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Species | S J KnechtleSummaryAffiliation: Emory University Country: USA Publications
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Unique aspects of rejection and tolerance in liver transplantationStuart J Knechtle
Department of Surgery, Emory Transplant Center, Emory University School of Medicine, Atlanta, Georgia, USA
Semin Liver Dis 29:91-101. 2009..Understanding the mechanisms of liver transplant rejection/tolerance and the availability of better immune monitoring could help develop strategies to recognize tolerance and reduce rejection...- Immunoregulation and toleranceS J Knechtle
Knechtle, Division of Transplantation, Emory University School of Medicine, Atlanta, GA 30322, USA
Transplant Proc 42:S13-5. 2010.... - Prevention trumps treatment of antibody-mediated transplant rejectionStuart J Knechtle
Emory University School of Medicine, 5105 WMB, 101 Woodruff Circle, Atlanta, GA 30322, USA
J Clin Invest 120:1036-9. 2010..The success of this preemptive strike implies a central role for B cells in graft rejection, and this approach may help to delay or prevent chronic rejection after solid organ transplantation... - Early and limited use of tacrolimus to avoid rejection in an alemtuzumab and sirolimus regimen for kidney transplantation: clinical results and immune monitoringS J Knechtle
Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
Am J Transplant 9:1087-98. 2009..Nevertheless, alloantibody was present in serum and/or C4d present on 1-year biopsy in half the patients. The combination of CKA and DSA monitoring or the performance of transvivo DTH correlated with immune status of the patients... - Successful conversion from conventional immunosuppression to anti-CD154 monoclonal antibody costimulatory molecule blockade in rhesus renal allograft recipientsC S Cho
Department of Surgery, University of Wisconsin Hospital and Clinics, Madison 53792, USA
Transplantation 72:587-97. 2001.... - Treatment with immunotoxinS J Knechtle
Department of Surgery, Division of Organ Transplantation, 600 Highland Avenue, University of Wisconsin Medical School, Madison, WI 53792 7375, USA
Philos Trans R Soc Lond B Biol Sci 356:681-9. 2001..The usefulness of immunotoxin is directly related to its tremendous potency for depleting T cells. Based on results in nonhuman primates, it is anticipated that it will become a useful agent in tolerance induction in humans... - Immunotoxin FN18-CRM9 induces stronger T cell signaling than unconjugated monoclonal antibody FN18M M Hamawy
Department of Surgery, Division of Transplantation, University of Wisconsin, Clinical Sciences Center H4 749, 600 Highland Avenue, Madison, WI 53792
Transplantation 72:496-503. 2001.... - CD4+ CD25+ FOXP3+ regulatory T cells increase de novo in kidney transplant patients after immunodepletion with Campath-1HD D Bloom
University of Wisconsin Madison, Department of Surgery, Division of Solid Organ Transplantation, Madison, WI, USA
Am J Transplant 8:793-802. 2008..Together, these data suggest that Campath-1H promotes an increase in peripheral Tregs and may act as an intrinsic generator of Tregs in vivo... - A comparison of alemtuzumab with basiliximab induction in simultaneous pancreas-kidney transplantationJ F Magliocca
Division of Transplantation, Department of Surgery, The University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
Am J Transplant 8:1702-10. 2008..Due to the results seen in this study, the low initial cost of the drug and the absence of any severe, short-term side effects, alemtuzumab has been selected as the induction drug of choice at our center for patients undergoing SPK... - Tolerance and near-tolerance strategies in monkeys and their application to human renal transplantationS J Knechtle
Department of Surgery, University of Wisconsin Medical School, Madison, WI 53792 7375, USA
Immunol Rev 183:205-13. 2001..Rather, principles can be derived from non-human primate studies that can be extended into human trials with the knowledge that regimens will likely differ in humans compared to non-human primates... - Clinical hepatitis after transplantation of hepatitis C virus-positive kidneys: HLA-DR3 as a risk factor for the development of posttransplant hepatitisA D Kirk
Department of Surgery, Division of Transplantation, University of Wisconsin School of Medicine, Madison 53792, USA
Transplantation 62:1758-62. 1996..Application of these associations may decrease the relative risk of a recipient contracting HCV hepatitis after cadaveric renal transplantation... - Dissociation of depletional induction and posttransplant lymphoproliferative disease in kidney recipients treated with alemtuzumabA D Kirk
The Emory Transplant Center, Emory University, Atlanta, GA, USA
Am J Transplant 7:2619-25. 2007..71%, p < 0.0001). Thus, depletional induction is not an independent risk factor for PTLD. Rather, maintenance drug selection or perhaps the balance between B- and T-cell depletion may be more relevant determinants of PTLD risk... - Calcineurin inhibitor withdrawal after renal transplantation with alemtuzumab: clinical outcomes and effect on T-regulatory cellsJ Pascual
Department of Surgery, Division of Transplantation, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
Am J Transplant 8:1529-36. 2008..With the exception of maintaining increased Treg levels, the benefits are not appreciable in this short follow-up, and a larger randomized trial is justified... - Donor-directed MHC class I antibody is preferentially cleared from sensitized recipients of combined liver/kidney transplantsW Dar
Department of Surgery, Emory Transplant Center, Emory University School of Medicine, Atlanta, GA, USA
Am J Transplant 11:841-7. 2011..Liver allografts may not be fully protective of the renal allograft, especially with pre-existing MHC class II DSA. Long-term and careful follow-up will be critical to determine the impact of DSA on both allografts... - Analysis of tumor characteristics and survival in liver transplant recipients with incidentally diagnosed hepatocellular carcinomaC S Cho
Division of Transplantation, Department of Surgery, University of Wisconsin Hospital and Clinics, Madison, Wis. 53792, USA
J Gastrointest Surg 5:594-601; discussion 601-2. 2001..Indeed, patient survival after OLTX appears to be adversely affected by the presence of incidental HCC... - Regulation of T cell receptor- and CD28-induced tyrosine phosphorylation of the focal adhesion tyrosine kinases Pyk2 and Fak by protein kinase C. A role for protein tyrosine phosphatasesM Tsuchida
Department of Surgery, University of Wisconsin, Madison, Wisconsin 53792, USA
J Biol Chem 275:1344-50. 2000..These results implicate PKC in the regulation of receptor-induced tyrosine phosphorylation of the focal adhesion PTKs in T cells. The data also suggest a role for PTPases in the PKC action... - The impact of donor variables on the outcome of orthotopic liver transplantation for hepatitis CG Yagci
Division of Transplantation, University of Wisconsin, Madison, WI, USA Gulhane Military Medical Academy, Ankara, Turkey
Transplant Proc 40:219-23. 2008..DCD donors and donors older than 60 years of age significantly impact patient and graft survival. Lower graft and patient survival in recipients from DCD donors does not appear to be related to early disease recurrence... - Graft survival in a rhesus renal transplant model after immunotoxin-mediated T-cell depletion is enhanced by mycophenolate and steroidsJ H Fechner
Department of Surgery, University of Wisconsin, Madison 53792, USA
Transplantation 72:581-7. 2001..We hypothesize that MMF and steroids suppress the initial T-cell activation mediated by IT... - Strategies for tolerance induction in nonhuman primatesM M Hamawy
Department of Surgery, University of Wisconsin Madison Medical School, H4 784 Clinical Science Center, 600 Highland Avenue, Madison, WI 53792, USA
Curr Opin Immunol 10:513-7. 1998..These include targeting the T cell receptor or costimulatory molecules and the generation of mixed chimerism. Tolerance can be reliably induced in several such models, although none with 100% success... - Knowledge about transplantation tolerance gained in primatesS J Knechtle
Department of Surgery, University of Wisconsin Hospital, Madison 53792 7375, USA
Curr Opin Immunol 12:552-6. 2000..Interactive work in these three areas has yielded much new information on mechanisms of tolerance and opened the door to pilot clinical trials. Clinical application of xenotransplantation is likely to depend on such strategies... - A new look at blockade of T-cell costimulation: a therapeutic strategy for long-term maintenance immunosuppressionC P Larsen
Emory Transplant Center, Department of Surgery, School of Medicine, Emory University Atlanta, GA, USA
Am J Transplant 6:876-83. 2006..Recent clinical data using the selective costimulation blocker, belatacept (LEA29Y), as a part of a CNI-free maintenance immunosuppressive regimen in renal transplantation is highlighted... - Unaltered graft survival and intragraft lymphocytes infiltration in the cardiac allograft of Cxcr3-/- mouse recipientsJ Kwun
Division of Transplantation, Department of Surgery, University of Wisconsin Madison, Madison, WI, USA
Am J Transplant 8:1593-603. 2008..We conclude Cxcr3 may contribute to, but does not govern, leukocyte trafficking in this transplant model... - Sirolimus monotherapy following Campath-1H inductionV Rao
University of Wisconsin Medical School, Madison, Wisconsin, USA
Transplant Proc 35:128S-130S. 2003..Wound healing, leukopenia, and anemia were not significant problems. In conclusion, monotherapy has been well tolerated with a favorable side effect profile. However, a rejection rate of 28% was noted... - Liver transplantation in pediatric patients: twenty years of experience at the University of WisconsinS J Knechtle
Department of Surgery, University of Wisconsin, Madison, WI 53792 7375, USA
Pediatr Transplant 11:661-70. 2007..Despite its technical challenges, the outcomes of liver transplantation in pediatric patients with end-stage liver disease are excellent and result in significant long-term patient and graft survival... - Novel immunosuppressive agents in tolerance inductionN R Krieger
Division of Organ Transplantation, Department of Surgery, University of Wisconsin Medical School, 600 Highland Avenue, Madison, WI 53792, USA
Curr Drug Targets Cardiovasc Haematol Disord 2:97-103. 2002..These preliminary results are briefly reviewed as well. Tolerance has been achieved in a small number of organ transplant patients and such successes suggest that progress in the clinical arena is happening and is an obtainable result... - The Art and Science of Immunosuppression: the Fifth Annual American Society of Transplant Surgeon's State-of-the-Art Winter SymposiumE A Pomfret
Department of Surgery, Division of Liver Transplantation and Hepatobiliary Surgery, Lahey Clinic Medical Center, Burlington, MA, USA
Am J Transplant 6:275-80. 2006..Finally, the available technologies for molecular and genetic diagnostics and the clinical correlation in the post-transplant setting were discussed...