Research Topics
Species | W SlikkerSummaryAffiliation: Food and Drug Administration Country: USA Publications
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Publications
Biologically-based dose-response model for neurotoxicity risk assessmentW Slikker
Division of Neurotoxicology, National Center for Toxicological Research FDA, Jefferson, AR 72079 9502, USA
Toxicol Lett 102:429-33. 1998..This quantitative approach uses all the available data, takes into account the variability of the data and provides an actual risk at a given dose of domoic acid...- Behavioral test methods workshopWilliam Slikker
National Center for Toxicological Research FDA, Division of Neurotoxicology, 3900 NCTR Rd Jefferson 72079, United States
Neurotoxicol Teratol 27:417-27. 2005.... - A microarray study of MPP+-treated PC12 Cells: Mechanisms of toxicity (MOT) analysis using bioinformatics toolsZengjun Xu
Division of Neurotoxicology, National Center for Toxicological Research, U S Food and Drug Administration, 3900 NCTR Road, Jefferson, Arkansas 72079, USA
BMC Bioinformatics 6:S8. 2005..MPP+ depletes dopamine content and elicits cell death in PC12 cells. However, the mechanism of MPP+-induced neurotoxicity is still unclear... - Systems biology/systems toxicology: application to developmental neurotoxicology/neuroprotectionWilliam Slikker
Division of Neurotoxicology, National Center for Toxicological Research/FDA, 3900 NCTR Road, Jefferson, Arkansas 72079, USA
Ann N Y Acad Sci 1053:309-10. 2005 - Mode of action: disruption of brain cell replication, second messenger, and neurotransmitter systems during development leading to cognitive dysfunction--developmental neurotoxicity of nicotineWilliam Slikker
Division of Neurotoxicology, NCTR FDA, Jefferson, Arkansas 72079, USA
Crit Rev Toxicol 35:703-11. 2005..As data become available with the advent of the use of the nicotine patch in pregnant humans, the question as to the relative importance of smoking per se versus nicotine alone may be determined... - Improving predictive modeling in pediatric drug development: pharmacokinetics, pharmacodynamics, and mechanistic modelingWilliam Slikker
Office of Research, National Center for Toxicological Research FDA, 3900 NCTR Road, Jefferson, Arkansas 72079 9502, USA
Ann N Y Acad Sci 1053:505-18. 2005..Issues addressed in this workshop should be considered in the development of new predictive and mechanistic models of drug kinetics and dynamics in the developing human... - Gender-based differences in rats after chronic dietary exposure to genisteinW Slikker
Division of Neurotoxicology, National Center for Toxicological Research Food and Drug Administration, Jefferson, Arkansas 72079 9502, USA
Int J Toxicol 20:175-9. 2001..Additional studies, perhaps in nonhuman primates, are necessary to further predict the effect(s) of genistein on human gender-based development... - Biomarkers of adult and developmental neurotoxicityWilliam Slikker
Division of Neurotoxicology, National Center for Toxicological Research FDA, HFT 132, 3900 NCTR Road, Jefferson, AR 72079 9502, USA
Toxicol Appl Pharmacol 206:255-60. 2005.... - Application of a systems biology approach to developmental neurotoxicologyWilliam Slikker
Division of Neurotoxicology, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079 9502, USA
Reprod Toxicol 19:305-19. 2005.... - Neuroimaging: strategies to illuminate environment-disease linkages. Session II. Summary and research needsWilliam Slikker
Division of Neurotoxicology, National Center for Toxicological Research/FDA, 3900 NCTR Road, Jefferson, AR 72079, USA
Neurotoxicology 25:501-2. 2004 - Chronic marijuana smoke exposure in the rhesus monkey. IV: Neurochemical effects and comparison to acute and chronic exposure to delta-9-tetrahydrocannabinol (THC) in ratsS F Ali
Division of Reproductive and Developmental Toxicology, National Center for Toxicological Research, Jefferson, AR 72079
Pharmacol Biochem Behav 40:677-82. 1991..In the monkey brain, we found no alterations in the concentration of neurotransmitters in caudate nucleus, frontal cortex, hypothalamus or brain stem.(ABSTRACT TRUNCATED AT 250 WORDS).. - Methamphetamine-induced dopaminergic neurotoxicity: role of peroxynitrite and neuroprotective role of antioxidants and peroxynitrite decomposition catalystsS Z Imam
Neurochemistry Laboratory Division of Neurotoxicology, HFT-132, National Center for Toxicological Research/FDA, 3900 NCTR Rd, Jefferson, AR 72079, USA
Ann N Y Acad Sci 939:366-80. 2001..These antioxidants and decomposition catalysts may have therapeutic potential in the treatment of psychostimulant addictions... - The effects of L-carnitine on the combination of, inhalation anesthetic-induced developmental, neuronal apoptosis in the rat frontal cortexX Zou
Division of Neurotoxicology, National Center for Toxicological Research, HFT 132, U S Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA
Neuroscience 151:1053-65. 2008.... - Changes in gene expression after phencyclidine administration in developing rats: a potential animal model for schizophreniaF Liu
Division of Neurotoxicology, National Center for Toxicological Research U S Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079 9502, USA
Int J Dev Neurosci 29:351-8. 2011..The changes in schizophrenia-relevant genes after repeated PCP exposure during development may provide important information concerning the validation of an animal model for this disorder... - L-carnitine protects neurons from 1-methyl-4-phenylpyridinium-induced neuronal apoptosis in rat forebrain cultureC Wang
Division of Neurotoxicology, HFT 132, National Center for Toxicological Research U S Food and Drug Administration, Jefferson, AR 72079, USA
Neuroscience 144:46-55. 2007..L-carnitine blocked these effects of MPP+ suggesting its potential therapeutic utility in degenerative disorders such as Parkinson's disease, Alzheimer's disease, ornithine transcarbamylase deficiency and other mitochondrial diseases... - Formation of artifactual metabolites of doxylamine following acid hydrolysisC L Holder
Department of Health and Human Services, Food and Drug Administration, Jefferson, AR 72079
J Chromatogr 419:113-22. 1987..These artifactual products were shown to originate from the acid hydrolysis of 2-[1-phenyl-1-(2-pyridinyl)ethoxy] acetic acid and not from doxylamine... - Effect of acute exposure to 3-nitropropionic acid on activities of endogenous antioxidants in the rat brainZ Binienda
Division of Neurotoxicology, National Center for Toxicological Research FDA, Jefferson, AR 72079, USA
Neurosci Lett 251:173-6. 1998..The depletion of GSH and induction of antioxidant enzyme activities after the 3-NPA exposure suggest conditions favorable for oxidative stress... - An evaluation of l-ephedrine neurotoxicity with respect to hyperthermia and caudate/putamen microdialysate levels of ephedrine, dopamine, serotonin, and glutamateJ F Bowyer
Division of Neurotoxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079, USA
Toxicol Sci 55:133-42. 2000.... - Gene expression profiling in the developing rat brain exposed to ketamineQ Shi
Division of Systems Toxicology, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA
Neuroscience 166:852-63. 2010.... - The effect of chronic cocaine exposure throughout pregnancy on maternal and infant outcomes in the rhesus monkeyP Morris
Division of Neurotoxicology, Food and Drug Administration, Jefferson, AR 72079, USA
Neurotoxicol Teratol 19:47-57. 1997..It was concluded that, in a rhesus monkey model, chronic cocaine exposure throughout pregnancy had no significant effect on maternal outcome, but did significantly affect infant outcome as assessed in this investigation... - Ketamine anesthesia during the first week of life can cause long-lasting cognitive deficits in rhesus monkeysM G Paule
Division of Neurotoxicology, National Center for Toxicological Research FDA, 3900 NCTR Road, Jefferson, AR 72079 9502, USA
Neurotoxicol Teratol 33:220-30. 2011..Supported by NICHD, CDER/FDA and NCTR/FDA... - Metabolism of doxylamine succinate in Fischer 344 rats. Part III: Conjugated urinary and fecal metabolitesC L Holder
Food and Drug Administration, National Center for Toxicological Research, Jefferson, Arkansas 72079
J Anal Toxicol 14:247-51. 1990..The conjugated doxylamine metabolites that were isolated, quantitated, and identified are doxylamine O-glucuronide, N-desmethyl-doxylamine O-glucuronide, and N,N-didesmethyldoxylamine O-glucuronide... - Gestational exposure to phencyclidine (PCP) in rats decreases PCP binding sites in term fetal brainS F Ali
Division of Reproductive and Developmental Toxicology, National Center for Toxicological Research, Jefferson, AR 72079
Int J Dev Neurosci 6:547-52. 1988..These data indicate that gestational exposure to PCP decreases high affinity binding of PCP in term fetal brain at doses which do not alter maternal PCP receptor binding... - MicroPET imaging of ketamine-induced neuronal apoptosis with radiolabeled DFNSHX Zhang
Division of Neurotoxicology, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079 9502, USA
J Neural Transm 118:203-11. 2011..This study demonstrates that microPET imaging is capable of distinguishing differences in retention of [(18)F]-DFNSH in ROI and suggests that this compound may serve as a minimally invasive biomarker of neuronal apoptosis in rodents... - Distribution of 2,4-dichlorophenoxyacetic acid (2,4-D) in maternal and fetal rabbitsJ A Sandberg
Division of Neurotoxicology, National Center for Toxicological Research FDA, Jefferson, Arkansas 72079, USA
J Toxicol Environ Health 49:497-509. 1996..However, its development may not be complete due to the higher brain tissue to plasma ratios in the fetus compared to the dam... - Selective alterations of transcription factors in MPP+-induced neurotoxicity in PC12 cellsZ Xu
Neurochemistry Laboratory, Division of Neurotoxicology, HFT-132, National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA
Neurotoxicology 26:729-37. 2005..The data indicates that selective transcription factors are involved in MPP(+)-induced neurotoxicity and it provides mechanistic information that may be applicable to animal studies with MPTP and clinical studies of Parkinson's disease... - Effects of gestational exposure to phencyclidine: distribution and neurochemical alterations in maternal and fetal brainS F Ali
Division of Reproductive and Developmental Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079
Neurotoxicology 10:383-92. 1989..These data demonstrated that maternal PCP exposure resulted in prolonged exposure of the developing CNS and also indicated that gestational exposure to PCP decreased high affinity binding sites of PCP in term fetal brain... - Pharmacokinetics of doxylamine, a component of Bendectin, in the rhesus monkeyW Slikker
Division of Reproductive and Developmental Toxicology, National Center for Toxicological Research, Jefferson, AR 72079
Reprod Toxicol 3:187-96. 1989.... - Application of electrophysiological method to study interactions between ibogaine and cocaineZ Binienda
Division of Neurotoxicology, National Center for Toxicological Research FDA, Jefferson, Arkansas 72079, USA
Ann N Y Acad Sci 914:387-93. 2000..DA turnover increased significantly after IBO alone but was not observed after IBO/COC treatment. The alterations in ECoG and neurotransmitter levels suggest a decreased response to COC following IBO pretreatment... - Plasma elimination and urinary excretion of methapyrilene in the ratD W Kelly
National Center for Toxicological Research, University of Arkansas for Medical Sciences, Jefferson, AR 72079 9502
Drug Metab Dispos 18:1018-24. 1990..The terminal plasma elimination t1/2 of methapyrilene did not increase with increasing doses (2.75 hr, 0.7 mg/kg; 2.81 hr, 3.5 mg/kg); thus, methapyrilene does not exhibit dose-dependent elimination over this 5-fold dose range... - Fast-atom bombardment and thermospray mass spectrometry for the characterization of two glucuronide metabolites of methapyrileneJ O Lay
Food and Drug Administration, National Center for Toxicological Research, Jefferson, Arkansas 72079
Rapid Commun Mass Spectrom 3:72-5. 1989..While loss of the sugar moiety indicated a glucuronide, additional fragmentation confirmed the presence of the underlying ethylenediamine substructure which is characteristic of this class of antihistamines... - Acute effects of dexfenfluramine (d-FEN) and methylenedioxymethamphetamine (MDMA) before and after short-course, high-dose treatmentD L Frederick
Division of Neurotoxicology, National Center for Toxicological Research, Jefferson Arkansas 72079, USA
Ann N Y Acad Sci 844:183-90. 1998..e., significant decreases of ca. 50% in serotonin in frontal cortex and hippocampus) were observed in all monkeys approximately six months after short-course, high-dose MDMA or d-FEN treatment... - Temporal development of 2',3'-dideoxyinosine (ddI)-induced peripheral myelinopathyT A Patterson
Division of Neurotoxicology, National Center for Toxicological Research FDA, 72079 9502, Jefferson, AR, USA
Neurotoxicol Teratol 22:429-34. 2000..Although abnormal morphology was present at 20 weeks of dosing, the effect was not as robust as at 15 weeks. This suggests that the nerve may partially recover from the effects of ddI with time. Published by Elsevier Science Inc... - Methamphetamine-induced alteration in striatal p53 and bcl-2 expressions in miceS Z Imam
Neurochemistry Laboratory, Division of Neurotoxicology, HFT-132, National Center for Toxicological Research/FDA, 3900 NCTR Rd, Jefferson, AR 72079-9502, USA
Brain Res Mol Brain Res 91:174-8. 2001..These data suggest that METH might cause its neurotoxic effects via the production of free radicals and secondary perturbations in the expression of genes known to be involved in apoptosis and cell death machinery... - Embryo-maternal distribution of basic compounds in the CD-1 mouse: doxylamine and nicotineL G Roberts
Division of Reproductive and Developmental Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079
Toxicol Appl Pharmacol 97:134-40. 1989..Our results indicate that the partitioning of these basic compounds between the maternal plasma and the early postimplantation rodent embryo is not a consequence of the pH gradient between the two compartments alone... - Transplacental pharmacokinetics and fetal distribution of 2', 3'-didehydro-3'-deoxythymidine (d4T) and its metabolites in late-term rhesus macaquesT A Patterson
Division of Neurotoxicology, National Center for Toxicological Research FDA, Jefferson, Arkansas 72079 9502, USA
Teratology 62:93-9. 2000.... - Black-gold: a simple, high-resolution histochemical label for normal and pathological myelin in brain tissue sectionsL Schmued
Division of Neurotoxicology, National Center for Toxicological Research FDA, 3900 NCTR Road, Jefferson, AR 72079 9502, USA
Brain Res 837:289-97. 1999..Advantages associated with the Black-Gold technique include high resolution, high contrast, short histochemical processing time, and consistent reproducibility... - Hypothermia enhances bcl-2 expression and protects against oxidative stress-induced cell death in Chinese hamster ovary cellsW Slikker
Division of Neurotoxicology, National Center for Toxicological Research/US FDA, 3900 NCTR Drive, Jefferson, AR 72079, USA
Free Radic Biol Med 31:405-11. 2001.... - Acute changes in dopamine release and turnover in rat caudate nucleus following a single dose of methamphetamineF C Pereira
Neurochemistry Laboratory, Division of Neurotoxicology, NCTR, Jefferson 72079, AR, USA
J Neural Transm 109:1151-8. 2002..A single dose of METH-induced an increase in DA turnover [(DOPAC + HVA)/DA] concomitant with an acute DA release followed by transient DA and DOPAC depletion in the rat CN... - Peroxynitrite plays a role in methamphetamine-induced dopaminergic neurotoxicity: evidence from mice lacking neuronal nitric oxide synthase gene or overexpressing copper-zinc superoxide dismutaseS Z Imam
Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research FDA, Jefferson, Arkansas, USA
J Neurochem 76:745-9. 2001..The dopaminergic damage induced by METH treatment was also attenuated in nNOS-/- or SOD-Tg mice. These data further confirm that METH causes its neurotoxic effects via the production of peroxynitrite... - Effect of manganese on the concentration of amino acids in different regions of the rat brainG W Lipe
Neurochemistry Laboratory, FDA, Jefferson, AR 72079, USA
J Environ Sci Health B 34:119-32. 1999..These data suggest that chronic Mn exposure can produce a decrease in body weight gain in adult rats and alterations in amino acids in different regions of weanling and adult rat brains... - The role of the N-methyl-D-aspartate receptor in ketamine-induced apoptosis in rat forebrain cultureC Wang
Division of Neurotoxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079 0502, USA
Neuroscience 132:967-77. 2005..These data suggest that NR1 antisense offers neuroprotection from apoptosis in vitro, and that upregulation of the NR1 following ketamine administration is, at least, partially responsible for the observed apoptosis... - Metabolism of methapyrilene by Fischer-344 rat and B6C3F1 mouse hepatocytesD W Kelly
National Center for Toxicological Research, Jefferson, Arkansas 72079 9502
Xenobiotica 22:1367-81. 1992.... - Selective alterations of gene expression in mice induced by MPTPZ Xu
Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas 72079, USA
Synapse 55:45-51. 2005..Future studies will focus on gene expression of other pathways that may be affected by MPTP treatment and investigation of gene expression in specific cell types in vivo using LCM technology... - Prediction of organophosphorus acetylcholinesterase inhibition using three-dimensional quantitative structure-activity relationship (3D-QSAR) methodsJ El Yazal
Division of Neurotoxicology, National Center for Toxicological Research/FDA, 3900 NCTR Road, Jefferson, Arkansas 72079, USA
Toxicol Sci 63:223-32. 2001..Also, the pharmacophores offer an additional means of designing AChE inhibitors as potential therapeutic agents for central nervous system diseases... - Developmental neurotoxicity of ketamine: morphometric confirmation, exposure parameters, and multiple fluorescent labeling of apoptotic neuronsA C Scallet
Division of Neurotoxicology, NCTR FDA, Jefferson, Arkansas 72079, USA
Toxicol Sci 81:364-70. 2004.... - The role of caspase III inhibition in methamphetamine-induced alterations in p53 and bcl-2 expression: correlation with dopaminergic neurotoxicitySyed Z Imam
Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research/FDA, Jefferson, Arkansas 72079, USA
Ann N Y Acad Sci 993:350; discussion 387-93. 2003 - Ontogeny of the N-methyl-D-aspartate (NMDA) receptor system and susceptibility to neurotoxicityKathleen A Haberny
Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Rockville, Maryland 20857, USA
Toxicol Sci 68:9-17. 2002.... - Adaptation to repeated cocaine administration in ratsZbigniew K Binienda
Division of Neurotoxicology, NCTR FDA, Jefferson, Arkansas 72029, USA
Ann N Y Acad Sci 965:172-9. 2002..Further studies are necessary to establish whether regional alterations in blood flow and metabolic activity may underlie such observations... - Blockade of N-methyl-D-aspartate receptors by ketamine produces loss of postnatal day 3 monkey frontal cortical neurons in cultureCheng Wang
Division of Neurotoxicology, National Center for Toxicological Research Food and Drug Administration, Jefferson, Arkansas 72079 0502, USA
Toxicol Sci 91:192-201. 2006..Ketamine-induced effects were blocked by NR1 antisenses and SN-50. These data suggest that NR1 antisenses and SN-50 offer neuroprotection from the enhanced degeneration induced by ketamine in vitro... - Systems biology approaches for toxicologyWilliam Slikker
National Center for Toxicological Research, U S Food and Drug Administration, Jefferson, Arkansas 72079 9502, USA
J Appl Toxicol 27:201-17. 2007..Published in 2007 John Wiley & Sons, Ltd... - Strategies and experimental models for evaluating anesthetics: effects on the developing nervous systemCheng Wang
Division of Neurotoxicology, National Center for Toxicological Research F3900 NCTR Road, Jefferson, AR 72079 9502, USA
Anesth Analg 106:1643-58. 2008..Our focus on ketamine should not be construed as implying that the risk of neurodegeneration with ketamine is greater, or less, than with other anesthetics. We are simply describing the effects where we have the most preclinical data... - Sex differences in cytochrome P450 1B1, an estrogen-metabolizing enzyme, in the rhesus monkey telencephalonAndrew C Scallet
Division of Neurotoxicology, National Center for Toxicological Research, NCTR FDA, 3900 NCTR Drive, Jefferson, AR 72079, USA
J Chem Neuroanat 29:71-80. 2005..These results suggest that CYP1B1 may subserve widespread metabolic functions in the female primate brain but have more restricted actions within the hippocampal pyramidal neurons of the male... - The differential JunB responses to inhibition of succinate dehydrogenase in rat hippocampus and liverBeata D Przybyla-Zawislak
Division of Neurotoxicology, FDA National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079 9502, USA
Neurosci Lett 381:354-7. 2005..In conclusion, out of the three ITFs transcripts examined here junb may activate different pathways depending on the tissue as indicated by differential responses to mitochondrial inhibition in the hippocampus and liver... - Incorporating children's toxicokinetics into a risk frameworkGary Ginsberg
Connecticut Department of Public Health, Hartford, Connecticut 06134, USA
Environ Health Perspect 112:272-83. 2004..This type of resource information is intended to help the assessor begin to address the issues raised in this paper... - Neuroimaging: new approaches for neurotoxicologyAmy Pogge
Division of Neurotoxicology, National Center for Toxicology Research, 3900 NCTR Road, Jefferson, AR 72079 9502, USA
Neurotoxicology 25:525-31. 2004..In addition, as these technologies have been primarily developed for clinical purposes, they provide an outstanding opportunity for cross-species and animal-to-human extrapolation and testing... - Sex-selective hippocampal alterations after adolescent nicotine administration: effects on neurospecific proteinsZengjun Xu
Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR, USA
Nicotine Tob Res 5:955-60. 2003..We conclude that administration of nicotine to adolescent rats alters neuroproteins in the female hippocampus during withdrawal, effects that could contribute to neurobehavioral deficits... - Neurobehavioral assessment: a survey of use and value in safety assessment studiesLawrence D Middaugh
Department of Psychiatry and Behavioral Science, Medical University of South Carolina, Charleston, South Carolina 29425, USA
Toxicol Sci 76:250-61. 2003..The survey results emphasize the need for further research into the methods of behavioral assessment as well as the mechanisms underlying the neurobehavioral alterations... - Neuroprotection or neurotoxicity: impact of discontinuous dose-response curves on risk assessmentWilliam Slikker
Division of Neurotoxicology, National Center for Toxicological Research/FDA, Jefferson, Arkansas 72079, USA
Ann N Y Acad Sci 993:158; discussion 159-60. 2003 - Plasma levels of parent compound and metabolites after doses of either d-fenfluramine or d-3,4-methylenedioxymethamphetamine (MDMA) that produce long-term serotonergic alterationsJohn F Bowyer
Division of Neurotoxicology and Biometry and Risk Assessment, National Center for Toxicological Research FDA, 72079 9502, Jefferson, AR, USA
Neurotoxicology 24:379-90. 2003..There were 80% reductions in the plasma membrane-associated 5-HT transporters 6 months after either the FEN or MDMA dosing regimen indicating that both treatments produced long-term serotonergic effects... - Role of the standard deviation in the estimation of benchmark doses with continuous dataDavid W Gaylor
Gaylor and Associates, LLC, Little Rock, AR, USA
Risk Anal 24:1683-7. 2004..The bias increases as s(m) increases relative to s(a). The bias is relatively small if s(m) is less than one-third of s(a), a condition achieved in most experimental designs... - Comparative effects of substituted amphetamines (PMA, MDMA, and METH) on monoamines in rat caudate: a microdialysis studyBobby Gough
Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research/FDA, Jefferson, Arkansas 72079, USA
Ann N Y Acad Sci 965:410-20. 2002..5 or 5 mg/kg. All dose levels of PMA significantly decreased 5-HIAA (50 to 70%). These data suggest that PMA, like MDMA and METH, is capable of producing dopaminergic and serotonergic neurotoxicity... - Protective effects of 7-nitroindazole on ketamine-induced neurotoxicity in rat forebrain cultureCheng Wang
Division of Neurotoxicology, National Center for Toxicological Research US Food and Drug Administration, HFT 132 Jefferson, AR, USA
Neurotoxicology 29:613-20. 2008..These data indicate a role for nitric oxide in the enhanced degeneration induced by ketamine in vitro and also suggest that blocking neuronal nitric oxide synthase (nNOS) may help reduce the risk of ketamine in pediatrics... - Flow cytometric analysis of micronuclei in peripheral blood reticulocytes IV: an index of chromosomal damage in the rhesus monkey (Macaca mulatta)Charlotte E Hotchkiss
The Bionetics Corporation, Jefferson, Arkansas 72079, USA
Toxicol Sci 102:352-8. 2008..Microscopy-based scoring is challenging due to the low frequency of RETs and MN-RET in monkeys, but sufficient numbers of cells are easily scored with the flow cytometric procedure... - Methylphenidate and chromosome damageDavid Jacobson-Kram
Cancer Lett 260:216-8. 2008 - Application of proteomics to the study of molecular mechanisms in neurotoxicologyRichard M LoPachin
Department of Anesthesiology, Montefiore Medical Center, Albert Einstein College of Medicine, Moses 7, 111 E, 210th St, Bronx, NY 10467, USA
Neurotoxicology 24:761-75. 2003.... - Postnatal growth considerations for PBPK modelingRichard H Luecke
Department of Chemical Engineering, University of Missouri Columbia, Columbia, Missouri, USA
J Toxicol Environ Health A 70:1027-37. 2007..Upper limits of body weight were chosen that reflect the available data used to define the algorithms; above these limits a set percent body weight was assigned to all organs/tissues... - Regional societies: fostering competitive research through virtual infrastructuresSteven F Jennings
Department of Applied Science at the University of Arkansas at Little Rock, USA
PLoS Biol 2:e372. 2004 - Methamphetamine-induced dopaminergic neurotoxicity and production of peroxynitrite are potentiated in nerve growth factor differentiated pheochromocytoma 12 cellsSyed Z Imam
Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Resarch/US FDA, Jefferson, Arkansas 72079, USA
Ann N Y Acad Sci 965:204-13. 2002..The current study supports the hypothesis that METH acts at the dopaminergic nerve terminals and produces dopaminergic damage by the production of free radical peroxynitrite... - Dose-dependent transitions in mechanisms of toxicityWilliam Slikker
US FDA National Center for Toxicological Research, Jefferson, AR 72079, USA
Toxicol Appl Pharmacol 201:203-25. 2004..This paper addresses the issues discussed at both workshops, and presents the consensus conclusions drawn by expert participants... - Overview: Using mode of action and life stage information to evaluate the human relevance of animal toxicity dataJennifer Seed
US Environmental Protection Agency, Washington, DC, USA
Crit Rev Toxicol 35:664-72. 2005.... - Concern over decreased training in embryology and developmental/reproductive toxicologyGary Kimmel
Birth Defects Res B Dev Reprod Toxicol 71:191-2. 2004 - Maternal smoking during pregnancy and childhood obesityRudiger Von Kries
Institute of Social Pediatrics and Adolescent Medicine, Ludwig Maximilian University of Munich, Munich, Germany
Am J Epidemiol 156:954-61. 2002.... - Ketamine-induced neuronal cell death in the perinatal rhesus monkeyWilliam Slikker
Division of Neurotoxicology, National Center for Toxicological Research, U S Food and Drug Administration, Jefferson, AR 72079 0502, USA
Toxicol Sci 98:145-58. 2007..However, a shorter duration of ketamine anesthesia (3 h) did not result in neuronal cell death in the 5-day-old monkey... - Effect of prolonged ketamine exposure on cardiovascular physiology in pregnant and infant rhesus monkeys (Macaca mulatta)Charlotte E Hotchkiss
The Bionetics Corporation, National Center for Toxicological Research FDA, Jefferson, AR, USA
J Am Assoc Lab Anim Sci 46:21-8. 2007..Investigators should consider these effects when designing experiments and evaluating experimental outcomes in monkeys...