Research Topics
| Mark A JensenSummaryAffiliation: Emory University Country: USA Publications
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Detail Information
Publications
A novel Fc gamma receptor ligand augments humoral responses by targeting antigen to Fc gamma receptorsMark A Jensen
Department of Neurology, University of Chicago, Chicago, IL 60637, USA
Eur J Immunol 37:1139-48. 2007..008). Immunization with HSA1R4 yields greater T cell reactivity to HSA1 ex vivo than immunization with HSA1Fc (p<0.004). Linking antigenic peptides to linear HCH2 polymers may facilitate vaccine development...- A reliable phenotype predictor for human immunodeficiency virus type 1 subtype C based on envelope V3 sequencesMark A Jensen
Department of Microbiology, University of Washington, Seattle, WA, USA
J Virol 80:4698-704. 2006..We present bioinformatic evidence that particular sites may influence coreceptor usage differently, depending on the subtype... - HIV type 1 superinfection with a dual-tropic virus and rapid progression to AIDS: a case reportGeoffrey S Gottlieb
Division of Allergy and Infectious Diseases, School of Medicine, University of Washington, Seattle, WA 98195, USA
Clin Infect Dis 45:501-9. 2007..The occurrence of human immunodeficiency virus type 1 (HIV-1) superinfection has implications for vaccine development and our understanding of HIV pathogenesis and transmission... - Improved coreceptor usage prediction and genotypic monitoring of R5-to-X4 transition by motif analysis of human immunodeficiency virus type 1 env V3 loop sequencesMark A Jensen
Department of Microbiology, University of Washington, Seattle, Washington 98195 8070, USA
J Virol 77:13376-88. 2003..We found that X4 viruses were lost in two ways: by the dying off of an established X4 lineage or by mutation back to low-scoring V3 loops... - Influence of random genetic drift on human immunodeficiency virus type 1 env evolution during chronic infectionDaniel Shriner
Department of Microbiology, University of Washington School of Medicine, Seattle, Washington 98195-8070, USA
Genetics 166:1155-64. 2004..We conclude that the genetic variation in these data sets can be explained by a predominance of random genetic drift of neutral mutations with brief episodes of natural selection that were frequently masked by recombination... - Molecular clock-like evolution of human immunodeficiency virus type 1Yi Liu
Department of Microbiology, University of Washington School of Medicine, Seattle, WA 98195, United States
Virology 329:101-8. 2004..Natural selection alone did not appear to obscure the clock-like evolution of HIV-1... - Reconstruction and function of ancestral center-of-tree human immunodeficiency virus type 1 proteinsMorgane Rolland
Department of Microbiology SC 42, University of Washington, Seattle, WA 98195 8070, USA
J Virol 81:8507-14. 2007.... - HIV-specific probabilistic models of protein evolutionDavid C Nickle
Department of Microbiology, University of Washington School of Medicine, Seattle, Washington, United States of America
PLoS ONE 2:e503. 2007..We argue that our model derivation procedure is immediately applicable to other organisms with extensive sequence data available, such as Hepatitis C and Influenza A viruses... - Dual HIV-1 infection associated with rapid disease progressionGeoffrey S Gottlieb
Department of Microbiology, School of Medicine, University of Washington, Seattle, WA 98195 8070, USA
Lancet 363:619-22. 2004..4 and <3.1 years, respectively). Our findings should prompt larger studies to assess the effect of dual infection at the population level... - Coping with viral diversity in HIV vaccine designDavid C Nickle
Department of Microbiology, University of Washington School of Medicine, Seattle, Washington, United States of America
PLoS Comput Biol 3:e75. 2007..These immunogens should elicit immune responses against high-frequency viral strains as well as against most mutant forms of the virus... - Predicting HIV-1 coreceptor usage with sequence analysisMark A Jensen
Department of Microbiology, Box 358070, University of Washington School of Medicine, Seattle, WA 98195-8070, USA
AIDS Rev 5:104-12. 2003..Further development of these methods, by extending analysis to regions outside the V3 loop and to clades beyond subtype B, will extend our understanding of HIV-1 pathogenesis and inform treatment strategies... - Clinical and immunological impact of HIV envelope V3 sequence variation after starting initial triple antiretroviral therapyZabrina L Brumme
BC Centre for Excellence in HIV/AIDS, St. Paul's Hospital, The Faculty of Medicine, University of British Columbia, 603-1081 Burrard Street, Vancouver, BC, Canada V6Z 1Y6
AIDS 18:F1-9. 2004..These results may prove to be useful for the clinical management of HIV-infected individuals... - Evolutionary indicators of human immunodeficiency virus type 1 reservoirs and compartmentsDavid C Nickle
Departmentof Microbiology, University of Washington School of Medicine, Seattle 98195, USA
J Virol 77:5540-6. 2003..We report that existing statistical methods work quite well at detecting viral compartments, and we learn from simulations that viral divergence from a calculated most recent common ancestor is a strong predictor of viral reservoirs... - Changes in human immunodeficiency virus type 1 fitness and genetic diversity during disease progressionRyan M Troyer
Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106, USA
J Virol 79:9006-18. 2005..These data provide in vivo evidence that increasing HIV-1 replication efficiency may be related to a concomitant increase in HIV-1 diversity, which in turn may be a determining factor in disease progression... - Consensus and ancestral state HIV vaccinesDavid C Nickle
Science 299:1515-8; author reply 1515-8. 2003 - Genetic characterization of rebounding human immunodeficiency virus type 1 in plasma during multiple interruptions of highly active antiretroviral therapyMark Dybul
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
J Virol 77:3229-37. 2003..In addition, the data suggest that there may be multiple compartments contributing to the rebound of plasma viremia and to viral diversity from cycle to cycle of intermittent therapy... - Anti-S-nitrosocysteine antibodies are a predictive marker for demyelination in experimental autoimmune encephalomyelitis: implications for multiple sclerosisAnne I Boullerne
Department of Neurology, University of Chicago, Chicago, Illinois 60637, USA
J Neurosci 22:123-32. 2002..Anti-SNO-cysteine Abs are also elevated at times of MS attacks and in progressive disease, suggesting a possible role for these Abs, measurable in blood, as a biological marker for clinical activity...