Research Topics
| George L WrightSummaryAffiliation: Eastern Virginia Medical School Country: USA Publications
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Detail Information
Publications
Serum protein profiles to identify head and neck cancerJ Trad Wadsworth
Departments of Otolaryngology Head and Neck Surgery, Eastern Virginia Medical School, Norfolk, Virginia 23507, USA
Clin Cancer Res 10:1625-32. 2004..The purpose of this study was to determine whether a new proteomic technology could correctly identify protein expression profiles for cancer in patient serum samples...- Computational protein biomarker prediction: a case study for prostate cancerMichael Wagner
Cincinnati Children s Hospital Research Foundation and Department of Biomedical Engineering, University of Cincinnati, Cincinnati, OH 45229, USA
BMC Bioinformatics 5:26. 2004..Our overall goal is to implicate peaks that have a high likelihood of being biologically linked to a given disease state, and thus to narrow the search for biomarker candidates... - Identification of a superimmunoglobulin gene family member overexpressed in benign prostatic hyperplasia G L Wright
Departments of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, Virginia 23501, USA
Prostate 42:230-8. 2000..Benign prostate hyperplasia (BPH), a nonmalignant disease with an increasing rate of occurrence associated with advancing age, requires auxiliary markers to help identify its presence and distinguish its progression from prostate cancer... - SELDI proteinchip MS: a platform for biomarker discovery and cancer diagnosisGeorge L Wright
Eastern Virginia Medical School, Sentara Cancer Institute, 700 West Olney Road, Norfolk, Virginia 23507, USA
Expert Rev Mol Diagn 2:549-63. 2002..The SELDI ProteinChip Biomarker mass spectrometry system appears to have potential in this effort, both for biomarker discovery and as a potential clinical diagnostic assay platform... - Prostate tumor microenvironment alters immune cells and prevents long-term survival in an orthotopic mouse model following flt3-ligand/CD40-ligand immunotherapyRichard P Ciavarra
Departments of Microbiology and Molecular Cell Biology, Virginia Prostate Center, Eastern Virginia Medical School, Norfolk, Virginia 23501, USA
J Immunother 27:13-26. 2004..Overall, these data suggest that long-term cures of established MHC-negative tumors may not be achieved until therapeutic interventions are engineered to overcome this immunosuppressive microenvironment... - Impact of the tumor microenvironment on host infiltrating cells and the efficacy of flt3-ligand combination immunotherapy evaluated in a treatment model of mouse prostate cancerRichard P Ciavarra
Department of Microbiology, Eastern Virginia Medical School, Norfolk, VA 23501, USA
Cancer Immunol Immunother 52:535-45. 2003..These data also highlight the importance of utilizing treatment versus vaccination models in the evaluation of immunotherapeutic modalities... - Normal, benign, preneoplastic, and malignant prostate cells have distinct protein expression profiles resolved by surface enhanced laser desorption/ionization mass spectrometryLisa H Cazares
Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School and Sentara Cancer Institute, Norfolk, Virginia 23501, USA
Clin Cancer Res 8:2541-52. 2002..Studies are under way to identify these protein/peptides, with the goal of developing a diagnostic test for the early detection of prostate cancer... - Protein profiling in urine for the diagnosis of bladder cancerAntonia Vlahou
Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, VA, USA
Clin Chem 50:1438-41. 2004 - SELDI-TOF serum profiling for prognostic and diagnostic classification of breast cancersChristine Laronga
Department of Surgery, Eastern Virginia Medical School, Norfolk, Virginia and the Virginia Prostate Center, Norfolk, VA, USA
Dis Markers 19:229-38. 2003..These initial results indicate the utility of protein profiling approaches for developing new diagnostic and prognostic assays for breast cancers... - A novel approach toward development of a rapid blood test for breast cancerAntonia Vlahou
Department of Microbiology, and Virginia Prostate Center, Eastern Virginia Medical School, Norfolk, VA 23507, USA
Clin Breast Cancer 4:203-9. 2003..The combination of SELDI ProteinChip mass spectrometry and a classification- and regression-tree algorithm has the potential to use serum protein expression profiles for detection and diagnosis of breast cancer... - Identification of patients with head and neck cancer using serum protein profilesJ Trad Wadsworth
Department of Otolaryngology Head and Neck Surgery, Eastern Virginia Medical School, Norfolk 23507, USA
Arch Otolaryngol Head Neck Surg 130:98-104. 2004..New and more consistent biomarkers of head and neck squamous cell carcinoma (HNSCC) are needed to improve early detection of disease and to monitor successful patient management... - Application of a novel protein chip mass spectrometry technology for the identification of bladder cancer-associated biomarkersAntonia Vlahou
Department of Microbiology, Eastern Virginia Medical School, Virginia Prostate Center, Norfolk 23510, USA
Adv Exp Med Biol 539:47-60. 2003 - Serum protein fingerprinting coupled with a pattern-matching algorithm distinguishes prostate cancer from benign prostate hyperplasia and healthy menBao-Ling Adam
Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, Virginia 23501, USA
Cancer Res 62:3609-14. 2002..This high-throughput proteomic classification system will provide a highly accurate and innovative approach for the early detection/diagnosis of PCA... - Orthotopic treatment model of prostate cancer and metastasis in the immunocompetent mouse: efficacy of flt3 ligand immunotherapyKenneth D Somers
Departments of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, VA 23507, USA
Int J Cancer 107:773-80. 2003..We demonstrate that flt3L treatment suppressed orthotopic prostate tumor growth and lymph node metastasis reinforcing a role for flt3L as an immunotherapeutic strategy for prostate cancer... - A data-analytic strategy for protein biomarker discovery: profiling of high-dimensional proteomic data for cancer detectionYutaka Yasui
Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109 1024, USA
Biostatistics 4:449-63. 2003..We discuss practical issues associated with our proposed approach to the analysis of SELDI output and its application in cancer biomarker discovery... - Prostein expression is highly restricted to normal and malignant prostate tissuesMichael Kalos
Corixa Corporation, Seattle, Washington 98104, USA
Prostate 60:246-56. 2004..A murine monoclonal antibody was developed, characterized, and used to evaluate the expression of prostein protein in prostatic, other normal tissue and tumor samples... - Pharmacoproteomic analysis of prechemotherapy and postchemotherapy plasma samples from patients receiving neoadjuvant or adjuvant chemotherapy for breast carcinomaLajos Pusztai
Department of Breast Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4009, USA
Cancer 100:1814-22. 2004..The authors also compared the plasma profiles of patients with cancer with the plasma profiles of healthy women to identify breast carcinoma-associated protein markers... - Boosted decision tree analysis of surface-enhanced laser desorption/ionization mass spectral serum profiles discriminates prostate cancer from noncancer patientsYinsheng Qu
Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Clin Chem 48:1835-43. 2002..CONCLUSIONS: The high sensitivity and specificity achieved in this study provides support of the potential for SELDI, coupled with a bioinformatics learning algorithm, to improve the early detection/diagnosis of PCA... - Data reduction using a discrete wavelet transform in discriminant analysis of very high dimensionality dataYinsheng Qu
Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N MP 702 Seattle, Washington, USA
Biometrics 59:143-51. 2003..The linear classifier with the 11 wavelet coefficients detected prostate cancer in a separate test set with a sensitivity of 97% and specificity of 100%... - SELDI-TOF MS whole serum proteomic profiling with IMAC surface does not reliably detect prostate cancerDale McLerran
Fred Hutchinson Cancer Research Center, Seattle, WA, USA
Clin Chem 54:53-60. 2008..This report is the 2nd of 2 companion articles describing a validation study of a SELDI-TOF MS approach with IMAC surface sample processing to identify prostatic adenocarcinoma...