Research Topics
| Paul W SpearmanSummaryAffiliation: Emory University Country: USA Publications
Research Grants
| Collaborators
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Detail Information
Publications
Tetherin does not significantly restrict dendritic cell-mediated HIV-1 transmission and its expression is upregulated by newly synthesized HIV-1 NefChristopher M Coleman
Center for Retrovirus Research, Department of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210, USA
Retrovirology 8:26. 2011..However, the role of type I IFN and tetherin in HIV-1 infection of DCs and DC-mediated viral transmission remains unknown...- Safety and immunogenicity of a CTL multiepitope peptide vaccine for HIV with or without GM-CSF in a phase I trialPaul Spearman
Department of Pediatrics, Pediatric Infectious Diseases, Emory University School of Medicine, 2015 Uppergate Drive, Atlanta, GA 30322, United States
Vaccine 27:243-9. 2009..This study failed to demonstrate that GM-CSF can substantially improve the overall weak immunogenicity of a multiepitope peptide-based HIV vaccine... - A trimeric, V2-deleted HIV-1 envelope glycoprotein vaccine elicits potent neutralizing antibodies but limited breadth of neutralization in human volunteersPaul Spearman
Department of Pediatrics, Emory University and Children s Healthcare of Atlanta, Georgia 30322, USA
J Infect Dis 203:1165-73. 2011..A key missing element in the development of a successful human immunodeficiency virus (HIV) vaccine is an immunogen that can generate broadly cross-neutralizing antibodies against primary isolates of the virus... - The tetherin/BST-2 coiled-coil ectodomain mediates plasma membrane microdomain localization and restriction of particle releaseJason Hammonds
Emory University Department of Pediatrics, Atlanta, Georgia, USA
J Virol 86:2259-72. 2012..We propose that focal clustering of tetherin via ectodomain interactions plays a role in restriction of particle release... - Comparison of systemic and mucosal delivery of 2 canarypox virus vaccines expressing either HIV-1 genes or the gene for rabies virus G proteinPeter F Wright
Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
J Infect Dis 189:1221-31. 2004.... - Emerging studies of human HIV-specific antibody repertoiresMark D Hicar
Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA
Vaccine 28:B18-23. 2010..The rapid isolation of large panels of novel human neutralizing antibodies promises to reveal new insights into the fundamental principles underlying antibody-mediated neutralization of HIV... - Pseudovirion particles bearing native HIV envelope trimers facilitate a novel method for generating human neutralizing monoclonal antibodies against HIVMark D Hicar
Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232 2905, USA
J Acquir Immune Defic Syndr 54:223-35. 2010..These data demonstrate that Gag-Env pseudovirions recapitulate CD4 and coreceptor binding pocket antigenic structures and can facilitate identification of B-cell clones that secrete neutralizing antibodies...
Research Grants
- Viral and Cellullar Determinants of HIV-1 AssemblyPaul W Spearman; Fiscal Year: 2010..Together, these experiments will provide important new insights into the interaction of HIV structural proteins with cellular transport pathways. ..
- Viral and Cellular Determinants of HIV-1 AssemblyPaul Spearman; Fiscal Year: 2005..These experiments will answer fundamental questions relevant to HIV-1 particle assembly and may lead to unique opportunities for therapeutic intervention. ..
- Role of VPU in Retroviral Particle AssemblyPaul Spearman; Fiscal Year: 2007..These studies will define the mechanism by which Vpu enhances HIV particle release and will characterize a novel host cell restriction to HIV replication that is present in human cells. ..
- Viral and Cellular Determinants of HIV-1 AssemblyPaul Spearman; Fiscal Year: 2007..Together, these experiments will provide important new insights into the interaction of HIV structural proteins with cellular transport pathways. ..
- Pseudovirion Formation by Live Vector HIV VaccinesPaul Spearman; Fiscal Year: 2007..Together, these experiments will provide important insights into the role of pseudovirions in generating HIV-specific immune responses following live vector immunization. ..
- Novel Assays for Inhibitors of HIV AssemblyPaul Spearman; Fiscal Year: 2007..abstract_text> ..
- Defining Neutralization Breadth in HIV+ Human SerumPaul W Spearman; Fiscal Year: 2010..By understanding in detail the antibody responses present in these HIV-infected individuals, we will gain insights into how we can better design a protective HIV vaccine that can generate similar responses in uninfected persons. ..
- Development of Enhanced HIV-1 Pseudovirion VaccinesPaul Spearman; Fiscal Year: 2006..abstract_text> ..
- Novel FRET-based Assays for HIV Assembly InhibitorsPaul Spearman; Fiscal Year: 2004..These assays will be used to screen libraries of compounds available from NIH, Vanderbilt, and industrial partners to identify candidate inhibitors of Gag-Gag interactions. ..
- Role of VPU in Retroviral Particle AssemblyPaul W Spearman; Fiscal Year: 2011..This project could reveal new ways to inhibit this aspect of HIV, resulting in new drugs against HIV and potentially against other harmful viruses. ..