Research Topics
| Keith P KlugmanSummaryAffiliation: Emory University Country: USA Publications
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Publications
Public health and economic impact of vaccination with 7-valent pneumococcal vaccine (PCV7) in the context of the annual influenza epidemic and a severe influenza pandemicJaime L Rubin
i3 Innovus, 10 Cabot Road, Suite 304, Medford, MA 02155, USA
BMC Infect Dis 10:14. 2010..The 2009 novel influenza A (H1N1) outbreak highlights the importance of interventions that may mitigate the impact of a pandemic...- Pneumococcal pneumonia and influenza: a deadly combinationKeith P Klugman
Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA
Vaccine 27:C9-C14. 2009..Vaccination with PCV for children and pneumococcal polysaccharide vaccine for adults should be considered essential to pandemic influenza preparedness... - Levofloxacin-resistant invasive Streptococcus pneumoniae in the United States: evidence for clonal spread and the impact of conjugate pneumococcal vaccineMathias W R Pletz
Department of International Health, Rollins School of Public Health, Emory University, 1518 Clifton Rd, Atlanta, GA 30322, USA
Antimicrob Agents Chemother 48:3491-7. 2004..Our results suggest that invasive pneumococcal isolates resistant to levofloxacin in the United States show considerable evidence of multiple resistance and of clonal spread... - In vitro evaluation of the antimicrobial activity of ceftaroline against cephalosporin-resistant isolates of Streptococcus pneumoniaeLesley McGee
Emory University, Atlanta, Georgia 30322, USA
Antimicrob Agents Chemother 53:552-6. 2009..pneumoniae strains resistant to existing parenteral cephalosporins and support its continued development for the treatment of infections caused by resistant S. pneumoniae strains... - Interspecies recombination in type II topoisomerase genes is not a major cause of fluoroquinolone resistance in invasive Streptococcus pneumoniae isolates in the United StatesMathias W R Pletz
Department of International Health, Rollins School of Public Health, Emory University, 1518 Clifton Rd, Atlanta, GA 30322, USA
Antimicrob Agents Chemother 49:779-80. 2005..We analyzed the nucleotide sequences of the quinolone resistance-determining regions of 49 invasive levofloxacin-resistant pneumococcal isolates and did not find any evidence for interspecies recombination... - Prevalence of first-step mutants among levofloxacin-susceptible invasive isolates of Streptococcus pneumoniae in the United StatesMathias W R Pletz
Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA
Antimicrob Agents Chemother 50:1561-3. 2006..Among those with a levofloxacin MIC of 2 mg/liter, 16.2% of isolates recovered from nursing home residents and 6.4% from non-nursing home residents had first-step mutations... - Increased prevalence of pediatric pneumococcal serotypes in elderly adultsDaniel R Feikin
Division of Bacterial and Mycotic Diseases, National Center for Infectious Disease, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Clin Infect Dis 41:481-7. 2005..CONCLUSIONS: The increased proportion of severe pneumococcal disease caused by pediatric serotypes in the elderly population might indicate opportunities for prevention with use of PCV7... - Five-year cohort study of hospitalization for respiratory syncytial virus associated lower respiratory tract infection in African childrenShabir A Madhi
University of the Witwatersrand Medical Research Council, Respiratory and Meningeal Pathogens Research Unit, Atlanta, GA, USA
J Clin Virol 36:215-21. 2006.... - Fitness costs of fluoroquinolone resistance in Streptococcus pneumoniaeDaniel E Rozen
Department of Biology, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA
Antimicrob Agents Chemother 51:412-6. 2007..We discuss the implications of these results for the epidemiology of fluoroquinolone resistance and the evolution of acquired resistance in treated patients... - Clinical impact of antibiotic resistance in respiratory tract infectionsKeith P Klugman
Hubert Department of Global Health, Rollins School of Public Health, and Division of Infectious Diseases, School of Medicine, Emory University, Atlanta, GA 30322, USA
Int J Antimicrob Agents 29:S6-10. 2007..pneumoniae present numerous clinical challenges, and require carefully selected treatment strategies to preserve antibacterial efficacy. Antibiotics with a low propensity for stimulating resistance should be chosen wherever possible... - HIV and pneumococcal diseaseKeith P Klugman
Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, Georgia 30322, USA
Curr Opin Infect Dis 20:11-5. 2007..To describe the impact of highly active antiretroviral therapy on the burden of pneumococcal disease and advances in our understanding of the impact of HIV on this disease... - Contribution of vaccines to our understanding of pneumococcal diseaseKeith P Klugman
Rollins School of Public Health, Emory University, 1518 Clifton Road, N E CNR Room 6009, Atlanta, GA 30322, USA
Philos Trans R Soc Lond B Biol Sci 366:2790-8. 2011..Finally, there has been a recent demonstration that pneumococcal pneumonia in children may be an important cause of hospitalization for those with underlying tuberculosis... - Hidden epidemic of macrolide-resistant pneumococciKeith P Klugman
Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, Georgia 30322, USA
Emerg Infect Dis 11:802-7. 2005..We provide an overview of macrolide-resistant S. pneumoniae and assess the impact of this resistance on the empiric treatment of community-acquired RTIs... - Outpatient antibiotic prescribing and nonsusceptible Streptococcus pneumoniae in the United States, 1996-2003Lauri A Hicks
Division of Bacterial Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
Clin Infect Dis 53:631-9. 2011..We evaluated the relationship between antibiotic prescribing and nonsusceptibility among invasive pneumococcal disease (IPD) isolates... - Emergence of Streptococcus pneumoniae with very-high-level resistance to penicillinStephanie J Schrag
Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
Antimicrob Agents Chemother 48:3016-23. 2004..The emergence, clonality, and association of very-high-level penicillin resistance with multiple drug resistance requires further monitoring and highlights the need for novel agents active against the pneumococcus... - Use of 2 pneumococcal common protein real-time polymerase chain reaction assays in healthy children colonized with Streptococcus pneumoniaeNadine Rouphael
Centers for Diseases Control and Prevention, Atlanta, GA 30329, USA
Diagn Microbiol Infect Dis 70:452-4. 2011..We found in serum no positive samples for pneumococcal DNA in 100 carriers and noncarriers using 2 different real-time PCR assays targeting lytA and psaA genes... - Novel approaches to the identification of Streptococcus pneumoniae as the cause of community-acquired pneumoniaKeith P Klugman
Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, Georgia 30322, USA
Clin Infect Dis 47:S202-6. 2008.... - Oral antibiotics for the treatment of severe pneumonia in childrenKeith P Klugman
Respiratory and Meningeal Pathogens Research Unit, Medical Research Council, University of the Witwatersrand, National Health Laboratory Service, Johannesburg, South Africa
Lancet 364:1104-5. 2004 - Pneumonia vaccines for all who need themKeith P Klugman
William H Foege Chair in Global Health, Rollins School of Public Health, Atlanta, GA, USA
Hum Vaccin 5:779-80. 2009.... - The role of clonality in the global spread of fluoroquinolone-resistant bacteriaKeith P Klugman
Department of International Health, Rollins School of Public Health, Atlanta, GA, USA
Clin Infect Dis 36:783-5. 2003..Although these clones remain fluoroquinolone susceptible in children, their widespread distribution argues against the extension of fluoroquinolone use to the management of respiratory tract infection in children... - A trial of a 9-valent pneumococcal conjugate vaccine in children with and those without HIV infectionKeith P Klugman
Medical Research Council, University of the Witwatersrand, National Institute for Communicable Diseases, Respiratory and Meningeal Pathogens Research Unit, Johannesburg, South Africa
N Engl J Med 349:1341-8. 2003..We evaluated the efficacy of a 9-valent pneumococcal conjugate vaccine in a randomized, double-blind study in Soweto, South Africa... - Gender as a risk factor for both antibiotic resistance and infection with pediatric serogroups/serotypes, in HIV-infected and -uninfected adults with pneumococcal bacteremiaKimberly A Buie
Department of International Health, Rollins School of Public Health, Emory University, Atlanta, Georgia 30322, USA
J Infect Dis 189:1996-2000. 2004..25-2.36]) than were men. Thus, conjugate pneumococcal vaccination of children may reduce, in particular, both antibiotic resistance and the burden of conjugate vaccine serotype pneumococcal disease in young, HIV-infected women... - Antibiotic resistance and serotype distribution of Streptococcus pneumoniae colonizing rural Malawian childrenDaniel R Feikin
Respiratory Diseases Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, PHS DHHS, 1600 Clifton Road, Mailstop C23, Atlanta, GA 30333, USA
Pediatr Infect Dis J 22:564-7. 2003..Forty-three percent of isolates were serotypes included in the 7-valent pneumococcal conjugate vaccine, and 37% were vaccine-related serotypes, particularly 6A and 19A... - Genotypic comparison of invasive Neisseria meningitidis serogroup Y isolates from the United States, South Africa, and Israel, isolated from 1999 through 2002Anne M Whitney
Coordinating Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
J Clin Microbiol 47:2787-93. 2009.... - Resurgence of the multiresistant pneumococcus in the United States: a commentaryKeith P Klugman
Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA
Pediatr Infect Dis J 26:473-4. 2007 - Historical changes in pneumococcal serogroup distribution: implications for the era of pneumococcal conjugate vaccinesDaniel R Feikin
Respiratory Diseases Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Clin Infect Dis 35:547-55. 2002..These historical trends in serogroup distribution may be explained by changes in antibiotic use, socioeconomic conditions, the immunocompromised status of populations, and blood-culturing practices... - Efficacy of whole-cell killed bacterial vaccines in preventing pneumonia and death during the 1918 influenza pandemicYu Wen Chien
Rollins School of Public Health, Emory University, Atlanta, Georgia 30322, USA
J Infect Dis 202:1639-48. 2010..Most deaths in the 1918 influenza pandemic were caused by secondary bacterial pneumonia... - The LuxS-dependent quorum-sensing system regulates early biofilm formation by Streptococcus pneumoniae strain D39Jorge E Vidal
Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA
Infect Immun 79:4050-60. 2011..In conclusion, the luxS-controlled QS system is a key regulator of early biofilm formation by S. pneumoniae strain D39... - Impact of haemophilus influenzae type b conjugate vaccine in South Africa and ArgentinaMichael Martin
Respiratory Diseases Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
Pediatr Infect Dis J 23:842-7. 2004..Surrogate indicators of bacterial meningitis also declined and might be useful measures of Hib conjugate vaccine impact at hospitals where capacity to culture Hib is not available... - Implications for antimicrobial prescribing of strategies based on bacterial eradicationKeith P Klugman
Department of International Health, Rollins School of Public Health, Division of Infectious Diseases, School of Medicine, Emory University, Atlanta, GA 30322, USA
Int J Infect Dis 7:S27-31. 2003..To maximize clinical cure and minimize the emergence and spread of resistance, antimicrobial prescribing should maximize bacterial eradication, and clinical drug evaluation needs to be brought into line with this need... - Recommendations for treatment of childhood non-severe pneumoniaGavin B Grant
National Center for Immunizations and Respiratory Diseases, Centers for Disease Control and Prevention CDC, Atlanta, GA 30333, USA
Lancet Infect Dis 9:185-96. 2009..If failure of the first-line agent remains a possible explanation, suitable second-line agents include high-dose amoxicillin-clavulanic acid with or without an affordable macrolide for children over 3 years of age... - Vaccines as tools against resistance: the example of pneumococcal conjugate vaccineCynthia G Whitney
Epidemiology Section, Respiratory Diseases Branch, Division of Bacterial and Mycotic Disease, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road NE, MS-C23, Atlanta, GA 30333, USA
Semin Pediatr Infect Dis 15:86-93. 2004..Surveillance is needed to monitor the spread of antimicrobial resistance into nonvaccine serotypes, which may lead to a resurgence of resistance... - Maternal influenza immunization and reduced likelihood of prematurity and small for gestational age births: a retrospective cohort studySaad B Omer
Hubert Department of Global Health, Emory University Rollins School of Public Health, Atlanta, Georgia, USA
PLoS Med 8:e1000441. 2011..Infections during pregnancy have the potential to adversely impact birth outcomes. We evaluated the association between receipt of inactivated influenza vaccine during pregnancy and prematurity and small for gestational age (SGA) births...