STACI BILBO

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. ncbi A lifespan approach to neuroinflammatory and cognitive disorders: a critical role for glia
    Staci D Bilbo
    Department of Psychology and Neuroscience, Duke University, Durham, NC 27708, USA
    J Neuroimmune Pharmacol 7:24-41. 2012
  2. ncbi Early-life infection is a vulnerability factor for aging-related glial alterations and cognitive decline
    Staci D Bilbo
    Duke University, Department of Psychology and Neuroscience, Durham, NC 27708, USA
    Neurobiol Learn Mem 94:57-64. 2010
  3. ncbi Enduring consequences of maternal obesity for brain inflammation and behavior of offspring
    Staci D Bilbo
    Duke University, Department of Psychology and Neuroscience, Durham, NC 27708, USA
    FASEB J 24:2104-15. 2010
  4. ncbi Neonatal bacterial infection alters fever to live and simulated infections in adulthood
    Staci D Bilbo
    Department of Psychology and Neuroscience, Duke University, Durham, NC 27708, United States
    Psychoneuroendocrinology 35:369-81. 2010
  5. ncbi Bacterial infection early in life protects against stressor-induced depressive-like symptoms in adult rats
    Staci D Bilbo
    Department of Psychology and Neuroscience, Duke University, Durham, NC 27708, USA
    Psychoneuroendocrinology 33:261-9. 2008
  6. ncbi Early-life infection leads to altered BDNF and IL-1beta mRNA expression in rat hippocampus following learning in adulthood
    Staci D Bilbo
    Department of Psychology and Neuroscience, Duke University, Durham, NC 27708, USA
    Brain Behav Immun 22:451-5. 2008
  7. ncbi Photoperiodic adjustments in immune function protect Siberian hamsters from lethal endotoxemia
    Brian J Prendergast
    Department of Psychology and Neuroscience, The Ohio State University, Columbus, OH 43210, USA
    J Biol Rhythms 18:51-62. 2003
  8. ncbi A behavioural characterization of neonatal infection-facilitated memory impairment in adult rats
    Staci D Bilbo
    Department of Psychology, Center for Neuroscience, University of Colorado at Boulder, Boulder, CO 80309 0345, USA
    Behav Brain Res 169:39-47. 2006
  9. ncbi Blunted stress responses in delayed type hypersensitivity in mice lacking the neuronal isoform of nitric oxide synthase
    Staci D Bilbo
    Department of Psychological and Brain Sciences, The Johns Hopkins University, Baltimore, MD 21218, USA
    J Neuroimmunol 140:41-8. 2003
  10. ncbi Differential effects of neonatal handling on early life infection-induced alterations in cognition in adulthood
    Staci D Bilbo
    Department of Psychology, Center for Neuroscience, University of Colorado, Campus Box 345, Boulder, CO 80309 0345, USA
    Brain Behav Immun 21:332-42. 2007

Research Grants

  1. Early Life Infection, Neuroinflammation, and Memory
    STACI BILBO; Fiscal Year: 2009
  2. Perinatal Infection and Memory
    STACI BILBO; Fiscal Year: 2006
  3. Early Life Origins of Risk & Resilience to Drugs of Abuse: Role of Glial Priming
    Staci D Bilbo; Fiscal Year: 2010
  4. Early Life Infection, Neuroinflammation, and Memory
    Staci D Bilbo; Fiscal Year: 2010

Detail Information

Publications16

  1. ncbi A lifespan approach to neuroinflammatory and cognitive disorders: a critical role for glia
    Staci D Bilbo
    Department of Psychology and Neuroscience, Duke University, Durham, NC 27708, USA
    J Neuroimmune Pharmacol 7:24-41. 2012
    ..g., stress, infection). An impact on glia, which in turn alters neural development, has the capacity to profoundly impact cognitive and mental health function at all stages of life...
  2. ncbi Early-life infection is a vulnerability factor for aging-related glial alterations and cognitive decline
    Staci D Bilbo
    Duke University, Department of Psychology and Neuroscience, Durham, NC 27708, USA
    Neurobiol Learn Mem 94:57-64. 2010
    ..Taken together, these data suggest that early-life infection leads to less successful cognitive aging, which may be linked to changes in glial reactivity...
  3. ncbi Enduring consequences of maternal obesity for brain inflammation and behavior of offspring
    Staci D Bilbo
    Duke University, Department of Psychology and Neuroscience, Durham, NC 27708, USA
    FASEB J 24:2104-15. 2010
    ..These effects were all observed in adulthood, even after the pups were placed on standard chow at weaning, suggesting these outcomes were programmed early in life...
  4. ncbi Neonatal bacterial infection alters fever to live and simulated infections in adulthood
    Staci D Bilbo
    Department of Psychology and Neuroscience, Duke University, Durham, NC 27708, United States
    Psychoneuroendocrinology 35:369-81. 2010
    ..Taken together, these data indicate that early-life infection is associated with marked changes in host temperature regulation in adulthood...
  5. ncbi Bacterial infection early in life protects against stressor-induced depressive-like symptoms in adult rats
    Staci D Bilbo
    Department of Psychology and Neuroscience, Duke University, Durham, NC 27708, USA
    Psychoneuroendocrinology 33:261-9. 2008
    ....
  6. ncbi Early-life infection leads to altered BDNF and IL-1beta mRNA expression in rat hippocampus following learning in adulthood
    Staci D Bilbo
    Department of Psychology and Neuroscience, Duke University, Durham, NC 27708, USA
    Brain Behav Immun 22:451-5. 2008
    ..Taken together, these data indicate that early infection strongly influences the induction of IL-1beta and BDNF within distinct regions of the hippocampus, which likely contribute to observed memory impairments in adulthood...
  7. ncbi Photoperiodic adjustments in immune function protect Siberian hamsters from lethal endotoxemia
    Brian J Prendergast
    Department of Psychology and Neuroscience, The Ohio State University, Columbus, OH 43210, USA
    J Biol Rhythms 18:51-62. 2003
    ..Adaptation to short days induces changes in immune parameters that affect survival in the face of immune challenges...
  8. ncbi A behavioural characterization of neonatal infection-facilitated memory impairment in adult rats
    Staci D Bilbo
    Department of Psychology, Center for Neuroscience, University of Colorado at Boulder, Boulder, CO 80309 0345, USA
    Behav Brain Res 169:39-47. 2006
    ..Taken together, we have demonstrated that neonatal infection results in robust hippocampal-dependent memory impairment following an immune challenge in adulthood using a number of conditioning paradigms...
  9. ncbi Blunted stress responses in delayed type hypersensitivity in mice lacking the neuronal isoform of nitric oxide synthase
    Staci D Bilbo
    Department of Psychological and Brain Sciences, The Johns Hopkins University, Baltimore, MD 21218, USA
    J Neuroimmunol 140:41-8. 2003
    ..Neuronal NO appears to be involved in the neuroendocrine-immune response to stress, perhaps via glucocorticoid regulation...
  10. ncbi Differential effects of neonatal handling on early life infection-induced alterations in cognition in adulthood
    Staci D Bilbo
    Department of Psychology, Center for Neuroscience, University of Colorado, Campus Box 345, Boulder, CO 80309 0345, USA
    Brain Behav Immun 21:332-42. 2007
    ..Taken together, these data suggest that maternal care may profoundly influence neuroinflammatory processes in adulthood, and that infection may also prevent maternal care influences on cognition later in life...
  11. ncbi Neonatal infection-induced memory impairment after lipopolysaccharide in adulthood is prevented via caspase-1 inhibition
    Staci D Bilbo
    Department of Psychology, University of Colorado, Boulder, Colorado 80309, USA
    J Neurosci 25:8000-9. 2005
    ..These data implicate IL-1beta in the set of immune/inflammatory events that occur in the brain as a result of neonatal infection, which likely contribute to cognitive alterations in adulthood...
  12. ncbi Stressor-specific alterations in corticosterone and immune responses in mice
    Stephanie L Bowers
    Departments of Psychology, Neuroscience, and Institute for Behavioral Medicine Research, The Ohio State University, Columbus, OH 43210, USA
    Brain Behav Immun 22:105-13. 2008
    ..The variation observed in the measured immune responses may reflect differential glucocorticoid activation, differential metabolic adjustments, or both processes in response to specific stressors...
  13. ncbi Cardiac arrest/cardiopulmonary resuscitation augments cell-mediated immune function and transiently suppresses humoral immune function
    Gretchen N Neigh
    Department of Psychology, The Ohio State University, Townshend Hall, Columbus, Ohio 43210, USA
    J Cereb Blood Flow Metab 25:1424-32. 2005
    ..These data highlight the potential impact of neuronal damage on cell-mediated immune function and the role of humoral immune activation in outcome after global ischemia...
  14. ncbi Neonatal infection induces memory impairments following an immune challenge in adulthood
    Staci D Bilbo
    Department of Psychology, University of Colorado, Boulder, CO 80309 0345, USA
    Behav Neurosci 119:293-301. 2005
    ..Infection during development appears to alter glia within the hippocampus, which may contribute to altered cytokine responses and memory impairment...
  15. ncbi Exogenous pyruvate prevents stress-evoked suppression of mitogen-stimulated proliferation
    Gretchen N Neigh
    Departments of Neuroscience and Psychology, The Ohio State University, Columbus, OH 43210, USA
    Brain Behav Immun 18:425-33. 2004
    ....
  16. ncbi Effects of photoperiod history on immune responses to intermediate day lengths in Siberian hamsters (Phodopus sungorus)
    Brian J Prendergast
    Departments of Psychology and Neuroscience, The Ohio State University, Columbus, OH 43210, USA
    J Neuroimmunol 149:31-9. 2004
    ..The data suggest that photoperiodic mechanisms that enhance and suppress several aspects of immunity in young-adult hamsters are not responsive to prenatally communicated photoperiod history information...

Research Grants6

  1. Early Life Infection, Neuroinflammation, and Memory
    STACI BILBO; Fiscal Year: 2009
    ....
  2. Perinatal Infection and Memory
    STACI BILBO; Fiscal Year: 2006
    ..The duration of memory impairment will also be measured, and a number of memory paradigms will be tested. ..
  3. Early Life Origins of Risk & Resilience to Drugs of Abuse: Role of Glial Priming
    Staci D Bilbo; Fiscal Year: 2010
    ....
  4. Early Life Infection, Neuroinflammation, and Memory
    Staci D Bilbo; Fiscal Year: 2010
    ....