Research Topics
Species | Karl CsakySummaryAffiliation: Duke University Medical Center Country: USA Publications
| Collaborators
|
Detail Information
Publications
Safety implications of vascular endothelial growth factor blockade for subjects receiving intravitreal anti-vascular endothelial growth factor therapiesKarl Csaky
Ophthalmic Unit, Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27710, USA
Am J Ophthalmol 148:647-56. 2009..To evaluate potential safety risks associated with nonspecific inhibition of vascular endothelial growth factor (VEGF)...- Report from the NEI/FDA Ophthalmic Clinical Trial Design and Endpoints SymposiumKarl G Csaky
Ophthalmic Unit, DCRI, Duke University Medical Center, Durham, NC 27710, USA
Invest Ophthalmol Vis Sci 49:479-89. 2008 - Investigating the movement of intravitreal human serum albumin nanoparticles in the vitreous and retinaHyuncheol Kim
Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina 27705, USA
Pharm Res 26:329-37. 2009..To investigate the movement of intravitreally injected human serum albumin nanoparticles (HSA-NP) with respect to nanoparticle surface charge and retinal injury... - Episcleral clearance of sodium fluorescein from a bioerodible sub-tenon's implant in the ratJessica E Chan
Duke University School of Medicine, Durham, NC, USA
Exp Eye Res 90:501-6. 2010..Interestingly, the choroid does not appear to play a prominent role as clearance of episcleral NaFl was not affected by elimination of choroidal blood flow. Further work is needed to delineate the pathways of episcleral drug clearance... - Central visual function and the NEI-VFQ-25 near and distance activities subscale scores in people with type 1 and 2 diabetesMichael Cusick
Division of Epidemiology and Clinical Research, National Eye Institute/NIH, Building 10, 10 Center Drive, Bethesda, MD 20892-1204, USA
Am J Ophthalmol 139:1042-50. 2005..Low scores on the NEI-VFQ-25 may reflect poor central visual fields and contrast sensitivity in addition to poor visual acuity... - Differences in gene expression profiles in dermal fibroblasts from control and patients with age-related macular degeneration elicited by oxidative injuryNataly Strunnikova
National Eye Institute, Bethesda, MD 20892-1857, USA
Free Radic Biol Med 39:781-96. 2005..Despite the small number of patients in the study, specific biological and statistical differences in gene expression profiles between control and AMD patients were identified but only in the presence of an environmental stimulus... - Nonlethal oxidant injury to human retinal pigment epithelium cells causes cell membrane blebbing but decreased MMP-2 activityMaria E Marin-Castano
Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami School of Medicine, 1638 NW 10th Avenue, Miami, FL 33136, USA
Invest Ophthalmol Vis Sci 46:3331-40. 2005.... - Serum inflammatory markers in diabetic retinopathyAnnal D Meleth
Howard Hughes Medical Institute, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
Invest Ophthalmol Vis Sci 46:4295-301. 2005..To evaluate the association of serum factors with the severity of diabetic retinopathy and to assess their presence in retinal tissue obtained at autopsy... - Intravitreal injection of triamcinolone acetonide for immune recovery uveitisMaytinee Sirimaharaj
Save Sight Institute, Department of Clinical Ophthalmology, University of Sydney, Australia
Retina 26:578-80. 2006 - An apolipoprotein E variant may protect against age-related macular degeneration through cytokine regulationChristine M Bojanowski
Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892 1857, USA
Environ Mol Mutagen 47:594-602. 2006..These results further confirm the association between ApoE112R and a decreased risk of AMD development. The underlying mechanisms may involve differential regulation of both CCL2 and VEGF by the ApoE isoforms... - Analysis of Hemicentin-1, hOgg1, and E-selectin single nucleotide polymorphisms in age-related macular degenerationChristine M Bojanowski
National Eye Institute, National Institutes of Health, Bethesda, Maryland, USA
Trans Am Ophthalmol Soc 103:37-44; discussion 44-5. 2005..This study investigates the Hemicentin-1 (an extracellular matrix protein) Q5345R, hOgg1 (DNA repair gene) S326C, and E-selectin (an adhesion molecule) S149R SNPs in association with AMD... - Angiogenesis inhibition and choroidal neovascularization suppression by sustained delivery of an integrin antagonist, EMD478761Yingli Fu
National Eye Institute, NIH, Bethesda, MD, USA
Invest Ophthalmol Vis Sci 48:5184-90. 2007.... - Late outgrowth endothelial progenitor cells in patients with age-related macular degenerationMichelle Thill
National Eye Institute, National Institutes of Health, Bethesda, Maryland, USA
Invest Ophthalmol Vis Sci 49:2696-708. 2008.... - Quantitative enumeration of vascular smooth muscle cells and endothelial cells derived from bone marrow precursors in experimental choroidal neovascularizationDiego G Espinosa-Heidmann
Department of Ophthalmology, Bascom Palmer Eye Institute, William L McKnight Vision Research Center, The University of Miami School of Medicine, 1638 N W 10th Avenue, Miami, FL 33136, USA
Exp Eye Res 80:369-78. 2005..Knowledge of the cellular composition and origin might help understand the pathogenic mechanisms controlling CNV severity as well as indicate potential targets for therapeutic intervention... - Indocyanine green enhanced retinal vessel laser closure in rats: histologic and immunohistochemical observationsJeremy D Wolfe
National Eye Institute, National Institutes of Health, Building 10-10B11, 9000 Rockville Pike, Bethesda, MD 20892-1857, USA
Exp Eye Res 79:631-8. 2004..These results suggest that more durable feeder vessel closure rates may be achievable with either the use of accompanying anti-inflammatory therapies or with a less vascular damaging photoactivating dye... - Survival of retinal pigment epithelium after exposure to prolonged oxidative injury: a detailed gene expression and cellular analysisNataly Strunnikova
National Eye Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892-1859, USA
Invest Ophthalmol Vis Sci 45:3767-77. 2004.... - Age as an independent risk factor for severity of experimental choroidal neovascularizationDiego G Espinosa-Heidmann
Bascom Palmer Eye Institute, Department of Ophthalmology, The University of Miami School of Medicine, 1638 NW 10th Avenue, Miami, FL 33136, USA
Invest Ophthalmol Vis Sci 43:1567-73. 2002..Age-related systemic susceptibility factors, independent of local changes in the retina, may contribute to the greater severity of CNV in older than in younger individuals... - Oxidant-induced cell death in retinal pigment epithelium cells mediated through the release of apoptosis-inducing factorCongxiao Zhang
National Eye Institute, Building 10 Room 10N119, 9000 Rockville Pike, Bethesda, Maryland 20892 1857, USA
J Cell Sci 116:1915-23. 2003..These findings demonstrate the complex nature of cell death in primary cells of the retina and highlight the role of caspase-independent signals, growth factors and intracellular survival factors in programmed cell death pathways... - In vivo gene transfer as a means to study the physiology and morphogenesis of the retinal pigment epithelium in the ratAlan D Marmorstein
Department of Ophthalmic Research, Cole Eye Institute, i31, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
Methods 30:277-85. 2003..In addition, there are substantial savings with respect to time and money in comparison to standard transgenic approaches... - Macrophage depletion diminishes lesion size and severity in experimental choroidal neovascularizationDiego G Espinosa-Heidmann
Bascom Palmer Eye Institute, Department of Ophthalmology, The University of Miami School of Medicine, Miami, Florida, USA
Invest Ophthalmol Vis Sci 44:3586-92. 2003..96 +/- 7 pixels, P < 0.019). CONCLUSIONS: Macrophage depletion using CL(2)MDP-lip reduces size, cellularity, and vascularity of CNV. This observation supports the hypothesis that macrophages contribute to the severity of CNV lesions... - The long-term effects of laser photocoagulation treatment in patients with diabetic retinopathy: the early treatment diabetic retinopathy follow-up studyEmily Y Chew
National Eye Institute/National Institutes of Health, Division of Epidemiology and Clinical Research, Bethesda, Maryland 20892-2510, USA
Ophthalmology 110:1683-9. 2003..The need for laser scatter photocoagulation with long-term follow-up seems to be high... - Identification of well-defined intrachoroidal neovascularization by high-speed indocyanine green angiographySunil K Srivastava
National Eye Institute, National Institutes of Health, Bethesda, MD 20892-1857, USA
Retina 23:712-4. 2003 - Bone marrow-derived progenitor cells contribute to experimental choroidal neovascularizationDiego G Espinosa-Heidmann
Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, Florida 33136, USA
Invest Ophthalmol Vis Sci 44:4914-9. 2003..CONCLUSIONS: This study is the first to demonstrate that bone marrow-derived progenitor cells are a source of endothelial and smooth musclelike cells in CNV... - Recruitment of marrow-derived endothelial cells to experimental choroidal neovascularization by local expression of vascular endothelial growth factorKarl G Csaky
National Institutes of Health, National Eye Institute, Building 10 10B11, 9000 Rockville Pike, Bethesda, MD 20892 1857, USA
Exp Eye Res 78:1107-16. 2004.... - The involvement of sequence variation and expression of CX3CR1 in the pathogenesis of age-related macular degenerationJingsheng Tuo
Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892 1857, USA
FASEB J 18:1297-9. 2004..Our data suggest that a decrease, caused by sequence variation and/or lower CX3CR1 expression, in CX3CR1-induced cellular activities could contribute to AMD development... - Monocyte activation in patients with age-related macular degeneration: a biomarker of risk for choroidal neovascularization?Scott W Cousins
Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, Fla 33136, USA
Arch Ophthalmol 122:1013-8. 2004.... - Intravitreal injection of triamcinolone for diffuse macular edemaHanna Rodriguez-Coleman
Arch Ophthalmol 122:1085-6; author reply 1086-8. 2004 - Fluorescein angiographic findings in primary intraocular lymphomaGisela Velez
Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland, USA
Retina 22:37-43. 2002..A noninvasive ancillary test such as fluorescein angiography could be helpful in raising the level of suspicion in the diagnosis of this disease...