Research Topics
Species | Feng GaoSummaryAffiliation: Duke University Medical Center Country: USA Publications
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Publications
Centralized HIV-1 envelope immunogens and neutralizing antibodiesFeng Gao
Duke Human Vaccine Institute, Duke University Medical Center, Durham NC 27710, USA
Curr HIV Res 5:572-7. 2007....- Cross-reactive monoclonal antibodies to multiple HIV-1 subtype and SIVcpz envelope glycoproteinsFeng Gao
Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC 27710, USA
Virology 394:91-8. 2009..Nonetheless, such mAbs represent valuable reagents to study the biochemistry and structural biology of Env protein oligomers... - Antigenicity and immunogenicity of a synthetic human immunodeficiency virus type 1 group m consensus envelope glycoproteinFeng Gao
Department of Medicine, Duke University Medical Center, 112 Research Park III, Research Dr, Box 3347, Durham, NC 27710, USA
J Virol 79:1154-63. 2005..Thus, the computer-generated "consensus" env genes are capable of expressing envelope glycoproteins that retain the structural, functional, and immunogenic properties of wild-type HIV-1 envelopes... - Unselected mutations in the human immunodeficiency virus type 1 genome are mostly nonsynonymous and often deleteriousFeng Gao
Department of Medicine, Duke University Medical Center, Duke University, Durham, North Carolina 27710, USA
J Virol 78:2426-33. 2004.... - Cross-subtype T-cell immune responses induced by a human immunodeficiency virus type 1 group m consensus env immunogenEric A Weaver
Duke Human Vaccine Institute, Duke University Medical Center, 112 RPIII, Research Drive, Box 3347, DUMC, Durham, NC 27710, USA
J Virol 80:6745-56. 2006.... - Genetic and neutralization properties of subtype C human immunodeficiency virus type 1 molecular env clones from acute and early heterosexually acquired infections in Southern AfricaMing Li
Department of Surgery, Laboratory for AIDS Vaccine Research and Development, Duke University Medical Center, Durham, NC 27710, USA
J Virol 80:11776-90. 2006..A subset of these gp160 clones are suitable for use as reference reagents to facilitate standardized assessments of vaccine-elicited neutralizing antibody responses... - Prolonged exposure of the HIV-1 gp41 membrane proximal region with L669S substitutionXiaoying Shen
Department of Surgery, Duke Human Vaccine Institute, Duke University, Durham, NC 27710, USA
Proc Natl Acad Sci U S A 107:5972-7. 2010..These data suggest that a major contribution to the L669S mutant virus phenotype of enhanced susceptibility to MPER mAbs is prolonged exposure of the MPER neutralizing epitope during viral entry... - A group M consensus envelope glycoprotein induces antibodies that neutralize subsets of subtype B and C HIV-1 primary virusesHua Xin Liao
Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA
Virology 353:268-82. 2006..Our study also shows the feasibility of iterative improvements in Env immunogenicity by rational design of centralized genes... - In vivo gp41 antibodies targeting the 2F5 monoclonal antibody epitope mediate human immunodeficiency virus type 1 neutralization breadthXiaoying Shen
Duke Human Vaccine Institute, Duke University Medicine Center, Durham, NC 27710, USA
J Virol 83:3617-25. 2009..Our findings suggest that multiple events (i.e., genetic predisposition and HIV-1 immune dysregulation) may be required for induction of broadly reactive gp41 MPER antibodies in natural infection... - Identification of amino acid substitutions associated with neutralization phenotype in the human immunodeficiency virus type-1 subtype C gp120Jennifer L Kirchherr
Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC 27710, USA
Virology 409:163-74. 2011..Identification of such potential neutralization signatures may have important implications for the development of HIV-1 vaccines capable of inducing Nabs to subtype C HIV-1... - Initial antibodies binding to HIV-1 gp41 in acutely infected subjects are polyreactive and highly mutatedHua Xin Liao
Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA
J Exp Med 208:2237-49. 2011..These data suggest that the majority of gp41-binding antibodies produced after acute HIV-1 infection are cross-reactive responses generated by stimulating memory B cells that have previously been activated by non-HIV-1 antigens... - Human immunodeficiency virus type 1 env clones from acute and early subtype B infections for standardized assessments of vaccine-elicited neutralizing antibodiesMing Li
Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
J Virol 79:10108-25. 2005..These reference reagents will facilitate proficiency testing and other validation efforts aimed at improving assay performance across laboratories and can be used for standardized assessments of vaccine-elicited neutralizing antibodies... - Centralized immunogens as a vaccine strategy to overcome HIV-1 diversityFeng Gao
The Duke Human Vaccine Institute, Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA
Expert Rev Vaccines 3:S161-8. 2004..It is biologically functional and preserves antigenicity similar to contemporary Env proteins. Most importantly, the group M consensus Env immunogen can elicit both T- and B-cell responses to wild-type HIV-1 isolates... - Dynamic antibody specificities and virion concentrations in circulating immune complexes in acute to chronic HIV-1 infectionPinghuang Liu
Duke Human Vaccine Institute, Duke University, Durham, North Carolina, USA
J Virol 85:11196-207. 2011.... - High throughput functional analysis of HIV-1 env genes without cloningJennifer L Kirchherr
Duke Human Vaccine Institute and Center for HIV AIDS Vaccine Immunology, Department of Medicine, Duke University Medical Center, 112 RPIII, Research Drive, Box 3347, Durham, NC 27710, USA
J Virol Methods 143:104-11. 2007..The new pPCR method eliminates cloning, transformation, and plasmid DNA preparation steps in the generation of HIV-1 pseudovirions. This allows for quick analysis of multiple env genes from HIV-1 infected individuals... - A prominent low-pH methotrexate transport activity in human solid tumors: contribution to the preservation of methotrexate pharmacologic activity in HeLa cells lacking the reduced folate carrierRongbao Zhao
Department of Medicine, Albert Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Clin Cancer Res 10:718-27. 2004.... - Generation of random mutant libraries with multiple primers in a single reactionXiaozhi Lu
Human Vaccine Institute, Duke University Medical Center, Durham, NC 27710, USA
J Virol Methods 167:146-51. 2010..This novel method can serve as a powerful tool to study the biological phenotypes of genes whose functions are determined by multiple sites... - Codon usage optimization of HIV type 1 subtype C gag, pol, env, and nef genes: in vitro expression and immune responses in DNA-vaccinated miceFeng Gao
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
AIDS Res Hum Retroviruses 19:817-23. 2003.... - New simian immunodeficiency virus infecting De Brazza's monkeys (Cercopithecus neglectus): evidence for a cercopithecus monkey virus cladeFrederic Bibollet-Ruche
Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
J Virol 78:7748-62. 2004..The vpu gene appears to have been acquired by a subset of these Cercopithecus viruses after the divergence of SIVdeb and SIVsyk... - Polyclonal B cell responses to conserved neutralization epitopes in a subset of HIV-1-infected individualsGeorgia D Tomaras
Duke Human Vaccine Institute and Department of Surgery, Duke University Medical Center, Box 2926, Durham, NC 27710, USA
J Virol 85:11502-19. 2011..The broadly reactive HIV-1 neutralization observed in some subjects is mediated by antibodies targeting several conserved regions on the HIV-1 envelope glycoprotein... - Barriers to enrollment in non-small cell lung cancer therapeutic clinical trialsMaria Q Baggstrom
Division of Oncology, Department of Medicine, Washington University School of Medicine, St Louis, Missouri, USA
J Thorac Oncol 6:98-102. 2011..Only a small fraction of patients with lung cancer are enrolled in clinical trials. It is critical to understand the barriers to participation in lung cancer clinical trials... - Amplification and cloning of near full-length HIV-2 genomesFeng Gao
Human Vaccine Institute, Department of Medicine, Duke University Medical Center, Durham, NC, USA
Methods Mol Biol 304:399-407. 2005..The long-range polymerase chain reaction technique has recently become a more preferred method than the lambda phage cloning method to obtain near-full-length HIV-2 genomes... - The role of antibody polyspecificity and lipid reactivity in binding of broadly neutralizing anti-HIV-1 envelope human monoclonal antibodies 2F5 and 4E10 to glycoprotein 41 membrane proximal envelope epitopesS Munir Alam
Department of Medicine, Duke Human Vaccine Institute, Duke University School of Medicine, RP1 Circuit Drive, Durham, NC 27710, USA
J Immunol 178:4424-35. 2007..Taken together, these data demonstrate the similarity of 2F5 and 4E10 mAbs to known anti-cardiolipin Abs and support the model that mAb 2F5 and 4E10 binding to HIV-1 involves both viral lipid membrane and gp41 membrane proximal epitopes... - Evolution of drug-resistant viral populations during interruption of antiretroviral therapyDongning Wang
Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC 27710, USA
J Virol 85:6403-15. 2011..These data provide a more comprehensive understanding of evolution and fitness of drug-resistant viruses in vivo and may lead to improved treatment strategies for ART-experienced patients... - Detection of minor drug-resistant populations by parallel allele-specific sequencingFangping Cai
Duke Human Vaccine Institute, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
Nat Methods 4:123-5. 2007..This assay may serve as a useful tool to study drug resistance in HIV and other infectious agents... - Viremia control despite escape from a rapid and potent autologous neutralizing antibody response after therapy cessation in an HIV-1-infected individualDavid C Montefiori
Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
J Immunol 170:3906-14. 2003..We postulate that an early effective neutralizing Ab response can provide long-term clinical benefits despite neutralization escape... - The cytoprotective effects of tumor necrosis factor are conveyed through tumor necrosis factor receptor-associated factor 2 in the heartJana S Burchfield
Center for Cardiovascular Research, Division of Cardiology, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
Circ Heart Fail 3:157-64. 2010..Noting that the scaffolding protein TNF receptor-associated factor 2 (TRAF2) is common to both TNF receptors, we hypothesized that the cytoprotective responses of TNF were mediated through TRAF2... - Comparative analysis of commercial assays for the detection and quantification of Human Immunodeficiency Virus Type 1 (HIV-1) RNA in plasma from patients infected with HIV-1 subtype CCraig J Hoesley
Department of Medicine, University of Alabama at Birmingham School of Medicine, Birmingham, AL, 35294, USA
Clin Infect Dis 35:323-5. 2002..Each assay detected plasma HIV-1 RNA, but they do not all measure statistically similar quantities of plasma HIV-1 RNA... - Analysis of low-frequency mutations associated with drug resistance to raltegravir before antiretroviral treatmentJia Liu
Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC 27710, USA
Antimicrob Agents Chemother 55:1114-9. 2011..Additional studies in larger populations are warranted to fully understand the clinical implications of these mutations... - Detection of HIV-2 by PCRFeng Gao
Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, Cleveland, OH, USA
Methods Mol Biol 304:191-200. 2005..Phylogenetic analysis of newly obtained sequences with reference sequences can determine the subtype classification or identify new subtypes if the sequences do not belong to any known subtypes... - Targeted and cytotoxic therapy in coordinated sequence (TACTICS): erlotinib, bevacizumab, and standard chemotherapy for non-small-cell lung cancer, a phase II trialEzra E W Cohen
Section of Hematology and Oncology, Department of Medicine, and Comprehensive Cancer Center, University of Chicago, Chicago, IL, USA
Clin Lung Cancer 13:123-8. 2012..This trial focused on optimally combining existing targeted therapies and cytotoxic chemotherapy in the treatment of unselected patients with advanced non-small-cell lung cancer (NSCLC)... - High-throughput isolation of immunoglobulin genes from single human B cells and expression as monoclonal antibodiesHua Xin Liao
Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC, 27710, United States
J Virol Methods 158:171-9. 2009..These Ig gene expression cassettes constitute a highly efficient strategy for rapid expression of Ig genes for high-throughput screening and analysis without cloning... - Molecular epidemiology of human immunodeficiency virus type 1 transmission in a heterosexual cohort of discordant couples in ZambiaStanley A Trask
Department of Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
J Virol 76:397-405. 2002.... - Residues 45 and 404 in the murine reduced folate carrier may interact to alter carrier binding and mobilityRongbao Zhao
Department of Medicine, Albert Einstein College of Medicine Cancer Center, Chanin 2, 1300 Morris Park Avenue, Bronx, NY 10461, USA
Biochim Biophys Acta 1613:49-56. 2003..The results suggest that there is an interaction between the E45 and K404 residues in the first and 11th TMDs, respectively, but that the E45 residue appears to be the more dominant determinant of binding and anion sensitivity... - Primary infection by a human immunodeficiency virus with atypical coreceptor tropismChunlai Jiang
Duke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina 27710, USA
J Virol 85:10669-81. 2011..These results suggest that the ZP6248 T/F virus established an acute in vivo infection by using coreceptor(s) other than CCR5 or CXCR4 or that the CCR5 coreceptor existed in an unusual conformation in this individual... - Dysfunctional high-density lipoprotein and the potential of apolipoprotein A-1 mimetic peptides to normalize the composition and function of lipoproteinsSatoshi Imaizumi
Department of Medicine, University of California, Los Angeles, CA, USA
Circ J 75:1533-8. 2011..This review focuses on recent studies of dysfunctional HDL in animal models and human disease, and the potential of apoA-I mimetic peptides to normalize the composition and function of lipoproteins... - Load-dependent and -independent regulation of proinflammatory cytokine and cytokine receptor gene expression in the adult mammalian heartGeorg Baumgarten
Winters Center for Heart Failure Research, Department of Medicine, Houston VAMC and Baylor College of Medicine, Houston, Tex 77030, USA
Circulation 105:2192-7. 2002.... - Distinctive characteristics of non-small cell lung cancer (NSCLC) in the young: a surveillance, epidemiology, and end results (SEER) analysisJanakiraman Subramanian
Division of Oncology, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Thorac Oncol 5:23-8. 2010..We conducted an analysis of Surveillance, Epidemiology, and End Results data to assess whether the presentation and outcomes of NSCLC in younger patients (age < or =40 years) are different from that in older patients (age >40 years)... - Hypotension induced by activation of the transient receptor potential vanilloid 4 channels: role of Ca2+-activated K+ channels and sensory nervesFeng Gao
Division of Nanomedicine and Molecular Intervention, Department of Medicine, Michigan State University, East Lansing, Michigan, USA
J Hypertens 28:102-10. 2010..To examine the mechanisms involved in hypotension induced by transient receptor potential vanilloid 4 (TRPV4) activation... - Critical role of CD4 help in CD154 blockade-resistant memory CD8 T cell activation and allograft rejection in sensitized recipientsZheng Wu
Department of Surgery, Division of Liver and Pancreas Transplantation, Dumont University of California Transplant Center, Los Angeles, CA 90095, USA
J Immunol 181:1096-102. 2008..These results provide the rationale to probe potential synergy of adjunctive therapy targeting CD4 and CD154 to overcome graft rejection in sensitized recipients... - Identification and characterization of transmitted and early founder virus envelopes in primary HIV-1 infectionBrandon F Keele
Departments of Medicine and Microbiology, University of Alabama at Birmingham, Birmingham, AL 35223, USA
Proc Natl Acad Sci U S A 105:7552-7. 2008.... - A centralized gene-based HIV-1 vaccine elicits broad cross-clade cellular immune responses in rhesus monkeysSampa Santra
Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 105:10489-94. 2008..These findings suggest that immunization with centralized genes is a promising vaccine strategy for developing a global vaccine for HIV-1 as well as vaccines for other genetically diverse viruses... - Replication and compartmentalization of HIV-1 in kidney epithelium of patients with HIV-associated nephropathyDaniele Marras
Division of Nephrology, Department of Medicien, Mount Sinai School of Medicine, New York, New York, USA
Nat Med 8:522-6. 2002..These data, along with the detection of HIV-1-specific proviral DNA and mRNA in tubular epithelium cells, argue strongly for localized replication of HIV-1 in the kidney and the existence of a renal viral reservoir... - Analysis of partial pol and env sequences indicates a high prevalence of HIV type 1 recombinant strains circulating in GabonIvona Pandrea
Laboratoire de Retroviologie, Centre International de Recherches Medicales, Franceville, Gabon
AIDS Res Hum Retroviruses 18:1103-16. 2002..The main advantage of this approach is that it also allows for evaluation of genotypic susceptibility to antiretroviral drugs without the need for supplementary analyses... - Allograft rejection by primed/memory CD8+ T cells is CD154 blockade resistant: therapeutic implications for sensitized transplant recipientsYuan Zhai
Division of Liver and Pancreas Transplantation, Department of Surgery, Dumont University of California Transplant Center, University of California School of Medicine, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
J Immunol 169:4667-73. 2002.... - Prediction of proteinase cleavage sites in polyproteins of coronaviruses and its applications in analyzing SARS-CoV genomesFeng Gao
Department of Physics, Tianjin University, 300072, Tianjin, PR China
FEBS Lett 553:451-6. 2003..Compared with known annotations, the performance of the present method is satisfactory. The software ZCURVE_CoV 2.0 is freely available at http://tubic.tju.edu.cn/sars/... - Antigenicity and immunogenicity of HIV-1 consensus subtype B envelope glycoproteinsDenise L Kothe
Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Virology 360:218-34. 2007.... - Ancestral and consensus envelope immunogens for HIV-1 subtype CDenise L Kothe
Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Virology 352:438-49. 2006..These results establish the utility of centralized HIV-1 subtype C Env immunogens and warrant their continued evaluation as potential components of future AIDS vaccines... - Diversity considerations in HIV-1 vaccine selectionBrian Gaschen
Los Alamos National Laboratory, Los Alamos, NM 87545, USA
Science 296:2354-60. 2002..Consensus or ancestor sequences could be used in vaccine design to minimize the genetic differences between vaccine strains and contemporary isolates, effectively reducing the extent of diversity by half... - An alternative and effective HIV vaccination approach based on inhibition of antigen presentation attenuators in dendritic cellsXiao-Tong Song
Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas, USA
PLoS Med 3:e11. 2006.... - Characterization of a thymus-tropic HIV-1 isolate from a rapid progressor: role of the envelopeEric G Meissner
Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27599, USA
Virology 328:74-88. 2004..These data suggest that SI viruses with unique envelope functions which can overcome barriers to transmission may hasten disease progression by perturbing T cell homeostasis... - Characterization of functional and phenotypic changes in anti-Gag vaccine-induced T cell responses and their role in protection after HIV-1 infectionMichael R Betts
Laboratory of Immunology, Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 40 Convent Drive, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 102:4512-7. 2005..These data suggest that control of HIV by vaccine-elicited HIV-specific T cell responses may be difficult, even when the T cell response has those characteristics predicted to provide optimal protection... - Probing lipid vesicles by bimolecular association and dissociation trajectories of single moleculesFeng Gao
Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Am Chem Soc 128:4814-22. 2006..Nile Red is shown to be a useful probe of the structural fluctuations and heterogeneity of these membrane structures, and it is a useful model with which to directly study a diffusion-influenced reversible bimolecular reaction... - Further investigation of simian immunodeficiency virus Vif function in human cellsNathan C Gaddis
Department of Microbiology, University of Pennsylvania, Philadelphia, USA
J Virol 78:12041-6. 2004.... - Stat4 and Stat6 signaling in hepatic ischemia/reperfusion injury in mice: HO-1 dependence of Stat4 disruption-mediated cytoprotectionXiu Da Shen
Dumont UCLA Transplant Center, Division of Liver and Pancreas Transplantation, Department of Surgery, Los Angeles, CA 90095, USA
Hepatology 37:296-303. 2003..In conclusion, Stat4 signaling is required for, whereas Stat4 disruption protects against, warm hepatic I/R injury in mice. The cytoprotection rendered by Stat4 disruption remains HO-1-dependent... - Crystallization and preliminary crystallographic analysis of a partial extracellular fragment of a sperm membrane protein YWK-II/APPH related to the Alzheimer betaA4-amyloid precursor proteinMaojun Yang
National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, 5 Dong Dan San Tiao, Beijing 100005, People s Republic of China
Acta Crystallogr D Biol Crystallogr 59:146-9. 2003..51 A(3) Da(-1) and a solvent content of 64.6% by Volume. A full set of X-ray diffraction data were collected to 2.8 A resolution from the native crystal... - The CD154-CD40 T-cell co-stimulation pathway in liver ischemia and reperfusion inflammatory responsesBibo Ke
The Dumont University of California, Los Angeles Transplant Center, Division of Liver and Pancreas Transplantation, Department of Surgery, David Geffen School of Medicine at University of California, Los Angeles, CA 90095, USA
Transplantation 79:1078-83. 2005.... - CD4+ T regulatory cell induction and function in transplant recipients after CD154 blockade is TLR4 independentYuan Zhai
Division of Liver and Pancreas Transplantation, Department of Surgery, The Dumont University of California Los Angeles UCLA Transplant Center, David Geffen School of Medicine, UCLA, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
J Immunol 176:5988-94. 2006..In conclusion, our data reveals a distinctive property of CD4(+) Treg in tolerant allograft recipients, whose induction and function are independent of TLR4 signaling... - Inflammatory responses in a new mouse model of prolonged hepatic cold ischemia followed by arterialized orthotopic liver transplantationXiu-Da Shen
Dumont-UCLA Transplant Center, Division of Liver and Pancreas Transplantation, Department of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
Liver Transpl 11:1273-81. 2005.... - Crystallization and preliminary X-ray structural studies of a high-affinity CD8alphaalpha co-receptor to pMHCDavid K Cole
Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Oxford University, Oxford OX3 9DU, England
Acta Crystallograph Sect F Struct Biol Cryst Commun 61:285-7. 2005..08, c = 56.54 A. VM calculations indicated one molecule per asymmetric unit. A 2 A data set was collected and the structure is currently being determined using molecular replacement... - Immunopathogenesis of accelerated allograft rejection in sensitized recipients: humoral and nonhumoral mechanismsWayne W Hancock
Transplantation, Millennium Pharmaceuticals, Inc, Cambridge, Massachusetts 02139, USA
Transplantation 73:1392-7. 2002..Accelerated rejection (AccR) in sensitized recipients (second-set rejection) is considered a classic humorally mediated form of allograft rejection, although additional effector mechanisms may be involved... - The CD154-CD40 T cell costimulation pathway is required for host sensitization of CD8(+) T cells by skin grafts via direct antigen presentationYuan Zhai
Dumont-University of California Transplant Center, University of California School of Medicine, Los Angeles, CA 90095, USA
J Immunol 169:1270-6. 2002.... - Heme oxygenase 1 gene transfer prevents CD95/Fas ligand-mediated apoptosis and improves liver allograft survival via carbon monoxide signaling pathwayBibo Ke
Dumont-UCLA Transplant Center, Division of Liver and Pancreas Transplantation, Department of Surgery, UCLA School of Medicine, Los Angeles, CA 90095, USA
Hum Gene Ther 13:1189-99. 2002..Thus, Ad-HO-1 gene transfer prevents CD95/FasL-mediated apoptosis, and significantly prolongs allogeneic OLT survival via a downstream HO-1-CO signaling pathway... - Effects of pretransplantation treatment with rituximab on outcomes of autologous stem-cell transplantation for non-Hodgkin's lymphomaAmy L Hoerr
School of Medicine, Siteman Cancer Center, Washington University, St. Louis, MO, USA
J Clin Oncol 22:4561-6. 2004.... - Crystallization and preliminary crystallographic analysis of extracellular fragment X3 of YWK-II/APPH: a human sperm membrane protein related to the Alzheimer betaA4-amyloid precursor proteinMaojun Yang
National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, 5 Dong Dan San Tiao, Beijing 100005, People s Republic of China
Acta Crystallogr D Biol Crystallogr 59:506-8. 2003..2, b = 44.0, c = 88.3 A, alpha = gamma = 90.0, beta = 103.6 degrees. The presence of one molecule per asymmetric unit gives a crystal Volume per protein mass (V(M)) of 2.8 A(3) Da(-1) and a solvent content of 56.4% by Volume... - A peptide with three hyaluronan binding motifs inhibits tumor growth and induces apoptosisXue Ming Xu
Department of Oncology, Lombardi Cancer Center, Georgetown University Medical School, Washington, DC 20057, USA
Cancer Res 63:5685-90. 2003..Taken together, these results suggest that the HA binding motif that is present in HA binding proteins may be responsible for the antitumor effect exerted by the members of this family... - Identification of unique genetic markers in Rv0927c among Mycobacterium tuberculosis W-Beijing strainsXin Jiang
State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, Shanghai 200433, PR China
Microbes Infect 9:241-6. 2007..Characteristic mutations of Rv0927c that are present in W-Beijing strains can be used as a novel genetic marker for rapid molecular typing of M. tuberculosis W-Beijing strains... - Fibronectin-alpha4beta1 integrin interactions regulate metalloproteinase-9 expression in steatotic liver ischemia and reperfusion injuryCarolina Moore
Dumont UCLA Transplant Center, Department of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 7054, USA
Am J Pathol 170:567-77. 2007..Hence, these findings reveal a novel aspect of the function of fibronectin-alpha4beta1 integrin interactions that holds significance for the successful use of marginal steatotic livers in transplantation... - A phase 1 escalating single-dose and weekly fixed-dose study of cetuximab: pharmacokinetic and pharmacodynamic rationale for dosingPaula M Fracasso
The Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri, USA
Clin Cancer Res 13:986-93. 2007..This phase 1 study evaluated the pharmacokinetic and pharmacodynamic effects of cetuximab on patients with epithelial malignancies... - Heme oxygenase 1 mediates the immunomodulatory and antiapoptotic effects of interleukin 13 gene therapy in vivo and in vitroBibo Ke
Dumont UCLA Transplant Center, Department of Surgery, UCLA School of Medicine, Los Angeles, CA 90095, USA
Hum Gene Ther 13:1845-57. 2002..Results of HO-1 neutralization studies suggest that HO-1 represents one of the putative IL-13 downstream effectors... - Structural basis of Robo proline-rich motif recognition by the srGAP1 Src homology 3 domain in the Slit-Robo signaling pathwayXiaofeng Li
Tsinghua-Nankai IBP Joint Research Group for Structural Biology, Tsinghua University, Beijing 100084, China
J Biol Chem 281:28430-7. 2006.... - A targeting approach for delivery of polymer microparticle-antibody conjugate against Vibrio parahaemolyticus-induced cytotoxicity to human intestinal epithelial cellsFeng Gao
Department of Pharmaceutical Sciences, School of Pharmacy, East China University of Science and Technology, Shanghai, People s Republic of China
J Drug Target 15:428-36. 2007..01), and reduced TDH-induced cytotoxicity in histology. These preliminary results suggest that it may be possible to effectively protect against Vp infection by using this microparticle-antibody conjugate delivery system... - Adiponectin improves endothelial function in hyperlipidemic rats by reducing oxidative/nitrative stress and differential regulation of eNOS/iNOS activityRong Li
Department of Physiology, The Fourth Military Medical University, Xian, China
Am J Physiol Endocrinol Metab 293:E1703-8. 2007.... - Predictors of incomplete adherence, virologic failure, and antiviral drug resistance among HIV-infected adults receiving antiretroviral therapy in TanzaniaHabib O Ramadhani
Kilimanjaro Christian Medical Centre, Tumaini University, Moshi, Tanzania
Clin Infect Dis 45:1492-8. 2007..Access to antiretroviral therapy is rapidly expanding in sub-Saharan Africa. Identifying the predictors of incomplete adherence, virologic failure, and antiviral drug resistance is essential to achieving long-term success... - A semi-rational design strategy of directed evolution combined with chemical synthesis of DNA sequencesAi Sheng Xiong
Biotechnology Research Institute of Shanghai Academy of Agricultural Sciences, 2901 Beidi Road, Shanghai 201106, China
Biol Chem 388:1291-300. 2007..The purified beta-galactosidase from YH8757 exhibited a lower specific activity at 25 degrees C than those purified from mutated YG6755 and YG8252... - Comparison of various algorithms for recognizing short coding sequences of human genesFeng Gao
Department of Physics, Tianjin University, Tianjin 300072, China
Bioinformatics 20:673-81. 2004..We hope that the Z curve methods presented in this paper would be beneficial to the further development of gene-finding algorithms. AVAILABILITY: The programs of various Z curve methods are available on request... - Kinetic and structural analysis of bisubstrate inhibition of the Salmonella enterica aminoglycoside 6'-N-acetyltransferaseMaria L B Magalhaes
Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
Biochemistry 47:579-84. 2008..These results are compared to previous studies of the interaction of similar bisubstrate analogs with other aminoglycoside N-acetyltransferases... - Ori-Finder: a web-based system for finding oriCs in unannotated bacterial genomesFeng Gao
Department of Physics, Tianjin University, Tianjin 300072, China
BMC Bioinformatics 9:79. 2008..Therefore, the increasing availability of genome sequences calls for improved software to identify oriCs in newly sequenced and unannotated bacterial genomes... - Anti-MHC class I antibody activation of proliferation and survival signaling in murine cardiac allograftsPeter T Jindra
UCLA Immunogenetics Center and Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, 1000 Veteran Avenue, Los Angeles, CA 90095, USA
J Immunol 180:2214-24. 2008..These results provide the first analysis of the interrelationships between these signaling molecules in vivo that reflects our knowledge of the signaling pathway derived from in vitro experiments... - Expression of single-chain Fv gene specific for gamma-seminoprotein by RTS and its biological activity identificationYuedong Han
Department of Nuclear Medicine, Xijing Hospital, Fourth Military Medical University, Xi an, PR China
Biotechnol Prog 22:1084-9. 2006..This ScFv peptide against human gamma-seminoprotein should be useful in improving the detection and therapy of prostate cancer at early stages and NMR imaging... - Sexual behavior of HIV discordant couples after HIV counseling and testingSusan Allen
Department of Epidemiology and International Health, School of Public Health, University of Alabama in Birmingham, 35294, USA
AIDS 17:733-40. 2003..Strategies that encourage truthful reporting of sexual behavior and sensitive biological markers of exposure are urgently needed. The impact of prevention programs should be assessed with both behavioral and biological measures... - Alternative splicing of 3-hydroxy-3-methylglutaryl coenzyme A reductase is associated with plasma low-density lipoprotein cholesterol response to simvastatinMarisa Wong Medina
Children s Hospital Oakland Research Institute, CA 94609, USA
Circulation 118:355-62. 2008..We hypothesized that HMGCR alternative splicing might be related to the interindividual variation in plasma low-density lipoprotein cholesterol response to statin treatment...
Research Grants
- Role of Virus Recombination in Multiple Drug ResisitanceFeng Gao; Fiscal Year: 2003..Knowledge obtained from this study can be broadly applied toward understanding mechanisms of viral escape from immune surveillance and other selective forces. ..
- Immunogenicity of an HIV virus-like particle vaccineFeng Gao; Fiscal Year: 2004..abstract_text> ..
- A Universal Env Immunogen for all HIV-1 SubtypesFeng Gao; Fiscal Year: 2004..Results from this study will determine if con/con Env protein can serve as a universal immunogen for all HIV-1 subtypes and will be used as a guideline to design broadly reactive immunization strategies. ..
- Role of Virus Recombination in Multiple Drug ResisitanceFeng Gao; Fiscal Year: 2006..Knowledge obtained from this study can be broadly applied toward understanding mechanisms of viral escape from immune surveillance and other selective forces. ..
- Role of Virus Recombination in Multiple Drug ResisitanceFeng Gao; Fiscal Year: 2007..Knowledge obtained from this study can be broadly applied toward understanding mechanisms of viral escape from immune surveillance and other selective forces. ..