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Genomes and GenesSpecies | Ashwin A PatkarSummaryAffiliation: Duke University Medical Center Country: USA Publications
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Relationship of the serotonin transporter with prolactin response to meta-chlorophenylpiperazine in cocaine dependenceAshwin A Patkar
Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, United States
J Psychiatr Res 42:1213-9. 2008..However, little is known about the relationship between the 5-HTT and 5-HT receptors following cocaine exposure in humans...- A randomized, controlled, trial of controlled release paroxetine in fibromyalgiaAshwin A Patkar
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27704, USA
Am J Med 120:448-54. 2007..We investigated the efficacy and tolerability of paroxetine controlled release, a selective serotonin reuptake inhibitor in fibromyalgia... - Relationship of disinhibition and aggression to blunted prolactin response to meta-chlorophenylpiperazine in cocaine-dependent patientsAshwin A Patkar
Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC 27704, USA
Psychopharmacology (Berl) 185:123-32. 2006..Considerable evidence indicates that serotonergic (5-HT) mechanisms may mediate central effects of cocaine, and disinhibition and aggression... - Changes in tobacco smoking following treatment for cocaine dependenceAshwin A Patkar
Department of Psychiatry Behavioral Sciences, Duke University, Durham, North Carolina 27704, USA
Am J Drug Alcohol Abuse 32:135-48. 2006..There is no evidence that reduction in crack cocaine smoking following treatment is accompanied by an increase in tobacco smoking. It appears that concerns over tobacco being substituted for cocaine may be unfounded in this population... - Transdermal selegiline: the new generation of monoamine oxidase inhibitorsAshwin A Patkar
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27704, USA
CNS Spectr 11:363-75. 2006..However, more research is needed. Clinicians should familiarize themselves with the properties and indications for the new generation of MAOIs... - Transdermal selegilineAshwin A Patkar
Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC 27705, USA
Drugs Today (Barc) 43:361-77. 2007..It is important for health-care professionals to be informed about the properties of STS... - Alterations in tryptophan and purine metabolism in cocaine addiction: a metabolomic studyAshwin A Patkar
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
Psychopharmacology (Berl) 206:479-89. 2009..Mapping metabolic "signatures" can provide new insights into addictive mechanisms and potentially identify biomarkers and therapeutic targets... - Relationship of prolactin response to meta-chlorophenylpiperazine with severity of drug use in cocaine dependenceAshwin A Patkar
Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA
Hum Psychopharmacol 21:367-75. 2006..Serotonergic (5-HT) mechanisms appear to mediate central effects of cocaine. Therefore 5-HT disturbances could be associated with drug severity... - A randomized, double-blind, placebo-controlled trial of augmentation with an extended release formulation of methylphenidate in outpatients with treatment-resistant depressionAshwin A Patkar
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27704, USA
J Clin Psychopharmacol 26:653-6. 2006..Combination of methylphenidate with antidepressants was well tolerated. Adequately powered, randomized, controlled trials are necessary to fully evaluate the efficacy of extended-release methylphenidate in TRD... - Medical symptoms associated with tobacco smoking with and without marijuana abuse among crack cocaine-dependent patientsAshwin A Patkar
Department of Psychiatry and Human Behavior, Department of Medicine, Thomas Jefferson University, Philadelphia, PA, USA
Am J Addict 14:43-53. 2005..Tobacco smoking was not related to changes in cocaine use. Also, marijuana smoking does not appear to be associated with a reduction in tobacco or cocaine use... - Relationship between platelet serotonin uptake sites and measures of impulsivity, aggression, and craving among African-American cocaine abusersAshwin A Patkar
Division of Substance Abuse Programs, Department of Psychiatry and Human Behavior, Thomas Jefferson University, Philadelphia, PA 19107, USA
Am J Addict 12:432-47. 2003..Our findings indicate that densities of serotonin uptake sites may be reduced among cocaine abusers and related to impulsive-aggressive behavioral dimensions... - Differences in platelet serotonin transporter sites between African-American tobacco smokers and non-smokersAshwin A Patkar
Department of Psychiatry and Human Behavior, Thomas Jefferson University, Philadelphia, PA 19107, USA
Psychopharmacology (Berl) 166:221-7. 2003..Although nicotine and other constituents of tobacco smoke may influence serotonin turnover among animals, few studies have examined whether smoking is associated with alteration in 5HTT in humans... - Polymorphism in the serotonin transporter gene and moderators of prolactin response to meta-chlorophenylpiperazine in African-American cocaine abusers and controlsPaolo Mannelli
Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA
Psychiatry Res 144:99-108. 2006.... - Seasonal variations in the binding of [3H]paroxetine to the platelet serotonin transporter sites in African-American cocaine-dependent patients and healthy volunteersAshwin A Patkar
Department of Psychiatry and Human Behavior, Thomas Jefferson University, Philadelphia, PA 19107, USA
Hum Psychopharmacol 18:103-11. 2003..Biological studies that employ platelet serotonin transporter sites as a marker of serotonin function should consider seasonal variations in these markers as a potential source of variance... - No association between polymorphisms in the serotonin transporter gene and susceptibility to cocaine dependence among African-American individualsAshwin A Patkar
Division of Substance Abuse Programs, Department of Psychiatry and Human Behavior, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
Psychiatr Genet 12:161-4. 2002..8%, 10 = 36.6%, 9 = 0.6%). Our findings do not seem to support a relationship between VNTR polymorphisms and cocaine dependence among African-American patients. Further studies involving larger samples are required to confirm our results... - Relationship between serotonin transporter gene polymorphisms and platelet serotonin transporter sites among African-American cocaine-dependent individuals and healthy volunteersAshwin A Patkar
Department of Psychiatry and Human Behavior, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
Psychiatr Genet 14:25-32. 2004.... - Polymorphism in the serotonin transporter gene and response to treatment in African American cocaine and alcohol-abusing individualsPaolo Mannelli
Department of Psychiatry, Duke University Medical Center, Durham, NC 27704, USA
Addict Biol 10:261-8. 2005..Further investigations are required to determine the role of the 5-HTTLPR polymorphism in influencing treatment - outcome among substance abusers... - Pre-treatment measures of impulsivity, aggression and sensation seeking are associated with treatment outcome for African-American cocaine-dependent patientsAshwin A Patkar
Division of Substance Abuse Programs, Department of Psychiatry and Human Behavior, Thomas Jefferson University, 833 Chestnut Street East, Suite 210E, Philadelphia, PA 19107, USA
J Addict Dis 23:109-22. 2004..Combining these behavioral measures with other clinical predictors may help in early identification of 'poor responders' who may benefit from additional or alternative treatment approaches... - Methylphenidate extended release (OROS MPH) for the treatment of antidepressant-related sexual dysfunction in patients with treatment-resistant depression: results from a 4-week, double-blind, placebo-controlled trialChi Un Pae
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Duke Clinical Research Institute, Durham, NC 27705, USA
Clin Neuropharmacol 32:85-8. 2009..Adequately powered controlled trials are needed to fully evaluate the efficacy of OROS MPH in this area... - Predicting treatment-outcome in cocaine dependence from admission urine drug screen and peripheral serotonergic measuresAshwin A Patkar
Division of Substance Abuse Programs, Department of Psychiatry and Human Behavior, Thomas Jefferson University, 833 Chestnut Street East, Suite 210E, Philadelphia, PA 19107, USA
J Subst Abuse Treat 23:33-40. 2002..Although both admission UDS and paroxetine binding seem to contribute individually in predicting outcome of cocaine patients, a combination of the two variables seems to have a stronger effect in terms of predicting treatment-outcome... - Relationship of serum prolactin with severity of drug use and treatment outcome in cocaine dependenceAshwin A Patkar
Department of Psychiatry and Human Behavior, Jefferson Medical College and Thomas Jefferson University Hospital, 33 South 9th Street, Suite 210E, Philadelphia, PA 19107, USA
Psychopharmacology (Berl) 176:74-81. 2004..Therefore, serum PRL may have a potential role as a biological marker of drug severity and treatment outcome in cocaine dependence... - History of depressive and/or anxiety disorders as a predictor of treatment response: a post hoc analysis of a 12-week, randomized, double-blind, placebo-controlled trial of paroxetine controlled release in patients with fibromyalgiaChi Un Pae
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27704, USA
Prog Neuropsychopharmacol Biol Psychiatry 33:996-1002. 2009..We investigated whether a history of depressive and/or anxiety disorders was associated with response to paroxetine controlled release (CR) in the treatment of fibromyalgia... - An item response theory modeling of alcohol and marijuana dependences: a National Drug Abuse Treatment Clinical Trials Network studyLi Tzy Wu
Department of Psychiatry and Behavioral Sciences, School of Medicine, Duke Clinical Research Institute, Duke University, Duke University Medical Center, Durham, North Carolina 27710, USA
J Stud Alcohol Drugs 70:414-25. 2009.... - Heterogeneity of stimulant dependence: a national drug abuse treatment clinical trials network studyLi Tzy Wu
Department of Psychiatry and Behavioral Sciences, Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina, USA
Am J Addict 18:206-18. 2009..Regardless of stimulants used, most female users were in the most severe or the physiological dependence group. These results lend support for subtyping dependence in the emerging DSM-V... - Early outcomes following low dose naltrexone enhancement of opioid detoxificationPaolo Mannelli
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27705, USA
Am J Addict 18:109-16. 2009..Further studies are needed to test the utility of this approach in easing the transition from detoxification to various follow-up treatment modalities designed to address opioid dependence... - Relationship between platelet serotonin uptake sites and treatment outcome among African-American cocaine dependent individualsAshwin A Patkar
Department of Psychiatry and Human Behavior, Thomas Jefferson University, Philadelphia, PA 19107, USA
J Addict Dis 22:79-92. 2003..The findings indicate that serotonergic mechanisms may be involved in cocaine dependence and may influence treatment-outcome among cocaine patients... - A double-blind, randomized, placebo-controlled trial of paroxetine controlled-release in irritable bowel syndromePrakash S Masand
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, 1001 Winstead Dr, Suite 200, Cary, NC 27513, USA
Psychosomatics 50:78-86. 2009..Irritable bowel syndrome (IBS) is a functional gastrointestinal (GI) disease that causes significant impairment in quality of life and accounts for $8 billion per year to the healthcare system and loss of productivity in the workplace... - History of early abuse as a predictor of treatment response in patients with fibromyalgia: a post-hoc analysis of a 12-week, randomized, double-blind, placebo-controlled trial of paroxetine controlled releaseChi Un Pae
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
World J Biol Psychiatry 10:435-41. 2009.... - Very low dose naltrexone addition in opioid detoxification: a randomized, controlled trialPaolo Mannelli
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, USA
Addict Biol 14:204-13. 2009..Further studies should explore the use of VLNTX, combined with full and partial opioid agonist medications, in detoxification and long-term treatment of opioid dependence... - Novel exonic mu-opioid receptor gene (OPRM1) polymorphisms not associated with opioid dependenceRachel J Smith
Department of Neuroscience, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Am J Med Genet B Neuropsychiatr Genet 133:105-9. 2005..The results indicate that polymorphisms in the novel splice variant are not associated with opioid dependence, but are in LD with other polymorphisms in OPRM1... - A functional prodynorphin promoter polymorphism and opioid dependenceRiju Ray
Department of Pharmacology, University of Pennsylvania, Philadelphia, 19104, USA
Psychiatr Genet 15:295-8. 2005..We examined this polymorphism for association in our sample of 168 opioid-dependent patients and 122 ethnically and geographically matched controls... - Effectiveness of low-dose naltrexone in the post-detoxification treatment of opioid dependencePaolo Mannelli
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27705, USA
J Clin Psychopharmacol 27:468-74. 2007..The present study evaluated whether the augmentation with low-dose NTX during the post-detoxification treatment of opioid dependence would improve outcomes... - The genetic determinants of smokingVikas Batra
Department of Medicine, Division of Critical Care, Pulmonary, Allergic and Immunologic Diseases, Thomas Jefferson University, Philadelphia, USA
Chest 123:1730-9. 2003..Insights into the genetic contributions to smoking can potentially lead to more effective strategies to reduce smoking... - High- and low-structure treatments for substance dependence: role of learned helplessnessCharles C Thornton
Department of Psychiatry and Human Behavior, Thomas Jefferson University, Philadelphia, Pennsylvannia 19107, USA
Am J Drug Alcohol Abuse 29:567-84. 2003..A matching approach that assigns patients to high- and low-structure treatments based on pretreatment levels of LH might improve treatment outcomes for substance-dependent patients... - Nicotine dependence and treatment outcome among African American cocaine-dependent patientsAshwin A Patkar
Department of Psychiatry and Human Behavior, Thomas Jefferson University, Philadelphia, PA, USA
Nicotine Tob Res 5:411-8. 2003..It seems that severity of tobacco use predicts poor outcome for cocaine-dependent patients who are cocaine free at the time of admission into outpatient treatment... - Prescription pain reliever abuse and dependence among adolescents: a nationally representative studyLi Tzy Wu
Department of Psychiatry and Behavioral Sciences, School of Medicine, Duke University, Durham, NC 27710, USA
J Am Acad Child Adolesc Psychiatry 47:1020-9. 2008.... - Tobacco smoking: current concepts in etiology and treatmentAshwin A Patkar
Department of Psychiatry, Thomas Jefferson University, 33 South 9th Street, Suite 210E, Philadelphia, PA 19107, USA
Psychiatry 66:183-99. 2003..It also makes recommendations for the rational use of these interventions to treat nicotine dependence in individuals with psychiatric disorders... - Problem drinking and low-dose naltrexone-assisted opioid detoxificationPaolo Mannelli
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, 2218 Elder Street, Suite 123, Durham, North Carolina 27705, USA
J Stud Alcohol Drugs 72:507-13. 2011..In a secondary analysis of these data, we sought to determine whether problem drinking affects detoxification outcomes and whether symptoms are influenced by VLNTX use... - Comparison of pretreatment characteristics and treatment outcomes for alcohol-, cocaine-, and multisubstance-dependent patientsAshwin A Patkar
Division of Substance Abuse Programs, Department of Psychiatry and Human Behavior, Thomas Jefferson University, Philadelphia, PA 19107, USA
J Addict Dis 23:93-109. 2004..Clinicians should be cautious about forecasting treatment-outcomes for addicted patients based on their primary substances of abuse... - Differences in peripheral noradrenergic function among actively drinking and abstinent alcohol-dependent individualsAshwin A Patkar
Department of Psychiatry and Human Behavior, Thomas Jefferson University, Philadelphia, PA, USA
Am J Addict 13:225-35. 2004..However, the changes in NA activity appears to normalize after a longer period of abstinence. Alterations in NA activity do not seem to be specific for Type I or Type II subtypes of alcoholism... - Paroxetine: safety and tolerability issuesDavid M Marks
Duke University Medical Center, Department of Psychiatry and Behavioural Sciences, 2218 Elder Street, Durham 27705, USA
Expert Opin Drug Saf 7:783-94. 2008.... - HIV risk behavior in treatment-seeking opioid-dependent youth: results from a NIDA clinical trials network multisite studyChristina S Meade
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
J Acquir Immune Defic Syndr 55:65-72. 2010..To assess baseline rates of and changes in HIV drug and sexual risk behavior as a function of gender and treatment in opioid-dependent youth... - Relationship between tobacco smoking and positive and negative symptoms in schizophreniaAshwin A Patkar
Department of Psychiatry and Human Behavior, Thomas Jefferson University, 833 Chestnut Street East, Suite 210E, Philadelphia, Pennsylvania, 19107, USA
J Nerv Ment Dis 190:604-10. 2002..A combination of negative symptoms, duration of illness, and alcohol use optimally predicted smoking in the sample. Neurobiological mechanisms could possibly underlie some of our findings and require further investigation... - The high prevalence of substance use disorders among recent MDMA users compared with other drug users: Implications for interventionLi Tzy Wu
Department of Psychiatry and Behavioral Sciences, School of Medicine, Duke Clinical Research Institute, Duke University Medical Center, Box 3419, Durham, NC 27710, USA
Addict Behav 34:654-61. 2009.... - Influence of BDNF variants on diagnosis and response to treatment in patients with major depression, bipolar disorder and schizophreniaChi Un Pae
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
Neuropsychobiology 65:1-11. 2012.... - Infrequent illicit methadone use among stimulant-using patients in methadone maintenance treatment programs: a national drug abuse treatment clinical trials network studyLi Tzy Wu
Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, North Carolina 27710, USA
Am J Addict 17:304-11. 2008..Illicit methadone use among patients in maintenance programs is infrequent; however, a number of factors may increase risk of illicit use... - The construct and measurement equivalence of cocaine and opioid dependences: a National Drug Abuse Treatment Clinical Trials Network (CTN) studyLi Tzy Wu
Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Duke Clinical Research Institute, Durham, NC 27710, USA
Drug Alcohol Depend 103:114-23. 2009.... - The impact of the CONSORT statement on reporting of randomized clinical trials in psychiatryChangsu Han
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center and Duke Clinical Research Institute, Durham, NC, USA
Contemp Clin Trials 30:116-22. 2009..Although the overall quality of reporting on psychiatric RCTs generally improved after publication of the CONSORT statement, reporting the details of randomization, blinding, and obtaining informed consent remain insufficient... - Long-acting injectable naltrexone for the treatment of alcohol dependencePaolo Mannelli
Duke University Medical Center, 2218 Elder Street, Suite 123, Durham, NC 27705, USA
Expert Rev Neurother 7:1265-77. 2007..The clinical availability of extended-release naltrexone has the potential to enhance treatment outcomes for alcohol and other drug dependence disorders... - A comparison of smoking habits among medical and nursing studentsAshwin A Patkar
Department of Psychiatry and Human Behavior, Jefferson Medical College and Thomas Jefferson University, Philadelphia, PA 19107, USA
Chest 124:1415-20. 2003..We compared smoking habits among medical and nursing students, and examined whether these habits changed during the course of education for each cohort... - Trends in nonheroin opioid abuse admissions: 1992-2004Kathleen S Peindl
Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, North Carolina, USA
J Opioid Manag 3:215-23. 2007..This study examines trends for treatment admissions for nonheroin opioid abuse from 1992 to 2004... - Tobacco and alcohol use and medical symptoms among cocaine dependent patientsAshwin A Patkar
Department of Psychiatry, Jefferson Medical College and Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA
Subst Abus 23:105-14. 2002.... - Relationship between tobacco smoking and medical symptoms among cocaine-, alcohol-, and opiate-dependent patientsAshwin A Patkar
Division of Substance Abuse Programs, Department of Psychiatry, Jefferson Medical College and Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA
Am J Addict 11:209-18. 2002..In particular, cocaine patients seem to be affected differently than alcohol and opiate patients... - A genetic association study of the mu opioid receptor and severe opioid dependenceJames J Crowley
Department of Pharmacology, University of Pennsylvania, 415 Curie Boulevard, Philadelphia, PA 19104, USA
Psychiatr Genet 13:169-73. 2003..A recent report (Hoehe et al., 2000) found a significant association between a specific combination of OPRM1 single nucleotide polymorphisms (SNPs) and substance dependence... - Non-prescribed use of pain relievers among adolescents in the United StatesLi Tzy Wu
Department of Psychiatry and Behavioral Sciences, School of Medicine, Duke University Medical Center, Box 17969, Durham, NC 27715, USA
Drug Alcohol Depend 94:1-11. 2008..We examined gender-specific prevalences, patterns, and correlates of non-prescribed use of pain relievers - mainly opioids - in a representative sample of American adolescents (N=18,678)... - Hallucinogen use disorders among adult users of MDMA and other hallucinogensLi Tzy Wu
Department of Psychiatry and Behavioral Sciences, School of Medicine, Duke University, Durham, North Carolina 27710, USA
Am J Addict 17:354-63. 2008..Subthreshold hallucinogen dependence is relatively prevalent and represents a clinically important subgroup that warrants future research and consideration in a major diagnostic classification system... - History of depressive and anxiety disorders and paroxetine response in patients with irritable bowel syndrome: post hoc analysis from a placebo-controlled studyDavid M Marks
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, N C and GlaxoSmithKline, King of Prussia, PA
Prim Care Companion J Clin Psychiatry 10:368-75. 2008..We investigated whether a history of depressive and/or anxiety disorders was associated with response to treatment in a double-blind, randomized, placebo-controlled trial of paroxetine controlled release (CR) in IBS... - Serotonin transporter polymorphisms and measures of impulsivity, aggression, and sensation seeking among African-American cocaine-dependent individualsAshwin A Patkar
Division of Substance Abuse Programs, Department of Psychiatry and Human Behavior, Thomas Jefferson University, Philadelphia, PA 19107, USA
Psychiatry Res 110:103-15. 2002..The findings do not seem to support an association between these polymorphisms in the 5HTT gene and impulsive-aggressive traits among cocaine-dependent African-American individuals... - An open-label, rater-blinded, flexible-dose, 8-week trial of escitalopram in patients with major depressive disorder with atypical featuresChi Un Pae
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, N C, and the Department of Psychiatry, College of Medicine, The Catholic University of Korea and Department of Psychiatry, Korea University, Seoul, South Korea
Prim Care Companion J Clin Psychiatry 10:205-10. 2008..Adequately powered, randomized, double-blind, placebo-controlled trials are necessary to determine the efficacy of escitalopram in this disorder.Trial Registration: clinicaltrials.gov Identifier: NCT00610506... - Serum prolactin and response to treatment among cocaine-dependent individualsAshwin A Patkar
Division of Substance Abuse Programs, Department of Psychiatry and Human Behavior, Jefferson Medical College and Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA
Addict Biol 7:45-53. 2002..Moreover, higher prolactin seems to be related negatively with certain measures of response to treatment among cocaine patients... - Paroxetine: current status in psychiatryChi Un Pae
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27705, USA
Expert Rev Neurother 7:107-20. 2007..It also discusses emerging evidence in other clinical areas and recent data that have led to modifications in the safety profile of paroxetine... - Short-, intermediate-, and long-term outcomes of Pennsylvania's continuum of tobacco education pilot projectFrank T Leone
Center for Tobacco Research and Treatment, Jefferson Medical College, Thomas Jefferson University, 834 Walnut Street, Suite 650, Philadelphia, PA 19107, USA
Nicotine Tob Res 11:387-93. 2009.... - Selegiline transdermal system: current awareness and promiseChi Un Pae
Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA
Prog Neuropsychopharmacol Biol Psychiatry 31:1153-63. 2007.... - Changes in plasma noradrenaline and serotonin levels and craving during alcohol withdrawalAshwin A Patkar
Department of Psychiatry, Thomas Jefferson University, Philadelphia, PA 19107, USA
Alcohol Alcohol 38:224-31. 2003..Also, while alterations in NA activity appear to normalize by late withdrawal, 5-HT changes seem to be more persistent. Neither craving nor subtypes of alcoholism seem to be related to alterations in NA or 5-HT during withdrawal... - Reduction in methamphetamine induced sensitization and reinstatement after combined pergolide plus ondansetron treatment during withdrawalColin Davidson
Psychiatry, Box 3870, Duke University Medical Center, NC 27710, United States
Eur J Pharmacol 565:113-8. 2007..These data suggest that pergolide plus ondansetron treatment may be useful as a therapy to reduce relapse in methamphetamine abusers... - Does minocycline have antidepressant effect?Chi Un Pae
Department of Psychiatry, Kangnam St Mary s Hospital, The Catholic University of Korea College of Medicine, 505 Banpo Dong, Seocho Gu, Seoul 137 701, South Korea
Biomed Pharmacother 62:308-11. 2008..Further studies of the potential therapeutic mechanism of minocycline and its therapeutic implications for major depression are warranted, and may substantially contribute to the development of newer and more effective antidepressants... - Clinical variables associated with early administration of antipsychotics in bipolar maniaChi Un Pae
Department of Psychiatry, Kangnam St Mary s Hospital, The Catholic University of Korea College of Medicine, 505 Banpo Dong, Seocho Gu, Seoul 137 701, Republic of Korea
Prog Neuropsychopharmacol Biol Psychiatry 30:151-4. 2006..0 and 13.1, respectively). This study suggests that some clinical factors in bipolar mania might be linked to the earlier antipsychotic treatment. However, more studies will be needed to confirm this finding... - Telephone enhancement of long-term engagement (TELE) in continuing care for substance abuse treatment: a NIDA clinical trials network (CTN) studyRobert L Hubbard
Duke University Medical Center, Durham, North Carolina, USA
Am J Addict 16:495-502. 2007..While the phone calls were feasible, the lack of clear evidence of efficacy of the calls suggests the need for further investigation of the role of telephone intervention to encourage compliance and improve outcomes... - Buprenorphine treatment: factors and first-hand experiences for providers to considerBradley R Meier
Department of Psychiatry, Thomas Jefferson University, Philadelphia, PA, USA
J Addict Dis 26:3-14. 2007.... - Changes in mu opioid receptors and rheological properties of erythrocytes among opioid abusersAllen R Zeiger
Department of Biochemistry and Molecular Pharmacology, Thomas Jefferson University, Philadelphia, PA, USA
Addict Biol 7:207-17. 2002..This study may offer clues to the biological properties of peripheral blood cells that may be mediated by mu opioid receptors and lead to a better understanding of some of the clinical effects of opioid use... - The implementation of buprenorphine/naloxone in college health practicePeter A Demaria
Tuttleman Counseling Services, Temple University, 1810 Liacouris Walk, Philadelphia, PA 19122, USA
J Am Coll Health 56:391-3. 2008..The authors review the pharmacology of buprenorphine/naloxone and discuss how it can be implemented in college health practice. They also present a case report... - Psychotic symptoms in patients with medical disordersAshwin A Patkar
Section of Biological Psychiatry and Clinical Trials, Thomas Jefferson University, 33 South 9th Street, Suite 210E, Philadelphia, PA 19107, USA
Curr Psychiatry Rep 6:216-24. 2004..Understanding the neuropsychiatric effects of medications and drug-drug interactions may help in preventing psychotic symptoms... - Management of fibromyalgiaAshwin A Patkar
Department of Psychiatry, Thomas Jefferson University, 833 Chestnut Street, Suite 210E, Philadelphia, PA 19107, USA
Curr Psychiatry Rep 5:218-24. 2003..Patience and positive attitude on part of the physician and active involvement of patients and their families in treatment are likely to enhance improvement... - Is there protective haplotype of dysbindin gene (DTNBP1) 3 polymorphisms for major depressive disorderJung Jin Kim
Department of Psychiatry, The Catholic University of Korea College of Medicine, 505 Banpo Dong, Seocho Gu, Seoul 137 701, South Korea
Prog Neuropsychopharmacol Biol Psychiatry 32:375-9. 2008..Coupled with previous findings on schizophrenia, our finding suggests that dysbindin gene variants may have a role in the susceptibility to MDD. Adequately powered further studies in different ethnic groups are warranted... - Heat-shock protein-70 genes and response to antidepressants in major depressionChi Un Pae
Department of Psychiatry, Kangnam St Mary s Hospital, The Catholic University of Korea College of Medicine, Seoul, South Korea
Prog Neuropsychopharmacol Biol Psychiatry 31:1006-11. 2007..In conclusion, genetic variants within the genes coding for HSP-70 family proteins may affect the action of antidepressants and thus their therapeutic efficacy... - Venlafaxine versus mirtazapine in the treatment of undifferentiated somatoform disorder: a 12-week prospective, open-label, randomized, parallel-group trialChangsu Han
Department of Psychiatry, Korea University, College of Medicine, Seoul, Korea
Clin Drug Investig 28:251-61. 2008..We set out to compare the efficacy and tolerability of mirtazapine versus venlafaxine in patients with undifferentiated somatoform disorder (USD) using the Patient Health Questionnaire-15 (PHQ-15)... - Fluoxetine versus sertraline in the treatment of patients with undifferentiated somatoform disorder: a randomized, open-label, 12-week, parallel-group trialChangsu Han
Department of Psychiatry, Korea University, College of Medicine, Seoul, South Korea
Prog Neuropsychopharmacol Biol Psychiatry 32:437-44. 2008..This study suggests that both agents may have a potential role in the treatment of USD. A double-blind, placebo-controlled trial and/or head-to-head comparison study with larger samples are required to draw more definite conclusions... - Dysbindin associated with selective serotonin reuptake inhibitor antidepressant efficacyChi Un Pae
Department of Psychiatry, Kangnam St Mary s Hospital, The Catholic University of Korea College of Medicine, Seocho Gu, Seoul, Korea
Pharmacogenet Genomics 17:69-75. 2007..In the search for further genes influencing antidepressant response we focused on the dysbindin gene (dystrobrevin-binding-protein 1, DTNBP1)... - Usefulness of long-acting injectable risperidone during 12-month maintenance therapy of bipolar disorderChangsu Han
Department of Psychiatry, Korea University, College of Medicine, Seoul, South Korea
Prog Neuropsychopharmacol Biol Psychiatry 31:1219-23. 2007.... - Comments on "Addition of lamotrigine to valproic acid: a successful outcome in a case of rapid-cycling bipolar affective disorder"Chi-Un Pae
Prog Neuropsychopharmacol Biol Psychiatry 32:595-6. 2008 - Rapid versus conventional initiation of quetiapine in the treatment of schizophrenia: a randomized, parallel-group trialChi Un Pae
Department of Psychiatry, Kangnam St Mary s Hospital, The Catholic University of Korea College of Medicine, Seocho Gu, Seoul, South Korea
J Clin Psychiatry 68:399-405. 2007..S. Food and Drug Administration (FDA). The secondary objectives included assessment of the efficacy of a rapid initiation of quetiapine compared with a conventional initiation approved by the FDA... - Aripiprazole augmentation for treatment of patients with inadequate antidepressants responseChi Un Pae
Department of Psychiatry, The Catholic University of Korea, College of Medicine, Seoul, South Korea
Depress Anxiety 24:522-6. 2007..These results highlight the potential benefits of aripiprazole for these patients. However, adequately powered, randomized, controlled trials are needed to confirm these results... - DTNBP1 haplotype influences baseline assessment scores of schizophrenic in-patientsChi Un Pae
Department of Psychiatry, Kangnam St Mary s Hospital, The Catholic University of Korea College of Medicine, South Korea
Neurosci Lett 440:150-4. 2008..008; 0.005). Covariate analysis revealed a more stable significant association between A-A haplotype and baseline scores. These results suggest a protective effect of A-A haplotype on psychotic positive symptoms at baseline... - A case of transient hallucination with ropinirole augmentation antidepressant in a patient with treatment-resistant depression: Is there differential effect of ropinirole dose on developing psychotic symptom?Chi-Un Pae
Prog Neuropsychopharmacol Biol Psychiatry 32:1087-8. 2008 - Do estradiol levels influence on the cognitive function during antidepressant treatments in post-menopausal women with major depressive disorder? A comparison with pre-menopausal womenChi Un Pae
Department of Psychiatry, The Catholic University of Korea College of Medicine, Seoul, South Korea
Neuro Endocrinol Lett 29:500-6. 2008..Hence, this study aimed to investigate the role of menopausal status including the level of sex hormones on cognitive function during antidepressant treatment... - Quinone oxidoreductase (NQO1) gene polymorphism may not confer a susceptibility to mood disordersChi Un Pae
Department of Psychiatry, Kangnam St Mary s Hospital, The Catholic University of Korea College of Medicine, 505 Banpo Dong, Seocho Gu, Seoul 137 701, South Korea
Psychiatry Res 153:83-6. 2007..These preliminary results showed that the NQO1 gene polymorphism was not related to a susceptibility to mood disorders... - Aripiprazole in the treatment of depressive and anxiety disorders: a review of current evidenceChi Un Pae
Department of Psychiatry, Kangnam St Mary s Hospital, The Catholic University of Korea College of Medicine, Seoul, South Korea
CNS Drugs 22:367-88. 2008..Clinical data also suggest that aripiprazole may have a lower adverse effect burden than the other atypical drugs. Future research may confirm the potential utility of aripiprazole in the treatment of depressive and anxiety disorders... - The atypical antipsychotics olanzapine and risperidone in the treatment of posttraumatic stress disorder: a meta-analysis of randomized, double-blind, placebo-controlled clinical trialsChi Un Pae
Department of Psychiatry, The Catholic University of Korea, College of Medicine, Seoul, South Korea
Int Clin Psychopharmacol 23:1-8. 2008..Clinical significance of the results, however, should be carefully interpreted and translated into clinical practice, given that the quality and availability of currently existing RCTs included in the analysis...
Research Grants
- Serotonin and cocaine dependence:Treatment implicationsAshwin Patkar; Fiscal Year: 2004..Moreover, the results may help to improve pharmacological strategies for the treatment of cocaine dependence. ..