Research Topics
| P L ChenSummaryAffiliation: Family Health International Country: USA Publications
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Detail Information
Publications
Participant characteristics associated with withdrawal from a large randomized trial of spermicide effectivenessElizabeth G Raymond
Family Health International, Research Triangle Park, NC, USA
BMC Med Res Methodol 4:23. 2004..The objective of this analysis was to explore characteristics of participants who failed to complete seven months of planned participation in a trial of spermicide efficacy...- Quality-adjusted survival estimation with periodic observationsP L Chen
Division of Biostatistics, Family Health International, Research Triangle Park, North Carolina 27709, USA
Biometrics 57:868-74. 2001..It is shown that the estimator is asymptotically normal with a simple variance calculation. A simulation study is conducted to investigate the behavior of the estimator, and a stroke study illustrates the use of the estimator... - Assessing learning effects and nonrandom dropout in a contraceptive device trialPai Lien Chen
Department of Biostatistics, Family Health International, Research Triangle Park, North Carolina, USA
J Biopharm Stat 18:382-92. 2008..We use data from a randomized contraceptive device trial to illustrate the usefulness of the proposed method. The potential impact of learning effects and nonrandom dropout on the primary study objective is discussed... - Monitoring a three-armed clinical trial with survival endpoints: Fisher's least significant difference approachPai Lien Chen
Division of Biostatistics, Family Health International, Research Triangle Park, NC 27709, USA
J Biopharm Stat 14:791-801. 2004..For the scenarios examined, the overall type I error rates and power of the proposed approach are virtually equivalent to those of the revised Proschan et al. approach... - Estimating cycle pregnancy probability with incomplete data in contraceptive studiesPai Lien Chen
Division of Biostatistics, Family Health International, Research Triangle Park, North Carolina 27709, USA
J Biopharm Stat 13:507-17. 2003..Our findings support the U.S. Food and Drug Administration's (FDA) sample size requirements for contraceptive studies. We use data from an effectiveness trial on vaginal contraceptive film (VCF) to illustrate the proposed methods... - "Actual use" study of emergency contraceptive pills provided in a simulated over-the-counter mannerElizabeth G Raymond
Family Health International, Research Triangle Park, North Carolina 27709, USA
Obstet Gynecol 102:17-23. 2003..To evaluate use of an emergency contraceptive pill product dispensed under simulated over-the-counter conditions. Secondary objectives were to assess repeat use, pregnancy, and adverse events... - Preventing copper intrauterine device removals due to side effects among first-time users: randomized trial to study the effect of prophylactic ibuprofenDavid Hubacher
Family Health International, Research Triangle Park, NC 27709, USA
Hum Reprod 21:1467-72. 2006..Ibuprofen and other non-steroidal anti-inflammatory drugs (NSAIDs) are proven treatments for such IUD-induced problems, but their effect on early IUD removal is unknown... - Day-specific pregnancy probability estimation in barrier contraceptive effectiveness trialsRosalie Dominik
Department of Biostatistics, Family Health Institute, Family Health International, Durham, NC 27709, USA
Paediatr Perinat Epidemiol 20:38-42. 2006..The proposed modelling approach should allow evaluation of the effects of other coitus-specific exposures on the chance of pregnancy in other prospective studies, including fertility studies... - Pain from copper intrauterine device insertion: randomized trial of prophylactic ibuprofenDavid Hubacher
Family Health International, Research Triangle Park, NC, USA
Am J Obstet Gynecol 195:1272-7. 2006..CONCLUSION: Even among first-time users, pain from IUD insertion is generally low. Prophylactic ibuprofen as used in this protocol does not reduce IUD insertion pain... - Effect of a levonorgestrel intrauterine system on women with type 1 diabetes: a randomized trialSvetlana Rogovskaya
Research Center of Obstetrics, Gynecology, and Perinatology, Russian Academy of Medical Science, Moscow, Russia
Obstet Gynecol 105:811-5. 2005..To examine the effect of the levonorgestrel-releasing intrauterine system on glucose metabolism in diabetic women...