T A Ahles

Summary

Affiliation: Dartmouth Medical School
Country: USA

Publications

  1. ncbi Psychologic and neuropsychologic functioning of patients with limited small-cell lung cancer treated with chemotherapy and radiation therapy with or without warfarin: a study by the Cancer and Leukemia Group B
    T A Ahles
    Dartmouth Hitchcock Medical Center and the Norris Cotton Cancer Center, Lebanon, NH 03756, USA
    J Clin Oncol 16:1954-60. 1998
  2. ncbi Quality of life of long-term survivors of breast cancer and lymphoma treated with standard-dose chemotherapy or local therapy
    Tim A Ahles
    Department of Psychiatry and Center for Psycho Oncology Research, Dartmouth Hitchcock Medical Center, One Medical Center Dr, Lebanon, NH 03756, USA
    J Clin Oncol 23:4399-405. 2005
  3. ncbi Breast cancer chemotherapy-related cognitive dysfunction
    Tim A Ahles
    1Department of Psychiatry and Center for Psycho Oncology Research, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Clin Breast Cancer 3:S84-90. 2002
  4. ncbi Quality of life impact of three different doses of suramin in patients with metastatic hormone-refractory prostate carcinoma: results of Intergroup O159/Cancer and Leukemia Group B 9480
    Tim A Ahles
    Norris Cotton Cancer Center, Department of Psychiatry, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
    Cancer 101:2202-8. 2004
  5. ncbi Neuropsychologic impact of standard-dose systemic chemotherapy in long-term survivors of breast cancer and lymphoma
    Tim A Ahles
    Department of Psychiatry and Center for Psycho Oncology Research, New Hampshire Hospital, Concord, NH, USA
    J Clin Oncol 20:485-93. 2002
  6. ncbi The relationship of APOE genotype to neuropsychological performance in long-term cancer survivors treated with standard dose chemotherapy
    Tim A Ahles
    Department of Psychiatry and Center for Psycho Oncology Research, USA
    Psychooncology 12:612-9. 2003
  7. ncbi Dyspnea, anxiety, body consciousness, and quality of life in patients with lung cancer
    E L Smith
    Comprehensive Thoracic Oncology Program, Norris Cotton Cancer Center, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756, USA
    J Pain Symptom Manage 21:323-9. 2001
  8. ncbi Private body consciousness, anxiety and pain symptom reports of chronic pain patients
    R J Ferguson
    Department of Psychiatry, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Behav Res Ther 36:527-35. 1998
  9. ncbi Cognitive effects of standard-dose chemotherapy in patients with cancer
    T A Ahles
    Department of Psychiatry and Center for Psycho-Oncology Research, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
    Cancer Invest 19:812-20. 2001
  10. ncbi Prevalence of mood disorders and utility of the PRIME-MD in patients undergoing radiation therapy
    K A Leopold
    Section of Radiation Oncology, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Int J Radiat Oncol Biol Phys 42:1105-12. 1998

Research Grants

  1. Genetics of Cognitive Decline Post Cancer Chemotherapy
    Tim Ahles; Fiscal Year: 2006

Detail Information

Publications31

  1. ncbi Psychologic and neuropsychologic functioning of patients with limited small-cell lung cancer treated with chemotherapy and radiation therapy with or without warfarin: a study by the Cancer and Leukemia Group B
    T A Ahles
    Dartmouth Hitchcock Medical Center and the Norris Cotton Cancer Center, Lebanon, NH 03756, USA
    J Clin Oncol 16:1954-60. 1998
    ....
  2. ncbi Quality of life of long-term survivors of breast cancer and lymphoma treated with standard-dose chemotherapy or local therapy
    Tim A Ahles
    Department of Psychiatry and Center for Psycho Oncology Research, Dartmouth Hitchcock Medical Center, One Medical Center Dr, Lebanon, NH 03756, USA
    J Clin Oncol 23:4399-405. 2005
    ..This study compared the quality of life (QOL) of long-term survivors of breast cancer and lymphoma who had been treated with standard-dose systemic chemotherapy or local therapy only...
  3. ncbi Breast cancer chemotherapy-related cognitive dysfunction
    Tim A Ahles
    1Department of Psychiatry and Center for Psycho Oncology Research, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Clin Breast Cancer 3:S84-90. 2002
    ..techniques and the development of animal models to study the mechanisms of chemotherapy-induced changes in cognitive functioning, and the development of interventions to prevent or reduce the negative cognitive effects of chemotherapy..
  4. ncbi Quality of life impact of three different doses of suramin in patients with metastatic hormone-refractory prostate carcinoma: results of Intergroup O159/Cancer and Leukemia Group B 9480
    Tim A Ahles
    Norris Cotton Cancer Center, Department of Psychiatry, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
    Cancer 101:2202-8. 2004
    ..The primary purpose of the current study was to evaluate whether there was evidence of palliative effects associated with suramin at any of the three doses administered in the original clinical trial...
  5. ncbi Neuropsychologic impact of standard-dose systemic chemotherapy in long-term survivors of breast cancer and lymphoma
    Tim A Ahles
    Department of Psychiatry and Center for Psycho Oncology Research, New Hampshire Hospital, Concord, NH, USA
    J Clin Oncol 20:485-93. 2002
    ..The primary purpose of this study was to compare the neuropsychologic functioning of long-term survivors of breast cancer and lymphoma who had been treated with standard-dose systemic chemotherapy or local therapy only...
  6. ncbi The relationship of APOE genotype to neuropsychological performance in long-term cancer survivors treated with standard dose chemotherapy
    Tim A Ahles
    Department of Psychiatry and Center for Psycho Oncology Research, USA
    Psychooncology 12:612-9. 2003
    ....
  7. ncbi Dyspnea, anxiety, body consciousness, and quality of life in patients with lung cancer
    E L Smith
    Comprehensive Thoracic Oncology Program, Norris Cotton Cancer Center, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756, USA
    J Pain Symptom Manage 21:323-9. 2001
    ..02, P = 0.03). Dyspnea was more severe in patients taking opioid analgesics when compared to non-opioids or no pain medications (P = 0.03). No significant association was found between dyspnea, anxiety, and private body consciousness...
  8. ncbi Private body consciousness, anxiety and pain symptom reports of chronic pain patients
    R J Ferguson
    Department of Psychiatry, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Behav Res Ther 36:527-35. 1998
    ..Implications for the importance of attentional self-focus in pain symptom reporting are discussed...
  9. ncbi Cognitive effects of standard-dose chemotherapy in patients with cancer
    T A Ahles
    Department of Psychiatry and Center for Psycho-Oncology Research, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
    Cancer Invest 19:812-20. 2001
    ....
  10. ncbi Prevalence of mood disorders and utility of the PRIME-MD in patients undergoing radiation therapy
    K A Leopold
    Section of Radiation Oncology, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Int J Radiat Oncol Biol Phys 42:1105-12. 1998
    ....
  11. ncbi Panel-based pain management in primary care. a pilot study
    T A Ahles
    Department of Psychiatry, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756, USA
    J Pain Symptom Manage 22:584-90. 2001
    ..Feasibility and acceptability of the approach were demonstrated; however, the conclusions based on analyses of the post-treatment outcomes were tempered by baseline imbalances across groups...
  12. ncbi Palliative care program effectiveness research: developing rigor in sampling design, conduct, and reporting
    Marie A Bakitas
    Norris Cotton Cancer Center, Lebanon, New Hampshire 03756, and Yale University, New Haven, Connecticut, USA
    J Pain Symptom Manage 31:270-84. 2006
    ....
  13. ncbi Distress, psychiatric syndromes, and impairment of function in women with newly diagnosed breast cancer
    Mark T Hegel
    Department of Psychiatry, Dartmouth Medical School, Hanover, New Hampshire, USA
    Cancer 107:2924-31. 2006
    ..Emotional distress and psychiatric syndromes are prevalent in the breast cancer population at large. However, to date there is a paucity of literature specifically concerning presurgical breast cancer patients...
  14. ncbi Cognitive-behavioral management of chemotherapy-related cognitive change
    Robert J Ferguson
    Department of Rehabilitation Medicine, Eastern Maine Medical Center, Bangor, ME 04401, USA
    Psychooncology 16:772-7. 2007
    ..Given these results, the treatment appears to be a feasible and practical cognitive-behavioral program that warrants continued evaluation among cancer survivors who experience persistent cognitive dysfunction...
  15. ncbi Candidate mechanisms for chemotherapy-induced cognitive changes
    Tim A Ahles
    Department of Psychiatry and Behavioural Sciences, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Nat Rev Cancer 7:192-201. 2007
    ....
  16. ncbi Brain structure and function differences in monozygotic twins: possible effects of breast cancer chemotherapy
    Robert J Ferguson
    Department of Rehabilitation Medicine, Eastern Maine Medical Center, Bangor, ME 04401, USA
    J Clin Oncol 25:3866-70. 2007
    ..Late cognitive effects after chemotherapy can have a deleterious impact on survivor quality of life and functional health; however, the etiology of chemotherapy-related cognitive dysfunction remains unknown...
  17. ncbi Sensitivity and specificity of the Distress Thermometer for depression in newly diagnosed breast cancer patients
    Mark T Hegel
    Department of Psychiatry, Dartmouth Hitchcock MedicalCenter, Lebanon, NH 03756, USA
    Psychooncology 17:556-60. 2008
    ..This study evaluated the receiver operating characteristics (ROC) of the single-item Distress Thermometer (DT) for detecting depression in women newly diagnosed with Stage I-III breast cancer...
  18. ncbi Proxy perspectives regarding end-of-life care for persons with cancer
    Marie Bakitas
    School of Nursing, Yale University, New Haven, Connecticut, USA
    Cancer 112:1854-61. 2008
    ..Family proxies have been proposed as valuable informants regarding the quality of end-of-life care. This article describes family proxy perspectives concerning care at the end of life in patients who died of advanced cancer...
  19. ncbi Effect of dose-intensive chemotherapy on quality of life
    Tim A Ahles
    Lancet Oncol 6:258-9. 2005
  20. ncbi Partner-guided cancer pain management at the end of life: a preliminary study
    Francis J Keefe
    Duke University Medical Center, Durham, North Carolina 27710, USA
    J Pain Symptom Manage 29:263-72. 2005
    ..Given the significance of pain at the end of life, future research in this area appears warranted...
  21. ncbi Expressive disclosure and health outcomes in a prostate cancer population
    Harriet J Rosenberg
    Dartmouth Medical School, Lebanon, New Hampshire, USA
    Int J Psychiatry Med 32:37-53. 2002
    ....
  22. ncbi Low neuropsychologic performance among adult cancer survivors treated with chemotherapy
    Robert J Ferguson
    Department of Psychiatry and Center for Psycho Oncology Research, Dartmouth Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH 03756, USA
    Curr Neurol Neurosci Rep 3:215-22. 2003
    ..Future research directions, with emphasis on longitudinal research design as well as treatment implications, are discussed...
  23. ncbi Cognitive adverse effects of chemotherapy in breast cancer patients
    Denise D Correa
    Department of Neurology, Memorial Sloan Kettering Cancer Center, New York 10022, USA
    Curr Opin Support Palliat Care 1:57-62. 2007
    ..This article reviews the most recent literature on chemotherapy-associated cognitive changes in women with breast cancer...
  24. ncbi The self-efficacy of family caregivers for helping cancer patients manage pain at end-of-life
    Francis J Keefe
    Pain Prevention and Treatment Research, Box 3159, Duke University Medical Center, Durham, NC 27710, USA
    Pain 103:157-62. 2003
    ..Considered overall, the results of this study suggest that caregiver self-efficacy in pain management is important in understanding how caregivers adjust to the demands of caring for cancer patients who have pain at the end of life...
  25. ncbi Mechanisms of chemotherapy-induced cognitive disorders: neuropsychological, pathophysiological, and neuroimaging perspectives
    Andrew J Saykin
    Brain Imaging Laboratory, Dartmouth Medical School, Lebanon, NH 03756, USA
    Semin Clin Neuropsychiatry 8:201-16. 2003
    ..Large-scale prospective studies are needed to help isolate the pathophysiological mechanisms underlying the cognitive deficits associated with chemotherapy...
  26. ncbi Do systemic cancer treatments affect cognitive function?
    Tim A Ahles
    Lancet Oncol 5:270-1. 2004
  27. ncbi Cognitive impairment associated with chemotherapy for cancer: report of a workshop
    Ian F Tannock
    Department of Medical Oncology and Hematology, Princess Margaret Hospital, 610 University Ave, Toronto, ON M5G 2M9, Canada
    J Clin Oncol 22:2233-9. 2004
    ....
  28. ncbi Cognitive effects of cytotoxic cancer chemotherapy: predisposing risk factors and potential treatments
    Thomas W McAllister
    Department of Psychiatry, Dartmouth Medical School and Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Curr Psychiatry Rep 6:364-71. 2004
    ..Emerging theories about the role of selected genetic polymorphisms in heightening the vulnerability to chemotherapy-induced cognitive decline will be described...
  29. ncbi Cognitive function in breast cancer patients prior to adjuvant treatment
    Tim A Ahles
    Department of Psychiatry and Center for Psycho Oncology, The Norris Cotton Cancer Center, Dartmouth Hitchcock Medical Center Lebanon, Lebanon, NH, USA
    Breast Cancer Res Treat 110:143-52. 2008
    ..To compare the neuropsychological functioning of breast cancer patients with invasive cancer and noninvasive cancer prior to adjuvant treatment...
  30. ncbi Ongoing distress from emotional trauma is related to pain, mood, and physical function in a primary care population
    Janette L Seville
    Department of Psychiatry, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756, USA
    J Pain Symptom Manage 25:256-63. 2003
    ..However, the report that one continued to be bothered by thoughts of a trauma was associated with greater impairments in functioning...
  31. ncbi Cancer chemotherapy impairs contextual but not cue-specific fear memory
    Jill E MacLeod
    Department of Psychological and Brain Sciences, Dartmouth College, Hanover, NH 03755, United States
    Behav Brain Res 181:168-72. 2007
    ..Together, these data indicate that administration of cyclophosphamide and doxorubicin may have toxic effects on the hippocampus and results in specific learning deficits shortly after treatment has ended...

Research Grants6

  1. Genetics of Cognitive Decline Post Cancer Chemotherapy
    Tim Ahles; Fiscal Year: 2006
    ....