Brenda L Petrella

Summary

Affiliation: Dartmouth Medical School
Country: USA

Publications

  1. ncbi Identification of membrane type-1 matrix metalloproteinase as a target of hypoxia-inducible factor-2 alpha in von Hippel-Lindau renal cell carcinoma
    Brenda L Petrella
    Department of Biochemistry, Norris Cotton Cancer Center, Dartmouth Medical School, Lebanon, NH 03756, USA
    Oncogene 24:1043-52. 2005
  2. ncbi Tumor cell invasion of von Hippel Lindau renal cell carcinoma cells is mediated by membrane type-1 matrix metalloproteinase
    Brenda L Petrella
    Department of Medicine, Norris Cotton Cancer Center, Dartmouth Medical School, Lebanon, NH, USA
    Mol Cancer 5:66. 2006
  3. ncbi PTEN suppression of YY1 induces HIF-2 activity in von-Hippel-Lindau-null renal-cell carcinoma
    Brenda L Petrella
    Department of Medicine, Norris Cotton Cancer Center, Dartmouth Medical School, Lebanon, NH 03756, USA
    Cancer Biol Ther 8:1389-401. 2009
  4. ncbi Assessment of local proteolytic milieu as a factor in tumor invasiveness and metastasis formation: in vitro collagen degradation and invasion assays
    Brenda L Petrella
    Department of Medicine, Norris Cotton Cancer Center, Dartmouth Medical School, Lebanon, NH, USA
    Methods Mol Biol 511:75-84. 2009

Detail Information

Publications4

  1. ncbi Identification of membrane type-1 matrix metalloproteinase as a target of hypoxia-inducible factor-2 alpha in von Hippel-Lindau renal cell carcinoma
    Brenda L Petrella
    Department of Biochemistry, Norris Cotton Cancer Center, Dartmouth Medical School, Lebanon, NH 03756, USA
    Oncogene 24:1043-52. 2005
    ..To our knowledge, this is the first report to show direct regulation of MT1-MMP by HIF-2 and to provide a direct link between the loss of VHL tumor suppressor function and an increase in MMP gene and protein expression...
  2. ncbi Tumor cell invasion of von Hippel Lindau renal cell carcinoma cells is mediated by membrane type-1 matrix metalloproteinase
    Brenda L Petrella
    Department of Medicine, Norris Cotton Cancer Center, Dartmouth Medical School, Lebanon, NH, USA
    Mol Cancer 5:66. 2006
    ..The aim of this study was to investigate the contribution of MT1-MMP to the invasive potential of RCC cells using in vitro type I collagen degradation and invasion assays...
  3. ncbi PTEN suppression of YY1 induces HIF-2 activity in von-Hippel-Lindau-null renal-cell carcinoma
    Brenda L Petrella
    Department of Medicine, Norris Cotton Cancer Center, Dartmouth Medical School, Lebanon, NH 03756, USA
    Cancer Biol Ther 8:1389-401. 2009
    ..We conclude that wild-type PTEN relieves the repressive nature of YY1 at certain HIF-2alpha target promoters and that this mechanism may promote early renal tumorigenesis resulting from VHL inactivation by increasing HIF-2alpha activity...
  4. ncbi Assessment of local proteolytic milieu as a factor in tumor invasiveness and metastasis formation: in vitro collagen degradation and invasion assays
    Brenda L Petrella
    Department of Medicine, Norris Cotton Cancer Center, Dartmouth Medical School, Lebanon, NH, USA
    Methods Mol Biol 511:75-84. 2009
    ..The modified collagen invasion assay system enables researchers to study the effects of transient overexpression and/or targeted knockdown (as with siRNAs) of a given gene on collagen invasion of tumor cells in a real-time format...