Research Topics
Species | Iqbal SayeedSummaryAffiliation: Emory University Country: USA Publications
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Publications
Progesterone as a neuroprotective factor in traumatic and ischemic brain injuryIqbal Sayeed
Department of Emergency Medicine, Emory University, Atlanta, GA, USA
Prog Brain Res 175:219-37. 2009..These properties make progesterone a unique and compelling natural agent to consider for testing in clinical trial for CNS injuries including TBI and stroke...- Direct inhibition of the mitochondrial permeability transition pore: a possible mechanism for better neuroprotective effects of allopregnanolone over progesteroneIqbal Sayeed
Department of Emergency Medicine, Brain Research Laboratory, Emory University School of Medicine, Atlanta, GA 30322, USA
Brain Res 1263:165-73. 2009..Our results demonstrate that AP inhibits the mtPTP current. This may help to explain its more potent anti-apoptotic and neuroprotective effects compared to PROG... - Progesterone and allopregnanolone attenuate blood-brain barrier dysfunction following permanent focal ischemia by regulating the expression of matrix metalloproteinasesTauheed Ishrat
Department of Emergency Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
Exp Neurol 226:183-90. 2010..We conclude that PROG and ALLO can help to protect BBB disruption following pMCAO... - Allopregnanolone, a progesterone metabolite, is more effective than progesterone in reducing cortical infarct volume after transient middle cerebral artery occlusionIqbal Sayeed
Department of Emergency Medicine, Emory University, Atlanta, GA, USA
Ann Emerg Med 47:381-9. 2006..Our results suggest that both neurosteroids should be examined for safety and efficacy in a clinical trial for ischemic stroke... - Genomic profile of Toll-like receptor pathways in traumatically brain-injured mice: effect of exogenous progesteroneFang Hua
Department of Emergency Medicine, Brain Research Laboratory, Emory University School of Medicine, 1365B Clifton Rd, Atlanta, GA 30322, USA
J Neuroinflammation 8:42. 2011..Therefore, in the present study, we examined the genomic profiles of TLR-mediated pathways in traumatically injured brain and PROG's effects on these genes... - Progesterone inhibits the growth of human neuroblastoma: in vitro and in vivo evidenceFahim Atif
Departments of Emergency Medicine Brain Research Laboratory, Emory University, Atlanta, Georgia, USA
Mol Med 17:1084-94. 2011.... - Effects of progesterone administration on infarct volume and functional deficits following permanent focal cerebral ischemia in ratsTauheed Ishrat
Department of Emergency Medicine, Brain Research Laboratory, 1365B Clifton Road NE, Emory University School of Medicine, Atlanta, GA 30322, USA
Brain Res 1257:94-101. 2009..Taken together, these data indicate that PROG is beneficial in one of the best-characterized models of stroke, and may warrant further testing in future clinical trials for human stroke... - Development and screening of water-soluble analogues of progesterone and allopregnanolone in models of brain injuryChristopher J MacNevin
Department of Chemistry, Emory University, Atlanta, Georgia 30322, USA
J Med Chem 52:6012-23. 2009..The new derivatives demonstrated greatly improved solubility and select compounds have shown equivalent effectiveness to progesterone in reducing cerebral edema after TBI... - Progesterone inhibits ischemic brain injury in a rat model of permanent middle cerebral artery occlusionIqbal Sayeed
Department of Emergency Medicine, Brain Research Laboratory, Emory University, Atlanta, GA 30322, USA
Restor Neurol Neurosci 25:151-9. 2007..Since most cases of human stroke are caused by permanent occlusion of cerebral arteries, we assessed the neuroprotective effects of PROG on cerebral infarction and behavioral deficits in a permanent MCAO (pMCAO) model... - Deoxygedunin, a natural product with potent neurotrophic activity in miceSung Wuk Jang
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
PLoS ONE 5:e11528. 2010..Hence, deoxygedunin imitates BDNF's biological activities through activating TrkB, providing a powerful therapeutic tool for treatment of various neurological diseases... - Progesterone with vitamin D affords better neuroprotection against excitotoxicity in cultured cortical neurons than progesterone aloneFahim Atif
Department of Emergency Medicine, Brain Research Laboratory, Emory University, Atlanta, Georgia, USA
Mol Med 15:328-36. 2009..In conclusion, the findings of the present study can be taken to suggest that VDH warrants study as a potential partner for combination therapy with PROG... - The TRIF-dependent signaling pathway is not required for acute cerebral ischemia/reperfusion injury in miceFang Hua
Department of Emergency Medicine, Brain Research Laboratory, Emory University School of Medicine, Atlanta, GA 30322, USA
Biochem Biophys Res Commun 390:678-83. 2009..Our results demonstrate that the TRIF-dependent signaling pathway is not required for the activation of NF-kappaB signaling and brain injury after acute cerebral I/R... - Improved behavioral outcomes after progesterone administration in aged male rats with traumatic brain injuryBushra Wali
Department of Emergency Medicine, Emory University School of Medicine, Atlanta, GA, USA
Restor Neurol Neurosci 29:61-71. 2011..The progesterone-treated rats had better functional outcomes than vehicle-treated rats with similar cortical injuries. The neurosteroid treatment did not affect the size of the necrotic cavity... - Combination treatment with progesterone and vitamin D hormone may be more effective than monotherapy for nervous system injury and diseaseMilos Cekic
Department of Emergency Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Front Neuroendocrinol 30:158-72. 2009..The combination of PROG and VDH in pre-clinical and clinical studies is a novel and compelling approach to TBI treatment... - Progesterone administration modulates AQP4 expression and edema after traumatic brain injury in male ratsQingmin Guo
Department of Emergency Medicine, Emory University, Atlanta, GA 30322, USA
Exp Neurol 198:469-78. 2006..Our results can be taken to show that the expression of AQP4 protein after TBI is time-dependent, region-specific, and possibly implicated in the formation and resolution of TBI-induced cerebral edema... - Gambogic amide, a selective agonist for TrkA receptor that possesses robust neurotrophic activity, prevents neuronal cell deathSung Wuk Jang
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
Proc Natl Acad Sci U S A 104:16329-34. 2007..Thus, gambogic amide might not only establish a powerful platform for dissection of the physiological roles of NGF and TrkA receptor but also provide effective treatments for neurodegenerative diseases and stroke...