Research Topics
| G M CoxSummaryAffiliation: Duke University Medical Center Country: USA Publications
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Detail Information
Publications
Dominant selection system for use in Cryptococcus neoformansG M Cox
Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
J Med Vet Mycol 34:385-91. 1996..This is the first dominant selection system for use in C. neoformans, and it should prove useful for molecular studies with this important pathogenic yeast...- Feasibility and willingness-to-pay for integrated community-based tuberculosis testingNeela D Goswami
Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
BMC Infect Dis 11:305. 2011..Community-based screening for TB, combined with HIV and syphilis testing, faces a number of barriers. One significant barrier is the value that target communities place on such screening... - Urease as a virulence factor in experimental cryptococcosisG M Cox
Division of Infectious Disease, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
Infect Immun 68:443-8. 2000..Our results suggest that urease activity is involved in the pathogenesis of cryptococcosis but that the importance may be species and/or infection site specific... - The STE12alpha homolog is required for haploid filamentation but largely dispensable for mating and virulence in Cryptococcus neoformansC Yue
Department of Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA
Genetics 153:1601-15. 1999..The association of the MATalpha locus with virulence may involve additional genes, and other transcription factors that regulate mating and virulence remain to be identified... - Extracellular phospholipase activity is a virulence factor for Cryptococcus neoformansG M Cox
Department of Medicine, Duke University Medical Center, Durham, NC, USA
Mol Microbiol 39:166-75. 2001..We also found that the plb1 strain exhibited a growth defect in a macrophage-like cell line. These data demonstrate that secretory phospholipase is a virulence factor for C. neoformans... - Calcineurin regulatory subunit is essential for virulence and mediates interactions with FKBP12-FK506 in Cryptococcus neoformansD S Fox
Department of Genetics, 322 CARL Bldg, Box 3546, Duke University Medical Center, Research Drive, Durham, NC 27710, USA
Mol Microbiol 39:835-49. 2001..In summary, our studies reveal a central role for calcineurin B in virulence and antifungal drug action in the human fungal pathogen C. neoformans... - A new dominant selectable marker for use in Cryptococcus neoformansH C McDade
Department of Microbiology, Duke University Medical Center, Durham, NC 27710, USA
Med Mycol 39:151-4. 2001..neoformans. The development of nourseothricin resistance as a second dominant selectable market will be helpful in future molecular studies on this important pathogenic fungus... - Cyclic AMP-dependent protein kinase controls virulence of the fungal pathogen Cryptococcus neoformansJ A Alspaugh
Departments of Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA
Mol Cell Biol 21:3179-91. 2001..These findings define a Galpha protein-cAMP-PKA signaling pathway regulating differentiation and virulence of a human fungal pathogen... - Identification and characterization of an SKN7 homologue in Cryptococcus neoformansF L Wormley
Department of Medicine Division of Infectious Diseases, Duke University Medical Center, Duke South, Stead Bldg, Box 3353, Durham, NC 27710, USA
Infect Immun 73:5022-30. 2005..neoformans. In addition, flocculation of C. neoformans skn7 mutants suggests a potentially unique function of SKN7 not previously observed in other cryptococcal strains or skn7 mutants... - Two cyclophilin A homologs with shared and distinct functions important for growth and virulence of Cryptococcus neoformansP Wang
Departments of Genetics, Duke University Medical Center, Durham, NC 27710, USA
EMBO Rep 2:511-8. 2001..Cyclophilin A active site mutants restored growth of cpa1 cpa2 mutants at ambient but not at higher temperatures, suggesting that the prolyl isomerase activity of cyclophilin A has an in vivo function... - Association of plasma levels of human immunodeficiency virus type 1 RNA and oropharyngeal Candida colonizationM Gottfredsson
Department of Medicine, Division of Infectious Diseases and International Health and Nephrology, Duke University Medical Center, Durham, NC 27710, USA
J Infect Dis 180:534-7. 1999..Further studies on the effect of HIV-1 on oropharyngeal yeast colonization, infection, and local immunity are warranted... - Identification and characterization of a highly conserved calcineurin binding protein, CBP1/calcipressin, in Cryptococcus neoformansJ Gorlach
Departments of Genetics, Medicine, Microbiology, Pharmacology and Cancer Biology, and the Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA
EMBO J 19:3618-29. 2000.... - Fungal phospholipase activity and susceptibility to lipid preparations of amphotericin BM Gottfredsson
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
Antimicrob Agents Chemother 45:3231-3. 2001.... - The impact of culture isolation of Aspergillus species: a hospital-based survey of aspergillosisJ R Perfect
Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
Clin Infect Dis 33:1824-33. 2001..Chronic necrotizing aspergillosis, aspergilloma, and allergic bronchopulmonary aspergillosis have variable management strategies and better short-term outcomes... - Identification and characterization of the Cryptococcus neoformans phosphomannose isomerase-encoding gene, MAN1, and its impact on pathogenicityE A Wills
University of Manchester, School of Biological Sciences, 1.800 Stopford Building, Manchester M13 9PT, UK
Mol Microbiol 40:610-20. 2001..neoformans in the host. The fact that the man1 mutant was not pathogenic suggests that blocking mannose synthesis could be fungicidal in the mammalian host and thus an excellent target for antifungal drug development...