Jacques Fellay

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. ncbi Host genetics: fine-tuning innate signaling
    Jacques Fellay
    Center for Population Genomics and Pharmacogenetics, Duke Institute for Genome Sciences and Policy, Duke University, Durham, NC 27710, USA
    Curr Biol 17:R516-8. 2007
  2. ncbi Host genetics influences on HIV type-1 disease
    Jacques Fellay
    Center for Human Genome Variation, Institute for Genome Sciences and Policy, Duke University, Durham, NC, USA
    Antivir Ther 14:731-8. 2009
  3. ncbi Host genetic determinants of T cell responses to the MRKAd5 HIV-1 gag/pol/nef vaccine in the step trial
    Jacques Fellay
    Center for Human Genome Variation, Duke University School of Medicine, Durham, NC 27708, USA
    J Infect Dis 203:773-9. 2011
  4. ncbi Common genetic variation and the control of HIV-1 in humans
    Jacques Fellay
    Center for Human Genome Variation, Duke Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina, USA
    PLoS Genet 5:e1000791. 2009
  5. ncbi Host determinants of HIV-1 control in African Americans
    Kimberly Pelak
    Center for Human Genome Variation, Duke University Medical School, Durham, North Carolina, USA
    J Infect Dis 201:1141-9. 2010
  6. ncbi Variants in the ITPA gene protect against ribavirin-induced hemolytic anemia and decrease the need for ribavirin dose reduction
    Alexander J Thompson
    Duke Clinical Research Institute, Durham, North Carolina 27715, USA
    Gastroenterology 139:1181-9. 2010
  7. ncbi ITPA gene variants protect against anaemia in patients treated for chronic hepatitis C
    Jacques Fellay
    Institute for Genome Sciences and Policy, Center for Human Genome Variation, Duke University, Durham, North Carolina 27708, USA
    Nature 464:405-8. 2010
  8. ncbi Inosine triphosphate protects against ribavirin-induced adenosine triphosphate loss by adenylosuccinate synthase function
    Yuki Hitomi
    Center for Human Genome Variation, School of Medicine, Duke University, Durham, North Carolina, USA
    Gastroenterology 140:1314-21. 2011
  9. ncbi Interleukin-28B polymorphism improves viral kinetics and is the strongest pretreatment predictor of sustained virologic response in genotype 1 hepatitis C virus
    Alexander J Thompson
    Duke Clinical Research Institute, Durham, North Carolina, USA
    Gastroenterology 139:120-9.e18. 2010
  10. ncbi A polymorphism in the HCP5 gene associated with HLA-B*5701 does not restrict HIV-1 in vitro
    Woohyun Yoon
    Center for Human Genome Variation, Duke Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina, USA
    AIDS 24:155-7. 2010

Detail Information

Publications18

  1. ncbi Host genetics: fine-tuning innate signaling
    Jacques Fellay
    Center for Population Genomics and Pharmacogenetics, Duke Institute for Genome Sciences and Policy, Duke University, Durham, NC 27710, USA
    Curr Biol 17:R516-8. 2007
    ....
  2. ncbi Host genetics influences on HIV type-1 disease
    Jacques Fellay
    Center for Human Genome Variation, Institute for Genome Sciences and Policy, Duke University, Durham, NC, USA
    Antivir Ther 14:731-8. 2009
    ..This review discusses these results in the context of the new genome-wide approaches that now make it possible to globally assess the influence of the host genome on HIV-1-related outcomes...
  3. ncbi Host genetic determinants of T cell responses to the MRKAd5 HIV-1 gag/pol/nef vaccine in the step trial
    Jacques Fellay
    Center for Human Genome Variation, Duke University School of Medicine, Durham, NC 27708, USA
    J Infect Dis 203:773-9. 2011
    ..Furthermore, our results demonstrate the importance of considering the host immunogenetic background in the analysis of immune responses to T cell vaccines...
  4. ncbi Common genetic variation and the control of HIV-1 in humans
    Jacques Fellay
    Center for Human Genome Variation, Duke Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina, USA
    PLoS Genet 5:e1000791. 2009
    ..This study thus represents a comprehensive assessment of common human genetic variation in HIV-1 control in Caucasians...
  5. ncbi Host determinants of HIV-1 control in African Americans
    Kimberly Pelak
    Center for Human Genome Variation, Duke University Medical School, Durham, North Carolina, USA
    J Infect Dis 201:1141-9. 2010
    ....
  6. ncbi Variants in the ITPA gene protect against ribavirin-induced hemolytic anemia and decrease the need for ribavirin dose reduction
    Alexander J Thompson
    Duke Clinical Research Institute, Durham, North Carolina 27715, USA
    Gastroenterology 139:1181-9. 2010
    ..We aimed to replicate this finding in an independent cohort from the Study of Viral Resistance to Antiviral Therapy of Chronic Hepatitis C and to investigate the effects of these variants beyond week 4...
  7. ncbi ITPA gene variants protect against anaemia in patients treated for chronic hepatitis C
    Jacques Fellay
    Institute for Genome Sciences and Policy, Center for Human Genome Variation, Duke University, Durham, North Carolina 27708, USA
    Nature 464:405-8. 2010
    ..Here we show that genetic variants leading to inosine triphosphatase deficiency, a condition not thought to be clinically important, protect against haemolytic anaemia in hepatitis-C-infected patients receiving RBV...
  8. ncbi Inosine triphosphate protects against ribavirin-induced adenosine triphosphate loss by adenylosuccinate synthase function
    Yuki Hitomi
    Center for Human Genome Variation, School of Medicine, Duke University, Durham, North Carolina, USA
    Gastroenterology 140:1314-21. 2011
    ..However, the biologic mechanism by which this occurs is unknown...
  9. ncbi Interleukin-28B polymorphism improves viral kinetics and is the strongest pretreatment predictor of sustained virologic response in genotype 1 hepatitis C virus
    Alexander J Thompson
    Duke Clinical Research Institute, Durham, North Carolina, USA
    Gastroenterology 139:120-9.e18. 2010
    ..We sought to confirm the polymorphism's clinical relevance by intention-to-treat analysis evaluating on-treatment virologic response and SVR...
  10. ncbi A polymorphism in the HCP5 gene associated with HLA-B*5701 does not restrict HIV-1 in vitro
    Woohyun Yoon
    Center for Human Genome Variation, Duke Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina, USA
    AIDS 24:155-7. 2010
    ....
  11. ncbi Copy number variation of KIR genes influences HIV-1 control
    Kimberly Pelak
    Center for Human Genome Variation, Duke University School of Medicine, Durham, North Carolina, USA
    PLoS Biol 9:e1001208. 2011
    ....
  12. ncbi Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance
    Dongliang Ge
    Institute for Genome Sciences and Policy, Center for Human Genome Variation, Duke University, Durham, North Carolina 27708, USA
    Nature 461:399-401. 2009
    ....
  13. ncbi IL28B genotype is associated with differential expression of intrahepatic interferon-stimulated genes in patients with chronic hepatitis C
    Thomas J Urban
    Center for Human Genome Variation, Duke University Medical Center, Durham, NC, USA
    Hepatology 52:1888-96. 2010
    ..IL28B-type was not associated with intrahepatic IL28B messenger RNA expression in vivo. Further investigation of the precise molecular mechanism(s) by which IL28B genetic variation influences HCV outcomes is warranted...
  14. ncbi Host genetics and HIV-1: the final phase?
    Jacques Fellay
    Center for Human Genome Variation, Duke University School of Medicine, Durham, North Carolina, United States of America
    PLoS Pathog 6:e1001033. 2010
    ....
  15. ncbi WGAViewer: software for genomic annotation of whole genome association studies
    Dongliang Ge
    Center for Population Genomics and Pharmacogenetics, Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina 27708, USA
    Genome Res 18:640-3. 2008
    ....
  16. ncbi Common human genetic variants and HIV-1 susceptibility: a genome-wide survey in a homogeneous African population
    Slave Petrovski
    Center for Human Genome Variation, School of Medicine, Duke University, Durham, North Carolina 27708, USA
    AIDS 25:513-8. 2011
    ..We investigated whether common genetic variants associate with HIV-1 susceptibility in Africans...
  17. ncbi Genome-wide association study of interferon-related cytopenia in chronic hepatitis C patients
    Alexander J Thompson
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27701, USA
    J Hepatol 56:313-9. 2012
    ..We performed a genome wide association study on a well-characterized genotype 1 HCV cohort to identify genetic determinants of peginterferon-? (pegIFN)-related thrombocytopenia, neutropenia, and leukopenia...
  18. ncbi A whole-genome association study of major determinants for host control of HIV-1
    Jacques Fellay
    Center for Population Genomics and Pharmacogenetics, Duke Institute for Genome Sciences and Policy, Duke University, Durham, NC 27710, USA
    Science 317:944-7. 2007
    ..These findings emphasize the importance of studying human genetic variation as a guide to combating infectious agents...