G Krishnaswamy

Summary

Affiliation: East Tennessee State University
Country: USA

Publications

  1. ncbi Human lung fibroblasts express interleukin-6 in response to signaling after mast cell contact
    S Matthew Fitzgerald
    Department of Internal Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    Am J Respir Cell Mol Biol 30:585-93. 2004
  2. ncbi Baicalein inhibits IL-1beta- and TNF-alpha-induced inflammatory cytokine production from human mast cells via regulation of the NF-kappaB pathway
    Chia Jung Hsieh
    Departments of Internal Medicine, James H, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614, USA
    Clin Mol Allergy 5:5. 2007
  3. ncbi Incense smoke: clinical, structural and molecular effects on airway disease
    Ta Chang Lin
    Department of Environmental Engineering, National Cheng Kung University, Tainan, Taiwan
    Clin Mol Allergy 6:3. 2008
  4. ncbi MAPK-dependent regulation of IL-1- and beta-adrenoreceptor-induced inflammatory cytokine production from mast cells: implications for the stress response
    David S Chi
    Department of Internal Medicine, James H, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614, USA
    BMC Immunol 5:22. 2004
  5. ncbi Human endothelium as a source of multifunctional cytokines: molecular regulation and possible role in human disease
    G Krishnaswamy
    Department of Internal Medicine, James H Quillen College of Medicine, East Tennessee State University, Johnson City 37614 0622, USA
    J Interferon Cytokine Res 19:91-104. 1999
  6. ncbi The inflammation paradigm and coronary artery disease: What Celsus, Virchow and gene knock outs have taught us
    Guha Krishnaswamy
    Department of Internal Medicine, Quillen College of Medicine, James H Quillen VA Medical Center, Johnson City, Tennessee, USA
    Cardiovasc Hematol Disord Drug Targets 10:246-56. 2010
  7. ncbi Molecular defects in the mannose binding lectin pathway in dermatological disease: Case report and literature review
    Christopher Miller
    Internal Medicine, Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    Clin Mol Allergy 8:6. 2010
  8. ncbi Regulation and dysregulation of immunoglobulin E: a molecular and clinical perspective
    Mariah B Pate
    Division of Allergy and Immunology, Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    Clin Mol Allergy 8:3. 2010
  9. ncbi Chronic granulomatous disease: a review of the infectious and inflammatory complications
    Eunkyung Song
    Department of Pediatrics, Division of Allergy and Clinical Immunology, Quillen College of Medicine, East Tennessee State University, USA
    Clin Mol Allergy 9:10. 2011
  10. ncbi The human mast cell: functions in physiology and disease
    G Krishnaswamy
    The Department of Medicine, East Tennessee State University, Johnson City, Tennessee 37614 1709, USA
    Front Biosci 6:D1109-27. 2001

Research Grants

  1. INDUCTION OF ATHEROGENESIS BY COCAINE AND HIV INFECTION
    Guha Krishnaswamy; Fiscal Year: 2001

Collaborators

Detail Information

Publications36

  1. ncbi Human lung fibroblasts express interleukin-6 in response to signaling after mast cell contact
    S Matthew Fitzgerald
    Department of Internal Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    Am J Respir Cell Mol Biol 30:585-93. 2004
    ..These novel studies reveal the importance of cell-cell interactions in the complex milieu of airway inflammation...
  2. ncbi Baicalein inhibits IL-1beta- and TNF-alpha-induced inflammatory cytokine production from human mast cells via regulation of the NF-kappaB pathway
    Chia Jung Hsieh
    Departments of Internal Medicine, James H, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614, USA
    Clin Mol Allergy 5:5. 2007
    ..We examined its effects and mechanisms on the expression of inflammatory cytokines in an IL-1beta- and TNF-alpha-activated human mast cell line, HMC-1...
  3. ncbi Incense smoke: clinical, structural and molecular effects on airway disease
    Ta Chang Lin
    Department of Environmental Engineering, National Cheng Kung University, Tainan, Taiwan
    Clin Mol Allergy 6:3. 2008
    ..In order to prevent airway disease and other health problem, it is advisable that people should reduce the exposure time when they worship at the temple with heavy incense smokes, and ventilate their house when they burn incense at home...
  4. ncbi MAPK-dependent regulation of IL-1- and beta-adrenoreceptor-induced inflammatory cytokine production from mast cells: implications for the stress response
    David S Chi
    Department of Internal Medicine, James H, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614, USA
    BMC Immunol 5:22. 2004
    ..The aim of this study was to determine the effects of epinephrine on IL-1-induced proatherogenic cytokine production from mast cells...
  5. ncbi Human endothelium as a source of multifunctional cytokines: molecular regulation and possible role in human disease
    G Krishnaswamy
    Department of Internal Medicine, James H Quillen College of Medicine, East Tennessee State University, Johnson City 37614 0622, USA
    J Interferon Cytokine Res 19:91-104. 1999
    ..Genetic and pharmacologic manipulation of endothelial-derived cytokines provides an additional approach to the management of chronic inflammatory diseases...
  6. ncbi The inflammation paradigm and coronary artery disease: What Celsus, Virchow and gene knock outs have taught us
    Guha Krishnaswamy
    Department of Internal Medicine, Quillen College of Medicine, James H Quillen VA Medical Center, Johnson City, Tennessee, USA
    Cardiovasc Hematol Disord Drug Targets 10:246-56. 2010
    ..This brief review will attempt to weave together the historical, biochemical, immunological and molecular developments that have led to our current understanding of a deadly but treatable and potentially preventable disease...
  7. ncbi Molecular defects in the mannose binding lectin pathway in dermatological disease: Case report and literature review
    Christopher Miller
    Internal Medicine, Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    Clin Mol Allergy 8:6. 2010
    ..The mechanisms may relate to the role of this pathway in innate immunity, removal of apoptotic cells and in immune complexes. Further study of MBL pathway defects in dermatological disease is required...
  8. ncbi Regulation and dysregulation of immunoglobulin E: a molecular and clinical perspective
    Mariah B Pate
    Division of Allergy and Immunology, Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    Clin Mol Allergy 8:3. 2010
    ..The object of this review is to summarize the historical and molecular aspects of IgE synthesis and the disorders associated with dysregulation of IgE production...
  9. ncbi Chronic granulomatous disease: a review of the infectious and inflammatory complications
    Eunkyung Song
    Department of Pediatrics, Division of Allergy and Clinical Immunology, Quillen College of Medicine, East Tennessee State University, USA
    Clin Mol Allergy 9:10. 2011
    ..Major advances have occurred in the diagnosis and treatment of this disease, with the potential for gene therapy or stem cell transplantation looming on the horizon...
  10. ncbi The human mast cell: functions in physiology and disease
    G Krishnaswamy
    The Department of Medicine, East Tennessee State University, Johnson City, Tennessee 37614 1709, USA
    Front Biosci 6:D1109-27. 2001
    ..Drugs, such as glucocorticoids, cyclosporine and cromolyn have been demonstrated to have inhibitory effects on mast cell degranulation or mediator release...
  11. ncbi Moraxella catarrhalis induces mast cell activation and nuclear factor kappa B-dependent cytokine synthesis
    G Krishnaswamy
    Department of Internal Medicine, East Tennessee State University, Johnson City, Tennessee 37614 1709, USA
    Front Biosci 8:a40-7. 2003
    ..These findings suggest the possibility of direct interactions between human mast cells and common bacteria and provide evidence for a novel role for human mast cells in innate immunity...
  12. ncbi Acute and chronic urticaria. Challenges and considerations for primary care physicians
    G Krishnaswamy
    Division of Allergy and Immunology, James H Quillen Veterans Affairs Medical Center, Department of Medicine, East Tennessee State University, PO Box 70622, Johnson City, TN 37614 0622, USA
    Postgrad Med 109:107-8, 111-4, 119-23. 2001
    ..Patient education is an important component of management and should include instructions on crisis management, particularly for patients who have angioedema or a tendency for anaphylaxis...
  13. ncbi Molecular regulation of interleukin-13 and monocyte chemoattractant protein-1 expression in human mast cells by interleukin-1beta
    Steven A Lee
    Department of Internal Medicine, East Tennessee State University, Johnson City, Tennessee 37614 1709, USA
    Am J Respir Cell Mol Biol 31:283-91. 2004
    ....
  14. ncbi GM-CSF induction in human lung fibroblasts by IL-1beta, TNF-alpha, and macrophage contact
    S Matthew Fitzgerald
    Department of Internal Medicine, Division of Allergy and Immunology, East Tennessee State University, Quillen College of Medicine, Johnson City, TN 37614, USA
    J Interferon Cytokine Res 23:57-65. 2003
    ..U937 membranes, as well as IL-1beta and TNF-alpha, induced nuclear translocation of NF-kappaB. These data support a prominent role for macrophage-fibroblast interactions in airway inflammation and fibrosis...
  15. ncbi The role of human mast cell-derived cytokines in eosinophil biology
    Bita Shakoory
    Department of Internal Medicine, Division of Allergy and Immunology, East Tennessee State University, Johnson City, TN 37614, USA
    J Interferon Cytokine Res 24:271-81. 2004
    ..This two-way interaction between eosinophils and mast cells can pave the way for chronic inflammatory responses in a variety of human diseases. This review summarizes this pivotal interaction between human mast cells and eosinophils...
  16. ncbi Mast cell histamine and cytokine assays
    David S Chi
    Department of Internal Medicine, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA
    Methods Mol Biol 315:203-15. 2006
    ..Cytokine gene expression was evaluated by reverse transcriptase polymerase chain reaction and cytokine production was assayed in culture supernatants using an enzyme-linked immunosorbent assay kit...
  17. ncbi Long-term exercise and atherogenic activity of blood mononuclear cells in persons at risk of developing ischemic heart disease
    J K Smith
    Department of Internal Medicine, James H Quillen College of Medicine, East Tennessee State University, Johnson City 37614, USA
    JAMA 281:1722-7. 1999
    ..It is not known whether long-term exercise alters this atherogenic and atheroprotective activity directly...
  18. ncbi Severe asthma and the omalizumab option
    Christopher Wt Miller
    Division of Allergy and Clinical Immunology, Quillen College of Medicine, Johnson City, TN, USA
    Clin Mol Allergy 6:4. 2008
    ..As currently practiced and as suggested by the new asthma guidelines, this biological agent is indicated in moderate or severe persistent allergic asthma (steps 5 and 6)...
  19. ncbi Regulation of eosinophil-active cytokine production from human cord blood-derived mast cells
    Guha Krishnaswamy
    Department of Medicine, East Tennessee State University, Johnson City, TN 37614 0622, USA
    J Interferon Cytokine Res 22:379-88. 2002
    ..A macrophage-mast cell-eosinophil axis may exist in vivo that may be susceptible to pharmacologic manipulation...
  20. ncbi Osteopontin: a novel inflammatory mediator of cardiovascular disease
    Mahipal Singh
    Department of Physiology, James H Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    Front Biosci 12:214-21. 2007
    ..In this review, we will discuss diverse roles of OPN related to cardiovascular diseases, including atherosclerosis, valvular stenosis, hypertrophy, myocardial infarction and heart failure...
  21. ncbi Hepatitis C virus and the lung: implications for therapy
    Jonathan Moorman
    Division of Infectious Diseases, Department of Internal Medicine, James H Quillen VAMC and James H Quillen College of Medicine, East Tennessee State University, Box 70622, Johnson City, TN 37614, USA
    Chest 128:2882-92. 2005
    ....
  22. ncbi Induction of p38- and gC1qR-dependent IL-8 expression in pulmonary fibroblasts by soluble hepatitis C core protein
    Jonathan P Moorman
    Department of Internal Medicine, James H Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA
    Respir Res 6:105. 2005
    ....
  23. ncbi HIV-1 Tat protein-induced VCAM-1 expression in human pulmonary artery endothelial cells and its signaling
    Kai Liu
    Department of Medicine, Tulane Univ School of Medicine, New Orleans, LA 70112 2699, USA
    Am J Physiol Lung Cell Mol Physiol 289:L252-60. 2005
    ....
  24. ncbi Regulation of nitric oxide production from macrophages by lipopolysaccharide and catecholamines
    David S Chi
    Department of Internal Medicine, James H Quillen College of Medicine, East Tennessee State University, P O Box 70622, Johnson City, TN 37614 1709, USA
    Nitric Oxide 8:127-32. 2003
    ....
  25. ncbi The human mast cell: an overview
    Guha Krishnaswamy
    Division of Allergy and Immunology, Department of Internal Medicine, James H Quillen VAMC and the Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA
    Methods Mol Biol 315:13-34. 2006
    ..This chapter summarizes the many well-known and novel functional aspects of human mast cell biology and emphasizes their unique role in the inflammatory response...
  26. ncbi Angiopoietin-1 inhibits doxorubicin-induced human umbilical vein endothelial cell death by modulating fas expression and via the PI3K/Akt pathway
    Deling Yin
    Department of Internal Medicine, East Tennessee State University, Johnson City, Tennessee 37614, USA
    Endothelium 11:247-52. 2004
    ..Moreover, Ang-1 inhibits DOX-induced up-regulation of p53 through PI3K/Akt. Therefore, Ang-1 is a potent inhibitor for DOX-induced cell death through Fas and PI3K/Akt-mediated pathways...
  27. ncbi Inhibition of GM-CSF production in fibroblast-monocyte coculture by prednisone and effects of rhGM-CSF on human lung fibroblasts
    S Matthew Fitzgerald
    Department of Internal Medicine, Quillen College of Medicine, East Tennessee State University, P.O. Box 70622 Johnson City, TN 37604, USA
    Front Biosci 9:342-8. 2004
    ..These data indicate mechanism of action and treatment for cell-cell contact mediated inflammation of infiltrating monocytes with fibroblasts as seen in asthma and other diseases like graft versus host disease...
  28. ncbi Atherosclerosis as an inflammatory disease: implications for therapy
    Nader Eldika
    Department of Internal Medicine, East Tennessee State University, Box70622, Johnson City, TN 37614-1709, USA
    Front Biosci 9:2764-77. 2004
    ..Therapeutic targets could include cytokine pathways, growth factors, transcription factors, defective genes and other intracellular metabolic pathways...
  29. ncbi Inflammatory aspects of sleep apnea and their cardiovascular consequences
    E Kasasbeh
    Division of Allergy and Immunology, Department of Internal Medicine, Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    South Med J 99:58-67; quiz 68-9, 81. 2006
    ..Leukocyte adhesion and accumulation on endothelial cells are common in both OSA and atherosclerosis. Clinicians should be aware that OSA may be a risk factor for the development of cardiovascular disease...
  30. ncbi Reactive and clonal thrombocytosis: proinflammatory and hematopoietic cytokines and acute phase proteins
    M Araneda
    Department of Internal Medicine, James H. Quillen VA Medical Center and James H. Quillen College of Medicine, East Tennessee State University, Johnson City 37614-0622, USA
    South Med J 94:417-20. 2001
    ..Interleukin 1beta levels were higher in the RT group than in the CT and control groups. CONCLUSIONS: In RT, IL-6, IL-1beta, and CRP levels are elevated. In both RT and CT, IL-11 is elevated, but thrombopoietin levels are not...
  31. ncbi Mast cell activation by lipoproteins
    Jim Kelley
    Department of Internal Medicine, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA
    Methods Mol Biol 315:341-8. 2006
    ..IL-8 mRNA levels were measured by reverse-transcription polymerase chain reaction and protein levels by enzyme-linked immunoassay...
  32. ncbi Obstructive sleep apnea, inflammation, and cardiopulmonary disease
    Jim L Arter
    Division of Allergy and Immunology, Department of Medicine, James H. Quillen College of Medicine and East Tennessee State University, Johnson City, Tennessee 37614-1709, USA
    Front Biosci 9:2892-900. 2004
    ..The purpose of this manuscript is to review the inflammatory responses that occur in patients with obstructive sleep apnea and relate them to the occurrence of cardiopulmonary disease...
  33. ncbi Paul Ehrlich's "Mastzellen"--from aniline dyes to DNA chip arrays: a historical review of developments in mast cell research
    Harsha Vyas
    Department of Internal Medicine, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA
    Methods Mol Biol 315:3-11. 2006
    ....
  34. ncbi C-reactive protein as a novel biomarker. Reactant can flag atherosclerosis and help predict cardiac events
    Nader Elgharib
    Division of Allergy and Immunology, Department of Internal Medicine, James H. Quillen College of Medicine, East Tennessee State University, PO Box 70622, Johnson City, TN 37614-1709, USA
    Postgrad Med 114:39-44; quiz 16. 2003
    ..In this article, the authors review the role of CRP in the diagnosis, monitoring, and treatment of various forms of ischemic and inflammatory cardiovascular disease...
  35. ncbi Potential mechanisms connecting asthma, esophageal reflux, and obesity/sleep apnea complex--a hypothetical review
    Aiman Kasasbeh
    Division of Allergy and Immunology, Department of Internal Medicine, Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614 0622, UK
    Sleep Med Rev 11:47-58. 2007
    ..In particular, the influence of continuous positive airway pressure therapy (for sleep apnea) on asthma outcomes (such as quality of life, steroid utilization, emergency room visits) and fatality needs to be studied further...
  36. ncbi Bacterial activation of mast cells
    David S Chi
    Department of Internal Medicine, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA
    Methods Mol Biol 315:383-92. 2006
    ..Direct bacterial contact with mast cells appears to be essential for this activation because neither cell-free bacterial supernatants nor bacterial lipopolysaccharide induce cytokine secretion...

Research Grants3

  1. INDUCTION OF ATHEROGENESIS BY COCAINE AND HIV INFECTION
    Guha Krishnaswamy; Fiscal Year: 2001
    ..abstract_text> ..