Hilary P Grocott

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. ncbi Genetic influences on cerebral outcome after cardiac surgery
    Hilary P Grocott
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    Semin Cardiothorac Vasc Anesth 10:291-6. 2006
  2. ncbi The influence of xenon, nitrous oxide and nitrogen on gas bubble expansion during cardiopulmonary bypass
    H P Grocott
    Duke University Medical Center, Division of Cardiothoracic Anesthesiology and Critical Care Medicine, Department of Anesthesiology, Durham, NC 27710, USA
    Eur J Anaesthesiol 22:353-8. 2005
  3. ncbi Cognitive dysfunction after cardiac surgery: revisiting etiology
    Hilary P Grocott
    Department of Anesthesiology, Division of Cardiothoracic Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    Semin Cardiothorac Vasc Anesth 9:123-9. 2005
  4. ncbi Lung isolation during port-access cardiac surgery: double-lumen endotracheal tube versus single-lumen endotracheal tube with a bronchial blocker
    Hilary P Grocott
    Department of Anesthesiology, Duke University Medical Center, Box 3094, Durham, NC 27710, USA
    J Cardiothorac Vasc Anesth 17:725-7. 2003
  5. ncbi Neuroprotection in cardiac surgery
    Hilary P Grocott
    Department of Anesthesiology, Room 3435, Duke North Hospital, Box 3094, Duke University Medical Center, Durham, NC 27710, USA
    Anesthesiol Clin North America 21:487-509, viii. 2003
  6. ncbi Genetic polymorphisms and the risk of stroke after cardiac surgery
    Hilary P Grocott
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    Stroke 36:1854-8. 2005
  7. ncbi Postoperative hyperthermia is associated with cognitive dysfunction after coronary artery bypass graft surgery
    Hilary P Grocott
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    Stroke 33:537-41. 2002
  8. ncbi Invited commentary
    Hilary P Grocott
    Department of Anesthesiology, Duke University Medical Center, Box 3094, Durham, NC 27710, USA
    Ann Thorac Surg 81:1406-7. 2006
  9. ncbi Neurological injury during cardiopulmonary bypass in the rat
    H P Grocott
    Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Perfusion 16:75-81. 2001
  10. ncbi "Other" neurologic complications after cardiac surgery
    Hilary P Grocott
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    Semin Cardiothorac Vasc Anesth 8:213-26. 2004

Detail Information

Publications84

  1. ncbi Genetic influences on cerebral outcome after cardiac surgery
    Hilary P Grocott
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    Semin Cardiothorac Vasc Anesth 10:291-6. 2006
    ..Our work has established key links between post-cardiac surgery stroke and C-reactive protein (3'UTR 1846C/T) and interleukin-6 (-174 G/C) single nucleotide polymorphisms...
  2. ncbi The influence of xenon, nitrous oxide and nitrogen on gas bubble expansion during cardiopulmonary bypass
    H P Grocott
    Duke University Medical Center, Division of Cardiothoracic Anesthesiology and Critical Care Medicine, Department of Anesthesiology, Durham, NC 27710, USA
    Eur J Anaesthesiol 22:353-8. 2005
    ..The purpose of this study was to compare the effects of xenon (Xe), nitrous oxide (N2O) and nitrogen (N2) on gas bubble size during cardiopulmonary bypass (CPB)...
  3. ncbi Cognitive dysfunction after cardiac surgery: revisiting etiology
    Hilary P Grocott
    Department of Anesthesiology, Division of Cardiothoracic Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    Semin Cardiothorac Vasc Anesth 9:123-9. 2005
    ..This review expands on these potential etiologies in detailing the evidence for their existence...
  4. ncbi Lung isolation during port-access cardiac surgery: double-lumen endotracheal tube versus single-lumen endotracheal tube with a bronchial blocker
    Hilary P Grocott
    Department of Anesthesiology, Duke University Medical Center, Box 3094, Durham, NC 27710, USA
    J Cardiothorac Vasc Anesth 17:725-7. 2003
    ..The purpose of this study was to compare the use of a double-lumen endotracheal tube to a single-lumen tube combined with a bronchial blocker for lung isolation during Port-Access cardiac surgery...
  5. ncbi Neuroprotection in cardiac surgery
    Hilary P Grocott
    Department of Anesthesiology, Room 3435, Duke North Hospital, Box 3094, Duke University Medical Center, Durham, NC 27710, USA
    Anesthesiol Clin North America 21:487-509, viii. 2003
    ..This article reviews past and present neuroprotective efforts and outlines a framework for the future development of techniques for neuroprotection during cardiac surgery...
  6. ncbi Genetic polymorphisms and the risk of stroke after cardiac surgery
    Hilary P Grocott
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    Stroke 36:1854-8. 2005
    ..Therefore, we tested the hypothesis that specific genetic polymorphisms are associated with an increased risk of stroke after cardiac surgery...
  7. ncbi Postoperative hyperthermia is associated with cognitive dysfunction after coronary artery bypass graft surgery
    Hilary P Grocott
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    Stroke 33:537-41. 2002
    ..Temperature is a well-known modulator of experimental cerebral injury. We hypothesized that hyperthermia would be associated with a worsened cognitive outcome after coronary artery bypass graft surgery (CABG)...
  8. ncbi Invited commentary
    Hilary P Grocott
    Department of Anesthesiology, Duke University Medical Center, Box 3094, Durham, NC 27710, USA
    Ann Thorac Surg 81:1406-7. 2006
  9. ncbi Neurological injury during cardiopulmonary bypass in the rat
    H P Grocott
    Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Perfusion 16:75-81. 2001
    ..016). This rat model of CPB may allow for the study of CPB-associated neurological injury...
  10. ncbi "Other" neurologic complications after cardiac surgery
    Hilary P Grocott
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    Semin Cardiothorac Vasc Anesth 8:213-26. 2004
    ..An overview of the current concepts of injury mechanisms/etiology, diagnosis, prognosis, and when possible, prevention of these injuries is presented...
  11. ncbi The effects of aprotinin on outcome from cerebral ischemia in the rat
    H P Grocott
    Neuroanesthesia Research Laboratory, Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Anesth Analg 88:1-7. 1999
    ..87). IMPLICATIONS: Aprotinin offers no neuroprotection against either global or focal cerebral ischemia in the rat when administered as a single preischemic bolus...
  12. ncbi Effects of a synthetic allosteric modifier of hemoglobin oxygen affinity on outcome from global cerebral ischemia in the rat
    H P Grocott
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27705, USA
    Stroke 29:1650-5. 1998
    ....
  13. ncbi Randomized, double-blinded, placebo controlled study of neuroprotection with lidocaine in cardiac surgery
    Joseph P Mathew
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    Stroke 40:880-7. 2009
    ..Based on experimental and clinical evidence, this study assessed the potential of intravenously administered lidocaine to reduce postoperative cognitive dysfunction after cardiac surgery using cardiopulmonary bypass...
  14. ncbi Aortic atheroma burden and cognitive dysfunction after coronary artery bypass graft surgery
    Shahar Bar-Yosef
    Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Ann Thorac Surg 78:1556-62. 2004
    ..Atherosclerotic disease of the aorta is a known risk factor for stroke after cardiac surgery, but its relationship to NCD is unclear. This study investigates the relationship between aortic atherosclerotic disease and NCD after CABG...
  15. ncbi Relationship of genetic variability and depressive symptoms to adverse events after coronary artery bypass graft surgery
    Barbara Phillips-Bute
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    Psychosom Med 70:953-9. 2008
    ..To assess genetic variability in two serotonin-related gene polymorphisms (MAOA-uVNTR and 5HTTLPR) and their relationships to depression and adverse cardiac events in a sample of patients undergoing coronary artery bypass surgery...
  16. ncbi Exacerbation of systemic inflammation and increased cerebral infarct volume with cardiopulmonary bypass after focal cerebral ischemia in the rat
    H Mayumi Homi
    Division of Cardiothoracic Anesthesiology and Critical Care Medicine, Department of Anesthesiology, Duke University Medical Center, Durham, NC, USA
    J Thorac Cardiovasc Surg 140:660-6, 666.e1. 2010
    ..We hypothesized that cardiopulmonary bypass, through an enhanced systemic inflammatory response, might affect outcomes after focal cerebral ischemia...
  17. ncbi Genetic variants in P-selectin and C-reactive protein influence susceptibility to cognitive decline after cardiac surgery
    Joseph P Mathew
    Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina
    J Am Coll Cardiol 49:1934-42. 2007
    ....
  18. ncbi Preliminary report on the interaction of apolipoprotein E polymorphism with aortic atherosclerosis and acute nephropathy after CABG
    G Burkhard Mackensen
    Division of Cardiothoracic Anesthesia and Critical Care Medicine, Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    Ann Thorac Surg 78:520-6. 2004
    ..We hypothesized that patients with and without the epsilon4 allele (E4/non-E4) would have different associations between atheroma burden and postoperative renal dysfunction...
  19. ncbi Aprotinin improves functional outcome but not cerebral infarct size in an experimental model of stroke during cardiopulmonary bypass
    H Mayumi Homi
    Department of Anesthesiology, Division of Pediatric Anesthesia, Duke University, Durham, North Carolina, USA
    Anesth Analg 111:38-45. 2010
    ..We designed this study to determine whether an antiinflammatory dose of aprotinin could improve the histologic and functional neurologic outcome in a rat model of focal cerebral ischemia during CPB...
  20. ncbi Effects of extreme hemodilution during cardiac surgery on cognitive function in the elderly
    Joseph P Mathew
    Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Anesthesiology 107:577-84. 2007
    ....
  21. ncbi Deterioration of regional wall motion immediately after coronary artery bypass graft surgery is associated with long-term major adverse cardiac events
    Madhav Swaminathan
    Duke University Medical Center, Department of Anesthesiology, Box 3094, Durham, North Carolina 27710, USA
    Anesthesiology 107:739-45. 2007
    ..Therefore, the authors hypothesized that deterioration in intraoperative left ventricular regional wall motion immediately after CABG surgery is associated with a higher risk of adverse cardiac events...
  22. ncbi Perfluorocarbon administration during cardiopulmonary bypass in rats: an inflammatory link to adverse outcome?
    Fellery de Lange
    Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina, USA
    Anesth Analg 106:24-31, table of contents. 2008
    ..We designed this study to evaluate the effect of a 60% PFC emulsion (perfluoro-tert-butylcyclohexane; PTBCH) on the inflammatory response and neurocognitive outcome of rats after CPB...
  23. ncbi Preoperative statin therapy does not reduce cognitive dysfunction after cardiopulmonary bypass
    Joseph P Mathew
    Division of Cardiothoracic Anesthesiology and Critical Care Medicine, Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    J Cardiothorac Vasc Anesth 19:294-9. 2005
    ....
  24. ncbi Intraoperative hyperglycemia and cognitive decline after CABG
    Ferenc Puskas
    Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Ann Thorac Surg 84:1467-73. 2007
    ..The factors influencing its incidence and severity are not completely known. We hypothesized that hyperglycemia, which is known to exacerbate other forms of cerebral injury, may exacerbate NCD after cardiac operations...
  25. ncbi The rewarming rate and increased peak temperature alter neurocognitive outcome after cardiac surgery
    Alina M Grigore
    Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Anesth Analg 94:4-10, table of contents. 2002
    ..These results suggest that a slower rewarming rate with lower peak temperatures during CPB may be an important factor in the prevention of neurocognitive decline after hypothermic CPB...
  26. ncbi Central nervous system injury associated with cardiac surgery
    Mark F Newman
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 277110, USA
    Lancet 368:694-703. 2006
    ..We describe these issues and the controversies that merit continued investigation...
  27. ncbi Xenon and the inflammatory response to cardiopulmonary bypass in the rat
    Jeffrey A Clark
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    J Cardiothorac Vasc Anesth 19:488-93. 2005
    ..CONCLUSIONS: Xenon appears to have no effect on the inflammatory response to cardiopulmonary bypass, making its previously described neuroprotective effect during cardiopulmonary bypass likely independent of any inflammation modulation...
  28. ncbi Cytokine secretion after cardiac surgery and its relationship to postoperative fever
    John D Mitchell
    Department of Anesthesiology and Critical Care Medicine, Division of Cardiothoracic Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    Cytokine 38:37-42. 2007
    ..Of note is the previously undescribed bimodal pattern of cytokines' secretion after CABG. The association of fever with IL-6 levels suggests inflammatory mediation...
  29. ncbi Transcranial Doppler emboli count predicts rise in creatinine after coronary artery bypass graft surgery
    Gautam M Sreeram
    Department of Anesthesiology, Duke Heart Center, Duke University Medical Center, Durham, NC, USA
    J Cardiothorac Vasc Anesth 18:548-51. 2004
    ..To examine the correlation between transcranial Doppler ultrasonography-detected emboli during coronary artery bypass graft surgery with cardiopulmonary bypass and renal dysfunction as determined by the postoperative change in creatinine...
  30. ncbi The effect of limited rewarming and postoperative hypothermia on cognitive function in a rat cardiopulmonary bypass model
    Fellery de Lange
    Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina, USA
    Anesth Analg 106:739-45, table of contents. 2008
    ..In this study, we investigated the relative influence of CPB temperature, rewarming strategies, and postoperative temperature in a rat CPB model...
  31. ncbi Preoperative low molecular weight heparin reduces heparin responsiveness during cardiac surgery
    Shahar Bar-Yosef
    Department of Anesthesiology, Duke University Medical Center, Box 3094, Durham, NC 27710, USA
    Can J Anaesth 54:107-13. 2007
    ..The current study examines the effect of preoperative LMWH therapy on subsequent heparin responsiveness during cardiac surgery...
  32. ncbi The impact of postoperative atrial fibrillation on neurocognitive outcome after coronary artery bypass graft surgery
    Timothy O Stanley
    Departments of Anesthesiology, Psychiatry and Behavioral Sciences, Medicine (Neurology, and Surgery, Duke University Medical Center, Durham, North Carolina
    Anesth Analg 94:290-5, table of contents. 2002
    ..The relationship between atrial fibrillation and neurocognitive dysfunction has not been examined. Our study shows that postoperative atrial fibrillation is associated with neurocognitive decline...
  33. ncbi Prevention of cerebral hyperthermia during cardiac surgery by limiting on-bypass rewarming in combination with post-bypass body surface warming: a feasibility study
    Shahar Bar-Yosef
    Department of Anesthesiology, Duke University Medical Center, Box 3094, Durham, NC 27710, USA
    Anesth Analg 99:641-6, table of contents. 2004
    ..7 degrees C +/- 0.5 degrees C; P = 0.024). We conclude that limiting rewarming during CPB, when used in combination with surface warming, can prevent cerebral hyperthermia while minimizing the risk of postoperative hypothermia[corrected]...
  34. ncbi Neuroprotection during cardiac surgery
    Hilary P Grocott
    Department of Anesthesiology, Duke University Medical Center, Box 3094, Durham, NC 27710, USA
    J Anesth 21:367-77. 2007
    ..Although numerous studies have focused on a pharmacologic solution, more success has been found with nonpharmacologic strategies, including optimal temperature management and reducing emboli generation...
  35. ncbi Cardiopulmonary bypass reduces the minimum alveolar concentration for isoflurane
    Hong Yang
    Department of Anesthesiology (Multidisciplinary Neuroprotection Laboratories, Duke University Medical Center, Durham, NC, USA
    J Cardiothorac Vasc Anesth 18:620-3. 2004
    ..99% +/- 0.14% (p = 0.0032). CONCLUSIONS: CPB resulted in a small (10%) but significant reduction in the MAC for isoflurane. The mechanism behind this reduction in MAC is not clear but may be related to CPB-induced cerebral injury...
  36. ncbi A randomized controlled trial of the Arctic Sun Temperature Management System versus conventional methods for preventing hypothermia during off-pump cardiac surgery
    Hilary P Grocott
    Department of Anesthesiology and Surgery, Duke University Medical Center, Durham, North Carolina
    Anesth Analg 98:298-302, table of contents. 2004
    ..IMPLICATIONS: The Arctic Sun Temperature Management System was more effective than conventional methods in preventing hypothermia during off-pump coronary artery bypass graft surgery...
  37. ncbi Novel diagnostic test for acute stroke
    John R Lynch
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Stroke 35:57-63. 2004
    ..Such a test may also be helpful in identifying stroke patients in the prehospital setting so that they could be fast-tracked to an institution equipped to care for patients with acute stroke...
  38. ncbi Association of neurocognitive function and quality of life 1 year after coronary artery bypass graft (CABG) surgery
    Barbara Phillips-Bute
    Department of Anesthesiology, Box 3094, DUMC, Duke University Medical Center, Durham, North Carolina 27710, USA
    Psychosom Med 68:369-75. 2006
    ..We sought to determine the impact of this postoperative cognitive dysfunction on quality of life (QOL) and to characterize the dysfunction from the patient's perspective...
  39. ncbi Cerebral physiology of cardiac surgical patients treated with the perfluorocarbon emulsion, AF0144
    Steven E Hill
    Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Ann Thorac Surg 80:1401-7. 2005
    ....
  40. ncbi The "sandblasting" effect of aortic cannula on arch atheroma during cardiopulmonary bypass
    Madhav Swaminathan
    Division of Cardiothoracic Anesthesiology and Critical Care Medicine, Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Anesth Analg 104:1350-1. 2007
  41. ncbi A novel survival model of cardioplegic arrest and cardiopulmonary bypass in rats: a methodology paper
    Fellery de Lange
    Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina, USA
    J Cardiothorac Surg 3:51. 2008
    ..We developed a new in vivo survival model that combines administration of antegrade cardioplegia with endoaortic crossclamping during cardiopulmonary bypass (CPB) in the rat...
  42. ncbi Severe hypotension is not essential for isoflurane neuroprotection against forebrain ischemia in mice
    H Mayumi Homi
    Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Anesthesiology 99:1145-51. 2003
    ..This indicates that beneficial effects of isoflurane are most likely attributable to direct effects at the neuronal level as opposed to indirect effects resulting from interactions with profound hypotension...
  43. ncbi Preliminary evaluation of the Arctic Sun temperature-controlling system during off-pump coronary artery bypass surgery
    Timothy O Stanley
    Department of Anesthesiology, Division of Cardiac Anesthesiology and Critical Care Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Ann Thorac Surg 75:1140-4. 2003
    ..8 degrees C vs 78.1 degrees C x minutes, p = 0.0001). CONCLUSIONS: The Arctic Sun temperature-controlling system is more effective than conventional warming methods in preventing hypothermia during OPCAB surgery...
  44. ncbi Postoperative hyperthermia following off-pump versus on-pump coronary artery bypass surgery
    Jeffrey A Clark
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    J Cardiothorac Vasc Anesth 19:426-9. 2005
    ..The reasons for a lower incidence and severity of hyperthermia after OPCAB surgery are not known, but may be related to a reduced inflammatory response...
  45. ncbi Differential cardiac gene expression during cardiopulmonary bypass: ischemia-independent upregulation of proinflammatory genes
    Mihai V Podgoreanu
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    J Thorac Cardiovasc Surg 130:330-9. 2005
    ..By using microarray technology, this study examines myocardial gene expression responses to cardiopulmonary bypass in the absence of cardioplegic arrest and ischemia-reperfusion injury...
  46. ncbi Change in plasma glutamate concentration during cardiac surgery is a poor predictor of cognitive outcome
    James D Reynolds
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    J Cardiothorac Vasc Anesth 16:431-6. 2002
    ....
  47. ncbi Hemodilution during cardiopulmonary bypass increases cerebral infarct volume after middle cerebral artery occlusion in rats
    H Mayumi Homi
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Anesth Analg 99:974-81, table of contents. 2004
    ..043). In this experimental model of CPB with reversible MCAO-induced focal cerebral ischemia, hemodilution worsened neurological function and increased cerebral infarct volume...
  48. ncbi Effect of combined anticoagulation using heparin and bivalirudin on the hemostatic and inflammatory responses to cardiopulmonary bypass in the rat
    Ian J Welsby
    Department of Anesthesiology, Duke University Medical Center, NC 27710, USA
    Anesthesiology 106:295-301. 2007
    ....
  49. ncbi The effect of blood pressure on cerebral outcome in a rat model of cerebral air embolism during cardiopulmonary bypass
    Ma Qing
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    J Thorac Cardiovasc Surg 142:424-9. 2011
    ..This study was designed to investigate the influence of mean arterial pressures on cerebral functional and histologic outcome after cerebral air embolism during cardiopulmonary bypass in an established rat model...
  50. ncbi Neuroprotection during cardiac surgery
    Niamh Conlon
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    Expert Rev Cardiovasc Ther 6:503-20. 2008
    ..Past, present and future directions in the field of neuroprotection in cardiac surgery will be discussed...
  51. ncbi Longitudinal assessment of neurocognitive function in rats after cardiopulmonary bypass: evidence for long-term deficits
    H Mayumi Homi
    Department of Anesthesiology, Duke University Medical Center, Durham, NC, USA
    J Cardiothorac Vasc Anesth 24:293-9. 2010
    ..The objective of this study was to evaluate the effects of CPB on long-term neurocognitive function in the rat...
  52. ncbi Perioperative temperature and cardiac surgery
    Hilary P Grocott
    Duke University Medical Center, Durham, North Carolina, USA
    J Extra Corpor Technol 38:77-80. 2006
  53. ncbi Renal medullary hypoxia during experimental cardiopulmonary bypass: a pilot study
    Mark Stafford-Smith
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    Perfusion 20:53-8. 2005
    ..To determine the effect of cardiopulmonary bypass (CPB) on renal medullary oxygenation...
  54. ncbi Brief report: The declining incidence of cerebral hyperthermia during cardiac surgery: a seven-year experience in 6,334 patients
    William B Corkey
    Department of Anesthesiology, Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Can J Anaesth 52:626-9. 2005
    ....
  55. ncbi Cardiopulmonary bypass decreases G protein-coupled receptor kinase activity and expression in human peripheral blood mononuclear cells
    Scott A Hagen
    Pediatric Critical Care Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Anesthesiology 98:343-8. 2003
    ..This is important because GRKs regulate the function of G protein-coupled receptors involved in inflammation...
  56. ncbi Apolipoprotein E4 increases aortic atheroma burden in cardiac surgical patients
    Lian K Ti
    Division of Cardiothoracic Anesthesiology, Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    J Thorac Cardiovasc Surg 125:211-3. 2003
  57. ncbi Left ventricular endocardial irregularity: evaluation using epicardial echocardiography
    Christopher F Sulzer
    Department of Anesthesiology, Division of Cardiothoracic Anesthesia, Duke University Medical Center, Durham, NC 27710, USA
    J Cardiothorac Vasc Anesth 21:305-6. 2007
  58. ncbi The neuroprotective effect of xenon administration during transient middle cerebral artery occlusion in mice
    H Mayumi Homi
    Department of Anesthesiology (Multidisciplinary Neuroprotection Laboratories, Duke University Medical Center, Durham, North Carolina, USA
    Anesthesiology 99:876-81. 2003
    ..0009). CONCLUSIONS: In this model of transient focal cerebral ischemia, xenon administration improved both functional and histologic outcome...
  59. ncbi Genetics and outcome after cardiac surgery
    Hilary P Grocott
    Duke University Medical Center, Durham, North Carolina, USA
    J Extra Corpor Technol 38:49-51. 2006
  60. ncbi Con: Methylprednisolone is not indicated for patients during cardiopulmonary bypass
    Christopher F Sulzer
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    J Cardiothorac Vasc Anesth 19:255-8. 2005
  61. ncbi Effect of apolipoprotein E genotype on cerebral autoregulation during cardiopulmonary bypass
    L K Ti
    Division of Cardiothoracic Anesthesiology and Critical Care, Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    Stroke 32:1514-9. 2001
    ....
  62. ncbi Reduction in air bubble size using perfluorocarbons during cardiopulmonary bypass in the rat
    Kenji Yoshitani
    Department of Anesthesiology, Duke University Medical Center, DMUC Box 3094, Durham, NC 27710, USA
    Anesth Analg 103:1089-93. 2006
    ..0001). CONCLUSION: The results suggest that PFC administration may be useful in reducing the volume of gaseous bubbles present during CPB...
  63. ncbi A phase II, double-blind, placebo-controlled, ascending-dose study of Eritoran (E5564), a lipid A antagonist, in patients undergoing cardiac surgery with cardiopulmonary bypass
    Elliott Bennett-Guerrero
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    Anesth Analg 104:378-83. 2007
    ..In this study we assessed the safety of eritoran administration in patients undergoing cardiac surgery and obtained preliminary efficacy data for the prophylaxis of endotoxin-mediated surgical complications...
  64. ncbi Asymmetric cerebral near-infrared oximetric measurements during cardiac surgery
    Shahar Bar-Yosef
    Department of Anesthesiology, Division of Veterans Affairs Anesthesia, Box 3094, Duke University Medical Center, Durham, NC 27710, USA
    J Cardiothorac Vasc Anesth 17:773-4. 2003
  65. ncbi Cerebral emboli and serum S100beta during cardiac operations
    H P Grocott
    Department of Anesthesiology, Duke Heart Center, Duke University Medical Center, Durham, North Carolina 27710, USA
    Ann Thorac Surg 65:1645-9; discussion 1649-50. 1998
    ..The purpose of this investigation was to determine the correlation between cerebral microemboli and S100beta levels during cardiac operations...
  66. ncbi Prospective randomized trial of normothermic versus hypothermic cardiopulmonary bypass on cognitive function after coronary artery bypass graft surgery
    A M Grigore
    Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Anesthesiology 95:1110-9. 2001
    ..CONCLUSIONS: Hypothermic CPB does not provide additional central nervous system protection in adult cardiac surgical patients who were maintained at either 30 or 35 degrees C during CPB...
  67. ncbi Apolipoprotein E polymorphisms and age at first coronary artery bypass graft
    M F Newman
    Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Anesth Analg 92:824-9. 2001
    ..Individuals with the apoE4 allele presented earlier for CABG, and the apoE4 allele is linked to age at first CABG...
  68. ncbi Post-ischemic RSR13 amplifies the effect of dizocilpine on outcome from transient focal cerebral ischemia in the rat
    G B Mackensen
    Department of Anesthesiology, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Brain Res 853:15-21. 2000
    ..The results also support the concept that neuroprotective strategies, which combine drugs with different mechanisms of action, may yield cumulative benefits...
  69. ncbi Report of the substudy assessing the impact of neurocognitive function on quality of life 5 years after cardiac surgery
    M F Newman
    Department of Anesthesiology, Division of Neurology, Duke University Medical Center, Durham, NC, USA
    Stroke 32:2874-81. 2001
    ..The purpose of our investigation was to determine the association between cognitive dysfunction and long-term quality of life after cardiac surgery...
  70. ncbi Cardiopulmonary bypass induces neurologic and neurocognitive dysfunction in the rat
    G B Mackensen
    Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Anesthesiology 95:1485-91. 2001
    ..CONCLUSIONS: CPB caused both neurologic and neurocognitive impairment in a rodent recovery model. This model could potentially facilitate the investigation of CPB-related injury mechanisms and possible neuroprotective interventions...
  71. ncbi Inflammatory gene polymorphisms and risk of postoperative myocardial infarction after cardiac surgery
    M V Podgoreanu
    Department of Anesthesiology, Box 3094, Duke University Medical Center, Durham, NC 27710, USA
    Circulation 114:I275-81. 2006
    ..We tested the hypothesis that candidate gene polymorphisms in inflammatory pathways contribute to risk of PMI after cardiac surgery...
  72. ncbi Differential cerebral gene expression during cardiopulmonary bypass in the rat: evidence for apoptosis?
    Yukie Sato
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    Anesth Analg 94:1389-94, table of contents. 2002
    ....
  73. ncbi Glucose and outcome after cardiac surgery: what are the issues?
    Hilary P Grocott
    Duke University Medical Center, Durham, North Carolina, USA
    J Extra Corpor Technol 38:65-7. 2006
  74. ncbi Cerebral embolization during cardiac surgery: impact of aortic atheroma burden
    G B Mackensen
    Division of Cardiothoracic Anesthesiology and Critical Care Medicine, Department of Anesthesiology, Box 3094, Duke University Medical Center, Durham, NC 27710, USA
    Br J Anaesth 91:656-61. 2003
    ..Previously demonstrated associations between TCD-detectable cerebral emboli and adverse cerebral outcome may be related to the presence of significant aortic atheromatous disease...
  75. ncbi Cardiopulmonary bypass and long-term neurocognitive dysfunction in the rat
    Jan M Dieleman
    Division of Perioperative Care and Emergency Medicine, University Medical Center Utrecht, PO Box 85500, mail stop Q04 2 313, 3508 GA Utrecht, The Netherlands
    Life Sci 79:551-8. 2006
    ..Similar cytokine patterns in both operated groups suggest that surgical trauma rather than exposure of blood to extra-corporeal circuit was probably responsible for the inflammatory response...
  76. ncbi False increase BIS values with forced-air head warming
    Hilary P Grocott
    Anesth Analg 96:1230. 2003
  77. ncbi Lower endotoxin immunity predicts increased cognitive dysfunction in elderly patients after cardiac surgery
    Joseph P Mathew
    Department of Anesthesiology
    Stroke 34:508-13. 2003
    ..Interventions that increase IgM EndoCAb levels might improve cognitive function after cardiac surgery...
  78. ncbi An evidence-based review of the practice of cardiopulmonary bypass in adults: a focus on neurologic injury, glycemic control, hemodilution, and the inflammatory response
    Kenneth G Shann
    J Thorac Cardiovasc Surg 132:283-90. 2006
  79. ncbi Oxygen toxicity during one-lung ventilation: is it time to re-evaluate our practice?
    Hilary P Grocott
    I H Asper Clinical Research Institute, CR3008 369 Tache Avenue, Winnipeg, Manitoba, Canada R2H 2A6
    Anesthesiol Clin 26:273-80, v. 2008
    ..Continued efforts are needed to improve overall outcome in these patients, including a reevaluation of our management of oxygen therapy...
  80. ncbi High spinal anesthesia for cardiac surgery: effects on beta-adrenergic receptor function, stress response, and hemodynamics
    Trevor W R Lee
    Department of Anesthesia, Health Sciences Center, University of Manitoba, Canada
    Anesthesiology 98:499-510. 2003
    ..CONCLUSIONS: High-dose intrathecal bupivacaine, when combined with general anesthesia, resulted in less beta-receptor dysfunction and a lower stress response during coronary artery bypass graft surgery...
  81. ncbi Pharmacologic neuroprotection: the search continues
    Hilary P Grocott
    University of Manitoba, Winnipeg, Canada
    J Extra Corpor Technol 39:296-301. 2007
    ..This review summarizes the past, present, and future of pharmacologic neuroprotection for cardiac surgery...
  82. ncbi Xenon attenuates cardiopulmonary bypass-induced neurologic and neurocognitive dysfunction in the rat
    Daqing Ma
    Department of Anesthetics, Imperial College of Science, Technology and Medicine, London, United Kingdom
    Anesthesiology 98:690-8. 2003
    ..CONCLUSION: These data indicate that CPB-induced neurologic and neurocognitive dysfunction can be attenuated by the administration of xenon, potentially related to its neuroprotective effect via N-methyl-D-aspartate receptor antagonism...
  83. ncbi S100beta and postcardiac surgery neurological dysfunction: reasons to disregard any link
    Hilary P Grocott
    Can J Anaesth 52:441-2; author reply 442-3. 2005
  84. ncbi Apolipoprotein E genotype and S100beta after cardiac surgery: is inflammation the link?
    Hilary P Grocott
    Anesth Analg 100:1869-70; author reply 1870. 2005