Research Topics
Genomes and GenesSpecies | C HeimSummaryAffiliation: Emory University Country: USA Publications
Research Grants
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Publications
Influence of child abuse on adult depression: moderation by the corticotropin-releasing hormone receptor geneRebekah G Bradley
Atlanta VA Medical Center, Georgia, USA
Arch Gen Psychiatry 65:190-200. 2008..Child abuse and trauma alter the endogenous stress response, principally corticotropin-releasing hormone and its downstream effectors, suggesting that a gene x environment interaction at this locus may be important in depression...- Differential responses to psychotherapy versus pharmacotherapy in patients with chronic forms of major depression and childhood traumaCharles B Nemeroff
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322
Proc Natl Acad Sci U S A 100:14293-6. 2003..Our results suggest that psychotherapy may be an essential element in the treatment of patients with chronic forms of major depression and a history of childhood trauma... - Regional prevalence of fatiguing illnesses in the United States before and after the terrorist attacks of September 11, 2001Christine Heim
Division of Viral and Rickettsial Diseases, Viral Exanthems and Herpesvirus Branch, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Psychosom Med 66:672-8. 2004..We used data obtained during this survey to estimate the effect of the coincidentally occurring terrorist attacks of September 11, 2001, on the regional prevalence of fatiguing illnesses... - Increased stress-induced inflammatory responses in male patients with major depression and increased early life stressThaddeus W W Pace
Emory University School of Medicine, Atlanta, GA 30322, USA
Am J Psychiatry 163:1630-3. 2006.... - A short review on the psychoneuroimmunology of posttraumatic stress disorder: from risk factors to medical comorbiditiesThaddeus W W Pace
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
Brain Behav Immun 25:6-13. 2011..This short article reviews immune alterations in PTSD, and considers possible mechanisms by which such changes may be related to neuroendocrine alterations and medical comorbidities of PTSD... - Sleep characteristics of persons with chronic fatigue syndrome and non-fatigued controls: results from a population-based studyWilliam C Reeves
Viral Exanthems and Herpesvirus Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
BMC Neurol 6:41. 2006.... - Perception versus polysomnographic assessment of sleep in CFS and non-fatigued control subjects: results from a population-based studyMatthias Majer
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, USA
BMC Neurol 7:40. 2007..We conducted this study to determine whether alterations in objective sleep characteristics are associated with subjective measures of poor sleep quality in persons with CFS... - Chronic fatigue syndrome--a clinically empirical approach to its definition and studyWilliam C Reeves
Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
BMC Med 3:19. 2005..The lack of standardized criteria for defining chronic fatigue syndrome (CFS) has constrained research. The objective of this study was to apply the 1994 CFS criteria by standardized reproducible criteria... - The dexamethasone/corticotropin-releasing factor test in men with major depression: role of childhood traumaChristine Heim
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Biol Psychiatry 63:398-405. 2008..We determined the impact of childhood trauma on dexamethasone/CRF test results in patients with MDD... - The link between childhood trauma and depression: insights from HPA axis studies in humansChristine Heim
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 101 Woodruff Circle, WMRB, Suite 4311, Atlanta, GA 30322, USA
Psychoneuroendocrinology 33:693-710. 2008..Taken together, this line of evidence demonstrates that psychoneuroendocrine research may ultimately promote optimized clinical care and help prevent the adverse outcomes of childhood trauma... - Lower CSF oxytocin concentrations in women with a history of childhood abuseC Heim
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, WMRB, Atlanta, GA 30322, USA
Mol Psychiatry 14:954-8. 2009..If replicated, the association of lower adult CSF OT levels with childhood trauma might indicate that alterations in central OT function may be involved in the adverse outcomes of childhood adversity... - Childhood trauma and risk for chronic fatigue syndrome: association with neuroendocrine dysfunctionChristine Heim
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Woodruff Memorial Research Bldg, Ste 4311, Atlanta, GA 30322, USA
Arch Gen Psychiatry 66:72-80. 2009..However, the contribution of childhood trauma to neuroendocrine dysfunction in CFS remains obscure... - Neurobiology of posttraumatic stress disorderChristine Heim
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
CNS Spectr 14:13-24. 2009..On the basis of these findings, important hypotheses for developing novel strategies to identify subjects at risk, promote resilience, and devise targets for the prevention or treatment of PTSD can be derived... - Early adverse experience and risk for chronic fatigue syndrome: results from a population-based studyChristine Heim
Viral Exanthems and Herpesvirus Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30322, USA
Arch Gen Psychiatry 63:1258-66. 2006..Identification of developmental risk factors for CFS is critical to inform pathophysiological research and devise targets for primary prevention... - Altered pituitary-adrenal axis responses to provocative challenge tests in adult survivors of childhood abuseC Heim
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1639 Pierce Dr, Atlanta, GA 30322, USA
Am J Psychiatry 158:575-81. 2001..On subsequent stress exposure, women with a history of childhood abuse may hypersecrete CRF, resulting in down-regulation of adenohypophyseal CRF receptors and symptoms of depression and anxiety... - Neurobiological effects of childhood abuse: implications for the pathophysiology of depression and anxietyK M Penza
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
Arch Womens Ment Health 6:15-22. 2003..These physiological maladaptations likely represent long-term risk factors for the development of psychopathology after exposure to additional stress... - The role of childhood trauma in the neurobiology of mood and anxiety disorders: preclinical and clinical studiesC Heim
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Biol Psychiatry 49:1023-39. 2001..The identification of the neurobiological substrates of early adverse experience is of paramount importance for the development of novel treatments for children, adolescents, and adults... - Effects of phenytoin on memory, cognition and brain structure in post-traumatic stress disorder: a pilot studyJ Douglas Bremner
Department of Psychiatry, Radiology and Emory Center for Positron Emission Tomography, Emory University School of Medicine, Atlanta, GA, USA
J Psychopharmacol 19:159-65. 2005..However, treatment associated improvements in memory and cognition did not achieve statistical significance. These findings suggest that phenytoin treatment may be associated with changes in brain structure in patients with PTSD... - Treatment of posttraumatic stress disorder with phenytoin: an open-label pilot studyJ Douglas Bremner
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30306, USA
J Clin Psychiatry 65:1559-64. 2004..The purpose of this study was to assess the effects of phenytoin on symptoms of PTSD... - Glucocorticoid receptor polymorphisms and haplotypes associated with chronic fatigue syndromeM S Rajeevan
Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Genes Brain Behav 6:167-76. 2007.... - Association of FKBP5 polymorphisms and childhood abuse with risk of posttraumatic stress disorder symptoms in adultsElisabeth B Binder
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30329, USA
JAMA 299:1291-305. 2008..Both genetic and environmental factors are contributory, with child abuse providing significant risk liability... - Assessing cortisol reactivity to a linguistic task as a marker of stress in individuals with left-hemisphere stroke and aphasiaJacqueline Laures-Gore
Department of Educational Psychology and Special Education, Communication Disorders Program, Georgia State University, P O Box 3979, Atlanta, Georgia 30302 3979, USA
J Speech Lang Hear Res 50:493-507. 2007.... - Higher heart rate and reduced heart rate variability persist during sleep in chronic fatigue syndrome: a population-based studyRoumiana S Boneva
Chronic Viral Diseases Branch, National Center for Zoonotic, Vector Borne and Enteric Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA
Auton Neurosci 137:94-101. 2007..Future research on the underlying pathophysiologic mechanisms of the association is needed...
Research Grants
- Neural Substrates of Depression Risk after Child AbuseChristine Heim; Fiscal Year: 2007..This K01 award will provide the candidate with depth and breadth in distinct disciplines, which is critical for considering the multifactorial contributors to complex psychiatric disorders in the future. ..