Research Topics
| Andrew YatesSummaryAffiliation: Emory University Country: USA Publications
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Detail Information
Publications
Visualizing recall immune responses with multi-photon microscopyAndrew Yates
Department of Biology, Emory University, Atlanta, GA 30322, USA
Immunology 128:461-2. 2009..In this issue of Immunology a study uses real-time imaging of lymph nodes to observe and compare the early events in naive, tolerized and primed CD4 T-cell responses...
Modelling pathways of CD8+ T-cell differentiationAndrew Yates
Department of Biology, Emory University, Atlanta, GA 30322, USA
Eur J Immunol 39:47-9. 2009....
Revisiting estimates of CTL killing rates in vivoAndrew Yates
Department of Biology, Emory University, Atlanta, Georgia, United States of America
PLoS ONE 2:e1301. 2007..We discuss extensions to the basic CTL killing model to explain this discrepancy and propose experimental tests to distinguish between them...
Understanding the slow depletion of memory CD4+ T cells in HIV infectionAndrew Yates
Department of Biology, Emory University, Atlanta, Georgia, United States of America
PLoS Med 4:e177. 2007..We explore this hypothesis using mathematical models...
Reconstruction of cell population dynamics using CFSEAndrew Yates
Department of Biology, Emory University, Atlanta, GA 30322, USA
BMC Bioinformatics 8:196. 2007..This gives rise to heterogeneity in proliferating cell populations. Branching processes provide a natural means of describing this behaviour...
Sharing the burden: antigen transport and firebreaks in immune responsesAndreas Handel
Department of Biology, Emory University, Atlanta, GA 30322, USA
J R Soc Interface 6:447-54. 2009..Our study thus shows the potential benefits of GMAT and illustrates how spatial effects may be crucial for the quantitative understanding of infection dynamics and immune responses...
Gap junction-mediated antigen transport in immune responsesAndreas Handel
Department of Biology, Emory University, Atlanta, GA 30322, USA
Trends Immunol 28:463-6. 2007..Here, we discuss this idea in more detail and suggest possible ways in which this mechanism might have both positive and negative impacts during an immune response...
The dynamics of acute malaria infections. I. Effect of the parasite's red blood cell preferenceRustom Antia
Department of Biology, Emory University, Atlanta, GA 30322, USA
Proc Biol Sci 275:1449-58. 2008..chabaudi, suggesting that it might be worth exploring if similar results might hold for other acute malaria infections, including those of humans...
How do pathogen evolution and host heterogeneity interact in disease emergence?Andrew Yates
Department of Biology, Emory University, 1510 Clifton Road NE, Atlanta, GA 30322, USA
Proc Biol Sci 273:3075-83. 2006..We discuss the application of these ideas to vaccination strategies...
Comparing antigen-independent mechanisms of T cell regulationMartin J Allan
Institute of Child Health, University College London, UK
J Theor Biol 228:81-95. 2004..To regulate (CD8+) T cells these mechanisms must change both apoptosis and division rates, and this change must occur with time not division number...
Mathematical models of cytotoxic T-lymphocyte killingRoland R Regoes
Institute of Integrative Biology, ETH Zurich, Zurich, Switzerland
Immunol Cell Biol 85:274-9. 2007..Here, we review the estimates of kinetic rates involved in CTL killing which were obtained in these studies, and elaborate on the differences between them...
Mathematical modeling reveals the biological program regulating lymphopenia-induced proliferationAndrew Yates
Division of Immune Cell Biology, National Institute for Medical Research, The Ridgeway, London, United Kingdom
J Immunol 180:1414-22. 2008..Our results suggest cell division induced by lymphopenia involves a process of single stochastic divisions, which is best suited to a homeostatic rather than differentiation role...
Combining cytokine signalling with T-bet and GATA-3 regulation in Th1 and Th2 differentiation: a model for cellular decision-makingAndrew Yates
Immunobiology Unit, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
J Theor Biol 231:181-96. 2004..It suggests a mechanism for switching between Th1 and Th2 in the so-called irreversible state that may be developed as a novel therapeutic means of manipulating Th1 and Th2 responses...
