Dongliang Ge

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. ncbi WGAViewer: software for genomic annotation of whole genome association studies
    Dongliang Ge
    Center for Population Genomics and Pharmacogenetics, Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina 27708, USA
    Genome Res 18:640-3. 2008
  2. ncbi SVA: software for annotating and visualizing sequenced human genomes
    Dongliang Ge
    Center for Human Genome Variation, Duke University School of Medicine, Durham, North Carolina 27708, USA
    Bioinformatics 27:1998-2000. 2011
  3. ncbi Host determinants of HIV-1 control in African Americans
    Kimberly Pelak
    Center for Human Genome Variation, Duke University Medical School, Durham, North Carolina, USA
    J Infect Dis 201:1141-9. 2010
  4. ncbi Common genetic variation and the control of HIV-1 in humans
    Jacques Fellay
    Center for Human Genome Variation, Duke Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina, USA
    PLoS Genet 5:e1000791. 2009
  5. ncbi Variants in the ITPA gene protect against ribavirin-induced hemolytic anemia and decrease the need for ribavirin dose reduction
    Alexander J Thompson
    Duke Clinical Research Institute, Durham, North Carolina 27715, USA
    Gastroenterology 139:1181-9. 2010
  6. ncbi Screening the human exome: a comparison of whole genome and whole transcriptome sequencing
    Elizabeth T Cirulli
    Center for Human Genome Variation, Duke University School of Medicine, Box 91009, Durham, NC 27708, USA
    Genome Biol 11:R57. 2010
  7. ncbi ITPA gene variants protect against anaemia in patients treated for chronic hepatitis C
    Jacques Fellay
    Institute for Genome Sciences and Policy, Center for Human Genome Variation, Duke University, Durham, North Carolina 27708, USA
    Nature 464:405-8. 2010
  8. ncbi Interleukin-28B polymorphism improves viral kinetics and is the strongest pretreatment predictor of sustained virologic response in genotype 1 hepatitis C virus
    Alexander J Thompson
    Duke Clinical Research Institute, Durham, North Carolina, USA
    Gastroenterology 139:120-9.e18. 2010
  9. ncbi Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance
    Dongliang Ge
    Institute for Genome Sciences and Policy, Center for Human Genome Variation, Duke University, Durham, North Carolina 27708, USA
    Nature 461:399-401. 2009
  10. ncbi Copy number variation of KIR genes influences HIV-1 control
    Kimberly Pelak
    Center for Human Genome Variation, Duke University School of Medicine, Durham, North Carolina, USA
    PLoS Biol 9:e1001208. 2011

Detail Information

Publications34

  1. ncbi WGAViewer: software for genomic annotation of whole genome association studies
    Dongliang Ge
    Center for Population Genomics and Pharmacogenetics, Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina 27708, USA
    Genome Res 18:640-3. 2008
    ....
  2. ncbi SVA: software for annotating and visualizing sequenced human genomes
    Dongliang Ge
    Center for Human Genome Variation, Duke University School of Medicine, Durham, North Carolina 27708, USA
    Bioinformatics 27:1998-2000. 2011
    ..We illustrate the annotation features of SVA using two simple examples of sequenced genomes that harbor Mendelian mutations. Availability and implementation: Freely available on the web at http://www.svaproject.org...
  3. ncbi Host determinants of HIV-1 control in African Americans
    Kimberly Pelak
    Center for Human Genome Variation, Duke University Medical School, Durham, North Carolina, USA
    J Infect Dis 201:1141-9. 2010
    ....
  4. ncbi Common genetic variation and the control of HIV-1 in humans
    Jacques Fellay
    Center for Human Genome Variation, Duke Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina, USA
    PLoS Genet 5:e1000791. 2009
    ..This study thus represents a comprehensive assessment of common human genetic variation in HIV-1 control in Caucasians...
  5. ncbi Variants in the ITPA gene protect against ribavirin-induced hemolytic anemia and decrease the need for ribavirin dose reduction
    Alexander J Thompson
    Duke Clinical Research Institute, Durham, North Carolina 27715, USA
    Gastroenterology 139:1181-9. 2010
    ..We aimed to replicate this finding in an independent cohort from the Study of Viral Resistance to Antiviral Therapy of Chronic Hepatitis C and to investigate the effects of these variants beyond week 4...
  6. ncbi Screening the human exome: a comparison of whole genome and whole transcriptome sequencing
    Elizabeth T Cirulli
    Center for Human Genome Variation, Duke University School of Medicine, Box 91009, Durham, NC 27708, USA
    Genome Biol 11:R57. 2010
    ..While whole-genome sequencing is the most complete, it remains sufficiently expensive that cost effective alternatives are important...
  7. ncbi ITPA gene variants protect against anaemia in patients treated for chronic hepatitis C
    Jacques Fellay
    Institute for Genome Sciences and Policy, Center for Human Genome Variation, Duke University, Durham, North Carolina 27708, USA
    Nature 464:405-8. 2010
    ..Here we show that genetic variants leading to inosine triphosphatase deficiency, a condition not thought to be clinically important, protect against haemolytic anaemia in hepatitis-C-infected patients receiving RBV...
  8. ncbi Interleukin-28B polymorphism improves viral kinetics and is the strongest pretreatment predictor of sustained virologic response in genotype 1 hepatitis C virus
    Alexander J Thompson
    Duke Clinical Research Institute, Durham, North Carolina, USA
    Gastroenterology 139:120-9.e18. 2010
    ..We sought to confirm the polymorphism's clinical relevance by intention-to-treat analysis evaluating on-treatment virologic response and SVR...
  9. ncbi Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance
    Dongliang Ge
    Institute for Genome Sciences and Policy, Center for Human Genome Variation, Duke University, Durham, North Carolina 27708, USA
    Nature 461:399-401. 2009
    ....
  10. ncbi Copy number variation of KIR genes influences HIV-1 control
    Kimberly Pelak
    Center for Human Genome Variation, Duke University School of Medicine, Durham, North Carolina, USA
    PLoS Biol 9:e1001208. 2011
    ....
  11. ncbi Common genetic variation and performance on standardized cognitive tests
    Elizabeth T Cirulli
    Center for Human Genome Variation, Duke Institute for Genome Sciences and Policy, Duke University, Durham, NC, USA
    Eur J Hum Genet 18:815-20. 2010
    ....
  12. ncbi A genome-wide comparison of the functional properties of rare and common genetic variants in humans
    Qianqian Zhu
    Center for Human Genome Variation, Duke University School of Medicine, Durham, NC 27708, USA
    Am J Hum Genet 88:458-68. 2011
    ....
  13. ncbi A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB
    Anna C Need
    Center for Human Genome Variation, Institute for Genome Sciences and Policy, Duke University, 450 Research Drive, Box 91009, Durham, NC 27708, USA
    Hum Mol Genet 18:4650-61. 2009
    ..We discuss a possible role for rare variation in cognitive genomics...
  14. ncbi Genome-wide association study of interferon-related cytopenia in chronic hepatitis C patients
    Alexander J Thompson
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27701, USA
    J Hepatol 56:313-9. 2012
    ..We performed a genome wide association study on a well-characterized genotype 1 HCV cohort to identify genetic determinants of peginterferon-? (pegIFN)-related thrombocytopenia, neutropenia, and leukopenia...
  15. ncbi Tissue-specific genetic control of splicing: implications for the study of complex traits
    Erin L Heinzen
    Institute for Genome Sciences and Policy, Center for Human Genome Variation, Duke University, Durham, North Carolina, USA
    PLoS Biol 6:e1. 2008
    ....
  16. ncbi A genome-wide investigation of SNPs and CNVs in schizophrenia
    Anna C Need
    Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina, USA
    PLoS Genet 5:e1000373. 2009
    ..On balance, these data suggest that very few schizophrenia patients share identical genomic causation, potentially complicating efforts to personalize treatment regimens...
  17. ncbi Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis
    Anna C Need
    Center for Human Genome Variation, Institute for Genome Sciences and Policy, Duke University, Durham, NC 27708, USA
    Eur J Hum Genet 17:946-57. 2009
    ..On current evidence it is impossible to know which of these associations may be real, although in total they form a valuable resource that is immediately available to the scientific community...
  18. ncbi A whole-genome association study of major determinants for host control of HIV-1
    Jacques Fellay
    Center for Population Genomics and Pharmacogenetics, Duke Institute for Genome Sciences and Policy, Duke University, Durham, NC 27710, USA
    Science 317:944-7. 2007
    ..These findings emphasize the importance of studying human genetic variation as a guide to combating infectious agents...
  19. ncbi Rare deletions at 16p13.11 predispose to a diverse spectrum of sporadic epilepsy syndromes
    Erin L Heinzen
    Center for Human Genome Variation, School of Medicine, Duke University, Durham, NC 27708, USA
    Am J Hum Genet 86:707-18. 2010
    ..Collectively, these data implicate 16p13.11 and possibly other large deletions as risk factors for a wide range of epilepsy disorders, and they appear to point toward haploinsufficiency as a contributor to the pathogenicity of deletions...
  20. ncbi Genetic regulation of alpha-synuclein mRNA expression in various human brain tissues
    Colton Linnertz
    Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, North Carolina, United States of America
    PLoS ONE 4:e7480. 2009
    ..We provide evidence for functional consequences of PD-associated SNCA gene variants in disease relevant brain tissues, suggesting that genetic regulation of SNCA expression plays an important role in the development of the disease...
  21. ncbi Association of common JAK2 variants with body fat, insulin sensitivity and lipid profile
    Dongliang Ge
    Center for Population Genomics and Pharmacogenetics, Duke University, Durham, NC, USA
    Obesity (Silver Spring) 16:492-6. 2008
    ..Although JAK2 is a critical element in leptin and insulin signaling and has a role in cellular cholesterol transport, we failed to establish associations of common SNPs with relevant phenotypes in this human study...
  22. ncbi The state of genome-wide association studies in pulmonary disease: a new perspective
    Jamie L Todd
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Am J Respir Crit Care Med 184:873-80. 2011
    ....
  23. ncbi Long-range LD can confound genome scans in admixed populations
    Alkes L Price
    Am J Hum Genet 83:132-5; author reply 135-9. 2008
  24. ncbi Genome-wide association scan identifies a prostaglandin-endoperoxide synthase 2 variant involved in risk of knee osteoarthritis
    Ana M Valdes
    Twin Research Unit, St Thomas Hospital Campus, Kings College London School of Medicine, London SE1 7EH, UK
    Am J Hum Genet 82:1231-40. 2008
    ..Our results and previous studies on the role of the cyclooxygenase 2 enzyme encoded by PTGS2 underscore the importance of this signaling pathway in the pathogenesis of knee OA...
  25. ncbi Genetic susceptibility loci for essential hypertension and blood pressure on chromosome 17 in 147 Chinese pedigrees
    Fangyi Gu
    Division of Population Genetics and Prevention, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China
    J Hypertens 22:1511-8. 2004
    ..82 for qualitative trait using GENEHUNTER. CONCLUSIONS: In the southern population of China, our results demonstrate that a 7-cM interval region flanked by D17S831 (7 cM) and D17S938 (15 cM) is suggestively linked with hypertension...
  26. ncbi Association study with 33 single-nucleotide polymorphisms in 11 candidate genes for hypertension in Chinese
    Dongfeng Gu
    Division of Population Genetics and Prevention, Fu Wai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China
    Hypertension 47:1147-54. 2006
    ..These findings support the multigenic nature of the etiology of essential hypertension and propose a potential gene-gene interactive model for future studies...
  27. ncbi Association of alpha1A adrenergic receptor gene variants on chromosome 8p21 with human stage 2 hypertension
    Dongfeng Gu
    Division of Population Genetics and Prevention, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    J Hypertens 24:1049-56. 2006
    ..2, with essential hypertension in a northern Han Chinese population...
  28. ncbi Joint linkage and association of six single-nucleotide polymorphisms in the factor XIII-A subunit gene point to V34L as the main functional locus
    Marlies de Lange
    Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, London, UK
    Arterioscler Thromb Vasc Biol 26:1914-9. 2006
    ..The current study investigated 6 single-nucleotide polymorphisms (SNPs) within the FXIII A-subunit gene to locate functional polymorphism(s) responsible for variation in FXIII activation...
  29. ncbi Multilocus analyses of Renin-Angiotensin-aldosterone system gene variants on blood pressure at rest and during behavioral stress in young normotensive subjects
    Dongliang Ge
    Georgia Prevention Institute, Department of Pediatrics, Medical College of Georgia, Augusta 30912 3715, USA
    Hypertension 49:107-12. 2007
    ..We proposed a viable approach to test for the multiple genetic contributions to BP and hypertension...
  30. ncbi The SH2B gene is associated with serum leptin and body fat in normal female twins
    Yalda Jamshidi
    Nutrition Food and Health Research Centre, King s College London, Franklin Wilkins Building, 150 Stamford Street, London SE1 9NH, UK
    Obesity (Silver Spring) 15:5-9. 2007
    ..If SH2-B signaling is attenuated in diet-induced obesity, it could become a target for drug-induced leptin sensitization...
  31. ncbi Large recurrent microdeletions associated with schizophrenia
    Hreinn Stefansson
    CNS Division, deCODE Genetics, Sturlugata 8, IS 101 Reykjavik, Iceland
    Nature 455:232-6. 2008
    ..CNV analysis may also point the way to the identification of additional and more prevalent risk variants in genes and pathways involved in schizophrenia...
  32. ncbi Multicentre search for genetic susceptibility loci in sporadic epilepsy syndrome and seizure types: a case-control study
    Gianpiero L Cavalleri
    Department of Clinical Neurological Sciences and Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland Research Institute, and Division of Neurology, Beaumont Hospital, Dublin, Ireland
    Lancet Neurol 6:970-80. 2007
    ..The Epilepsy Genetics (EPIGEN) Consortium was established to undertake genetic mapping analyses with augmented statistical power to detect variants that influence the development and treatment of common forms of epilepsy...
  33. ncbi A functional intronic variant in the tyrosine hydroxylase (TH) gene confers risk of essential hypertension in the Northern Chinese Han population
    Laiyuan Wang
    Department of Evidence Based Medicine, Division of Population Genetics, Cardiovascular Institute, Fu Wai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China
    Clin Sci (Lond) 115:151-8. 2008
    ..These results provide evidence for an association of the functional intronic rs2070762 with essential hypertension...
  34. ncbi Lipoprotein lipase gene polymorphisms and blood pressure levels in the Northern Chinese Han population
    Biao Li
    Institute of Biophysics, Chinese Academy of Sciences, Beijing, PR China
    Hypertens Res 27:373-8. 2004
    ....