Deborah A Hogan

Summary

Affiliation: Dartmouth Medical School
Country: USA

Publications

  1. ncbi The Ras/cAMP/PKA signaling pathway and virulence in Candida albicans
    Deborah A Hogan
    Department of Microbiology and Immunology, Dartmouth Medical School, Hanover, NH 03755, USA
    Future Microbiol 4:1263-70. 2009
  2. ncbi Candida albicans developmental regulation: adenylyl cyclase as a coincidence detector of parallel signals
    Deborah A Hogan
    Department of Microbiology and Immunology, Dartmouth Medical School, Hanover, NH 03755, United States
    Curr Opin Microbiol 14:682-6. 2011
  3. ncbi Candida albicans-produced farnesol stimulates Pseudomonas quinolone signal production in LasR-defective Pseudomonas aeruginosa strains
    Carla Cugini
    Department of Microbiology and Immunology, Dartmouth Medical School, Hanover, NH 03755, USA
    Microbiology 156:3096-107. 2010
  4. ncbi GbdR regulates Pseudomonas aeruginosa plcH and pchP transcription in response to choline catabolites
    Matthew J Wargo
    Department of Microbiology and Immunology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Infect Immun 77:1103-11. 2009
  5. ncbi Farnesol and dodecanol effects on the Candida albicans Ras1-cAMP signalling pathway and the regulation of morphogenesis
    Amber Davis-Hanna
    Department of Microbiology and Immunology, Dartmouth Medical School, Hanover, NH 03755, USA
    Mol Microbiol 67:47-62. 2008
  6. ncbi Antifungal mechanisms by which a novel Pseudomonas aeruginosa phenazine toxin kills Candida albicans in biofilms
    Diana K Morales
    Department of Microbiology and Immunology, Dartmouth Medical School, Hanover, NH 03755, USA
    Mol Microbiol 78:1379-92. 2010
  7. ncbi Farnesol, a common sesquiterpene, inhibits PQS production in Pseudomonas aeruginosa
    Carla Cugini
    Department of Microbiology and Immunology, Dartmouth Medical School, Hanover, NH 03755, USA
    Mol Microbiol 65:896-906. 2007
  8. ncbi Identification of two gene clusters and a transcriptional regulator required for Pseudomonas aeruginosa glycine betaine catabolism
    Matthew J Wargo
    Department of Microbiology and Immunology, Dartmouth Medical School, Hanover, NH 03755, USA
    J Bacteriol 190:2690-9. 2008
  9. ncbi Farnesol induces hydrogen peroxide resistance in Candida albicans yeast by inhibiting the Ras-cyclic AMP signaling pathway
    Aurélie Deveau
    Department of Microbiology and Immunology, Dartmouth Medical School, Hanover, NH 03755, USA
    Eukaryot Cell 9:569-77. 2010
  10. ncbi PEPped up: induction of Candida albicans virulence by bacterial cell wall fragments
    Amy E Piispanen
    Department of Microbiology and Immunology, Dartmouth Medical School, Hanover, NH 03755, USA
    Cell Host Microbe 4:1-2. 2008

Collaborators

  • Matthew J Wargo
  • Fritz A Muhlschlegel
  • Martine Bassilana
  • P Sundstrom
  • Amy E Piispanen
  • Aurélie Deveau
  • Adel A Malek
  • Diana K Morales
  • Carla Cugini
  • Eyal Amiel
  • Jane Gibson
  • Amber Davis-Hanna
  • Sarah Carden
  • Chiliang Chen
  • Ophelie Bonnefoi
  • Gwyn A Beattie
  • GEORGE A O'TOOLE
  • Angelyca A Jackson
  • Brent Berwin
  • Malathy Krishnamurthy
  • Nicholas J Jacobs
  • Rustin R Lovewell
  • Juan R Cubillos-Ruiz
  • Sathish Rajamani
  • Arpana Sood
  • Lubomira I Stateva
  • John M Farrow
  • Everett C Pesci
  • M Worth Calfee

Detail Information

Publications19

  1. ncbi The Ras/cAMP/PKA signaling pathway and virulence in Candida albicans
    Deborah A Hogan
    Department of Microbiology and Immunology, Dartmouth Medical School, Hanover, NH 03755, USA
    Future Microbiol 4:1263-70. 2009
    ..Here, we present an overview of the components of the pathway and their functions, how the pathway may be activated in human hosts and recent updates regarding the role of Ras/cAMP/PKA signaling in virulence...
  2. ncbi Candida albicans developmental regulation: adenylyl cyclase as a coincidence detector of parallel signals
    Deborah A Hogan
    Department of Microbiology and Immunology, Dartmouth Medical School, Hanover, NH 03755, United States
    Curr Opin Microbiol 14:682-6. 2011
    ..We discuss the possibility that Cyr1 acts as a coincidence detector that tightly regulates fungal development in response to parallel environmental stimuli, and highlight ways in which this might occur...
  3. ncbi Candida albicans-produced farnesol stimulates Pseudomonas quinolone signal production in LasR-defective Pseudomonas aeruginosa strains
    Carla Cugini
    Department of Microbiology and Immunology, Dartmouth Medical School, Hanover, NH 03755, USA
    Microbiology 156:3096-107. 2010
    ..aeruginosa. The finding that C. albicans, farnesol or ROS stimulate virulence factor production in lasR strains provides new insight into the virulence potential of these strains...
  4. ncbi GbdR regulates Pseudomonas aeruginosa plcH and pchP transcription in response to choline catabolites
    Matthew J Wargo
    Department of Microbiology and Immunology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Infect Immun 77:1103-11. 2009
    ....
  5. ncbi Farnesol and dodecanol effects on the Candida albicans Ras1-cAMP signalling pathway and the regulation of morphogenesis
    Amber Davis-Hanna
    Department of Microbiology and Immunology, Dartmouth Medical School, Hanover, NH 03755, USA
    Mol Microbiol 67:47-62. 2008
    ..Because several cAMP-controlled outputs are affected by farnesol and dodecanol, our findings suggest that these compounds impact activity of the Ras1-Cdc35 pathway, thus leading to an alteration of C. albicans morphology...
  6. ncbi Antifungal mechanisms by which a novel Pseudomonas aeruginosa phenazine toxin kills Candida albicans in biofilms
    Diana K Morales
    Department of Microbiology and Immunology, Dartmouth Medical School, Hanover, NH 03755, USA
    Mol Microbiol 78:1379-92. 2010
    ....
  7. ncbi Farnesol, a common sesquiterpene, inhibits PQS production in Pseudomonas aeruginosa
    Carla Cugini
    Department of Microbiology and Immunology, Dartmouth Medical School, Hanover, NH 03755, USA
    Mol Microbiol 65:896-906. 2007
    ..Related isoprenoid compounds, but not other long-chain alcohols, also inhibited PQS production at micromolar concen-trations, suggesting that related compounds may participate in interspecies interactions with P. aeruginosa...
  8. ncbi Identification of two gene clusters and a transcriptional regulator required for Pseudomonas aeruginosa glycine betaine catabolism
    Matthew J Wargo
    Department of Microbiology and Immunology, Dartmouth Medical School, Hanover, NH 03755, USA
    J Bacteriol 190:2690-9. 2008
    ..These studies provided important insight into both the mechanism and the regulation of the catabolism of GB in P. aeruginosa...
  9. ncbi Farnesol induces hydrogen peroxide resistance in Candida albicans yeast by inhibiting the Ras-cyclic AMP signaling pathway
    Aurélie Deveau
    Department of Microbiology and Immunology, Dartmouth Medical School, Hanover, NH 03755, USA
    Eukaryot Cell 9:569-77. 2010
    ..Our results suggest that farnesol effects on the Ras-adenylate cyclase cascade are responsible for many of the observed activities of this fungal signaling molecule...
  10. ncbi PEPped up: induction of Candida albicans virulence by bacterial cell wall fragments
    Amy E Piispanen
    Department of Microbiology and Immunology, Dartmouth Medical School, Hanover, NH 03755, USA
    Cell Host Microbe 4:1-2. 2008
    ..Conserved elements in human and fungal detection of muramyl dipeptides highlight a common ability to perceive proximal bacterial populations...
  11. ncbi Linking quorum sensing regulation and biofilm formation by Candida albicans
    Aurélie Deveau
    Department of Microbiology and Immunology, Dartmouth Medical School, Hanover, NH, USA
    Methods Mol Biol 692:219-33. 2011
    ..albicans biofilm cells, perhaps rendering biofilms more sensitive to antibiotics. Here, we describe several methods for the analysis of the effects of farnesol on biofilm formation and function...
  12. ncbi Roles of three transporters, CbcXWV, BetT1, and BetT3, in Pseudomonas aeruginosa choline uptake for catabolism
    Adel A Malek
    Department of Microbiology and Immunology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    J Bacteriol 193:3033-41. 2011
    ..This work represents the first systematic approach to unravel the mechanisms of choline uptake in P. aeruginosa, which has the most complex bacterial choline uptake systems characterized to date...
  13. ncbi Pseudomonas aeruginosa-Candida albicans interactions: localization and fungal toxicity of a phenazine derivative
    Jane Gibson
    Department of Microbiology and Immunology, Dartmouth Medical School, HB7550 Vail Building 208, Hanover, NH 03755, USA
    Appl Environ Microbiol 75:504-13. 2009
    ..These findings suggest that intracellular targeting of some phenazines may contribute to their toxicity and that this strategy could be useful in developing new antifungals...
  14. ncbi Pseudomonas aeruginosa evasion of phagocytosis is mediated by loss of swimming motility and is independent of flagellum expression
    Eyal Amiel
    Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    Infect Immun 78:2937-45. 2010
    ..These findings provide an explanation for the well-documented observation of nonmotility in clinical P. aeruginosa isolates and for how this phenotype confers upon the bacteria an advantage in the context of immune evasion...
  15. ncbi Examination of Pseudomonas aeruginosa lasI regulation and 3-oxo-C12-homoserine lactone production using a heterologous Escherichia coli system
    Matthew J Wargo
    Department of Microbiology and Immunology, Dartmouth Medical School, Hanover, NH 03755, USA
    FEMS Microbiol Lett 273:38-44. 2007
    ..It is proposed that this system will be useful for the study of factors that impact lasI regulation and 3OC12HSL production, and for the examination of the role of LasI-produced AHLs in bacterial interactions with other organisms...
  16. ncbi Fungal--bacterial interactions: a mixed bag of mingling microbes
    Matthew J Wargo
    Department of Microbiology and Immunology, Dartmouth Medical School, Hanover, NH 03755, USA
    Curr Opin Microbiol 9:359-64. 2006
    ..Clinical studies, in combination with in vitro model systems, are necessary to understand how bacterial-fungal interactions impact human health...
  17. ncbi Absence of membrane phosphatidylcholine does not affect virulence and stress tolerance phenotypes in the opportunistic pathogen Pseudomonas aeruginosa
    Adel A Malek
    Department of Microbiology and Immunology, Dartmouth Medical School, Hanover, New Hampshire, United States of America
    PLoS ONE 7:e30829. 2012
    ..Membrane PC may serve a highly specific role during P. aeruginosa interactions with its eukaryotic hosts based on all the clinical strains tested retaining the ability to synthesize it during availability of choline...
  18. ncbi Roles of Ras1 membrane localization during Candida albicans hyphal growth and farnesol response
    Amy E Piispanen
    Department of Microbiology and Immunology, Dartmouth Medical School, Hanover, NH 03755, USA
    Eukaryot Cell 10:1473-84. 2011
    ..Our findings imply that Ras1 is farnesylated and palmitoylated, and that the Ras1 stimulation of adenylate cyclase-dependent phenotypes can occur in the absence of these lipid modifications...
  19. ncbi Talking to themselves: autoregulation and quorum sensing in fungi
    Deborah A Hogan
    Department of Microbiology and Immunology, HB7550, Dartmouth Medical School, Hanover NH 03755, USA
    Eukaryot Cell 5:613-9. 2006