Research Topics
Genomes and Genes | Marc C LevesqueSummaryAffiliation: Duke University Medical Center Country: USA Publications
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Publications
Determinants of exhaled nitric oxide levels in healthy, nonsmoking African American adultsMarc C Levesque
Department of Medicine, Division of Rheumatology and Immunology, Duke University Medical Center, Durham, NC 27710, USA
J Allergy Clin Immunol 121:396-402.e3. 2008..More needs to be known about the factors that regulate FeNO. There is a need for FeNO reference values for African Americans...- CLL cell apoptosis induced by nitric oxide synthase inhibitors: correlation with lipid solubility and NOS1 dissociation constantMarc C Levesque
Department of Medicine, Division of Rheumatology and Clinical Immunology, Duke University and Durham VA Medical Centers, Durham, NC 27710, United States
Leuk Res 32:1061-70. 2008..CLL cell RNA and protein analyses confirmed CLL cell NOS1 expression. Our studies permit the rational selection of NOS inhibitors for testing as CLL therapeutics... - B cell-directed therapies for autoimmune disease and correlates of disease response and relapseMarc C Levesque
Department of Medicine, Division of Rheumatology and Immunology, Duke University Medical Center, Durham, NC 27710, USA
J Allergy Clin Immunol 121:13-21; quiz 22-3. 2008..Moreover, pathologic B-cell responses may be favorably influenced by other targeted approaches such as those using anti-B-cell activating factor belonging to the TNF family (BAFF) or anti-CD22 antibodies... - Chronic lymphocytic leukemia cell CD38 expression and inducible nitric oxide synthase expression are associated with serum IL-4 levelsMarc C Levesque
Department of Medicine, Division of Rheumatology, Duke University and Durham VA Medical Centers, Durham, NC 27710, USA
Leuk Res 30:24-8. 2006..IL-4 levels, but not IFN-gamma levels, differed between normal individuals and CLL patients. Furthermore, there was an association of IL-4 levels, but not IFN-gamma levels, with CD38 and NOS2 expression in CLL patients... - The dichotomous role of nitric oxide in the pathogenesis of accelerated atherosclerosis associated with systemic lupus erythematosusMarc C Levesque
From Department of Medicine, Division of Rheumatology, Duke University and Durham VA Medical Centers, Durham, NC, USA
Curr Mol Med 4:777-86. 2004..Therefore, the balance between normal vascular function and atherogenesis may be mediated by differences in the quantity, location, and timing of NO production within vessel walls... - Normative values for exhaled breath condensate pH and its relationship to exhaled nitric oxide in healthy African AmericansDavid W Hauswirth
Department of Medicine, Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Ohio State University Medical Center, Columbus, Ohio 43221, USA
J Allergy Clin Immunol 122:101-6. 2008..EBC pH values below 6.5 have been associated with asthma exacerbations. Protonation of airway nitrite occurs at low pH and may contribute to FeNO... - Malaria severity and human nitric oxide synthase type 2 (NOS2) promoter haplotypesMarc C Levesque
Durham VA Medical Center, Durham, NC, USA
Hum Genet 127:163-82. 2010..Taken together, these studies suggest that the relationship between NOS2 promoter polymorphisms and malaria severity is more complex than previously described... - Identification of genetic polymorphisms associated with risk for pulmonary hypertension in sickle cell diseaseAllison E Ashley-Koch
Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
Blood 111:5721-6. 2008..These findings may offer new promise for identifying patients at risk for pHTN, developing new therapeutic targets, and reducing the occurrence of this life-threatening SCD complication... - High-throughput isolation of immunoglobulin genes from single human B cells and expression as monoclonal antibodiesHua Xin Liao
Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC, 27710, United States
J Virol Methods 158:171-9. 2009..These Ig gene expression cassettes constitute a highly efficient strategy for rapid expression of Ig genes for high-throughput screening and analysis without cloning... - Progressive immunoglobulin gene mutations in chronic lymphocytic leukemia: evidence for antigen-driven intraclonal diversificationAlicia D Volkheimer
Department of Medicine, Duke University and Durham VA Medical Centers, NC 27710, USA
Blood 109:1559-67. 2007..Taken together, these studies support the hypothesis that in some CLL cases intraclonal diversification is dependent on antigen interactions with immunoglobulin receptors... - Polyclonal B cell differentiation and loss of gastrointestinal tract germinal centers in the earliest stages of HIV-1 infectionMarc C Levesque
Department of Medicine, Duke University School of Medicine, Durham, North Carolina, United States of America
PLoS Med 6:e1000107. 2009..While the effect of HIV-1 on depletion of gut CD4(+) T cells in acute HIV-1 infection is well described, we studied blood and tissue B cells soon after infection to determine the effect of early HIV-1 on these cells... - Clinical and molecular predictors of disease severity and survival in chronic lymphocytic leukemiaJ Brice Weinberg
Department of Medicine, Division of Hematology, VA and Duke University Medical Centers, 508 Fulton Street, Durham, North Carolina 27705, USA
Am J Hematol 82:1063-70. 2007.... - Genetic polymorphisms associated with priapism in sickle cell diseaseLaine Elliott
Department of Medicine, Duke University and VA Medical Centers, Durham, NC 27710, USA
Br J Haematol 137:262-7. 2007..Our data suggest that genes involved in the TGFbeta pathway, coagulation, cell adhesion and cell hydration pathways may be important in risk for priapism... - Nitric oxide synthase 2 promoter polymorphisms and systemic lupus erythematosus in african-americansJim C Oates
Department of Medicine, Ralph H Johnson VA Medical Center VAMC and Medical University of South Carolina, Charleston 29425, USA
J Rheumatol 30:60-7. 2003..This study was designed to determine if these polymorphisms are associated with SLE... - Activation-induced cytidine deaminase expression and activity in the absence of germinal centers: insights into hyper-IgM syndromeMasayuki Kuraoka
Department of Immunology, Duke University, Durham, NC 27710, USA
J Immunol 183:3237-48. 2009.... - Inducible nitric oxide synthase (NOS2) promoter CCTTT repeat polymorphism: relationship to in vivo nitric oxide production/NOS activity in an asymptomatic malaria-endemic populationCraig S Boutlis
International Health Program, Infectious Diseases Division, Menzies School of Health Research, Darwin, Northern Territory, Australia
Am J Trop Med Hyg 69:569-73. 2003..Neither the G-954C nor the C-1173T polymorphisms were identified in this population, indicating the variability and complexity of selection for NOS2 promoter polymorphisms in different malaria-endemic populations... - Guidelines for assessing immunocompetency in clinical trials for autoimmune diseasesR John Looney
Autoimmunity Centers of Excellence ACE Immunocompetency Committee, Rochester, USA
Clin Immunol 123:235-43. 2007..Banking genetic material to allow genotyping should be considered particularly if a central repository for samples from different trials can be established... - Low plasma arginine concentrations in children with cerebral malaria and decreased nitric oxide productionBert K Lopansri
Division of Infectious Diseases, VA and University of Utah Medical Centers, Salt Lake City, UT, USA
Lancet 361:676-8. 2003..Hypoargininaemia may contribute to limited NO production in children with cerebral malaria and to severe disease... - A new NOS2 promoter polymorphism associated with increased nitric oxide production and protection from severe malaria in Tanzanian and Kenyan childrenMaurine R Hobbs
Department of Internal Medicine, University of Utah and VA Medical Centers, Salt Lake City, UT, USA
Lancet 360:1468-75. 2002..We postulated that NOS2 promoter polymorphisms would affect resistance to severe malaria...
Research Grants
- Prevention of Chronic Lymphocytic Leukemia (CLL)MARC LEVESQUE; Fiscal Year: 2007..We plan to use these and other techniques to perform a pilot study that will determine characteristics of MBL that are associated with transition to CLL by longitudinal analysis of samples from familial MBL subjects. ..
- Human TNFa-Induced Pre-B Cell Bone Marrow EmigrantsMARC LEVESQUE; Fiscal Year: 2007..We will also determine whether anti-TNFa therapy is associated with reductions in peripheral populations of TNFa- induced pre-B cell bone marrow emigrants in RA patients. ..