Research Topics
| James D GorhamSummaryAffiliation: Dartmouth Medical School Country: USA Publications
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Publications
Transforming growth factor-beta1, Th1 responses, and autoimmune liver diseaseJames D Gorham
Department of Pathology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
Transfusion 45:51S-59S. 2005..In this review, I summarize findings published or in press from our laboratory on disease pathogenesis in TGF-beta1-/- mice and then discuss some of the exciting (as-yet-unpublished) directions our laboratory is currently taking...- End-organ damage in a mouse model of fulminant liver inflammation requires CD4+ T cell production of IFN-gamma but is independent of FasRichard T Robinson
Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, NH 03756, USA
J Immunol 182:3278-84. 2009.... - TGF-beta 1 regulates antigen-specific CD4+ T cell responses in the peripheryRichard T Robinson
Department of Pathology, Dartmouth Medical School, One Medical Center Drive, Lebanon, NH 03756, USA
J Immunol 179:71-9. 2007..These results indicate that CD4+ T cells in TGF-beta1(-/-) mice are activated by and respond to self-Ags present in the periphery, and define a key role for TGF-beta1 in the peripheral regulation of Ag-specific CD4+ T cell responses... - TGF-beta1 inhibits T-bet induction by IFN-gamma in murine CD4+ T cells through the protein tyrosine phosphatase Src homology region 2 domain-containing phosphatase-1Il Kyoo Park
Department of Pathology, Dartmouth Medical School, Lebanon, NH 03756, USA
J Immunol 175:5666-74. 2005..Together, these data show that TGF-beta1 suppresses IFN-gamma signaling and transcriptional responses in CD4+ T cells through the PTP Shp-1... - TGF-beta 1 inhibition of IFN-gamma-induced signaling and Th1 gene expression in CD4+ T cells is Smad3 independent but MAP kinase dependentIl Kyoo Park
Department of Pathology, Dartmouth Medical School, One Medical Center Drive, Lebanon, NH 03756, USA
Mol Immunol 44:3283-90. 2007..Thus, TGF-beta1's inhibition of IFN-gamma signaling in T cells is mediated through a highly specific Smad3 independent, MEK/ERK-dependent signaling pathway... - TGF-beta 1 uses distinct mechanisms to inhibit IFN-gamma expression in CD4+ T cells at priming and at recall: differential involvement of Stat4 and T-betJack T Lin
Department of Microbiology and Immunology and the Norris Cotton Cancer Center, Dartmouth Medical School, Lebanon, NH 03756, USA
J Immunol 174:5950-8. 2005..These data show that TGF-beta1 uses distinct mechanisms to inhibit IFN-gamma expression in CD4(+) T cells at priming and at recall... - Restriction of the CD4+ T-cell receptor repertoire prevents immune pathology in TGF-beta1 knockout miceRichard T Robinson
Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, NH 03756, USA
Lab Invest 86:815-28. 2006..Rather, T-cell activation and pathology in TGF-beta1-/- mice appear to be functions of typical TCR activation pathways. This supports the hypothesis that immune pathology in TGF-beta1-/- mice is self-antigen triggered... - Type 1 T helper cells induce the accumulation of myeloid-derived suppressor cells in the inflamed Tgfb1 knockout mouse liverJames G Cripps
Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, NH 03756, USA
Hepatology 52:1350-9. 2010..We propose that MDSCs serve an important negative feedback function in liver immune homeostasis, and that insufficient or inappropriate activity of this cell population may contribute to inflammatory liver pathology... - MHC-independent genetic regulation of liver damage in a mouse model of autoimmune hepatocellular injuryJack T Lin
Department of Microbiology and Immunology, The Norris Cotton Cancer Center, Dartmouth Medical School, Lebanon, NH 03756, USA
Lab Invest 85:550-61. 2005..This constitutes the first direct evidence that susceptibility to autoimmune hepatocellular damage, at least in mice, can be determined by genetic loci distinct from the MHC... - The role of Ifng in alterations in liver gene expression in a mouse model of fulminant autoimmune hepatitisMichael W Milks
Department of Pathology, Dartmouth Medical School, Dartmouth Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH 03756, USA
Liver Int 29:1307-15. 2009..These results provide a clearer understanding of the role of Ifng in the molecular basis of necroinflammatory liver disease... - MDSC in autoimmunityJames G Cripps
Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, NH 03756, USA
Int Immunopharmacol 11:789-93. 2011..A logical corollary of this hypothesis is that a failure of endogenous MDSC to appropriately control autoimmune T cell responses in vivo may actually contribute to the pathogenesis of autoimmune disease... - Enhanced efficacy and reduced toxicity of multifactorial adjuvants compared with unitary adjuvants as cancer vaccinesCory L Ahonen
Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, NH 03756, USA
Blood 111:3116-25. 2008..These findings provide intelligent strategies for the formulation of multifactorial vaccines to achieve maximal efficacy in cancer vaccine trials in humans... - Necroinflammatory liver disease in BALB/c background, TGF-beta 1-deficient mice requires CD4+ T cellsLynnie A Rudner
Department of Pathology, Dartmouth Medical School, Lebanon, NH 03756, USA
J Immunol 170:4785-92. 2003..Furthermore, TGF-beta1 has a critical role in homeostatic regulation of the hepatic immune system, inhibiting the development or expansion of hepatic cytolytic CD4(+) T cells... - CD28 co-stimulation regulates the effect of transforming growth factor-beta1 on the proliferation of naïve CD4+ T cellsJames L Sung
Department of Pathology, Dartmouth Medical School, One Medical Center Drive, Lebanon, NH 03756, USA
Int Immunopharmacol 3:233-45. 2003.... - The effects of additive solution pH and metabolic rejuvenation on anaerobic storage of red cellsTatsuro Yoshida
Biomedical Engineering Department, Boston University College of Engineering, Boston, Massachusetts 02215, USA
Transfusion 48:2096-105. 2008..Our objective was to determine whether anaerobic storage with acidified additive solution (AS) coupled with metabolic rejuvenation might further improve the benefits of anaerobic storage...