William F C Rigby

Summary

Affiliation: Dartmouth Medical School
Country: USA

Publications

  1. ncbi Analysis of the function, expression, and subcellular distribution of human tristetraprolin
    Seth A Brooks
    Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire, USA
    Arthritis Rheum 46:1362-70. 2002
  2. ncbi Distinct mechanisms of action of tumor necrosis factor antagonists: what are the clinical implications?
    William F C Rigby
    Dartmouth Medical School, Department of Medicine, Lebanon, NH 03756, USA
    Semin Arthritis Rheum 34:1-2. 2005
  3. ncbi Drug insight: different mechanisms of action of tumor necrosis factor antagonists-passive-aggressive behavior?
    William F C Rigby
    Dartmouth Medical School, Lebanon, NH 03756, USA
    Nat Clin Pract Rheumatol 3:227-33. 2007
  4. ncbi Structure/function analysis of tristetraprolin (TTP): p38 stress-activated protein kinase and lipopolysaccharide stimulation do not alter TTP function
    William F C Rigby
    Department of Medicine, Dartmouth College, Lebanon, NH 03756, USA
    J Immunol 174:7883-93. 2005
  5. ncbi The role of mRNA turnover in the regulation of tristetraprolin expression: evidence for an extracellular signal-regulated kinase-specific, AU-rich element-dependent, autoregulatory pathway
    Seth A Brooks
    Department of Medicine, Dartmouth Medical School, Lebanon, NH 03756, USA
    J Immunol 172:7263-71. 2004
  6. ncbi Separate cis-trans pathways post-transcriptionally regulate murine CD154 (CD40 ligand) expression: a novel function for CA repeats in the 3'-untranslated region
    B JoNell Hamilton
    Department of Medicine, Dartmouth Medical School, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    J Biol Chem 283:25606-16. 2008
  7. ncbi A flexible approach to studying post-transcriptional gene regulation in stably transfected mammalian cells
    Ralph C Nichols
    Veterans Administration Research Service, Veterans Affairs Medical Center, Mailstop 151, 215 North Main Street, White River Junction, VT 05009 0001, USA
    Mol Biotechnol 48:210-7. 2011
  8. ncbi Delineation of a novel pathway that regulates CD154 (CD40 ligand) expression
    B JoNell Hamilton
    Departments of Medicine Microbiology and Immunology, Dartmouth Medical School, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
    Mol Cell Biol 23:510-25. 2003
  9. ncbi Lactate dehydrogenase is an AU-rich element-binding protein that directly interacts with AUF1
    Patricia A Pioli
    Department of Medicine, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    J Biol Chem 277:35738-45. 2002
  10. ncbi MK2-induced tristetraprolin:14-3-3 complexes prevent stress granule association and ARE-mRNA decay
    Georg Stoecklin
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    EMBO J 23:1313-24. 2004

Collaborators

Detail Information

Publications11

  1. ncbi Analysis of the function, expression, and subcellular distribution of human tristetraprolin
    Seth A Brooks
    Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire, USA
    Arthritis Rheum 46:1362-70. 2002
    ..We also generated a specific polyclonal antibody against hTTP that enabled the examination of the subcellular distribution of hTTP and its RNA binding in vivo...
  2. ncbi Distinct mechanisms of action of tumor necrosis factor antagonists: what are the clinical implications?
    William F C Rigby
    Dartmouth Medical School, Department of Medicine, Lebanon, NH 03756, USA
    Semin Arthritis Rheum 34:1-2. 2005
  3. ncbi Drug insight: different mechanisms of action of tumor necrosis factor antagonists-passive-aggressive behavior?
    William F C Rigby
    Dartmouth Medical School, Lebanon, NH 03756, USA
    Nat Clin Pract Rheumatol 3:227-33. 2007
    ..Reverse signaling by transmembrane TNF in response to anti-TNF antibodies, but not soluble receptor, might also influence the therapeutic response...
  4. ncbi Structure/function analysis of tristetraprolin (TTP): p38 stress-activated protein kinase and lipopolysaccharide stimulation do not alter TTP function
    William F C Rigby
    Department of Medicine, Dartmouth College, Lebanon, NH 03756, USA
    J Immunol 174:7883-93. 2005
    ..Moreover, the interaction of TTP with 14-3-3, which may limit entry into the stress granule, is not involved in the downstream message stabilization events...
  5. ncbi The role of mRNA turnover in the regulation of tristetraprolin expression: evidence for an extracellular signal-regulated kinase-specific, AU-rich element-dependent, autoregulatory pathway
    Seth A Brooks
    Department of Medicine, Dartmouth Medical School, Lebanon, NH 03756, USA
    J Immunol 172:7263-71. 2004
    ..In this manner, TTP is able to limit the production of its own proteins as well as that of TNF-alpha and thus limit the response of the cell to LPS...
  6. ncbi Separate cis-trans pathways post-transcriptionally regulate murine CD154 (CD40 ligand) expression: a novel function for CA repeats in the 3'-untranslated region
    B JoNell Hamilton
    Department of Medicine, Dartmouth Medical School, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    J Biol Chem 283:25606-16. 2008
    ..These findings suggest a mechanism for the association of 3'-UTR CA-rich response element polymorphisms with CD154 overexpression and the subsequent risk of autoimmune disease...
  7. ncbi A flexible approach to studying post-transcriptional gene regulation in stably transfected mammalian cells
    Ralph C Nichols
    Veterans Administration Research Service, Veterans Affairs Medical Center, Mailstop 151, 215 North Main Street, White River Junction, VT 05009 0001, USA
    Mol Biotechnol 48:210-7. 2011
    ....
  8. ncbi Delineation of a novel pathway that regulates CD154 (CD40 ligand) expression
    B JoNell Hamilton
    Departments of Medicine Microbiology and Immunology, Dartmouth Medical School, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
    Mol Cell Biol 23:510-25. 2003
    ..These data identify a specific pathway that regulates CD154 expression that can potentially be selectively targeted for the treatment of autoimmune disease and allograft rejection...
  9. ncbi Lactate dehydrogenase is an AU-rich element-binding protein that directly interacts with AUF1
    Patricia A Pioli
    Department of Medicine, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    J Biol Chem 277:35738-45. 2002
    ..The interaction between LDH and AUF1 is direct as it can be demonstrated in vitro with purified proteins. Collectively these data implicate a role for LDH in the post-transcriptional regulation of gene expression...
  10. ncbi MK2-induced tristetraprolin:14-3-3 complexes prevent stress granule association and ARE-mRNA decay
    Georg Stoecklin
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    EMBO J 23:1313-24. 2004
    ..Our data reveal the mechanism by which the p38-MAPK/MK2 kinase cascade inhibits TTP-mediated degradation of ARE-containing transcripts and thereby contributes to lipopolysaccharide-induced TNFalpha expression...
  11. ncbi Role of the RNA-binding protein tristetraprolin in glucocorticoid-mediated gene regulation
    Faoud T Ishmael
    Division of Allergy and Clinical Immunology, Johns Hopkins University, Baltimore, MD 21224, USA
    J Immunol 180:8342-53. 2008
    ..These results reveal a strong and previously unrecognized contribution of PTR to the anti-inflammatory action of GCs and point at TTP as a key factor mediating this process through a complex mechanism of action...