Research Topics
| Lloyd H KasperSummaryAffiliation: Dartmouth Medical School Country: USA Publications
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Detail Information
Publications
Multiple sclerosis immunology: The healthy immune system vs the MS immune systemLloyd H Kasper
Department of Neurology, Dartmouth Medical School, Rubin Building 701 HB 7556, 1 Medical Center Drive, Lebanon, NH 03756, USA
Neurology 74:S2-8. 2010....- A phase I trial of an interleukin-12/23 monoclonal antibody in relapsing multiple sclerosisLloyd H Kasper
Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
Curr Med Res Opin 22:1671-8. 2006..To assess the safety, tolerability and pharmacokinetics of an interleukin (IL)-12/23 monoclonal antibody (mAb) in subjects with a relapsing form of multiple sclerosis (MS)... - Lamina propria CD4+ T lymphocytes synergize with murine intestinal epithelial cells to enhance proinflammatory response against an intracellular pathogenFranck J D Mennechet
Department of Microbiology, Dartmouth Medical School, Lebanon, NH 03756, USA
J Immunol 168:2988-96. 2002..The interaction between these two components of the gut mucosal compartment (CD4(+) T cells and enterocytes) may play a role in the immunopathogenesis of this pathogen-driven experimental inflammatory bowel disease model... - TLR9 is required for the gut-associated lymphoid tissue response following oral infection of Toxoplasma gondiiLaurie A Minns
Department of Medicine, Dartmouth Medical School, Lebanon, NH 03756, USA
J Immunol 176:7589-97. 2006..These observations demonstrate that TLR9 mediates the innate response to oral parasite infection and is involved in the development of an effective Th1-type immune response... - Repeated subcutaneous injections of IL12/23 p40 neutralising antibody, ustekinumab, in patients with relapsing-remitting multiple sclerosis: a phase II, double-blind, placebo-controlled, randomised, dose-ranging studyBenjamin M Segal
Department of Neurology, Holtom Garrett Programme in Neuroimmunology, University of Michigan, Ann Arbor, MI 48109 2200, USA
Lancet Neurol 7:796-804. 2008.... - Downregulation of IL-17 and IL-6 in the central nervous system by glatiramer acetate in experimental autoimmune encephalomyelitisSakhina Begum-Haque
Department of Medicine, Dartmouth Medical School, Lebanon, NH 03756, USA
J Neuroimmunol 204:58-65. 2008..The increased expression of TNF-alpha, IL-6, and IL-17 in CNS of CD25+ depleted animals was suppressed by GA treatment. This study demonstrates that both Th1 polarization and Th17 expression are modulated by GA... - Role of gut commensal microflora in the development of experimental autoimmune encephalomyelitisJavier Ochoa-Repáraz
Department of Medicine, Dartmouth Medical School, Lebanon, NH 03756, USA
J Immunol 183:6041-50. 2009..This approach may offer a new therapeutic paradigm in the treatment of multiple sclerosis and perhaps other autoimmune conditions... - Increased expression of B cell-associated regulatory cytokines by glatiramer acetate in mice with experimental autoimmune encephalomyelitisSakhina Begum-Haque
Department of Medicine, Dartmouth Medical School, Lebanon, NH 03756, USA Multiple Sclerosis Center at Dartmouth College, Lebanon, NH 03756, USA
J Neuroimmunol 219:47-53. 2010..Thus, GA impacts both B cell survival and B cell cytokine production during CNS inflammatory disease in an EAE model... - Gut, bugs, and brain: role of commensal bacteria in the control of central nervous system diseaseJavier Ochoa-Repáraz
Department of Neurology, Dartmouth Medical School, Lebanon, NH, USA
Ann Neurol 69:240-7. 2011..In contrast, other commensal bacteria and their antigenic products, when presented in the correct context, can protect against inflammation within the CNS... - The induction of acute ileitis by a single microbial antigen of Toxoplasma gondiiNicolas Rachinel
Department of Medicine, Dartmouth Medical School, Lebanon, NH 03756, USA
J Immunol 173:2725-35. 2004..This process was associated with a shift toward a Th1 response. These findings demonstrate that a single Ag (SAG1) of T. gondii can elicit a lethal inflammatory process in this experimental model of pathogen-driven ileitis... - Intestinal intraepithelial lymphocytes prevent pathogen-driven inflammation and regulate the Smad/T-bet pathway of lamina propria CD4+ T cellsFranck J D Mennechet
Department of Microbiology, Dartmouth Medical School, Lebanon, NH, USA
Eur J Immunol 34:1059-67. 2004..These effects are linked to the secretion of TGF-beta and are correlated with a shift in the balance between Smad7/T-bet down-regulation and Smad2/Smad3 up-regulation in LP CD4(+) T lymphocytes... - Central nervous system demyelinating disease protection by the human commensal Bacteroides fragilis depends on polysaccharide A expressionJavier Ochoa-Repáraz
Section of Neurology, Department of Medicine, Dartmouth Medical School, Lebanon, NH 03756, USA
J Immunol 185:4101-8. 2010..Our results suggest an important role for commensal bacterial Ags, in particular B. fragilis expressing polysaccharide A, in protecting against CNS demyelination in EAE and perhaps human multiple sclerosis... - Augmentation of regulatory B cell activity in experimental allergic encephalomyelitis by glatiramer acetateSakhina Begum-Haque
Department of Medicine, Dartmouth Medical School, Lebanon, NH 03756 Multiple Sclerosis Center Dartmouth College, Hanover, NH 03755, USA
J Neuroimmunol 232:136-44. 2011..Thus B cells can protect against EAE, and GA augments this effect in maintaining immune homeostasis and controlling EAE disease progression... - Toxoplasma gondii induces granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor secretion by human fibroblasts: implications for neutrophil apoptosisJacqueline Y Channon
Department of Microbiology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
Infect Immun 70:6048-57. 2002..gondii-infected human fibroblasts. This enhanced neutrophil survival may contribute to the robust proinflammatory response elicited in the T. gondii-infected host... - Confronting potential influenza A (H5N1) pandemic with better vaccinesAzizul Haque
Centre National de la Recherche Scientifique, Paris, France
Emerg Infect Dis 13:1512-8. 2007..Better understanding of host-virus interaction is essential to identify tools to produce effective vaccines against influenza (H5N1)... - TLR9-dependent induction of intestinal alpha-defensins by Toxoplasma gondiiDavid M Foureau
Department of Medicine, Dartmouth Medical School, Lebanon, NH 03756, USA
J Immunol 184:7022-9. 2010..Crps have a limited direct effect against T. gondii but may indirectly affect the early control of T. gondii invasiveness by promoting the initiation of a protective Th1 response against the parasite... - CD40/CD154 ligation is required for the development of acute ileitis following oral infection with an intracellular pathogen in miceWen Li
Department of Medicine, Dartmouth Medical School, Lebanon, New Hampshire, USA
Gastroenterology 122:762-73. 2002..Acute inflammatory ileitis occurs in C57BL/6 mice after oral infection with Toxoplasma gondii. We evaluated the role of CD40/CD154 interaction in the development of acute ileitis in this experimental model... - Interleukin-10 and pathogenesis of murine ocular toxoplasmosisFangli Lu
Department of Medicine and Microbiology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
Infect Immun 71:7159-63. 2003..In contrast, there was no evidence of necrosis in the eye tissue from IL-10 transgenic mice following parasite exposure. Our results demonstrate that IL-10 is important in the regulation of inflammation during acute ocular toxoplasmosis... - Novel approaches and cutting edge immunotherapies in multiple sclerosisToni M Bauman
Department of Neurology, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA
Front Biosci 9:2302-22. 2004.... - CD4+ T cells in the pathogenesis of murine ocular toxoplasmosisFangli Lu
Department of Medicine and Microbiology, Dartmouth Medical School, Rubin Bldg. 7, Lebanon, NH 03756, USA
Infect Immun 72:4966-72. 2004..Mice deficient in CD8(+) CD4(+) T cells or B cells exhibit diminished vaccine-induced resistance and increased ocular parasite burden after challenge... - CCR5 mediates specific migration of Toxoplasma gondii-primed CD8 lymphocytes to inflammatory intestinal epithelial cellsSouphalone Luangsay
Department of Microbiology/Immunology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
Gastroenterology 125:491-500. 2003..CONCLUSIONS: Our data emphasize the biologic role of CCR5 as an important component in the migration of intraepithelial CD8(+) T cells and the regulation of the inflammatory response following parasite infection... - FLAIR lesion volume in multiple sclerosis: relation to processing speed and verbal memoryJohn J Randolph
Brain Imaging Laboratory, Department of Psychiatry, Dartmouth Medical School, Lebanon, New Hampshire 03756 0001, USA
J Int Neuropsychol Soc 11:205-9. 2005..These findings, considered in the context of prior work, suggest that FLAIR TLV is a useful predictor of commonly impaired cognitive functions in MS, and shows promise as a functionally relevant biomarker for disease status... - Rituximab in patients with primary progressive multiple sclerosis: results of a randomized double-blind placebo-controlled multicenter trialKathleen Hawker
Department of Neurology, The Ohio State University Medical Center, Columbus, USA
Ann Neurol 66:460-71. 2009..We evaluated rituximab in adults with primary progressive MS (PPMS) through 96 weeks and safety through 122 weeks... - Interferon therapy in relapsing-remitting multiple sclerosis: a systematic review and meta-analysis of the comparative trialsBrant J Oliver
Evaluative Sciences Research, MS Center at Dartmouth, DHMC, Lebanon, NH, USA
J Neurol Sci 302:96-105. 2011..A limitation of these reviews is that they have derived their findings almost entirely from the pivotal trials and placebo controlled studies... - Apoptosis in Toxoplasma gondii activated T cells: the role of IFNgamma in enhanced alteration of Bcl-2 expression and mitochondrial membrane potentialSakhina Begum-Haque
Department of Medicine and Microbiology, Dartmouth Medical School Hanover, Lebanon, NH 03755, USA
Microb Pathog 47:281-8. 2009..These changes were less noticeable in CD8+ T cells following treatment with anti-IFNgamma mAb. These findings provide further insight into the mechanisms of T cell apoptosis in T. gondii infection... - Experimental ocular toxoplasmosis in genetically susceptible and resistant miceFangli Lu
Department of Medicine and Microbiology, Dartmouth Medical School, Rubin Building 7, Lebanon, NH 03756, USA
Infect Immun 73:5160-5. 2005..Our data indicate that genetic factors of the host as well as the parasite strain are critical in determining susceptibility to experimental ocular toxoplasmosis in murine models... - A novel triterpenoid induces transforming growth factor beta production by intraepithelial lymphocytes to prevent ileitisLaurie A Minns
Department of Medicine, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
Gastroenterology 127:119-26. 2004..This could represent a new treatment of inflammatory bowel disease... - IL-9 as a mediator of Th17-driven inflammatory diseaseElizabeth C Nowak
Department of Microbiology and Immunology, Dartmouth Medical School and the Norris Cotton Cancer Center, Lebanon, NH 03756, USA
J Exp Med 206:1653-60. 2009..Collectively, these data implicate IL-9 as a Th17-derived cytokine that can contribute to inflammatory disease... - B cells amplify IFN-gamma production by T cells via a TNF-alpha-mediated mechanismLaurence C Menard
Department of Microbiology, Dartmouth Medical School, Lebanon, NH 03756, USA
J Immunol 179:4857-66. 2007..However, TNF-alpha expressed on the surface of B cells appears to mediate in part the up-regulation of IFN-gamma by the effector T cells...