Research Topics
Genomes and Genes
| Jorg J GoronzySummaryAffiliation: Emory University Country: USA Publications
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Detail Information
Publications
Rheumatoid arthritis is an independent risk factor for multi-vessel coronary artery disease: a case control studyKenneth J Warrington
Division of Rheumatology, Mayo Clinic, Rochester, MN, USA
Arthritis Res Ther 7:R984-91. 2005..Expansion of CD4+CD28null T cells in these patients may contribute to the progression of atherosclerosis...- The impact of HLA-DRB1 genes on extra-articular disease manifestations in rheumatoid arthritisCarl Turesson
Department of Rheumatology, Malmo University Hospital, Södra Förstadsgatan 101, 205 02 Malmo, Sweden
Arthritis Res Ther 7:R1386-93. 2005..This confirms that SE genes contribute to RA disease severity and ExRA. Other genetic and environmental factors may have a more specific impact on individual ExRA manifestations... - Telomeres, immune aging and autoimmunityJorg J Goronzy
Lowance Center for Human Immunology, Department of Medicine, Emory University School of Medicine, Room 1003 Woodruff Memorial Research Building, 101 Woodruff Cricle, Atlanta, GA 30322, USA
Exp Gerontol 41:246-51. 2006..Equally interestingly, accelerated T-cell aging combined with telomeric shortening may predispose for autoimmune responses and thereby explain the increased susceptibility for chronic inflammatory diseases in the elderly... - Developments in the scientific understanding of rheumatoid arthritisJorg J Goronzy
Lowance Center for Human Immunology and Rheumatology, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
Arthritis Res Ther 11:249. 2009..Targeting mediators involved in this process has greatly improved the management of this chronic inflammatory syndrome... - Costimulatory pathways in rheumatoid synovitis and T-cell senescenceJorg J Goronzy
Kathleen B and Mason I Lowance Center for Human Immunology, Emory University School of Medicine, Rm 1003, Woodruff Memorial Research Bldg, 101 Woodruff Circle, Atlanta, GA 30322, USA
Ann N Y Acad Sci 1062:182-94. 2005..By acquiring a new set of regulatory receptors, senescent CD4 T cells become responsive to novel environmental cues and find ideal stimulatory conditions in the synovial microenvironment... - T cell development and receptor diversity during agingJorg J Goronzy
Kathleen B and Mason I Lowance Center for Human Immunology, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
Curr Opin Immunol 17:468-75. 2005..Elucidation of the underlying mechanisms will allow for extending this turning point to later in life; ultimately, interventions have to aim at restoring thymic function and complementary modes of T cell reconstitution... - Aging and T-cell diversityJorg J Goronzy
Lowance Center for Human Immunology, Emory University School of Medicine, 101 Woodruff Circle 1003, Atlanta, GA 30322, USA
Exp Gerontol 42:400-6. 2007..Research efforts need to aim at understanding T-cell homeostatic control mechanisms to ultimately expand the time period of repertoire stability... - Rheumatoid arthritisJorg J Goronzy
Department of Medicine, Kathleen B and Mason I Lowance Center for Human Immunology, Emory School of Medicine, Atlanta, GA 30322, USA
Immunol Rev 204:55-73. 2005.... - T-cell regulation in rheumatoid arthritisJorg J Goronzy
Lowance Center for Human Immunology, Emory University School of Medicine, 1364 Clifton Road NE, Atlanta, GA 30322, USA
Curr Opin Rheumatol 16:212-7. 2004..This review summarizes recent insights in pathways that are functional in RA and that favor continuous and pathogenic T-cell activation... - T-cell co-stimulatory pathways in autoimmunityJorg J Goronzy
Kathleen B and Mason I Lowance Center for Human Immunology and Rheumatology, Emory University, Woodruff Circle, Atlanta, Georgia 30322, USA
Arthritis Res Ther 10:S3. 2008..By intercepting these signals, we may be able to influence disease-relevant T-cell responses in autoimmune diseases while potentially minimizing broad immunosuppression... - Inhibitory CD8+ T cells in autoimmune diseaseMasakatsu Suzuki
The Kathleen B and Mason I Lowance Center for Human Immunology and Rheumatology, Emory University, Atlanta, GA, USA
Hum Immunol 69:781-9. 2008..In essence, disease-specific approaches may be necessary to identify CD8(+) Ts optimally suited to treat immune dysfunctions in different autoimmune syndromes... - Rejuvenating the immune system in rheumatoid arthritisCornelia M Weyand
Kathleen B and Mason I Lowance Center for Human Immunology and Rheumatology, Emory University, Atlanta, GA 30322, USA
Nat Rev Rheumatol 5:583-8. 2009..Therapeutic attempts to reset the immune systems of patients with RA and prevent premature immunosenescence should include restoration of DNA repair capability... - Promoter choice and translational repression determine cell type-specific cell surface density of the inhibitory receptor CD85j expressed on different hematopoietic lineagesDavid L Lamar
Kathleen B and Mason I Lowance Center for Human Immunology and Rheumatology, Emory University, Atlanta, GA, USA
Blood 115:3278-86. 2010..These cell-specific mechanisms allow tailoring of CD85j levels to the distinct roles it plays in different hematopoietic lineages... - T cell subset-specific susceptibility to agingMarta Czesnikiewicz-Guzik
Kathleen B and Mason I Lowance Center for Human Immunology, Emory University School of Medicine, Atlanta, GA30322, USA
Clin Immunol 127:107-18. 2008..The data show that CD8 T cells are age sensitive by at least two partially independent mechanisms: fragile homeostatic control and gene expression instability in a large set of regulatory cell surface molecules... - Telomerase insufficiency in rheumatoid arthritisHiroshi Fujii
Department of Medicine, Lowance Center for Human Immunology and Rheumatology, Emory University School of Medicine, 101 Woodruff Circle, Atlanta, GA 30322, USA
Proc Natl Acad Sci U S A 106:4360-5. 2009..Restoring defective telomerase activity emerges as a therapeutic target in resetting immune abnormalities in RA... - Synoviocyte stimulation by the LFA-1-intercellular adhesion molecule-2-Ezrin-Akt pathway in rheumatoid arthritisKarnail Singh
Kathleen B and Mason I Lowance Center for Human Immunology, Emory University, Atlanta, GA 30322, USA
J Immunol 180:1971-8. 2008..These findings identify ICAM-2 as a potential therapeutic target to inhibit FLS activation in RA, allowing for a more selective intervention than broad LFA-1 inhibition... - Unchecked CD70 expression on T cells lowers threshold for T cell activation in rheumatoid arthritisWon Woo Lee
Kathleen B and Mason I Lowance Center for Human Immunology, Emory University, Atlanta, GA 30322, USA
J Immunol 179:2609-15. 2007..The data support a model in which CD70 expressed on T cells causes degeneracy in T cell responses and undermines tolerance mechanisms that normally control T cell autoreactivity... - Regulation of T cell receptor signaling by activation-induced zinc influxMingcan Yu
Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
J Exp Med 208:775-85. 2011..By calibrating TCR activation thresholds, increased extracellular zinc bioavailability facilitated the induction of T cell proliferative responses to suboptimal stimuli... - Uncoupling of T-cell effector functions by inhibitory killer immunoglobulin-like receptorsGabriella Henel
Kathleen B and Mason I Lowance Center for Human Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
Blood 107:4449-57. 2006..We propose that KIRs on memory T cells operate to uncouple effector functions by modifying the transcriptional profile while leaving granule exocytosis unabated... - Telomeres and immunological diseases of agingNicolas P Andrews
Lowance Center for Human Immunology, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
Gerontology 56:390-403. 2010.... - Epigenetic mechanisms of age-dependent KIR2DL4 expression in T cellsGuangjin Li
Kathleen B and Mason I Lowance Center for Human Immunology and Rheumatology, Emory University School of Medicine, 101 Woodruff Circle, 1003, Atlanta, GA 30322, USA
J Leukoc Biol 84:824-34. 2008..The partially accessible promoter is sensitive to DNMT inhibition, which is sufficient to induce full transcription without further histone acetylation and methylation... - ERK-dependent T cell receptor threshold calibration in rheumatoid arthritisKarnail Singh
Department of Medicine, Kathleen B and Mason I Lowance Center for Human Immunology and Rheumatology, Emory UniversitySchool of Medicine, Atlanta, GA 30322, USA
J Immunol 183:8258-67. 2009..Treatment with subtherapeutic doses of a MEK-1/2 inhibitor delayed arthritis onset and reduced severity, suggesting that increased ERK phosphorylation predisposes for autoimmunity and can be targeted to prevent disease... - TLR-mediated induction of negative regulatory ligands on dendritic cellsStefan Gröschel
Kathleen B and Mason I Lowance Center for Human Immunology, Department of Medicine, Emory University School of Medicine, Room 1003 Woodruff Memorial Research Building, 101 Woodruff Circle, Atlanta, GA 30322, USA
J Mol Med (Berl) 86:443-55. 2008..Conversely, TLR3 ligands may have therapeutic value in silencing pathogenic immune responses... - Insufficient deactivation of the protein tyrosine kinase lck amplifies T-cell responsiveness in acute coronary syndromeSergey Pryshchep
Lowance Center for Human Immunology and Rheumatology, Emory University, Atlanta, GA, USA
Circ Res 106:769-78. 2010..The balance between protein phosphorylation and dephosphorylation defines the signal transduction threshold and determines appropriate T-cell responses... - Toll-like receptors 4 and 5 induce distinct types of vasculitisJiusheng Deng
Lowance Center for Human Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
Circ Res 104:488-95. 2009..Thus, depending on the original danger signal, vascular DCs edit the emerging immune response by differentially recruiting specialized T effector cells and direct the disease process toward distinct types of vasculitis... - Fractalkine mediates T cell-dependent proliferation of synovial fibroblasts in rheumatoid arthritisHirokazu Sawai
Emory University School of Medicine, Atlanta, Georgia 30322, USA
Arthritis Rheum 56:3215-25. 2007..The aim of this study was to examine the mechanisms through which CD4 T cells, the dominant lymphocyte population in patients with rheumatoid synovitis, regulate synoviocyte proliferation... - Epigenetic regulation of killer immunoglobulin-like receptor expression in T cellsGuangjin Li
Kathleen B and Mason I Lowance Center for Human Immunology and Rheumatology, Emory University, Atlanta, GA 30322, USA
Blood 114:3422-30. 2009..The ensuing partial demethylation lowers the threshold for transcriptional activation and renders CD8 T cells more susceptible to express KIR, thereby contributing to the immune defect in the elderly... - Deficiency of the DNA repair enzyme ATM in rheumatoid arthritisLan Shao
The Kathleen B and Mason I Lowance Center for Human Immunology and Rheumatology, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
J Exp Med 206:1435-49. 2009..Restoration of DNA repair mechanisms emerges as an important therapeutic target in RA... - Defective proliferative capacity and accelerated telomeric loss of hematopoietic progenitor cells in rheumatoid arthritisInes Colmegna
Lowance Center for Human Immunology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Arthritis Rheum 58:990-1000. 2008..The purpose of this study was to examine the functional competence (proliferative capacity, maintenance of telomeric reserve) of CD34+ HPCs in RA... - Age-dependent signature of metallothionein expression in primary CD4 T cell responses is due to sustained zinc signalingWon Woo Lee
Kathleen B and Mason I Lowance Center for Human Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
Rejuvenation Res 11:1001-11. 2008.... - Synoviocyte-mediated expansion of inflammatory T cells in rheumatoid synovitis is dependent on CD47-thrombospondin 1 interactionAbbe N Vallejo
Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA
J Immunol 171:1732-40. 2003..Because TSP1 is abundantly expressed in the rheumatoid synovium, CD47-TSP1 interaction is proposed to be a key component of an FLS/T cell regulatory circuit that perpetuates the inflammatory process in the rheumatoid joint... - Blocking the NOTCH pathway inhibits vascular inflammation in large-vessel vasculitisKisha Piggott
Lowance Center for Human Immunology and Rheumatology, Emory University, Atlanta, GA, USA
Circulation 123:309-18. 2011.... - Synergistic proinflammatory effects of the antiviral cytokine interferon-alpha and Toll-like receptor 4 ligands in the atherosclerotic plaqueAlexander Niessner
Kathleen B and Mason I Lowance Center for Human Immunology, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
Circulation 116:2043-52. 2007..In rupture-prone atherosclerotic plaques, plasmacytoid dendritic cells produce IFN-alpha. In the present study we explored the contribution of IFN-alpha to inflammation and tissue injury in the plaque microenvironment... - Vessel wall-embedded dendritic cells induce T-cell autoreactivity and initiate vascular inflammationJi W Han
Kathleen B and Mason I Lowance Center for Human Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
Circ Res 102:546-53. 2008..DCs are superior in sensing pathogen-derived motifs and are highly efficient in breaking T-cell tolerance, guiding T cells toward proinflammatory and tissue-invasive behavior... - Vascular damage in giant cell arteritisKisha Piggott
Lowance Center for Human Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
Autoimmunity 42:596-604. 2009..Differences in vascular damage pattern encountered in different patients may relate to distinct instigators of vasculitis... - Immune aging and rheumatoid arthritisJorg J Goronzy
Division of Immunology and Rheumatology, Department of Medicine, Stanford University, 269 West Campus Drive, Stanford, CA 94305 5166, USA
Rheum Dis Clin North Am 36:297-310. 2010.... - Inhibition and genetic ablation of the B7/CD28 T-cell costimulation axis prevents experimental hypertensionAntony Vinh
Cardiology Division, Emory University School of Medicine, 1639 Pierce Dr, Atlanta, GA 30322, USA
Circulation 122:2529-37. 2010..The latter often involves interaction between B7 ligands (CD80 and CD86) on antigen-presenting cells with the T-cell coreceptor CD28. This study was therefore performed to examine the role of this pathway in hypertension... - DNA-dependent protein kinase catalytic subunit mediates T-cell loss in rheumatoid arthritisLan Shao
Department of Medicine, Immunology and Rheumatology, Stanford University, Stanford, CA, USA
EMBO Mol Med 2:415-27. 2010..Therapeutic blockade of the DNA-PK-dependent cell-death machinery may rejuvenate the immune system in RA... - BLyS and APRIL in rheumatoid arthritisThorsten M Seyler
Department of Medicine, Lowance Center for Human Immunology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
J Clin Invest 115:3083-92. 2005..We propose that BLyS and APRIL regulate B cell as well as T cell function and have pro- and antiinflammatory activities in RA... - T-cell senescence: a culprit of immune abnormalities in chronic inflammation and persistent infectionAbbe N Vallejo
Division of Rheumatology, Department of Medicine, Mayo Clinic and Foundation, Rochester, MN 55905, USA
Trends Mol Med 10:119-24. 2004..Indeed, studies on the molecular basis for the loss of CD28 are already providing information on methods to functionally rescue senescent T cells... - Vessel-specific Toll-like receptor profiles in human medium and large arteriesOlga Pryshchep
Lowance Center for Human Immunology and Rheumatology, Emory University, School of Medicine, Atlanta, GA 30322, USA
Circulation 118:1276-84. 2008.... - B cells in rheumatoid synovitisCornelia M Weyand
Lowance Center for Human Immunology, Emory University School of Medicine, Atlanta, Georgia, USA
Arthritis Res Ther 7:S9-12. 2005..Furthermore, studies of rheumatoid lesions implanted in immunodeficient mice suggest that T cell activation in synovitis is B cell dependent, indicating the role played by B cells in presenting antigens and providing survival signals... - Dampened ERK signaling in hematopoietic progenitor cells in rheumatoid arthritisInes Colmegna
Department of Medicine, Division of Immunology and Rheumatology, Stanford University, USA
Clin Immunol 143:73-82. 2012..Thus, hyporesponsiveness of RA HPC to growth factors results from dampening of the ERK signaling pathways; with a defect localized in the very early steps of the ERK signaling cascade... - Giant cell arteritis: immune and vascular aging as disease risk factorsShalini V Mohan
Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA 94305 5166, USA
Arthritis Res Ther 13:231. 2011..Thus, the aging process impacts the two major biologic systems that liaise to promote giant cell arteritis; the immune system and the vessel wall niche... - Mechanisms of immunosenescence: lessons from models of accelerated immune agingSabine Le Saux
Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, California, USA
Ann N Y Acad Sci 1247:69-82. 2012..Studies of accelerated immune aging in autoimmune diseases have identified an unexpected link to chronic DNA damage responses that are known to be important in aging, but so far had not been implicated in immune aging... - Pathogen-sensing plasmacytoid dendritic cells stimulate cytotoxic T-cell function in the atherosclerotic plaque through interferon-alphaAlexander Niessner
Kathleen B and Mason I Lowance Center for Human Immunology, Emory University School of Medicine, 101 Woodruff Circle, Atlanta, GA 30322, USA
Circulation 114:2482-9. 2006..We therefore explored whether plasmacytoid dendritic cells (pDCs) that specialize in sensing bacterial and viral products can regulate effector functions of plaque-residing T cells and thus connect host infection and plaque instability... - Pathomechanisms in rheumatoid arthritis--time for a string theory?Cornelia M Weyand
Kathleen B and Mason I Lowance Center for Human Immunology, Department of Medicine, Emory School of Medicine, Atlanta, Georgia 30322, USA
J Clin Invest 116:869-71. 2006..We may want to seek guidance from our colleagues in physics and mathematics who have successfully integrated their knowledge of elementary particles and the complexity of their interacting forces by formulating the string theory... - T cells in arteritis and atherosclerosisCornelia M Weyand
Kathleen B and Mason Lowance Center for Human Immunology and Rheumatology, Emory University, Atlanta, Georgia 30322, USA
Curr Opin Lipidol 19:469-77. 2008..Pro-inflammatory and anti-inflammatory T cells regulate master pathogenic pathways, providing a framework for novel immunotherapeutic strategies... - CD28 loss in senescent CD4+ T cells: reversal by interleukin-12 stimulationKenneth J Warrington
Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA
Blood 101:3543-9. 2003..The re-expressed CD28 was functional and restored the ability of CD4(+)CD28(null) T cells to express CD25 and CD40 ligand. Our data suggest that IL-12 may, in part, functionally rescue senescent CD4(+) T cells... - Treating autoimmune disease by targeting CD8(+) T suppressor cellsChristine Konya
Emory University School of Medicine, Kathleen B and Mason I Lowance Center for Human Immunology and Rheumatology, Atlanta, GA 30322, USA
Expert Opin Biol Ther 9:951-65. 2009.... - T-cell-targeted therapies in rheumatoid arthritisCornelia M Weyand
Kathleen B and Mason I Lowance Center for Human Immunology, Department of Medicine, Emory School of Medicine, Atlanta, GA 30322, USA
Nat Clin Pract Rheumatol 2:201-10. 2006.... - IFN-? and IL-17: the two faces of T-cell pathology in giant cell arteritisCornelia M Weyand
Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, CA 94305 5166, USA
Curr Opin Rheumatol 23:43-9. 2011..Recent data demonstrate that at least two separate lineages of CD4 T cells participate in vascular inflammation, providing an important clue that multiple disease instigators may initiate pathogenic immunity... - Vascular dendritic cells in giant cell arteritisCornelia M Weyand
Kathleen B and Mason I Lowance Center for Human Immunology, Emory University School of Medicine, Rm 1003, Woodruff Memorial Research Bldg, 101 Woodruff Cir, Atlanta, GA 30322, USA
Ann N Y Acad Sci 1062:195-208. 2005..A switch of adventitial DCs from being nonstimulatory to T-cell activating emerges as a critical event in the initiation of vasculitis... - Pathogenic mechanisms in giant cell arteritisCornelia M Weyand
Department of Medicine, Mayo Medical and Graduate Schools, Rochester, MN, USA
Cleve Clin J Med 69:SII28-32. 2002....