Research Topics
| Kevin C ChenSummaryAffiliation: Florida State University Country: USA Publications
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Detail Information
Publications
Modeling recombinant immunotoxin efficacies in solid tumorsKevin C Chen
Department of Biomedical Engineering, FAMU FSU College of Engineering, Florida State University, Tallahassee, FL, 32310, USA
Ann Biomed Eng 36:486-512. 2008..Simulations reinforced the idea of binding site barrier for drug diffusion and suggested that optimal antitumor activity was achieved when the binding affinity is logarithmically dependent on the target binding site density...- Evidence on extracellular dopamine level in rat striatum: implications for the validity of quantitative microdialysisKevin C Chen
Department of Chemical and Biomedical Engineering, FAMU FSU College of Engineering, Tallahassee, Florida 32310, USA
J Neurochem 92:46-58. 2005..Chronic microdialysis damages both neurotransmitter release and uptake, but it does so in a somewhat relative and proportional way for both processes. Thus the validity of the microdialysis ZNF method is not seriously undermined... - Extracting the basal extracellular dopamine concentrations from the evoked responses: re-analysis of the dopamine kineticsKevin C Chen
Department of Chemical and Biomedical Engineering, Florida A and M University Florida State University College of Engineering, Tallahassee, FL 32310 6046, USA
J Neurosci Methods 164:27-42. 2007..Inconsistency in the measured uptake strengths in the literature studying endogenous and exogenous DA remains to be investigated in the future... - Effects of tissue trauma on the characteristics of microdialysis zero-net-flux method sampling neurotransmittersKevin C Chen
Department of Chemical and Biomedical Engineering, Joint College of Engineering for Florida A and M University, Florida State University, 2525 Pottsdamer Street, Tallahassee, 32310, USA
J Theor Biol 238:863-81. 2006..A criterion for this rising trend of microdialysis relative recovery is discussed in terms of trauma parameters and neurotransmitter uptake inhibition... - Preferentially impaired neurotransmitter release sites not their discreteness compromise the validity of microdialysis zero-net-flux methodKevin C Chen
Department of Chemical and Biomedical Engineering, FAMU FSU College of Engineering, Tallahassee, Florida 32310, USA
J Neurochem 92:29-45. 2005..It is concluded that homogeneous models can adequately describe microdialysis operating processes as long as the corresponding tissue damage parameters in such models are appropriately incorporated... - Measurement of diffusion parameters using a sinusoidal iontophoretic source in rat cortexKevin C Chen
Department of Physiology and Neuroscience, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
J Neurosci Methods 122:97-108. 2002..The relative merits of the frequency method compared to the pulse method are discussed... - Quantitative dual-probe microdialysis: mathematical model and analysisKevin C Chen
Department of Physiology and Neuroscience, New York University Medical School, New York 10016, USA
J Neurochem 81:94-107. 2002.... - Theory relating in vitro and in vivo microdialysis with one or two probesKevin C Chen
Department of Physiology and Neuroscience, New York University Medical School, New York 10016, USA
J Neurochem 81:108-21. 2002..5 x 10(-5) s(-1). This minimum rate constant establishes a criterion, below which inhibition of the active clearance processes does not show detectable influences on the microdialysis extraction efficiency... - Insensitivity of the microdialysis zero-net-flux method to nonlinear uptake and release processesKevin C Chen
Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Drive MSC 4264, Building 37, Room 5120, Bethesda, MD 20892 4264, USA
Neurosci Res 46:251-6. 2003..During electrical stimulation, neurotransmitter overflow may cause the microdialysis ZNF method to exhibit nonlinearity... - Cell balance equation for chemotactic bacteria with a biphasic tumbling frequencyKevin C Chen
Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 4264, USA
J Math Biol 47:518-46. 2003....