Research Topics
Species | Konstantin G ArbeevSummaryAffiliation: Duke University Medical Center Country: USA Publications
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Detail Information
Publications
Leukocyte telomere length, breast cancer risk in the offspring: the relations with father's age at birthKonstantin G Arbeev
Center for Population Health and Aging, Duke University, Durham, NC 27708 0408, USA
Mech Ageing Dev 132:149-53. 2011..However, with couples delaying having children in today's society, studies exploring the LTL association with increased breast cancer risk in daughters of older fathers might be timely and relevant...- Age trajectories of physiological indices in relation to healthy life courseKonstantin G Arbeev
Centre for Population Health and Aging, Duke University, Department of Sociology, Durham, NC 27708 0408, USA
Mech Ageing Dev 132:93-102. 2011.... - Evaluation of genotype-specific survival using joint analysis of genetic and non-genetic subsamples of longitudinal dataKonstantin G Arbeev
Center for Population Health and Aging, Duke University, Durham, NC 27708 0408, USA
Biogerontology 12:157-66. 2011.... - Genetic model for longitudinal studies of aging, health, and longevity and its potential application to incomplete dataKonstantin G Arbeev
Center for Population Health and Aging, Duke University, Trent Hall, Room 002, Box 90408, Durham, NC 27708 0408, USA
J Theor Biol 258:103-11. 2009..Simulation studies illustrate the increase in the accuracy in different scenarios for datasets structurally similar to the Framingham Heart Study. Possible applications of the model and its further generalizations are discussed... - Trade-off in the effects of the apolipoprotein E polymorphism on the ages at onset of CVD and cancer influences human lifespanAlexander M Kulminski
Center for Population Health and Aging, Duke University, Durham, NC 27708, USA
Aging Cell 10:533-41. 2011..Deeper insights into biological mechanisms mediating gene action are critical for understanding the genetic regulation of a healthy lifespan and for personalizing medical care... - Association between APOE epsilon 2/epsilon 3/epsilon 4 polymorphism and disability severity in a national long-term care survey sampleAlexander Kulminski
Center for Population Health and Aging, Duke University Population Research Institute, Department of Sociology, Duke University, Trent Hall, Room 002, Durham, NC 27708, USA
Age Ageing 37:288-93. 2008..early studies reported controversial findings on association of apolipoprotein E (APOE) polymorphism with disability... - Maintaining physiological state for exceptional survival: What is the normal level of blood glucose and does it change with age?Anatoli I Yashin
Center for Population Health and Aging, Duke University, Durham, NC 27708 0408, USA
Mech Ageing Dev 130:611-8. 2009..The results show that analyzing longitudinal data using advanced methods may substantially increase our knowledge on factors and mechanisms responsible for aging-related changes in humans... - Cumulative deficits and physiological indices as predictors of mortality and long lifeAlexander M Kulminski
Center for Population Health and Aging, Duke University Population Research Institute, Durham, NC 27708, USA
J Gerontol A Biol Sci Med Sci 63:1053-9. 2008..The DI appears to be a more important determinant of long-term risks of death and longevity than are the physiological indices... - Exceptional survivors have lower age trajectories of blood glucose: lessons from longitudinal dataAnatoli I Yashin
Center for Population Health and Aging, Duke University, Durham, NC 27708 0408, USA
Biogerontology 11:257-65. 2010..We concluded that individuals whose age trajectories of BG are located around the curve minimizing chances of premature death at each given age have highest chances of reaching exceptional longevity... - Accelerated accumulation of health deficits as a characteristic of agingAlexander Kulminski
Center for Population Health and Aging, Duke University Population Research Institute, Trent Drive, Box 90408, Durham, NC 27708, USA
Exp Gerontol 42:963-70. 2007..Longitudinal analysis provides strong evidence that the cumulative index of health/well-being deficits can characterize aging-associated processes in humans and predict death better than chronological age during short-term periods... - Beta2-adrenergic receptor gene polymorphisms as systemic determinants of healthy aging in an evolutionary contextAlexander M Kulminski
Center for Population Health and Aging, Duke University Population Research Institute, Durham, NC 27708, USA
Mech Ageing Dev 131:338-45. 2010..The ADRB2 gene can play an important systemic role in healthy aging in evolutionary context that warrants exploration in other populations... - Trade-off between cancer and aging: what role do other diseases play? Evidence from experimental and human population studiesAnatoli I Yashin
Center for Population Health and Aging, Duke University, Durham, NC 27708 0408, USA
Mech Ageing Dev 130:98-104. 2009..Possible mechanisms of the observed dependencies and emerging perspectives of using dependent competing risks models for evaluating the effects of reduction of mortality from cancer on life expectancy are discussed... - Do gender, disability, and morbidity affect aging rate in the LLFS? Application of indices of cumulative deficitsAlexander M Kulminski
Center for Population Health and Aging, Duke University, Durham, NC 27708 0408, USA
Mech Ageing Dev 132:195-201. 2011..This study highlights importance of aggregated approaches to better understand systemic mechanisms of health deterioration in long-living individuals... - Modeling hematopoietic system response caused by chronic exposure to ionizing radiationIgor V Akushevich
Center for Population Health and Aging, Duke University, 002 Trent Hall, Box 90408, Durham, NC 27708 0408, USA
Radiat Environ Biophys 50:299-311. 2011..g., leukopenia, thrombocytopenia)... - Cumulative deficits better characterize susceptibility to death in elderly people than phenotypic frailty: lessons from the Cardiovascular Health StudyAlexander M Kulminski
Center for Population Health and Aging, Duke University, Durham, North Carolina 27708, USA
J Am Geriatr Soc 56:898-903. 2008..To compare how well frailty measures based on a phenotypic frailty approach proposed in the Cardiovascular Health Study (CHS) and a cumulative deficits approach predict mortality... - Stochastic model for analysis of longitudinal data on aging and mortalityAnatoli I Yashin
Duke University, Center for Demographic Studies, 2117 Campus Drive, Box 90408, Durham, NC 27708 0408, USA
Math Biosci 208:538-51. 2007..The results show that the model may characterize complicated interplay among different components of aging-related changes in humans and that the model parameters are identifiable from the data... - What age trajectories of cumulative deficits and medical costs tell us about individual aging and mortality risk: Findings from the NLTCS-Medicare dataAnatoli I Yashin
Center for Population Health and Aging, Duke University, Durham, NC 27708 0408, USA
Mech Ageing Dev 129:191-200. 2008..We found that males show a faster decline in stress resistance with age than females... - Polymorphisms in the ACE and ADRB2 genes and risks of aging-associated phenotypes: the case of myocardial infarctionAlexander M Kulminski
Center for Population Health and Aging, Duke University Population Research Institute and Department of Sociology, Duke University, Durham, North Carolina 27708, USA
Rejuvenation Res 13:13-21. 2010..Multimarker genetic analyses should benefit studies of complex aging-associated phenotypes... - Model of hidden heterogeneity in longitudinal dataAnatoli I Yashin
Center for Population Health and Aging, Duke University, Trent Hall, Room 002, Box 90408, Durham, NC 27708 0408, USA
Theor Popul Biol 73:1-10. 2008..Simulation experiments confirm identifiability of model's parameters... - Changes in health status among participants of the Framingham Heart Study from the 1960s to the 1990s: application of an index of cumulative deficitsAlexander M Kulminski
Center for Population Health and Aging, Duke University Population Research Institute, and Department of Sociology, Duke University
Ann Epidemiol 18:696-701. 2008..Health of the general population is improving along a number of major health dimensions. Using a cumulative deficits approach, we investigated whether such improvements were evident at the level of minor health traits... - Trade-offs between cancer and other diseases: do they exist and influence longevity?Svetlana V Ukraintseva
Center for Population Health and Aging, Duke University, Durham, North Carolina 27708, USA
Rejuvenation Res 13:387-96. 2010..We discuss factors modulating the potential trade-offs between major disorders in populations, e.g., disease treatments. Further study is needed to clarify possible impact of such trade-offs on longevity... - The accuracy of statistical estimates in genetic studies of aging can be significantly improvedAnatoli I Yashin
Center for Demographic Studies, Duke University, 2117 Campus Drive, Box 90408, Durham, NC 27708 0408, USA
Biogerontology 8:243-55. 2007.... - Sex-specific health deterioration and mortality: the morbidity-mortality paradox over age and timeAlexander M Kulminski
Center for Population Health and Aging, Duke University Population Research Institute, Department of Sociology, Duke University, Durham, NC 27708, USA
Exp Gerontol 43:1052-7. 2008..The time-trends suggest the presence of a strong exogenous effect modifier affecting the rate of health deterioration and mortality risk... - Cumulative index of health deficiencies as a characteristic of long lifeAlexander M Kulminski
Center for Population Health and Aging, Duke University Population Research Institute, and Department of Sociology, Duke University, Durham, NC 27708, USA
J Am Geriatr Soc 55:935-40. 2007.... - Health decline, aging and mortality: how are they related?Anatoli I Yashin
Center for Demographic Studies, Duke University, 2117 Campus Drive, 90408, Durham, NC 27708, USA
Biogerontology 8:291-302. 2007..Comparison of these results with findings from early studies using the Cox's-like model of risk function indicates that the results are likely to describe regularities of deterioration in human health during the aging process... - Cumulative index of elderly disorders and its dynamic contribution to mortality and longevityAnatoli I Yashin
Sociology Department, Duke University, Durham, North Carolina 27708, USA
Rejuvenation Res 10:75-86. 2007..This suggests increasing the role of senescence per se in the increasing risk of death with age compared to the role of specific pathology... - Health-related phenotypes and longevity in danish twinsAlexander M Kulminski
Center for Population Health and Aging, Duke University Population Research Institute, Durham, North Carolina 27708, USA
J Gerontol A Biol Sci Med Sci 64:1-8. 2009..The cumulative-trait approach is more promising for such studies compared with the individual-trait approach. Heritable health dimensions contributing to a decrease of life span have sex-insensitive and sex-specific components... - Health-protective and adverse effects of the apolipoprotein E epsilon2 allele in older menAlexander M Kulminski
Center for Population Health and Aging, Duke University, Trent Hall, Room 002, Trent Drive, Box 90408, Durham, NC 27708, USA
J Am Geriatr Soc 56:478-83. 2008.... - Modeling deterministic effects in hematopoietic system caused by chronic exposure to ionizing radiation in large human cohortsIgor V Akushevich
Center for Population Health and Aging, Duke University, Durham, NC, 27708 0408, USA
Health Phys 99:322-9. 2010.... - Body mass index and nine-year mortality in disabled and nondisabled older U.S. individualsAlexander M Kulminski
Department of Sociology, Center for Population Health and Aging, Population Research Institute, Duke University, Durham, North Carolina 27708, USA
J Am Geriatr Soc 56:105-10. 2008..To investigate the relationship between body mass index (BMI) and 9-year mortality in older (> or = 65) Americans with and without disability... - "Predicting" parental longevity from offspring endophenotypes: data from the Long Life Family Study (LLFS)Anatoli I Yashin
Duke University, Center for Population Health and Aging, Durham, NC 27708 0408, USA
Mech Ageing Dev 131:215-22. 2010..We conclude that the study of endophenotypes within families is a valid approach to the genetics of human longevity... - Joint influence of small-effect genetic variants on human longevityANATOLIY I YASHIN
Center for Population Health and Aging, Duke University, Durham, NC 27708 0408, USA
Aging (Albany NY) 2:612-20. 2010..We show that this joint influence can be described by a relatively simple "genetic dose - phenotypic response" relationship... - Date of eclosion modulates longevity: insights across dietary-restriction gradients and female reproduction in the mexfly Anastrepha ludensAlexander M Kulminski
Center for Population Health and Aging, Duke University Population Research Institute, Department of Sociology, Duke University, Trent Hall, Room 002, Box 90408, Durham, NC 27708, USA
Exp Gerontol 44:718-26. 2009..We present evidence for the presence of two frailty-sensitive weakly interacting mechanisms of longevity in female flies associated with differences in predisposed fitness... - Epidemiology of hormone-associated cancers as a reflection of ageSvetlana V Ukraintseva
Center for Population Health and Aging, Duke University, Durham, NC 27708, USA
Adv Exp Med Biol 630:57-71. 2008..We emphasize the comparative analysis of the age specific incidence rate curves as a valuable source of hypotheses about factors influencing cancer risks in populations in addition to the analysis of the age-adjusted rates... - Decrease in the lgl tumor suppressor dose in Drosophila increases survival and longevity in stress conditionsMikhail D Golubovsky
Center for Demographic Studies, Duke University, 2117 Campus Drive, Box 90408, Durham, NC 27708 0408, USA
Exp Gerontol 41:819-27. 2006..One possible explanation of this stress-adaptive effect of reduced tumor suppressor dose might be a better resistance of Drosophila post-mitotic cells to a stress-associated apoptosis at old ages... - Antiaging treatments have been legally prescribed for approximately thirty yearsSvetlana V Ukraintseva
Max Planck Institute for Demographic Research, 18057 Rostock, Germany
Ann N Y Acad Sci 1019:64-9. 2004..We provide evidence in support of the idea that the consumption of medicines exerting antiaging properties may contribute to the increase in human longevity...