Research Topics
Species | ALAN SPECTORSummaryAffiliation: Florida State University Country: USA Publications
Research Grants
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Publications
Roux-en-Y gastric bypass in rats increases sucrose taste-related motivated behavior independent of pharmacological GLP-1-receptor modulationC M Mathes
Department of Psychology and Program in Neuroscience, Florida State University, Tallahassee, Florida 32306 4301, USA
Am J Physiol Regul Integr Comp Physiol 302:R751-67. 2012..Collectively, these results highlight the fact that changes in taste-driven motivated behavior to sucrose after RYGB and/or GLP-1R modulation are very model and measure dependent...- Rewiring the gustatory system: specificity between nerve and taste bud field is critical for normal salt discriminationAlan C Spector
Department of Psychology and Center for Smell and Taste, University of Florida, Gainesville, FL 32611 2250, USA
Brain Res 1310:46-57. 2010.... - Linking peripheral taste processes to behaviorAlan C Spector
Department of Psychology and Program in Neuroscience, Florida State University, Tallahassee, FL 32306, USA
Curr Opin Neurobiol 19:370-7. 2009..This review will discuss recent advances in peripheral gustatory mechanisms, primarily from rodent models, in the context of these three major categories of taste function... - T1R2 and T1R3 subunits are individually unnecessary for normal affective licking responses to Polycose: implications for saccharide taste receptors in miceYada Treesukosol
Dept of Psychology, Florida State Univ, Tallahassee FL 32306 4301, USA
Am J Physiol Regul Integr Comp Physiol 296:R855-65. 2009..Whether at least one of these T1R protein subunits is necessary for normal Polycose responsiveness remains untested. Alternatively, there may be a novel taste receptor(s) that mediates polysaccharide taste... - Learning-based recovery from perceptual impairment in salt discrimination after permanently altered peripheral gustatory inputGinger Blonde
Department of Psychology, Center for Smell and Taste, University of Florida, Gainesville, 32306 4301, USA
Am J Physiol Regul Integr Comp Physiol 299:R1027-36. 2010.... - Effects of selective lingual gustatory deafferentation on suprathreshold taste intensity discrimination of NaCl in ratsConnie L Colbert
Psychology Department and Center for Smell and Taste, University of Florida, USA
Behav Neurosci 118:1409-17. 2004..1 M NaCl was the standard. Although the perceived intensity of NaCl might be reduced by CTX, input from remaining taste nerves sufficiently maintains the relative discriminability of suprathreshold NaCl concentrations... - Constructing quality profiles for taste compounds in rats: a novel paradigmCONNIE L GROBE
University of Florida Psychology Department and Center for Smell and Taste, Gainesville, Florida 32611, USA
Physiol Behav 95:413-24. 2008.... - Nerve regeneration-induced recovery of quinine avoidance after complete gustatory deafferentation of the tongueLaura C Geran
Department of Psychology, Center for Smell and Taste, University of Florida, Gainesville, FL 32611-2250, USA
Am J Physiol Regul Integr Comp Physiol 287:R1235-43. 2004..This represents the first reported instance to our knowledge in which the capacity of a regenerated nerve to maintain taste-guided behavior was distinctly different from that of an intact nerve in a rodent model... - The relative affective potency of glycine, L-serine and sucrose as assessed by a brief-access taste test in inbred strains of miceCedrick D Dotson
Department of Psychology, University of Florida, PO Box 112250, Gainesville, FL 32611-2250, USA
Chem Senses 29:489-98. 2004..However, the profile of strain responsiveness to these tastants in the brief-access test does not appear to be simply explained by the sweetener 'taster' status of the strain... - A psychophysical and electrophysiological analysis of salt taste in Trpv1 null miceYada Treesukosol
Department of Psychology and Center for Smell and Taste, University of Florida, Gainesville, FL 32611 2250, USA
Am J Physiol Regul Integr Comp Physiol 292:R1799-809. 2007..Additionally, there may be other amiloride-insensitive salt transduction mechanisms in taste receptor fields other than the anterior tongue that maintain normal salt detection performance in the KO mice... - Stimulus processing of glycine is dissociable from that of sucrose and glucose based on behaviorally measured taste signal detection in Sac 'taster' and 'non-taster' miceShachar Eylam
Department of Psychology and the Center for Smell and Taste, University of Florida, Gainesville, FL 32611 2250, USA
Chem Senses 29:639-49. 2004..The mechanism underlying this difference may be related to the ability of glycine to bind with the T1R1+3 heterodimer... - The functional consequences of gustatory nerve regeneration as assessed behaviorally in a rat modelAlan C Spector
Department of Psychology and Center for Smell and Taste, University of Florida, Gainesville, FL 32611-2250, USA
Chem Senses 30:i66-7. 2005 - Melanocortin-4 receptor-null mice display normal affective licking responses to prototypical taste stimuli in a brief-access testShachar Eylam
Department of Psychology and the Center for Smell and Taste, University of Florida, P O Box 112250, Gainesville, FL 32611 2250, USA
Peptides 26:1712-9. 2005.... - Necessity of the glossopharyngeal nerve in the maintenance of normal intake and ingestive bout size of corn oil by ratsYada Treesukosol
Dept of Psychology, Florida State Univ, Tallahassee, 32306 4301, USA
Am J Physiol Regul Integr Comp Physiol 299:R1050-8. 2010..Whatever the mechanism, an intact GL is clearly necessary in maintaining normal intake of corn oil... - Greater superficial petrosal nerve transection in rats does not change unconditioned licking responses to putatively sweet taste stimuliEnshe Jiang
Department of Psychology and Program in Neuroscience, Florida State University, Tallahassee, FL 32306, USA
Chem Senses 33:709-23. 2008..The disparity between our results and others in the literature where GSPX reduced licking responses to sucrose is possibly related to differences in surgical technique or test trial duration... - Behavioral discrimination between sucrose and other natural sweeteners in mice: implications for the neural coding of T1R ligandsCedrick D Dotson
Department of Psychology and Center for Smell and Taste, University of Florida, Gainesville, Florida 32611 2250, USA
J Neurosci 27:11242-53. 2007..However, the results of these experiments also imply that sweet-tasting L-amino acids may possess qualitative taste characteristics that are distinguishable from the prototypical sweetener sucrose... - The representation of taste quality in the mammalian nervous systemAlan C Spector
Department of Psychology and Center for Smell and Taste, University of Florida
Behav Cogn Neurosci Rev 4:143-91. 2005..Ultimately, until specific classes of neurons can be selectively manipulated and perceptual consequences assessed, it will be difficult to go beyond mere correlation and conclusively discern the validity of these coding models... - Rats fail to discriminate quinine from denatonium: implications for the neural coding of bitter-tasting compoundsAlan C Spector
Department of Psychology, University of Florida, Gainesville, Florida 32611, USA
J Neurosci 22:1937-41. 2002..These results also highlight the need to confirm predictions about the downstream properties of the gustatory system, or any sensory system, based on upstream molecular and biophysical events... - Taste discrimination between NaCl and KCl is disrupted by amiloride in inbred mice with amiloride-insensitive chorda tympani nervesShachar Eylam
Dept. of Psychology, PO Box 112250, Univ. of Florida, Gainesville, FL 32611-2250, USA
Am J Physiol Regul Integr Comp Physiol 288:R1361-8. 2005.... - Amiloride is an ineffective conditioned stimulus in taste aversion learning in C57BL/6J and DBA/2J miceShachar Eylam
Department of Psychology and the Center for Smell and Taste, University of Florida, Gainesville, FL 32611, USA
Chem Senses 28:681-9. 2003.... - The effect of amiloride on operantly conditioned performance in an NaCl taste detection task and NaCl preference in C57BL/6J miceShachar Eylam
Department of Psychology, University of Florida, Gainesville 32611-2250, USA
Behav Neurosci 116:149-59. 2002.... - Transecting the gustatory branches of the facial nerve impairs NH(4)Cl vs. KCl discrimination in ratsLaura C Geran
Department of Psychology and Center for Smell and Taste, University of Florida, Gainesville, Florida 32611-2250, USA
Am J Physiol Regul Integr Comp Physiol 283:R739-47. 2002..This experiment supports the hypothesis that the facial nerve is important for salt taste recognition and discrimination... - PLCbeta2-independent behavioral avoidance of prototypical bitter-tasting ligandsCedrick D Dotson
Department of Psychology, University of Florida, PO Box 112250, Gainesville, FL 32611 2250, USA
Chem Senses 30:593-600. 2005.... - Oral amiloride treatment decreases taste sensitivity to sodium salts in C57BL/6J and DBA/2J miceShachar Eylam
Department of Psychology and the Center for Smell and Taste, University of Florida, Gainesville, FL 32611, USA
Chem Senses 28:447-58. 2003..81 both strains) suggests that ENaCs are also sufficient to support the detection of sodium in weak solutions by B6 and D2 mice... - Citric acid and quinine share perceived chemosensory features making oral discrimination difficult in C57BL/6J miceYada Treesukosol
Department of Psychology, Program in Neuroscience, Florida State University, Tallahassee, FL 32306 4301, USA
Chem Senses 36:477-89. 2011..Collectively, the findings from these experiments suggest that in mice, citric acid and quinine share chemosensory features making discrimination difficult but are not perceptually identical... - Anion size does not compromise sodium recognition by rats after acute sodium depletionLaura C Geran
Department of Psychology and Center for Smell and Taste, University of Florida, Gainesville, FL 32611-2250, USA
Behav Neurosci 118:178-83. 2004..Overall, these findings provide compelling support for the primacy of the amiloride-sensitive taste transduction mechanism and its associated neural pathway in the recognition of the sodium cation...
Research Grants
- PSYCHOPHYSICAL EVALUATION OF TASTE FUNCTIONAlan C Spector; Fiscal Year: 2010..These experiments will psychophysically define the contribution of an important class of taste receptors to normal gustatory function in the mouse model, which is becoming widely adopted for study of mammalian chemosensory processes. ..
- Functional Organization of the Central Gustatory SystemAlan C Spector; Fiscal Year: 2010....
- PSYCHOPHYSICAL EVALUATION OF TASTE FUNCTIONALAN SPECTOR; Fiscal Year: 2005....
- FUNCTIONAL ORGANIZATION OF PERIPHERAL GUSTATORY SYSTEMALAN SPECTOR; Fiscal Year: 2006..abstract_text> ..
- PSYCHOPHYSICAL EVALUATION OF TASTE FUNCTIONALAN SPECTOR; Fiscal Year: 2007..These experiments will psychophysically define the contribution of an important class of taste receptors to normal gustatory function in the mouse model, which is becoming widely adopted for study of mammalian chemosensory processes. ..
- FUNCTIONAL ORGANIZATION OF PERIPHERAL GUSTATORY SYSTEMALAN SPECTOR; Fiscal Year: 2001..A better understanding of the neural organization of taste processes should facilitate the diagnosis and treatment of chemosensory and neurological disorders. ..