Research Topics
| Claude BurgoyneSummaryAffiliation: Devers Eye Institute Country: USA Publications
Research Grants
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Detail Information
Publications
A biomechanical paradigm for axonal insult within the optic nerve head in aging and glaucomaClaude F Burgoyne
Optic Nerve Head Research Laboratory, Part of the Discoveries in Sight Research Laboratories of the Devers Eye Institute, Legacy Health System, 1225 NE 2nd Ave, Portland, OR 97232, USA
Exp Eye Res 93:120-32. 2011..The optic nerve head in glaucoma: role of astrocytes in tissue remodeling. Prog Retin Eye Res. 19, 297-321.; Hernandez, M.R., Pena, J.D., 1997. The optic nerve head in glaucomatous optic neuropathy. Arch Ophthalmol. 115, 389-395.)...- Premise and prediction-how optic nerve head biomechanics underlies the susceptibility and clinical behavior of the aged optic nerve headClaude F Burgoyne
Optic Nerve Head Research Laboratories, Devers Eye Institute, Portland, OR 97232, USA
J Glaucoma 17:318-28. 2008.... - Correlation between local stress and strain and lamina cribrosa connective tissue volume fraction in normal monkey eyesMichael D Roberts
Ocular Biomechanics, Legacy Health System, Portland, Oregon, USA
Invest Ophthalmol Vis Sci 51:295-307. 2010..To investigate the biomechanical response to IOP elevation of normal monkey eyes using eye-specific, three-dimensional (3-D) finite element (FE) models of the ONH that incorporate lamina cribrosa (LC) microarchitectural information... - Remodeling of the connective tissue microarchitecture of the lamina cribrosa in early experimental glaucomaMichael D Roberts
Ocular Biomechanics Laboratory, Devers Eye Institute, Legacy Health System, Portland, Oregon 97232, USA
Invest Ophthalmol Vis Sci 50:681-90. 2009.... - Physiologic intereye differences in monkey optic nerve head architecture and their relation to changes in early experimental glaucomaHongli Yang
Optic Nerve Head Research Laboratory, Devers Eye Institute, Legacy Health System, Portland, Oregon 97208 3950, USA
Invest Ophthalmol Vis Sci 50:224-34. 2009.... - Changes in the biomechanical response of the optic nerve head in early experimental glaucomaMichael D Roberts
Ocular Biomechanics Laboratories, Devers Eye Institute, Legacy Health System, Portland, Oregon 97232, USA
Invest Ophthalmol Vis Sci 51:5675-84. 2010..To investigate the biomechanical response of the optic nerve head (ONH) connective tissues to IOP elevation in three pairs of monkey eyes in which one eye had early experimental glaucoma (EG)... - Scleral biomechanics in the aging monkey eyeMichaël J A Girard
Ocular Biomechanics Laboratory, Devers Eye Institute, Portland, Oregon 97232, USA
Invest Ophthalmol Vis Sci 50:5226-37. 2009..To investigate the age-related differences in the inhomogeneous, anisotropic, nonlinear biomechanical properties of posterior sclera from old (22.9 +/- 5.3 years) and young (1.5 +/- 0.7 years) rhesus monkeys... - Idiopathic bilateral optic atrophy in the rhesus macaqueBrad Fortune
Discoveries in Sight, Devers Eye Institute, Legacy Health System, Portland, OR 97232, USA
Invest Ophthalmol Vis Sci 46:3943-56. 2005..CONCLUSIONS: The existence of BOA in nonhuman primates warrants caution on the part of investigators who use these animals in experimental models of ophthalmic disease... - Deformation of the normal monkey optic nerve head connective tissue after acute IOP elevation within 3-D histomorphometric reconstructionsHongli Yang
Optic Nerve Head Research Laboratory, Devers Eye Institute, Legacy Health System, Portland, Oregon 97208 3950, USA
Invest Ophthalmol Vis Sci 50:5785-99. 2009..To characterize optic nerve head (ONH) connective tissue deformation after acute (15 or 30 minutes) intraocular pressure (IOP) elevation in six adult normal monkeys using three-dimensional (3-D) histomorphometry... - Relative course of retinal nerve fiber layer birefringence and thickness and retinal function changes after optic nerve transectionBrad Fortune
Discoveries in Sight Research Laboratories, Devers Eye Institute, LegacyHealth System, Portland, Oregon 97232, USA
Invest Ophthalmol Vis Sci 49:4444-52. 2008.... - Experimental surface strain mapping of porcine peripapillary sclera due to elevations of intraocular pressureMichaël J A Girard
Department of Biomedical Engineering, Tulane University, 6823 St Charles Avenue, New Orleans, LA 70118, USA
J Biomech Eng 130:041017. 2008..Peripapillary deformation following an acute IOP elevation may be governed by the underlying scleral collagen microstructure and is likely in the high-stiffness region of the scleral stress-strain curve when IOP is above 10 mm Hg... - Mechanical environment of the optic nerve head in glaucomaJ Crawford Downs
Devers Eye Institute, Legacy Health System, Portland, Oregon 97232, USA
Optom Vis Sci 85:425-35. 2008..Our current understanding of the mechanical environment of the ONH is described, with particular emphasis on the influence of biomechanics in glaucoma... - The effect of acute intraocular pressure elevation on peripapillary retinal thickness, retinal nerve fiber layer thickness, and retardanceBrad Fortune
Discoveries in Sight Research Laboratories, Devers Eye Institute, Legacy Health System, Portland, Oregon 97232, USA
Invest Ophthalmol Vis Sci 50:4719-26. 2009..To determine whether acutely elevated intraocular pressure (IOP) alters peripapillary retinal thickness, retinal nerve fiber layer thickness (RNFLT), or retardance... - Detection of optic nerve head neural canal opening within histomorphometric and spectral domain optical coherence tomography data setsNicholas G Strouthidis
Optic Nerve Head Research Laboratory, Devers Eye Institute, Legacy Health System, Portland, OR 97208 3950, USA
Invest Ophthalmol Vis Sci 50:214-23. 2009.... - Multiscale finite element modeling of the lamina cribrosa microarchitecture in the eyeJ Crawford Downs
Ocular Biomechanics Laboratory, Devers Eye Institute, 1225 NE 2nd Avenue, Portland, OR 97232, USA
Conf Proc IEEE Eng Med Biol Soc 2009:4277-80. 2009.... - Three-dimensional histomorphometry of the normal and early glaucomatous monkey optic nerve head: neural canal and subarachnoid space architectureJ Crawford Downs
Devers Eye Institute, Legacy Health System, Portland, Oregon 97208 3950, USA
Invest Ophthalmol Vis Sci 48:3195-208. 2007.... - A comparison of optic nerve head morphology viewed by spectral domain optical coherence tomography and by serial histologyNicholas G Strouthidis
Optic Nerve Head Research Laboratory, Devers Eye Institute, Legacy Health System, Portland, Oregon 97208 3950, USA
Invest Ophthalmol Vis Sci 51:1464-74. 2010..To compare serial optic nerve head (ONH) histology with interpolated B-scans generated from a three-dimensional (3-D) spectral domain (SD)-OCT ONH volume acquired in vivo from the same normal monkey eye... - Comparison of clinical and spectral domain optical coherence tomography optic disc margin anatomyNicholas G Strouthidis
Optic Nerve Head Research Laboratory, Devers Eye Institute, Legacy Health System, Portland, Oregon 97208 3950, USA
Invest Ophthalmol Vis Sci 50:4709-18. 2009..To investigate spectral domain optical coherence tomography (SD-OCT)-detected optic disc margin anatomy in the monkey eye by colocalizing disc photographs to SD-OCT scans acquired from the same eyes... - Comparison of clinical and three-dimensional histomorphometric optic disc margin anatomyNicholas G Strouthidis
Optic Nerve Head Research Laboratory, Devers Eye Institute, Portland, Oregon 97208 3950, USA
Invest Ophthalmol Vis Sci 50:2165-74. 2009..To investigate the anatomic basis of the optic disc margin in the normal monkey eye by colocalizing optic disc photographs to three-dimensional (3D) histomorphometric reconstructions of the same optic nerve head... - Peripapillary scleral thickness in perfusion-fixed normal monkey eyesJ Crawford Downs
Department of Biomedical Engineering, Tulane University, New Orleans, LA 70112, USA
Invest Ophthalmol Vis Sci 43:2229-35. 2002..These differences are substantial and are likely to affect the magnitude of IOP-related stress and strain within these tissues for a given level of IOP... - Deformation of the lamina cribrosa and anterior scleral canal wall in early experimental glaucomaAnthony J Bellezza
Department of Biomedical Engineering, Tulane University, New Orleans, Louisiana, USA
Invest Ophthalmol Vis Sci 44:623-37. 2003..These findings suggest that damage to the ONH connective tissues occurs early in the monkey model of experimental glaucoma... - Viscoelastic characterization of peripapillary sclera: material properties by quadrant in rabbit and monkey eyesJ Crawford Downs
Department of Biomedical Engineering, Tulane University, Lindy Boggs Center, Suite 500, New Orleans, LA 70118, USA
J Biomech Eng 125:124-31. 2003.... - The optic nerve head as a biomechanical structure: a new paradigm for understanding the role of IOP-related stress and strain in the pathophysiology of glaucomatous optic nerve head damageClaude F Burgoyne
LSU Eye Center, Louisiana State University Health Sciences Center, 2020 Gravier Street, Suite B, New Orleans, LA 70112, USA
Prog Retin Eye Res 24:39-73. 2005.... - Viscoelastic material properties of the peripapillary sclera in normal and early-glaucoma monkey eyesJ Crawford Downs
LSU Eye Center, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
Invest Ophthalmol Vis Sci 46:540-6. 2005..To test the hypothesis that changes in the viscoelastic material properties of peripapillary sclera are present within monkey eyes at the onset of early experimental glaucoma detected by confocal scanning laser tomography (CSLT)... - Effects of storage time on the mechanical properties of rabbit peripapillary sclera after enucleationMichael Girard
Department of Biomedical Engineering, Tulane University, New Orleans, Louisiana, USA
Curr Eye Res 32:465-70. 2007..No statistically significant differences were found in the material properties of each group, which suggests that sclera can be stored up to 3 days without risking mechanical deterioration... - 3-D histomorphometry of the normal and early glaucomatous monkey optic nerve head: lamina cribrosa and peripapillary scleral position and thicknessHongli Yang
Department of Biomedical Engineering, Tulane University, New Orleans, Louisiana, USA
Invest Ophthalmol Vis Sci 48:4597-607. 2007.... - 3-D histomorphometry of the normal and early glaucomatous monkey optic nerve head: prelaminar neural tissues and cuppingHongli Yang
Department of Biomedical Engineering, Tulane University, New Orleans, LA, USA
Invest Ophthalmol Vis Sci 48:5068-84. 2007.... - Clinician change detection viewing longitudinal stereophotographs compared to confocal scanning laser tomography in the LSU Experimental Glaucoma (LEG) StudyJohn C Ervin
LSU Eye Center, Louisiana State University Health Sciences Center, 2020 Gravier Street, Suite B, New Orleans, LA 70112, USA
Ophthalmology 109:467-81. 2002.... - Change detection in regional and volumetric disc parameters using longitudinal confocal scanning laser tomographyClaude F Burgoyne
LSU Eye Center, Louisiana State University Health Sciences Center, 2020 Gravier Street, Suite B, New Orleans, LA 70112, USA
Ophthalmology 109:455-66. 2002..CONCLUSIONS: Clinically specific detection of the onset and progression of glaucomatous ONH surface change is possible within longitudinally acquired CSLT images... - Segmentation of trabeculated structures using an anisotropic Markov random field: application to the study of the optic nerve head in glaucomaVicente Grau
LSU Eye Center, Louisiana State University Health Sciences Center, New Orleans 70112, USA
IEEE Trans Med Imaging 25:245-55. 2006..Results on the real datasets demonstrate the ability of the new algorithm to obtain accurate, spatially consistent segmentations of this structure... - Three-dimensional reconstruction of normal and early glaucoma monkey optic nerve head connective tissuesClaude F Burgoyne
LSU Eye Center, Louisiana State University Health Sciences Center, 2020 Gravier Street, Suite B, New Orleans, LA 70112, USA
Invest Ophthalmol Vis Sci 45:4388-99. 2004..To introduce high-resolution, digital three-dimensional (3-D) reconstruction of the connective tissues of the optic nerve head (ONH)...
Research Grants
- IOP-Related Force and Failure in the Optic Nerve HeadClaude F Burgoyne; Fiscal Year: 2010....
- IOP-Related Force and Failure in the Optic Nerve HeadClaude Burgoyne; Fiscal Year: 2009....
- IOP-Related Force and Failure in the Optic Nerve HeadClaude Burgoyne; Fiscal Year: 2007....
- IOP-Related Force and Failure in the Optic Nerve HeadClaude Burgoyne; Fiscal Year: 2006..abstract_text> ..
- IOP RELATED FORCE AND FAILURE IN THE OPTIC NERVE HEADClaude Burgoyne; Fiscal Year: 2001..These studies lay the foundation for the clinical estimation of an individual patient's susceptibility to glaucomatous damage at a given level of IOP. ..
- Optic Nerve Head SDOCT Imaging in GlaucomaClaude F Burgoyne; Fiscal Year: 2011..In this project we will translate 11 years of NIH-funded, post-mortem monkey work to an in-vivo imaging modality that will be shown to have important and novel clinical care applications in humans. ..