Research Topics | William KellySummaryAffiliation: Emory University Country: USA Publications
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Publications
Meiotic silencing and the epigenetics of sexWilliam G Kelly
Biology Department, Emory University, Atlanta, GA, USA
Chromosome Res 15:633-51. 2007..We will additionally propose that the functions of meiotic silencing originate in genome defense, and discuss its potential contributions to genome evolution and speciation...- X-chromosome silencing in the germline of C. elegansWilliam G Kelly
Biology Department, Emory University, Atlanta, GA 30322, USA
Development 129:479-92. 2002..Silencing of the sex chromosome during early meiosis is a conserved feature throughout the nematode phylum, and is not limited to hermaphroditic species... - EGO-1, a putative RNA-dependent RNA polymerase, is required for heterochromatin assembly on unpaired dna during C. elegans meiosisEleanor M Maine
Department of Biology, Syracuse University, Syracuse, New York 13244, USA
Curr Biol 15:1972-8. 2005..ego-1 interacts genetically with him-17, another regulator of chromatin and meiosis, to promote germline development. We conclude that EGO-1 is an essential component of meiotic silencing in C. elegans... - Standing guard: Perinuclear localization of an RNA-dependent RNA polymeraseWilliam G Kelly
Department of Biology, Emory University, 1510 Clifton Road, Atlanta, GA 30322, USA
Proc Natl Acad Sci U S A 103:2007-8. 2006 - Trans-generational epigenetic regulation of C. elegans primordial germ cellsHirofumi Furuhashi
Biology Department, Emory University, Atlanta, GA 30322, USA
Epigenetics Chromatin 3:15. 2010..abstract:.. - Chromatin remodeling in dosage compensationJohn C Lucchesi
Department of Biology, Emory University, Atlanta, Georgia 30322, USA
Annu Rev Genet 39:615-51. 2005..The study of dosage compensation in these different forms has revealed the existence of an amazing number of interacting chromatin remodeling mechanisms that affect the function of entire chromosomes... - Meiotic pairing and imprinted X chromatin assembly in Caenorhabditis elegansChristopher J Bean
Biology Department, 1510 Clifton Road, Rollins Research Center, Emory University, Atlanta, Georgia 30322, USA
Nat Genet 36:100-5. 2004..Targeting unpaired DNA for silencing during meiosis, a potential hallmark of genome defense, could therefore have a conserved role in imprinted X-chromosome inactivation and, ultimately, in sex chromosome evolution... - Functional genomic analysis of the ADP-ribosylation factor family of GTPases: phylogeny among diverse eukaryotes and function in C. elegansYawei Li
Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, USA
FASEB J 18:1834-50. 2004..elegans, at least three are required for embryogenesis. These data represent the first analysis of the role(s) of multiple members of this family in the development of a multicellular organism... - emb-4 is a conserved gene required for efficient germline-specific chromatin remodeling during Caenorhabditis elegans embryogenesisPaula M Checchi
Biology Department, Emory University, Atlanta, Georgia 30322, USA
Genetics 174:1895-906. 2006..We also find that, as in early somatic blastomeres, the degradation of PIE-1 in Z2/Z3 is facilitated by zinc-finger-interacting protein ZIF-1, and in the absence of either zif-1 or emb-4, PIE-1 is abnormally retained in Z2/Z3... - A C. elegans LSD1 demethylase contributes to germline immortality by reprogramming epigenetic memoryDavid J Katz
Biology Department, Emory University, Atlanta, GA 30322, USA
Cell 137:308-20. 2009..Thus, our results provide direct mechanistic insights into the processes that are required for epigenetic reprogramming between generations... - A conserved chromatin architecture marks and maintains the restricted germ cell lineage in worms and fliesChristine E Schaner
Biology Department, Emory University, Atlanta, GA 30322, USA
Dev Cell 5:747-57. 2003..These results indicate that genome-wide repression via a nanos-regulated, germ cell-specific chromatin organization is a conserved feature of germline maintenance during embryogenesis... - RNA helicase A is important for germline transcriptional control, proliferation, and meiosis in C. elegansKatherine M Walstrom
Division of Natural Sciences, New College of Florida, 5700 N Tamiami Trail, Sarasota, FL 34243, USA
Mech Dev 122:707-20. 2005..Our results suggest that RHA-1 is a conserved transcription regulation protein that controls germline proliferation and development in C. elegans... - The genomic distribution and function of histone variant HTZ-1 during C. elegans embryogenesisChristina M Whittle
Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
PLoS Genet 4:e1000187. 2008..Our experiments indicate that HTZ-1 functions in establishing or maintaining an essential chromatin state at promoters regulated dynamically during C. elegans embryogenesis...
Research Grants
- Epigenetic Regulation of the Embryonic Germ LineWilliam Kelly; Fiscal Year: 2009..This could also provide a better foundation for understanding how pluripotency is achieved and hopefully lead to therapies involving somatic stem cells. ..
- Genetic Silencing in Germline Maintenance and FunctionWilliam Kelly; Fiscal Year: 2007..abstract_text> ..
- Genetic Silencing in Germline Maintenance and FunctionWilliam Kelly; Fiscal Year: 2007..Epigenetic mechanisms operating in the germ line are essential for the establishment of imprinting and the prevention of heritable genetic mutations, both of which are crucial for normal human health and normal human development. ..
- Epigenetic Regulation of the Embryonic Germ LineWilliam Kelly; Fiscal Year: 2007..This could also provide a better foundation for understanding how pluripotency is achieved and hopefully lead to therapies involving somatic stem cells. ..
- Genetic Silencing in Germline Maintenance and FunctionWilliam Kelly; Fiscal Year: 2006..It is hoped that an understanding of these processes in the germ lineage will provide an understanding of the underlying mechanisms that are common to all descendents of this founding lineage. ..
- Genetic Silencing in Germline Maintenance and FunctionWilliam G Kelly; Fiscal Year: 2010..Epigenetic mechanisms operating in the germ line are essential for the establishment of imprinting and the prevention of heritable genetic mutations, both of which are crucial for normal human health and normal human development. ..