Research Topics
| James G HerndonSummaryAffiliation: Emory University Country: USA Publications
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Detail Information
Publications
The grandmother effect and the uniqueness of the human aging phenotypeJames G Herndon
Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA
Gerontology 56:217-9. 2010....- The grandmother effect: implications for studies on aging and cognitionJames G Herndon
Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA
Gerontology 56:73-9. 2010..One prominent line of thought explaining this selection process is the grandmother hypothesis... - Multiprotein HIV type 1 clade B DNA/MVA vaccine: construction, safety, and immunogenicity in MacaquesJames M Smith
Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia 30329, USA
AIDS Res Hum Retroviruses 20:654-65. 2004.... - Different patterns of immune responses but similar control of a simian-human immunodeficiency virus 89.6P mucosal challenge by modified vaccinia virus Ankara (MVA) and DNA/MVA vaccinesRama Rao Amara
Vaccine Research Center and Yerkes Regional Primate Research Center, Emory University, Atlanta, Georgia 30329, USA
J Virol 76:7625-31. 2002..Thus, MVA vaccines, as well as DNA/MVA vaccines, merit further evaluation for their ability to control the current AIDS pandemic... - DNA/MVA vaccine for HIV type 1: effects of codon-optimization and the expression of aggregates or virus-like particles on the immunogenicity of the DNA primeJames M Smith
Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia 30329, USA
AIDS Res Hum Retroviruses 20:1335-47. 2004..Based on the breadth of the T cell response and a trend toward higher titers of anti-Env Ab, we are moving forward with human trials of the noncodon-optimized VLP-expressing DNA... - A combination DNA and attenuated simian immunodeficiency virus vaccine strategy provides enhanced protection from simian/human immunodeficiency virus-induced diseaseRama Rao Amara
Divisions of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, 954 N. Gatewood Rd, Atlanta, GA 30329, USA
J Virol 79:15356-67. 2005..These results demonstrate that addition of a DNA prime to a live attenuated virus provided better protection from disease following challenge than live attenuated virus alone... - Studies on the cross-clade and cross-species conservation of HIV-1 Gag-specific CD8 and CD4 T cell responses elicited by a clade B DNA/MVA vaccine in macaquesRama Rao Amara
Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30322, USA
Virology 334:124-33. 2005..Our results demonstrate that the clade B DNA/MVA HIV vaccine elicits T cell responses against epitopes that are conserved in multiple clades and recognized by humans and macaques... - Gp120-alum boosting of a Gag-Pol-Env DNA/MVA AIDS vaccine: poorer control of a pathogenic viral challengeSuzan L Buge
Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA 30333, USA
AIDS Res Hum Retroviruses 19:891-900. 2003..This trend did not reach significance in our animal groups of 8. We conclude that gp120 inoculations that fail to raise neutralizing antibody do not improve the efficacy of Gag-Pol-Env DNA/MVA vaccines... - Studies in macaques on cross-clade T cell responses elicited by a DNA/MVA AIDS vaccine, better conservation of CD8 than CD4 T cell responsesJames M Smith
Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia 30329, USA
AIDS Res Hum Retroviruses 21:140-4. 2005..Thus, the ability of an HIV vaccine for one clade to protect against other clades may be more limited by the ability to provide CD4 T cell help than the ability to elicit CD8 effector functions... - Slowly declining levels of viral RNA and DNA in DNA/recombinant modified vaccinia virus Ankara-vaccinated macaques with controlled simian-human immunodeficiency virus SHIV-89.6P challengesYuyang Tang
Vaccine Research Center, Yerkes National Primate Research Center, 954 Gatewood Road NE, Atlanta, GA 30329, USA
J Virol 76:10147-54. 2002..Thus, to date, control of the challenge infection has appeared to improve with time, with the decay rates for viral DNA being at the lower end of values reported for patients on highly active antiretroviral therapy... - Defective IL-2 production by HIV-1-specific CD4 and CD8 T cells in an adolescent/young adult cohortBill G Kapogiannis
Division of Infectious Diseases, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30329, USA
AIDS Res Hum Retroviruses 22:272-82. 2006..Longitudinal studies are clearly necessary to assess the impact of HAART on these parameters... - Effects of estradiol and aging on fine manual performance in female rhesus monkeysAGNES LACREUSE
Division of Neuroscience, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30322, USA
Horm Behav 43:359-66. 2003..These results confirm the slowing of fine motor performance with aging in female rhesus monkeys. They also indicate that estradiol, at least as administered in this study, does not benefit fine manual performance... - Longitudinal diffusion tensor imaging and perfusion MRI investigation in a macaque model of neuro-AIDS: a preliminary studyChunxia Li
Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA
Neuroimage 58:286-92. 2011..These longitudinal changes in CBF and FA are correlated with CD4+ T-cell depletion and/or CD4:CD8 ratio. The MRI findings from this pilot study agree with previous results in HIV(+) patients... - Effects of aging and hormonal status on bimanual motor coordination in the rhesus monkeyAGNES LACREUSE
Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, United States
Neurobiol Aging 28:186-93. 2007..Finally, performance on the bimanual task was significantly correlated with performance on a previously administered unimanual motor test emphasizing speed, suggesting that age-related motor slowing may explain deficits in both tasks... - Sex, age, and training modulate spatial memory in the rhesus monkey (Macaca mulatta)AGNES LACREUSE
Yerkes National Primate Research Center, Emory University, Atlanta, GA, 30322 USA
Behav Neurosci 119:118-26. 2005..The results confirm a male advantage in spatial working memory at a young age and confirm a greater decline with age in males than in females. It is important to note that prior training completely reverses the deficits of young females... - Sex differences in age-related motor slowing in the rhesus monkey: behavioral and neuroimaging dataAGNES LACREUSE
Division of Neuroscience, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30322, USA
Neurobiol Aging 26:543-51. 2005..Further studies will be necessary to uncover the neurohormonal bases of the differential age-related motor decline between males and females... - Menopause in nonhuman primates?Margaret L Walker
Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30322, USA
Biol Reprod 79:398-406. 2008..The existing data support the view that menopause occurs in a number of primate species and is not unique to humans... - Effect of menstrual cycle on resting brain metabolism in female rhesus monkeysJames K Rilling
Department of Anthropology, Emory University, Atlanta, Georgia 30322, USA
Neuroreport 19:537-41. 2008..In summary, the data suggest that in primates, fluctuations of ovarian hormones across the menstrual cycle influence activity in brain areas involved in emotion and its regulation... - Correlation of acute humoral response with brain virus burden and survival time in pig-tailed macaques infected with the neurovirulent simian immunodeficiency virus SIVsmmFGbSHAWN P O'NEIL
Division of Microbiology, Yerkes National Primate Research Center, Emory University School of Medicine, Atlanta, GA, USA
Am J Pathol 164:1157-72. 2004..614; P < 0.01). The close association between immune response and SIVE in this model should prove useful for identifying correlates of immune protection against primate lentiviral encephalitis... - Ocular measurements throughout the adult life span of rhesus monkeysAlcides Fernandes
Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30322, USA
Invest Ophthalmol Vis Sci 44:2373-80. 2003..To examine the relationship of ocular components to refraction throughout the adult life span of the rhesus monkey (Macaca mulatta)... - Ovarian aging in squirrel monkeys (Saimiri sciureus)Margaret L Walker
Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30329, USA
Reproduction 138:793-9. 2009..Analysis of GCCs in older squirrel monkeys also could yield insights into the pathophysiology of granulosa cell tumors in humans... - Mosaic agingLary C Walker
Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA
Med Hypotheses 74:1048-51. 2010.... - Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/MVA vaccineRama Rao Amara
Vaccine Research Center, Yerkes Regional Primate Research Center, Emory University, 954 Gatewood Road NE, Atlanta, GA 30329, USA
Vaccine 20:1949-55. 2002..These highly promising findings provide hope that a relatively simple multiprotein DNA/MVA vaccine can help to control the AIDS epidemic... - Critical role for Env as well as Gag-Pol in control of a simian-human immunodeficiency virus 89.6P challenge by a DNA prime/recombinant modified vaccinia virus Ankara vaccineRama Rao Amara
Vaccine Research Center, Emory University School of Medicine, Atlanta, Georgia 30322, USA
J Virol 76:6138-46. 2002..Our results highlight the importance of immune responses to Env, as well as to Gag-Pol, in the control of immunodeficiency virus challenges and the protection of CD4(+) cells... - Estradiol, but not raloxifene, improves aspects of spatial working memory in aged ovariectomized rhesus monkeysAGNES LACREUSE
Yerkes Regional Primate Research Center, Emory University, Atlanta, GA 30322, USA
Neurobiol Aging 23:589-600. 2002..Further, they suggest that raloxifene does not affect cognitive function after long-term ovarian hormone deprivation...