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Genomes and Genes | Arturo HernandezSummaryAffiliation: Dartmouth Medical School Country: USA Publications
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Publications
Type 3 deiodinase is critical for the maturation and function of the thyroid axisArturo Hernandez
Department of Medicine, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
J Clin Invest 116:476-84. 2006..These mice provide a new model of central hypothyroidism and reveal a critical role for D3 in the maturation and function of the thyroid axis...- Thyroid hormone deiodinases: physiology and clinical disordersArturo Hernandez
Department of Medicine, Dartmouth Medical School, Lebanon, New Hampshire 03755, USA
Curr Opin Pediatr 15:416-20. 2003..Current research focusing on a better understanding of the biochemistry, regulation, and physiologic role of these enzymes is the focus of this review... - Activity and response to serum of the mammalian thyroid hormone deiodinase 3 gene promoter: identification of a conserved enhancerArturo Hernandez
Departments of Medicine and Physiology, Dartmouth Medical School, Lebanon, NH 03756, USA
Mol Cell Endocrinol 206:23-32. 2003..The cell-specific serum response of the Dio3 promoter and the identified enhancer may play critical roles in the regulation of gene expression at this imprinted locus... - Complex organization and structure of sense and antisense transcripts expressed from the DIO3 gene imprinted locusArturo Hernandez
Department of Medicine, Dartmouth Medical School, Lebanon, NH 03756, USA
Genomics 83:413-24. 2004..These results suggest that the DIO3 gene may lie within the structure of the antisense gene, a complex arrangement often observed in imprinted loci... - Type 3 deiodinase deficiency causes spatial and temporal alterations in brain T3 signaling that are dissociated from serum thyroid hormone levelsArturo Hernandez
Department of Medicine, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
Endocrinology 151:5550-8. 2010.... - Type 3 deiodinase deficiency results in functional abnormalities at multiple levels of the thyroid axisArturo Hernandez
Dartmouth Medical School, Lebanon, NH 03756, USA
Endocrinology 148:5680-7. 2007..In conclusion, the absence of D3 activity results in impaired clearance of T(3) and significant defects in the mechanisms regulating the thyroid axis at all levels: hypothalamus, pituitary, and thyroid... - Gene expression from the imprinted Dio3 locus is associated with cell proliferation of cultured brown adipocytesArturo Hernandez
Department of Medicine, Dartmouth Medical School, Borwell Building, Room 720W, Lebanon, New Hampshire 03755, USA
Endocrinology 148:3968-76. 2007..Our results suggest that genomic imprinting and gene expression at the Dlk1/Dio3 imprinted domain may play a role in the regulation of adipocyte proliferation and differentiation... - The gene locus encoding iodothyronine deiodinase type 3 (Dio3) is imprinted in the fetus and expresses antisense transcriptsArturo Hernandez
Department of Medicine, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
Endocrinology 143:4483-6. 2002.... - Thyroid hormone receptor ? and regulation of type 3 deiodinaseOlga Barca-Mayo
Department of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
Mol Endocrinol 25:575-83. 2011..We conclude that the absence of TR? results in decreased clearance of TH by D3 and contributes to the TH hypersensitivity... - Distinct roles of deiodinases on the phenotype of Mct8 defect: a comparison of eight different mouse genotypesXiao Hui Liao
Department of Medicine, The University of Chicago, MC3090, 5841 South Maryland Avenue, Chicago, Illinois 60637, USA
Endocrinology 152:1180-91. 2011.... - Structure and function of the type 3 deiodinase geneArturo Hernandez
Department of Medicine, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
Thyroid 15:865-74. 2005..Knowledge of these details will be important for understanding the physiologic function of an enzyme that appears to be critical for normal mammalian development... - Minireview: Defining the roles of the iodothyronine deiodinases: current concepts and challengesDonald L St Germain
Department of Medicine, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
Endocrinology 150:1097-107. 2009..This review will briefly assess these functional roles and others proposed for the deiodinases and examine some of the current challenges in expanding our knowledge of these important components of the thyroid homeostatic system... - Dexamethasone inhibits growth factor-induced type 3 deiodinase activity and mRNA expression in a cultured cell line derived from rat neonatal brown fat vascular-stromal cellsArturo Hernandez
Department of Medicine, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
Endocrinology 143:2652-8. 2002..In summary, we have established BVS-1 cells as a continuous cell line useful for studying the regulation of D3 expression. Furthermore, we have shown that DEX inhibits growth factor-induced D3 expression in these cells... - Insights into the role of deiodinases from studies of genetically modified animalsDonald L St Germain
Department of Medicine and Physiology, Dartmouth Medical School Lebanon, New Hampshire 03755, USA Donald
Thyroid 15:905-16. 2005..This review focuses on the progress being made in using these animal models to define the physiologic functions and significance of this important class of enzymes... - Coordinated diurnal regulation of genes from the Dlk1-Dio3 imprinted domain: implications for regulation of clusters of non-paralogous genesStephane Labialle
Department of Obstetrics and Gynecology, McGill University, Montreal, QC, Canada
Hum Mol Genet 17:15-26. 2008....