Seth A Brooks

Summary

Affiliation: Dartmouth Medical School
Country: USA

Publications

  1. ncbi The role of mRNA turnover in the regulation of tristetraprolin expression: evidence for an extracellular signal-regulated kinase-specific, AU-rich element-dependent, autoregulatory pathway
    Seth A Brooks
    Department of Medicine, Dartmouth Medical School, Lebanon, NH 03756, USA
    J Immunol 172:7263-71. 2004
  2. ncbi Functional interactions between mRNA turnover and surveillance and the ubiquitin proteasome system
    Seth A Brooks
    Veterans Administration Medical Center Research, White River Junction, VT 05009, USA
    Wiley Interdiscip Rev RNA 1:240-52. 2010
  3. ncbi Tristetraprolin regulates TNF TNF-alpha mRNA stability via a proteasome dependent mechanism involving the combined action of the ERK and p38 pathways
    Kristen M Deleault
    Department of Medicine, Dartmouth Medical School, 1 Medical Center Dr, Lebanon, NH 03756, USA
    Mol Immunol 45:13-24. 2008
  4. ncbi Structure/function analysis of tristetraprolin (TTP): p38 stress-activated protein kinase and lipopolysaccharide stimulation do not alter TTP function
    William F C Rigby
    Department of Medicine, Dartmouth College, Lebanon, NH 03756, USA
    J Immunol 174:7883-93. 2005
  5. ncbi Extracellular signal-regulated kinase regulation of tumor necrosis factor-alpha mRNA nucleocytoplasmic transport requires TAP-NxT1 binding and the AU-rich element
    Stephen J Skinner
    Veterans Affairs Medical Center, White River Junction, Vermont 05009, USA
    J Biol Chem 283:3191-9. 2008
  6. ncbi Analysis of the function, expression, and subcellular distribution of human tristetraprolin
    Seth A Brooks
    Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire, USA
    Arthritis Rheum 46:1362-70. 2002
  7. ncbi CARHSP1 is required for effective tumor necrosis factor alpha mRNA stabilization and localizes to processing bodies and exosomes
    Jason R Pfeiffer
    VA Medical Center, Research 151, 215 North Main St, White River Junction, VT 05009, USA
    Mol Cell Biol 31:277-86. 2011
  8. ncbi Cullin 4B is recruited to tristetraprolin-containing messenger ribonucleoproteins and regulates TNF-? mRNA polysome loading
    Jason R Pfeiffer
    Veterans Administration Medical Center, White River Junction, VT 05009, USA
    J Immunol 188:1828-39. 2012
  9. ncbi Identification of TTP mRNA targets in human dendritic cells reveals TTP as a critical regulator of dendritic cell maturation
    Jillian Emmons
    Department of Microbiology and Immunology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    RNA 14:888-902. 2008
  10. ncbi A flexible approach to studying post-transcriptional gene regulation in stably transfected mammalian cells
    Ralph C Nichols
    Veterans Administration Research Service, Veterans Affairs Medical Center, Mailstop 151, 215 North Main Street, White River Junction, VT 05009 0001, USA
    Mol Biotechnol 48:210-7. 2011

Collaborators

  • William F C Rigby
  • Donald B Bloch
  • Kristen M Deleault
  • Jason R Pfeiffer
  • Stephen J Skinner
  • Ralph C Nichols
  • Jillian Emmons
  • Jane E Collins
  • Victoria Uribe
  • Xiao Wei Wang
  • John Botson
  • Bethany L McAvoy
  • Ryan E Fecteau
  • B JoNell Hamilton
  • Moe Zan
  • Michael L Whitfield
  • Robert H Gross
  • Ryan Fecteau
  • W H Davin Townley-Tilson

Detail Information

Publications10

  1. ncbi The role of mRNA turnover in the regulation of tristetraprolin expression: evidence for an extracellular signal-regulated kinase-specific, AU-rich element-dependent, autoregulatory pathway
    Seth A Brooks
    Department of Medicine, Dartmouth Medical School, Lebanon, NH 03756, USA
    J Immunol 172:7263-71. 2004
    ..In this manner, TTP is able to limit the production of its own proteins as well as that of TNF-alpha and thus limit the response of the cell to LPS...
  2. ncbi Functional interactions between mRNA turnover and surveillance and the ubiquitin proteasome system
    Seth A Brooks
    Veterans Administration Medical Center Research, White River Junction, VT 05009, USA
    Wiley Interdiscip Rev RNA 1:240-52. 2010
    ..How these events interact with the 5'-to-3' and 3'-to-5' decay pathways is unclear at this time; however, data is provided indicating that proteasomes colocalize with Xrn1 and the exosome RNases Rrp44 and Rrp6 in untreated HeLa cells...
  3. ncbi Tristetraprolin regulates TNF TNF-alpha mRNA stability via a proteasome dependent mechanism involving the combined action of the ERK and p38 pathways
    Kristen M Deleault
    Department of Medicine, Dartmouth Medical School, 1 Medical Center Dr, Lebanon, NH 03756, USA
    Mol Immunol 45:13-24. 2008
    ..Together these data indicate that the proteasome is a critical control point for TTP mediated TNF-alpha mRNA decay and activation of both ERK and p38 is required to inhibit TTP function and stabilize TNF-alpha mRNA...
  4. ncbi Structure/function analysis of tristetraprolin (TTP): p38 stress-activated protein kinase and lipopolysaccharide stimulation do not alter TTP function
    William F C Rigby
    Department of Medicine, Dartmouth College, Lebanon, NH 03756, USA
    J Immunol 174:7883-93. 2005
    ..Moreover, the interaction of TTP with 14-3-3, which may limit entry into the stress granule, is not involved in the downstream message stabilization events...
  5. ncbi Extracellular signal-regulated kinase regulation of tumor necrosis factor-alpha mRNA nucleocytoplasmic transport requires TAP-NxT1 binding and the AU-rich element
    Stephen J Skinner
    Veterans Affairs Medical Center, White River Junction, Vermont 05009, USA
    J Biol Chem 283:3191-9. 2008
    ..It is unclear at this time if ARE-binding protein(s) directly interact with the TAP-NxT1 complex, if each complex is independently targeted by ERK1, or if only one complex is targeted...
  6. ncbi Analysis of the function, expression, and subcellular distribution of human tristetraprolin
    Seth A Brooks
    Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire, USA
    Arthritis Rheum 46:1362-70. 2002
    ..We also generated a specific polyclonal antibody against hTTP that enabled the examination of the subcellular distribution of hTTP and its RNA binding in vivo...
  7. ncbi CARHSP1 is required for effective tumor necrosis factor alpha mRNA stabilization and localizes to processing bodies and exosomes
    Jason R Pfeiffer
    VA Medical Center, Research 151, 215 North Main St, White River Junction, VT 05009, USA
    Mol Cell Biol 31:277-86. 2011
    ..We conclude CARHSP1 is a TNF-? mRNA stability enhancer required for effective TNF-? production, demonstrating the importance of both stabilization and destabilization pathways in regulating the TNF-? mRNA half-life...
  8. ncbi Cullin 4B is recruited to tristetraprolin-containing messenger ribonucleoproteins and regulates TNF-? mRNA polysome loading
    Jason R Pfeiffer
    Veterans Administration Medical Center, White River Junction, VT 05009, USA
    J Immunol 188:1828-39. 2012
    ..We conclude that Cul4B licenses the TTP-containing TNF-? messenger ribonucleoprotein for loading onto polysomes, and reduction of Cul4B expression shunts the messenger ribonucleoproteins into the degradative pathway...
  9. ncbi Identification of TTP mRNA targets in human dendritic cells reveals TTP as a critical regulator of dendritic cell maturation
    Jillian Emmons
    Department of Microbiology and Immunology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    RNA 14:888-902. 2008
    ..The data implicate TTP as having a broader role in regulating and limiting the immune response than previously suspected...
  10. ncbi A flexible approach to studying post-transcriptional gene regulation in stably transfected mammalian cells
    Ralph C Nichols
    Veterans Administration Research Service, Veterans Affairs Medical Center, Mailstop 151, 215 North Main Street, White River Junction, VT 05009 0001, USA
    Mol Biotechnol 48:210-7. 2011
    ....