David Leib

..Taken together, these data suggest a role for the BBD of ICP34.5 in precluding autophagy-mediated class II antigen presentation, thereby enhancing the virulence and pathogenesis of HSV-1...

..Taken together, our results indicated an essential role for normal Stat1-dependent signaling in mediating a nonpathological immune response to viral CNS infection...

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..We reason that a better definition of the mechanisms and domains of vhs function will provide targets for therapeutic intervention against HSV ocular disease, as well as aiding in the design of HSV vaccines. ..

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..The successful outcome of this work will likely pave the way for new treatments and vaccines for therapy of herpes infections. ..

..A better understanding of vhs will allow further insight into the mechanisms by which HSV can persist for the lifetime of its host and indicate novel therapeutic approaches and targets for control of this blinding disease. ..

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..A better understanding, at the molecular level, of factors involved in HSV pathogenesis will lead to improved therapies for these diseases. ..