cultured rat embryos
    T J Flynn
    Offices of Applied Research and Safety Assessment, FDA, MOD 1 Laboratories, 8301 Muirkirk Road, Laurel, MD 20708, USA
    Food Chem Toxicol 41:835-40. 2003
    ..This finding is consistent with the findings of a parallel in vivo rat teratology study where no significant embryotoxicity attributable to flaxseed exposure was observed...
  7. ncbi A potential mechanism for fumonisin B(1)-mediated hepatocarcinogenesis: cyclin D1 stabilization associated with activation of Akt and inhibition of GSK-3beta activity
    D Ramljak
    Laboratory of Comparative Carcinogenesis, National Cancer Institute, Frederick Cancer Research and Development Center, Building 538, Room 205E, Frederick, MD 21702, USA
    Carcinogenesis 21:1537-46. 2000
    ..This is the first report suggesting the mechanism by which FB(1) acts as a carcinogen...