Lan Ko

Summary

Affiliation: Eli Lilly and Company
Country: USA

Publications

  1. ncbi Identification and characterization of a tissue-specific coactivator, GT198, that interacts with the DNA-binding domains of nuclear receptors
    Lan Ko
    Department of Gene Regulation, Bone and Inflammation Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    Mol Cell Biol 22:357-69. 2002
  2. ncbi Ser-884 adjacent to the LXXLL motif of coactivator TRBP defines selectivity for ERs and TRs
    Lan Ko
    Lilly Research Laboratories, Department of Gene Regulation, Bone and Inflammation Research, Eli Lilly and Co, Indianapolis, Indiana 46285, USA
    Mol Endocrinol 16:128-40. 2002
  3. ncbi Nuclear receptor coactivator thyroid hormone receptor-binding protein (TRBP) interacts with and stimulates its associated DNA-dependent protein kinase
    Lan Ko
    Department of Gene Regulation, Bone and Inflammation Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    J Biol Chem 278:11471-9. 2003
  4. ncbi Deletion of the cancer-amplified coactivator AIB3 results in defective placentation and embryonic lethality
    Shao Qing Kuang
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 277:45356-60. 2002
  5. ncbi CoAA, a nuclear receptor coactivator protein at the interface of transcriptional coactivation and RNA splicing
    Didier Auboeuf
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Cell Biol 24:442-53. 2004
  6. ncbi The long terminal repeat (LTR) of ERV-9 human endogenous retrovirus binds to NF-Y in the assembly of an active LTR enhancer complex NF-Y/MZF1/GATA-2
    Xiuping Yu
    Department of Biochemistry and Molecular Biology and Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Biol Chem 280:35184-94. 2005
  7. ncbi Switched alternative splicing of oncogene CoAA during embryonal carcinoma stem cell differentiation
    Zheqiong Yang
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
    Nucleic Acids Res 35:1919-32. 2007

Collaborators

Detail Information

Publications7

  1. ncbi Identification and characterization of a tissue-specific coactivator, GT198, that interacts with the DNA-binding domains of nuclear receptors
    Lan Ko
    Department of Gene Regulation, Bone and Inflammation Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    Mol Cell Biol 22:357-69. 2002
    ..These data suggest that GT198 is a tissue-specific, kinase-regulated nuclear receptor coactivator that interacts with the DNA-binding domains of nuclear receptors...
  2. ncbi Ser-884 adjacent to the LXXLL motif of coactivator TRBP defines selectivity for ERs and TRs
    Lan Ko
    Lilly Research Laboratories, Department of Gene Regulation, Bone and Inflammation Research, Eli Lilly and Co, Indianapolis, Indiana 46285, USA
    Mol Endocrinol 16:128-40. 2002
    ..As the differential recruitment of TRBP to ERalpha and ERbeta may rely on S884, our finding provides insight into estrogen signaling and may lead to the development of therapeutic receptor-selective peptide antagonists...
  3. ncbi Nuclear receptor coactivator thyroid hormone receptor-binding protein (TRBP) interacts with and stimulates its associated DNA-dependent protein kinase
    Lan Ko
    Department of Gene Regulation, Bone and Inflammation Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    J Biol Chem 278:11471-9. 2003
    ..The activation of DNA-PK in the absence of DNA ends by the coactivator TRBP suggests a novel mechanism of coactivator-stimulated DNA-PK phosphorylation in transcriptional regulation...
  4. ncbi Deletion of the cancer-amplified coactivator AIB3 results in defective placentation and embryonic lethality
    Shao Qing Kuang
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 277:45356-60. 2002
    ..These results also indicate that the biological function of AIB3 is not redundant with other classes of nuclear receptor coactivators such as PBP and members of the steroid receptor coactivator family...
  5. ncbi CoAA, a nuclear receptor coactivator protein at the interface of transcriptional coactivation and RNA splicing
    Didier Auboeuf
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Cell Biol 24:442-53. 2004
    ..This contributes to the promoter-preferential effects mediated by CoAA on RNA splicing during the course of steroid hormone action...
  6. ncbi The long terminal repeat (LTR) of ERV-9 human endogenous retrovirus binds to NF-Y in the assembly of an active LTR enhancer complex NF-Y/MZF1/GATA-2
    Xiuping Yu
    Department of Biochemistry and Molecular Biology and Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Biol Chem 280:35184-94. 2005
    ....
  7. ncbi Switched alternative splicing of oncogene CoAA during embryonal carcinoma stem cell differentiation
    Zheqiong Yang
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
    Nucleic Acids Res 35:1919-32. 2007
    ....