Research Topics
Genomes and Genes | R S SurwitSummaryAffiliation: Duke University Medical Center Country: USA Publications
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Publications
Metabolic and behavioral effects of a high-sucrose diet during weight lossR S Surwit
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
Am J Clin Nutr 65:908-15. 1997..01). Results showed that a high sucrose content in a hypoenergetic, low-fat diet did not adversely affect weight loss, metabolism, plasma lipids, or emotional affect...- Low plasma leptin in response to dietary fat in diabetes- and obesity-prone miceR S Surwit
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA
Diabetes 46:1516-20. 1997..From these results, we suggest that the response of leptin to fat feeding may be an important predictor of the development of subsequent obesity... - Transient effects of long-term leptin supplementation in the prevention of diet-induced obesity in miceR S Surwit
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA
Diabetes 49:1203-8. 2000..In summary, this study demonstrates that leptin supplementation in animals that show low plasma leptin levels in response to fat feeding may slow but does not prevent the subsequent development of diet-induced obesity... - Diazoxide restores beta3-adrenergic receptor function in diet-induced obesity and diabetesR S Surwit
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA
Endocrinology 141:3630-7. 2000..CLDz was more effective in reducing percent body fat, lowering nonesterified fatty acids, improving glucose tolerance, and reducing feed efficiency than either treatment alone... - Pharmacologic manipulation of ob expression in a dietary model of obesityS Collins
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA
J Biol Chem 271:9437-40. 1996.... - Changes in depressive symptoms and glycemic control in diabetes mellitusAnastasia Georgiades
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Box 3842, Durham, NC 27710, USA
Psychosom Med 69:235-41. 2007..To investigate if changes in depressive symptoms would be associated with changes in glycemic control over a 12-month period in patients with Type 1 and Type 2 diabetes... - Role of leptin in fat regulationS Collins
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA
Nature 380:677. 1996 - Personality correlates of glycemic control in type 2 diabetesJ D Lane
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA
Diabetes Care 23:1321-5. 2000..To determine whether traits of normal personality are associated with variations in glycemic control in patients with type 2 diabetes... - Muscarinic stimulation and antagonism and glucoregulation in nondiabetic and obese hyperglycemic miceS Fukudo
Department of Psychiatry, Duke University Medical Center, Durham, North Carolina 27710
Diabetes 38:1433-8. 1989.... - Exaggeration of postprandial hyperglycemia in patients with type 2 diabetes by administration of caffeine in coffeeJames D Lane
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA
Endocr Pract 13:239-43. 2007..To test whether caffeine administered in coffee increases postprandial hyperglycemia in patients with type 2 diabetes who are habitual coffee drinkers... - Is there a glycemic threshold for impaired autonomic control?L L Watkins
Department of Psychiatry and Behavioral Sciences, Duke University, Durham, North Carolina 27710, USA
Diabetes Care 23:826-30. 2000..This study examined whether fasting plasma glucose (FPG) or fasting plasma insulin (FPI) is associated with reductions in baroreflex sensitivity (BRS) in healthy volunteers... - The beta-adrenergic receptors and the control of adipose tissue metabolism and thermogenesisS Collins
Department of Pharmacology, Duke University Medical Center, Durham, North Carolina 27710, USA
Recent Prog Horm Res 56:309-28. 2001..The impact of understanding these pathways and their potential role in modulating adaptive thermogenesis is discussed... - Depressed mood is a factor in glycemic control in type 1 diabetesM A van Tilburg
Duke University Medical Center, Durham, North Carolina 27710, USA
Psychosom Med 63:551-5. 2001..Preliminary data analysis suggests that this effect may be mediated, at least in part, by decreased self-care behaviors in patients with more depressed mood... - Hostility and fasting glucose in African American womenAnastasia Georgiades
Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, North Carolina 27710, USA
Psychosom Med 71:642-5. 2009..HOST has been associated with abnormalities in glucose metabolism. Prior studies suggested that this association may be more prevalent in women and in African American (AA) individuals... - A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistanceChristopher B Newgard
Sarah W Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC 27710, USA
Cell Metab 9:311-26. 2009..Our findings show that in the context of a dietary pattern that includes high fat consumption, BCAA contributes to development of obesity-associated insulin resistance... - HPA axis function in male caregivers: effect of the monoamine oxidase-A gene promoter (MAOA-uVNTR)Beverly H Brummett
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
Biol Psychol 79:250-5. 2008..5/4 repeats) (cortisol p<.043). Individuals with less active MAOA-uVNTR alleles who are under chronic stress may be at increased risk for exhaustion of the HPA response to such stress... - Caffeine increases ambulatory glucose and postprandial responses in coffee drinkers with type 2 diabetesJames D Lane
Duke University Medical Center, Durham, NC 27710-0001, USA
Diabetes Care 31:221-2. 2008 - Depressive symptoms, race, and glucose concentrations: the role of cortisol as mediatorStephen H Boyle
Department of Psychiatry and Behavioral Medicine, Duke University Medical Center, Box 2969, Durham, NC 27745, USA
Diabetes Care 30:2484-8. 2007..This study examined the associations of depressive symptoms with glucose concentrations and morning cortisol levels in 665 African-American and 4,216 Caucasian Vietnam-era veterans... - Hostility and minimal model of glucose kinetics in African American womenRichard S Surwit
Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, North Carolina 27710, USA
Psychosom Med 71:646-51. 2009.... - Associations of a regulatory polymorphism of monoamine oxidase-A gene promoter (MAOA-uVNTR) with symptoms of depression and sleep qualityBeverly H Brummett
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
Psychosom Med 69:396-401. 2007..MAOA-uVNTR genotype has been associated with both psychological and physical measures... - Childhood socioeconomic status and serotonin transporter gene polymorphism enhance cardiovascular reactivity to mental stressRedford B Williams
Department of Psychiatry and Behavioral Sciences, Box 3926, Duke University Medical Center, Durham, NC 27710, USA
Psychosom Med 70:32-9. 2008..We found the long allele associated with larger CVR to mental stress in a preliminary study of 54 normal volunteers... - Neighborhood characteristics moderate effects of caregiving on glucose functioningBeverly H Brummett
Department of Psychiatry and Behavioral Medicine, Duke University Medical Center, Durham, North Carolina, 27710, USA
Psychosom Med 67:752-8. 2005.... - Stress management improves long-term glycemic control in type 2 diabetesRichard S Surwit
Duke University Medical Center, Durham, North Carolina 27710, USA
Diabetes Care 25:30-4. 2002.... - Hostility, race, and glucose metabolism in nondiabetic individualsRichard S Surwit
Department of Psychiatry, Duke University School of Medicine, Durham, North Carolina 27710, USA
Diabetes Care 25:835-9. 2002..The present study was designed to determine whether hostility is differentially related to measures of glucose metabolism in African-Americans and Caucasians... - Central nervous system serotonin and clustering of hostility, psychosocial, metabolic, and cardiovascular endophenotypes in menRedford B Williams
Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA
Psychosom Med 72:601-7. 2010.... - Fat, carbohydrate, and calories in the development of diabetes and obesity in the C57BL/6J mouseAnn E Petro
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
Metabolism 53:454-7. 2004..We conclude that reducing the number of kilocalories consumed from a high-fat diet attenuates but does not prevent the development of type 2 diabetes and obesity in the B6 mouse... - Genetic vulnerability to diet-induced obesity in the C57BL/6J mouse: physiological and molecular characteristicsSheila Collins
Department of Pharmacology, Duke University Medical Center, Durham, NC 27710, USA
Physiol Behav 81:243-8. 2004..This review highlights metabolic and signal transduction features that are altered during the course of disease progression, many of which mirror the human situation... - Caffeine impairs glucose metabolism in type 2 diabetesJames D Lane
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710-0001, USA
Diabetes Care 27:2047-8. 2004 - Treatment regimen determines the relationship between depression and glycemic controlRichard S Surwit
Division of Medical Psychology, Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, P O Box 3842, Durham, NC 27710, USA
Diabetes Res Clin Pract 69:78-80. 2005..We hypothesize that complexity of self-care regimen rather than the type of diabetes, is more important in determining this relationship of depression to glycemic control... - Glycogen synthase: a putative locus for diet-induced hyperglycemiaM F Seldin
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710
J Clin Invest 94:269-76. 1994..These data, taken together, raise the possibility that defects in the Gys gene may in part be responsible for the propensity to develop type 2 diabetes... - Distinct properties and advantages of a novel peroxisome proliferator-activated protein [gamma] selective modulatorJoel P Berger
RY80N C31, Merck Research Laboratories, 126 East Lincoln Avenue, Rahway, New Jersey 07065, USA
Mol Endocrinol 17:662-76. 2003..Such compounds may lead to preferred therapies for diabetes, obesity, or metabolic syndrome...
Research Grants
- DIFFERENTIAL RESPONSE TO CBT IN TYPE 1 & TYPE 2 DIABETESRichard Surwit; Fiscal Year: 2003..Changes in cortisol and self-care are predicted to impact blood glucose levels to a greater extent in type 1 diabetes because these individuals are metabolically more sensitive to any variation. ..
- Hostility, Race, and Glucose MetabolismRichard Surwit; Fiscal Year: 2006..These studies will further our understanding of the differences in the etiology of diabetes in these ethnic groups and may help explain the racial disparity in this disease. ..