Research Topics
Genomes and Genes
| Roberto PacificiSummaryAffiliation: Emory University Country: USA Publications
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Detail Information
Publications
Increased production of IL-7 uncouples bone formation from bone resorption during estrogen deficiencyM Neale Weitzmann
Division of Bone and Mineral Diseases, Washington University School of Medicine and Barnes Jewish Hospital, St Louis, Missouri, USA
J Clin Invest 110:1643-50. 2002..Thus, because it targets both the osteoclast and the osteoblast pathways, IL-7 is central to the altered bone turnover characteristic of estrogen deficiency...- Oxidative stress causes bone loss in estrogen-deficient mice through enhanced bone marrow dendritic cell activationFrancesco Grassi
Division of Endocrinology, Metabolism, and Lipids, Department of Medicine, Emory University, Atlanta, GA 30322, USA
Proc Natl Acad Sci U S A 104:15087-92. 2007.... - T cells and post menopausal osteoporosis in murine modelsRoberto Pacifici
Division of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
Arthritis Res Ther 9:102. 2007..The experimental evidence that suggests that estrogen prevents bone loss by regulating T cell function and the interactions between immune cells and bone is reviewed here... - Estrogen deficiency, T cells and bone lossRoberto Pacifici
Division of Endocrinology, Metabolism and Lipids, Department of Medicine and Molecular Pathogenesis Program, Emory University School of Medicine, 101 Woodruff Circle, Room 1307, Atlanta, GA 30322, USA
Cell Immunol 252:68-80. 2008..This review presents our current understanding of the process of estrogen deficiency mediated bone destruction and explores some of the most recent findings and hypotheses to explain estrogen action in bone... - T cells: critical bone regulators in health and diseaseRoberto Pacifici
Division of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University, Atlanta, Georgia 30322, USA
Bone 47:461-71. 2010..This article examines the connection between T cells and bone in health and disease and reviews the evidence in favor of the hypothesis that T cells play an unexpected critical role in the mechanism of action of estrogen and PTH in bone... - The immune system and boneRoberto Pacifici
Department of Medicine, Emory University, Atlanta, GA, USA
Arch Biochem Biophys 503:41-53. 2010.... - Inhibition of antigen presentation and T cell costimulation blocks PTH-induced bone lossBrahmchetna Bedi
Department of Medicine, Emory University, Atlanta, Georgia, USA
Ann N Y Acad Sci 1192:215-21. 2010.... - Ovariectomy disregulates osteoblast and osteoclast formation through the T-cell receptor CD40 ligandJau Yi Li
Division of Endocrinology, Metabolism, and Lipids, Department of Medicine, Emory University, Atlanta, GA 30322, USA
Proc Natl Acad Sci U S A 108:768-73. 2011..Therefore, cross-talk between T cells and SCs mediated by CD40L plays a pivotal role in the disregulation of osteoblastogenesis and osteoclastogenesis induced by ovx... - T cells potentiate PTH-induced cortical bone loss through CD40L signalingYuhao Gao
Division of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University, Atlanta, GA 30322, USA
Cell Metab 8:132-45. 2008..T cell-SC crosstalk pathways may thus provide pharmacological targets for PTH-induced bone disease... - Disruption of PTH receptor 1 in T cells protects against PTH-induced bone lossHesham Tawfeek
Division of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University, Atlanta, Georgia, United States of America
PLoS ONE 5:e12290. 2010..However it is unknown whether direct PTH stimulation of T cells is required for cPTH to induce bone loss, and whether T cells contribute to the bone catabolic activity of PTH with mechanisms other than induction of CD40 signaling in SCs... - An IL-7-dependent rebound in thymic T cell output contributes to the bone loss induced by estrogen deficiencyMichaela Robbie Ryan
Division of Endocrinology, Emory University School of Medicine, Atlanta, GA 30322, USA
Proc Natl Acad Sci U S A 102:16735-40. 2005..We conclude that IL-7 is a pivotal upstream target through which estrogen regulates hematopoietic and immune functions that are critical for bone homeostasis... - Estrogen prevents bone loss through transforming growth factor beta signaling in T cellsYuhao Gao
Division of Endocrinology, Metabolism and Lipids, Emory University School of Medicine, Atlanta, GA 30322, USA
Proc Natl Acad Sci U S A 101:16618-23. 2004.... - Estrogen regulation of immune cell bone interactionsM Neale Weitzmann
Division of Endocrinology, Metabolism and Lipids, Emory University School of Medicine, 1639 Pierce Drive, Room 1309, Atlanta, GA 30322, USA
Ann N Y Acad Sci 1068:256-74. 2006..Herein we review the experimental evidence that suggests that estrogen prevents bone loss by regulating T cell function and immune cell bone interactions... - IFN-gamma stimulates osteoclast formation and bone loss in vivo via antigen-driven T cell activationYuhao Gao
Division of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University, Atlanta, Georgia 30322, USA
J Clin Invest 117:122-32. 2007..Inhibition of IFN-gamma signaling may thus represent a novel strategy to simultaneously reduce inflammation and bone loss in common forms of osteoporosis... - The role of T lymphocytes in bone metabolismM Neale Weitzmann
Division of Endocrinology, Metabolism and Lipids, Emory University School of Medicine, Atlanta, GA 30322, USA
Immunol Rev 208:154-68. 2005..Herein, we review the experimental evidence that suggests estrogen prevents bone loss by regulating T-cell function and immune cell bone interactions... - Role of the immune system in postmenopausal bone lossM Neale Weitzmann
Division of Endocrinology and Metabolism and Lipids, Emory University School of Medicine, WMRB 1305, 101 Woodruff Circle, Atlanta, GA 30322, USA
Curr Osteoporos Rep 3:92-7. 2005..This paper presents recent findings pertaining to this new view of postmenopausal osteoporosis... - T cells: unexpected players in the bone loss induced by estrogen deficiency and in basal bone homeostasisM Neale Weitzmann
Division of Endocrinology, Metabolism and Lipids, Emory University School of Medicine, Atlanta, GA 30322, USA
Ann N Y Acad Sci 1116:360-75. 2007.... - T lymphocytes amplify the anabolic activity of parathyroid hormone through Wnt10b signalingMasakazu Terauchi
Division of Endocrinology, Metabolism, and Lipids, Department of Medicine, Emory University, Atlanta, GA 30322, USA
Cell Metab 10:229-40. 2009.... - Silencing of parathyroid hormone (PTH) receptor 1 in T cells blunts the bone anabolic activity of PTHBrahmchetna Bedi
Division of Endocrinology, Metabolism, and Lipids, Department of Medicine, Emory University, Atlanta, GA 30322, USA
Proc Natl Acad Sci U S A 109:E725-33. 2012.... - IL-7 drives T cell-mediated bone loss following ovariectomyMichaela Robbie-Ryan
Division of Endocrinology and Metabolism and Lipids, Emory University School of Medicine, 101 Woodruff Circle, 1305 WMRB, Atlanta, GA 30322-0001, USA
Ann N Y Acad Sci 1068:348-51. 2006..The mechanisms of IL-7 action are intricate and poorly defined. We present herein an overview of our current understanding of IL-7 action on bone turnover and the role of IL-7 in ovariectomy-induced bone loss... - Estrogen deficiency and bone loss: an inflammatory taleM Neale Weitzmann
Division of Endocrinology, Metabolism, and Lipids and Molecular Pathogenesis Program, Emory University, Atlanta, Georgia 30322, USA
J Clin Invest 116:1186-94. 2006..Due to the inherent difficulties associated with human investigation, many of the lessons learned have been in animal models. Consequently, many of these principles await further validation in humans... - Estrogen deficiency induces bone loss by increasing T cell proliferation and lifespan through IFN-gamma-induced class II transactivatorSimone Cenci
Division of Endocrinology and Metabolism, Emory University School of Medicine, Atlanta, GA 30322, USA
Proc Natl Acad Sci U S A 100:10405-10. 2003..Thus, increased IFN-gamma-induced class II transactivator expression and the resulting enhanced T cell proliferation and lifespan are critical to the bone wasting effect of estrogen deficiency... - IL-7 induces bone loss in vivo by induction of receptor activator of nuclear factor kappa B ligand and tumor necrosis factor alpha from T cellsGianluca Toraldo
Division of Bone and Mineral Diseases, Washington University School of Medicine and Barnes Jewish Hospital, St Louis, MO 63110, USA
Proc Natl Acad Sci U S A 100:125-30. 2003..Importantly, T cell adoptive transfer into nude mice restored IL-7-induced bone loss, and RANKL and TNF-alpha secretion, demonstrating that T cells are essential mediators of IL-7-induced bone loss in vivo... - Marked decrease in plasma antioxidants in aged osteoporotic women: results of a cross-sectional studyDario Maggio
Gerontology and Geriatrics, University of Perugia, 06122 Perugia, Italy
J Clin Endocrinol Metab 88:1523-7. 2003..Our results reveal that antioxidant defenses are markedly decreased in osteoporotic women. The mechanisms underlying antioxidant depletion and its relevance to the pathogenesis of osteoporosis deserve further investigation...