Barney E Dwyer

Summary

Affiliation: Dartmouth Medical School
Country: USA

Publications

  1. ncbi Homocysteine and Alzheimer's disease: a modifiable risk?
    Barney E Dwyer
    Research Service, VA Medical and Regional Office Center, White River Junction, VT 05009 0001, USA
    Free Radic Biol Med 36:1471-5. 2004
  2. ncbi Ferric cycle activity and Alzheimer disease
    Barney E Dwyer
    Research Service, VA Medical and Regional Office Center, White River Junction, Vermont 05009, USA
    Curr Neurovasc Res 2:261-7. 2005
  3. ncbi Getting the iron out: phlebotomy for Alzheimer's disease?
    Barney E Dwyer
    Research Service, Department of Veterans Affairs Medical Center, White River Junction, VT 05009 0001, United States
    Med Hypotheses 72:504-9. 2009
  4. ncbi Down-regulation of aminolevulinate synthase, the rate-limiting enzyme for heme biosynthesis in Alzheimer's disease
    Barney E Dwyer
    Research Service, Department of Veterans Affairs Medical Center, White River Junction, VT 05009 0001, USA
    Neurosci Lett 460:180-4. 2009
  5. ncbi Heme-a, the heme prosthetic group of cytochrome c oxidase, is increased in Alzheimer's disease
    Barney E Dwyer
    Research Service, VA Medical Center, White River Junction, VT 05009 0001, USA
    Neurosci Lett 461:302-5. 2009
  6. ncbi Effect of insulin and glucagon on accumulation of uroporphyrin and coproporphyrin from 5-aminolevulinate in hepatocyte cultures
    Heidi W Trask
    VA Medical Center, White River Junction, VT 05009, USA
    Arch Biochem Biophys 439:1-11. 2005
  7. ncbi Hematoma removal, heme, and heme oxygenase following hemorrhagic stroke
    Kenneth R Wagner
    Medical Research Service, Department of Veterans Affairs Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45220, USA
    Ann N Y Acad Sci 1012:237-51. 2004
  8. ncbi Heme catabolism and heme oxygenase in neurodegenerative disease
    Atsushi Takeda
    Department of Neurology, Tohoku University School of Medicine, Sendai 980 8574, Japan
    Antioxid Redox Signal 6:888-94. 2004

Collaborators

Detail Information

Publications8

  1. ncbi Homocysteine and Alzheimer's disease: a modifiable risk?
    Barney E Dwyer
    Research Service, VA Medical and Regional Office Center, White River Junction, VT 05009 0001, USA
    Free Radic Biol Med 36:1471-5. 2004
    ..We propose homocysteine is involved in an iron dysregulation/oxidative stress cycle that has a central role in the pathogenesis of AD. The implications of the hypothesis and some strategies for testing it are discussed...
  2. ncbi Ferric cycle activity and Alzheimer disease
    Barney E Dwyer
    Research Service, VA Medical and Regional Office Center, White River Junction, Vermont 05009, USA
    Curr Neurovasc Res 2:261-7. 2005
    ....
  3. ncbi Getting the iron out: phlebotomy for Alzheimer's disease?
    Barney E Dwyer
    Research Service, Department of Veterans Affairs Medical Center, White River Junction, VT 05009 0001, United States
    Med Hypotheses 72:504-9. 2009
    ..Testing this hypothesis could provide valuable insight into the causation of AD and suggest novel preventive and treatment strategies...
  4. ncbi Down-regulation of aminolevulinate synthase, the rate-limiting enzyme for heme biosynthesis in Alzheimer's disease
    Barney E Dwyer
    Research Service, Department of Veterans Affairs Medical Center, White River Junction, VT 05009 0001, USA
    Neurosci Lett 460:180-4. 2009
    ..Taken together, our results suggest regulation of cerebral heme biosynthesis is profoundly altered in AD and may contribute toward disease pathogenesis by affecting cell metabolism as well as iron homeostasis...
  5. ncbi Heme-a, the heme prosthetic group of cytochrome c oxidase, is increased in Alzheimer's disease
    Barney E Dwyer
    Research Service, VA Medical Center, White River Junction, VT 05009 0001, USA
    Neurosci Lett 461:302-5. 2009
    ..These animal studies suggest that increased levels of cerebral heme-a in AD were not due to blood in postmortem brain or variation in postmortem interval...
  6. ncbi Effect of insulin and glucagon on accumulation of uroporphyrin and coproporphyrin from 5-aminolevulinate in hepatocyte cultures
    Heidi W Trask
    VA Medical Center, White River Junction, VT 05009, USA
    Arch Biochem Biophys 439:1-11. 2005
    ..Apparently, this increased flux could particularly affect the utilization of the intermediate hydroxymethylbilane, which would result in accumulation of uroporphyrin I...
  7. ncbi Hematoma removal, heme, and heme oxygenase following hemorrhagic stroke
    Kenneth R Wagner
    Medical Research Service, Department of Veterans Affairs Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45220, USA
    Ann N Y Acad Sci 1012:237-51. 2004
    ..Last, new data are presented that support the concept that heme, although primarily a pro-oxidant, can also have antioxidant properties...
  8. ncbi Heme catabolism and heme oxygenase in neurodegenerative disease
    Atsushi Takeda
    Department of Neurology, Tohoku University School of Medicine, Sendai 980 8574, Japan
    Antioxid Redox Signal 6:888-94. 2004
    ..This places heme oxygenase at the center of disease pathogenesis and offers a novel therapeutic approach targeted at either the causes or consequences of enzyme induction...