Jang Yen Wu

Summary

Affiliation: Florida Atlantic University
Country: USA

Publications

  1. ncbi Mechanism of neuroprotective function of taurine
    Jang Yen Wu
    Department of Biomedical Science, Florida Atlantic University, Boca Raton, FL, USA
    Adv Exp Med Biol 643:169-79. 2009
  2. ncbi Role of taurine in the central nervous system
    Jang Yen Wu
    Charles E, Schmidt College of Biomedical Science, Florida Atlantic University, Boca Raton, FL 33431, USA
    J Biomed Sci 17:S1. 2010
  3. ncbi Protective function of taurine in glutamate-induced apoptosis in cultured neurons
    Rebecca Leon
    Department of Biomedical Science, Florida Atlantic University, Boca Raton, Florida 33431, USA
    J Neurosci Res 87:1185-94. 2009
  4. ncbi Role of glutamate decarboxylase (GAD) isoform, GAD65, in GABA synthesis and transport into synaptic vesicles-Evidence from GAD65-knockout mice studies
    Heng Wu
    Department of Biomedical Science, Florida Atlantic University, Boca Raton, FL 33431, USA
    Brain Res 1154:80-3. 2007
  5. ncbi Protein phosphorylation of human brain glutamic acid decarboxylase (GAD)65 and GAD67 and its physiological implications
    Jianning Wei
    Department of Biomedical Sciences, Florida Atlantic University, Boca Raton, Florida 33431, USA
    Biochemistry 43:6182-9. 2004
  6. ncbi Role of mu-calpain in proteolytic cleavage of brain L-glutamic acid decarboxylase
    Di Sha
    Department of Biomedical Sciences, Florida Atlantic University, Boca Raton, FL 33431, USA
    Brain Res 1207:9-18. 2008
  7. ncbi Genistein and daidzein induce neurotoxicity at high concentrations in primary rat neuronal cultures
    Ying Jin
    Department of Biomedical Science, Florida Atlantic University, Boca Raton, FL 33431, USA
    J Biomed Sci 14:275-84. 2007
  8. ncbi Protection of taurine and granulocyte colony-stimulating factor against excitotoxicity induced by glutamate in primary cortical neurons
    Chunliu Pan
    Department of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton, FL 33431, USA
    J Biomed Sci 17:S18. 2010
  9. ncbi Identification and functional analysis of truncated human glutamic acid decarboxylase 65
    Jianning Wei
    Department of Biomedical Science, Florida Atlantic University, Boca Raton, FL 33431, USA
    J Biomed Sci 10:617-24. 2003
  10. ncbi Calpain cleavage of brain glutamic acid decarboxylase 65 is pathological and impairs GABA neurotransmission
    Chandana Buddhala
    Department of Biomedical Science, Charles E Schmidt College of Medicine, Florida Atlantic University, Boca Raton, Florida, United States of America
    PLoS ONE 7:e33002. 2012

Research Grants

  1. REGULATION OF GABA BIOSYNTHESIS IN THE BRAIN
    Jang Yen Wu; Fiscal Year: 2003

Collaborators

  • Jianning Wei
  • Ying Jin
  • Rui Tao
  • Hong Jin
  • Chunliu Pan
  • Kunihiko Obata
  • LUIS COLOM
  • Chandana Buddhala
  • Heng Wu
  • Di Sha
  • Rebecca Leon
  • Zhiyuan Ma
  • Howard Prentice
  • Mark McCollum
  • Eric Cohen
  • Rong Chen
  • Jigar Modi
  • Marjorie Suarez
  • Dipnarine Maharaj
  • Che Chang Hsu
  • Chun-Hua Lin
  • Shafi Kuchay
  • Yi Hsuan Lee
  • Yi-Hsuan Lee
  • Chun hua Lin
  • Athar H Chishti
  • Gregory Osterhaus
  • Kathleen Davis
  • Stephen C Fowler
  • Gregory L Osterhaus

Detail Information

Publications22

  1. ncbi Mechanism of neuroprotective function of taurine
    Jang Yen Wu
    Department of Biomedical Science, Florida Atlantic University, Boca Raton, FL, USA
    Adv Exp Med Biol 643:169-79. 2009
    ....
  2. ncbi Role of taurine in the central nervous system
    Jang Yen Wu
    Charles E, Schmidt College of Biomedical Science, Florida Atlantic University, Boca Raton, FL 33431, USA
    J Biomed Sci 17:S1. 2010
    ..The presence of metabotropic taurine receptors which are negatively coupled to phospholipase C (PLC) signaling pathway through inhibitory G proteins is proposed, and the evidence supporting this notion is also presented...
  3. ncbi Protective function of taurine in glutamate-induced apoptosis in cultured neurons
    Rebecca Leon
    Department of Biomedical Science, Florida Atlantic University, Boca Raton, Florida 33431, USA
    J Neurosci Res 87:1185-94. 2009
    ..The antiapoptotic function of taurine is due to its inhibition of glutamate-induced membrane depolarization...
  4. ncbi Role of glutamate decarboxylase (GAD) isoform, GAD65, in GABA synthesis and transport into synaptic vesicles-Evidence from GAD65-knockout mice studies
    Heng Wu
    Department of Biomedical Science, Florida Atlantic University, Boca Raton, FL 33431, USA
    Brain Res 1154:80-3. 2007
    ..However, GAD67 could serve this role under some pathological conditions...
  5. ncbi Protein phosphorylation of human brain glutamic acid decarboxylase (GAD)65 and GAD67 and its physiological implications
    Jianning Wei
    Department of Biomedical Sciences, Florida Atlantic University, Boca Raton, Florida 33431, USA
    Biochemistry 43:6182-9. 2004
    ..Furthermore, mutation of T91 to aspartic acid or glutamic acid mimics the effect of phosphorylation. A model depicting the effect of phosphorylation on GAD activity upon neuronal stimulation is also proposed...
  6. ncbi Role of mu-calpain in proteolytic cleavage of brain L-glutamic acid decarboxylase
    Di Sha
    Department of Biomedical Sciences, Florida Atlantic University, Boca Raton, FL 33431, USA
    Brain Res 1207:9-18. 2008
    ..mu-calpain is activated by neuronal stimulation and Ca(2+)-influx. The physiological significance of calpain in regulation of GABA synthesis and GABAergic neurotransmission is also discussed...
  7. ncbi Genistein and daidzein induce neurotoxicity at high concentrations in primary rat neuronal cultures
    Ying Jin
    Department of Biomedical Science, Florida Atlantic University, Boca Raton, FL 33431, USA
    J Biomed Sci 14:275-84. 2007
    ....
  8. ncbi Protection of taurine and granulocyte colony-stimulating factor against excitotoxicity induced by glutamate in primary cortical neurons
    Chunliu Pan
    Department of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton, FL 33431, USA
    J Biomed Sci 17:S18. 2010
    ..However, the mechanisms of their underlying neuroprotective effects are not fully understood...
  9. ncbi Identification and functional analysis of truncated human glutamic acid decarboxylase 65
    Jianning Wei
    Department of Biomedical Science, Florida Atlantic University, Boca Raton, FL 33431, USA
    J Biomed Sci 10:617-24. 2003
    ....
  10. ncbi Calpain cleavage of brain glutamic acid decarboxylase 65 is pathological and impairs GABA neurotransmission
    Chandana Buddhala
    Department of Biomedical Science, Charles E Schmidt College of Medicine, Florida Atlantic University, Boca Raton, Florida, United States of America
    PLoS ONE 7:e33002. 2012
    ....
  11. ncbi Post-translational regulation of L-glutamic acid decarboxylase in the brain
    Jianning Wei
    Department of Basic Science, Charles E Schmidt College of Biomedical Science, Florida Atlantic University, Boca Raton, FL 33431, USA
    Neurochem Res 33:1459-65. 2008
    ..The results from these studies have improved our understanding of the regulation of GAD function in the brain...
  12. ncbi Structural and functional analysis of cysteine residues in human glutamate decarboxylase 65 (GAD65) and GAD67
    Jianning Wei
    Department of Biomedical Sciences, Florida Atlantic University, Boca Raton, Florida 33431, USA
    J Neurochem 93:624-33. 2005
    ..3702,a mass increase of 125.1 daltons (Da) as a result of modification of cysteine by NEM. Parallel studies have also been conducted with hGAD67. Cysteine 455 was found to be important for GAD67 activity...
  13. ncbi Post-MPTP treatment with granulocyte colony-stimulating factor improves nigrostriatal function in the mouse model of Parkinson's disease
    Mark McCollum
    Department of Basic Science, Charles E Schmidt College of Biomedical Science, Florida Atlantic University, Boca Raton, FL 33431, USA
    Mol Neurobiol 41:410-9. 2010
    ..This might indicate an indirect effect of G-CSF on cell proliferation. The underlying mechanism of G-CSF is under further investigation...
  14. ncbi Taurine protection of PC12 cells against endoplasmic reticulum stress induced by oxidative stress
    Chunliu Pan
    Department of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton, FL 33431, USA
    J Biomed Sci 17:S17. 2010
    ..Taurine is a free amino acid present in high concentrations in a variety of organs of mammalians. As an antioxidant, taurine has been found to protect cells against oxidative stress, but the underlying mechanism is still unclear...
  15. ncbi A novel mechanism for GABA synthesis and packaging into synaptic vesicles
    Chandana Buddhala
    Department of Basic Science, Florida Atlantic University, Boca Raton, FL 33431, United States
    Neurochem Int 55:9-12. 2009
    ....
  16. ncbi Activity-dependent cleavage of brain glutamic acid decarboxylase 65 by calpain
    Jianning Wei
    Department of Biomedical Sciences, Florida Atlantic University, Boca Raton, Florida 33431, USA
    J Neurochem 98:1688-95. 2006
    ..Results of our in vitro cleavage assay using purified calpain and immunopurified rat GAD65 also supported the idea that GAD65 could be directly cleaved by calpain...
  17. ncbi Molecular cloning, expression, purification, and characterization of shorter forms of human glutamic decarboxylase 67 in an E. coli expression system
    Di Sha
    Department of Biomedical Sciences, Florida Atlantic University, Biomedical Science Program, 777 Glades Road, Boca Raton, FL 33431-0991, USA
    Brain Res Mol Brain Res 136:255-61. 2005
    ..The cleavage of GAD67 seems to be Ca+(2)-dependent. The model for the conversion of GAD from full-length GAD to shorter forms of GAD and its physiological implications was proposed...
  18. ncbi Effect of taurine on regulation of GABA and acetylcholine biosynthesis
    Di Sha
    Department of Molecular Biosciences, University of Kansas, Lawrence, KS 66045, USA
    Adv Exp Med Biol 526:499-505. 2003
  19. ncbi Effect of apocalmodulin on recombinant human brain glutamic acid decarboxylase
    Hong Jin
    Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas, USA
    J Neurochem 92:739-48. 2005
    ..The physiological significance of the interaction between GAD and ApoCaM is discussed...
  20. ncbi Demonstration of functional coupling between dopamine synthesis and its packaging into synaptic vesicles
    Rong Chen
    Department of Pharmacology and Toxicology, University of Kansas, Lawrence, KS, USA
    J Biomed Sci 10:774-81. 2003
    ..Hence, it is concluded that there is a general coupling mechanism between neurotransmitter synthesis and packaging of transmitter into synaptic vesicles...
  21. ncbi Demonstration of functional coupling between gamma -aminobutyric acid (GABA) synthesis and vesicular GABA transport into synaptic vesicles
    Hong Jin
    Departments of Molecular Biosciences and Medicinal Chemistry, University of Kansas, Lawrence, KS 66045, USA
    Proc Natl Acad Sci U S A 100:4293-8. 2003
    ..Third, VGAT and SV-associated Ca(2+)calmodulin-dependent kinase II have been found to form a protein complex with GAD. A model is also proposed to link the neuronal stimulation to enhanced synthesis and packaging of GABA into SVs...

Research Grants4

  1. REGULATION OF GABA BIOSYNTHESIS IN THE BRAIN
    Jang Yen Wu; Fiscal Year: 2003
    ..The success of a large scale purification of recombinant human brain GAD65 and GAD67 and the availability of subtype specific antibodies for GAD65 and GAD67, ensure the high feasibility of this proposal. ..